Biography

Education: BSc in Biochemistry (National University of Ireland)PhD protein chemistry/enzymology (National University of Ireland) Employment history:
  • Research Fellow - Food Science Department, North Carolina State University, USA & at the Food Biotechnology Centre, University College, Cork.
  • Senior Research Officer - Chemistry Department, Teagasc, Moorepark.
  • Lecturer, Senior Lecturer and Associate Professor - Department of Life Sciences, University of Limerick.
  • Professor (personal chair) of Food Protein-Derived Bioactive Peptides - Department of Biological Sciences, University of Limerick
Research interests:
  • Food protein chemistry/biochemistry.
  • Food protein ingredients (extraction of proteins from different sources - animal, plant and marine proteins).
  • Generation and characterisation of enzymatic hydrolysates of food proteins using microbial, mammalian and plant derived food-grade proteinase and peptidase preparations.
  • Characterisation of the functional properties of food proteins and their enzymatic hydrolysates, e.g., solubility, heat stability, emulsification, foaming, turbidity, viscosity properties.
  • Bioactive peptides/nutraceuticals, i.e., enzymatic generation, characterisation and identification (LC-MS/MS) of bioactive peptides having blood pressure reducing, serum glucose regulation, antioxidant, immune-modulatory, mineral binding, etc, properties.
  • LC-MS/MS-based characterisation of the hydrolytic specificity of different enzyme activities on purified food protein substrates.
  • Enzymatic cross-linking (using transglutaminase) of food proteins and their hydrolysates.
  • Role of microbial and mammalian exopeptidases in food protein hydrolysate debittering.

Research Interests

Food protein ingredients,Functional food ingredients/nutraceuticals,Food protein chemistry/biochemistry,Enzymatic hydrolysis of food proteins, Enzymatic cross-linking of food proteins, Purification and characterisation of starter culture-derived aminopeptidases, Role of aminopeptidases in food protein hydrolysate debittering.

Peer Reviewed Journals

2020

Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity

Harnedy-Rothwell P.;McLaughlin C.;O'Keeffe M.;Le Gouic A.;Allsopp P.;McSorley E.;Sharkey S.;Whooley J.;McGovern B.;O'Harte F.;FitzGerald R. (2020) Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity. Food Research International

2019

Integration of high and low field H-1 NMR to analyse the effects of bovine dietary regime on milk metabolomics and protein-bound moisture characterisation of the resulting mozzarella cheeses during ripening

Boiani, M;Sundekilde, U;Bateman, LM;McCarthy, DG;Maguire, AR;Gulati, A;Guinee, TP;Fenelon, M;Hennessy, D;FitzGerald, RJ;Kelly, PM (2019) Integration of high and low field H-1 NMR to analyse the effects of bovine dietary regime on milk metabolomics and protein-bound moisture characterisation of the resulting mozzarella cheeses during ripening. OXFORD : ELSEVIER SCI LTD International Dairy Journal :155-164

2019

Boarfish (Capros aper) protein hydrolysate has potent insulinotropic and GLP-1 secretory activity in vitro and acute glucose lowering effects in mice

Parthsarathy, V;McLaughlin, CM;Harnedy, PA;Allsopp, PJ;Crowe, W;McSorley, EM;FitzGerald, RJ;O'Harte, FPM (2019) Boarfish (Capros aper) protein hydrolysate has potent insulinotropic and GLP-1 secretory activity in vitro and acute glucose lowering effects in mice. HOBOKEN : WILEY International Journal Of Food Science And Technology :271-281

2018

Fourier transform infrared spectral analysis in tandem with P-31 nuclear magnetic resonance spectroscopy elaborates detailed insights into phosphate partitioning during skimmed milk microfiltration and diafiltration

Boiani, M;FitzGerald, RJ;Kelly, PM (2018) Fourier transform infrared spectral analysis in tandem with P-31 nuclear magnetic resonance spectroscopy elaborates detailed insights into phosphate partitioning during skimmed milk microfiltration and diafiltration. NEW YORK : ELSEVIER SCIENCE INC Journal Of Dairy Science :10750-10758

2016

A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome-mediated inflammation and improving insulin signaling

Healy, NP,Kirwan, AM,McArdle, MA,Holohan, K,Nongonierma, AB,Keane, D,Kelly, S,Celkova, L,Lyons, CL,McGillicuddy, FC,Finucane, OM,Murray, BA,Kelly, PM,Brennan, L,FitzGerald, RJ,Roche, HM (2016) A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome-mediated inflammation and improving insulin signaling. Molecular nutrition & food research :2421-2432

2016

The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults

Allsopp, P,Crowe, W,Bahar, B,Harnedy, PA,Brown, ES,Taylor, SS,Smyth, TJ,Soler-Vila, A,Magee, PJ,Gill, CIR,Strain, CR,Hegan, V,Devaney, M,Wallace, JMW,Cherry, P,FitzGerald, RJ,Strain, JJ,O'Doherty, JV,McSorley, EM (2016) The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults. European journal of nutrition :1951-1962

2015

A study of the ability of bioactive extracts from brewers' spent grain to enhance the antioxidant and immunomodulatory potential of food formulations following in vitro digestion

McCarthy, AL,O'Callaghan, YC,Connolly, A,Piggott, CO,FitzGerald, RJ,O'Brien, NM (2015) A study of the ability of bioactive extracts from brewers' spent grain to enhance the antioxidant and immunomodulatory potential of food formulations following in vitro digestion. International Journal Of Food Sciences And Nutrition :230-235

2013

The hydroxycinnamic acid content of barley and brewers' spent grain (BSG) and the potential to incorporate phenolic extracts of BSG as antioxidants into fruit beverages

McCarthy, AL,O'Callaghan, YC,Neugart, S,Piggott, CO,Connolly, A,Jansen, MAK,Krumbein, A,Schreiner, M,FitzGerald, RJ,O'Brien, NM (2013) The hydroxycinnamic acid content of barley and brewers' spent grain (BSG) and the potential to incorporate phenolic extracts of BSG as antioxidants into fruit beverages. Food Chemistry :2567-2574

2005

Cheddar cheese cooking temperature induces differential lactococcal cell permeabilization and autolytic responses as detected by flow cytometry: implications for intracellular enzyme accessibility

Sheehan, A; O'Loughlin, C; O'Cuinn, G; FitzGerald, RJ; Wilkinson, MG (2005) Cheddar cheese cooking temperature induces differential lactococcal cell permeabilization and autolytic responses as detected by flow cytometry: implications for intracellular enzyme accessibility. Journal Of Applied Microbiology :1007-1018

2005

Cheddar cheese cooking temperature induces differential lactococcal cell permeabilization and autolytic responses as detected by flow cytometry: Implications for intracellular enzyme accessibility

Sheehan A.;O'Loughlin C.;O'Cuinn G.;FitzGerald R.;Wilkinson M. (2005) Cheddar cheese cooking temperature induces differential lactococcal cell permeabilization and autolytic responses as detected by flow cytometry: Implications for intracellular enzyme accessibility. Journal of applied microbiology :1007-1018

Books

This author has not written any publications of this type yet.

Book Chapters

2013

Antihypertensive peptides from marine origin.

Norris, R; Harnedy, PA; FitzGerald, RJ (2013) Antihypertensive peptides from marine origin.. Chichester, UK. : John Wiley & Sons Ltd. Bioactive Compounds from Marine Foods: Plant and Animal Sources :27-56

2006

ACE Inhibitory Peptides.

Meisel, H; Walsh, DJ; Murray, BA; FitzGerald, RJ (2006) ACE Inhibitory Peptides.. Nutraceutical proteins and peptides in health and disease :269-315

Edited Books

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Other Journals

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Conference Publications

2013

Proceedings of the Nutrition Society

McCarthy A.;O'Callaghan Y.;Piggott C.;FitzGerald R.;O'Brien N. (2013) Proceedings of the Nutrition Society. The Proceedings of the Nutrition Society :117-125

2004

Journal of Nutrition

FitzGerald R.;Murray B.;Walsh D. (2004) Journal of Nutrition. The Journal of nutrition

2001

EuroLab Conference

Sheehan, A., O¿Cuinn, G., FitzGerald, R.J and Wilkinson, M.G (2001) EuroLab Conference. :*-*

2001

NIZO LAB Conference

Sheehan,A., O¿ Quinn, G, FitzGerald, R.J, and Wilkinson, M.G (2001) NIZO LAB Conference. :*-*

2000

IDF Symposium

Bouchier, P.J., Kilcawley, K.N., O'Cuinn, G., Fitzgerald, R.P., Harrington, D. and Wilkinson, M.G. (2000) IDF Symposium. :*-*

1999

Biochemical Society Transactions

O'Cuinn G., FitzGerald R., Bouchier P., McDonnell M. (1999) Biochemical Society Transactions. Biochemical Society Transactions :730-734

1999

EUROLAB conference

Sheehan, A., O'Cuinn, G., Fitzgerald, R. J. and Wilkinson, M. G. (1999) EUROLAB conference. :63-*

1996

Immunology

Miller, K., Matthews, G., Smyth, M. and FitzGerald. R. (1996) Immunology. :*-*

1995

Proceedings 4th Cheese Symposium, Moorepark

O'Cuinn, G., Jennings, P. V., Ni Fhaolain, I., Booth, M., Bacon, C. L., McDonnell, M., Wilkinson, M., O¿Callaghan, D. M., and FitzGerald, R. J (1995) Proceedings 4th Cheese Symposium, Moorepark. :68-71

1995

4th Moorepark Cheese Symposium

O'Cuinn, G., Jennings, P.V., Ni Fhaolain, I., Booth, M., Bacon, C.L., McDonnell, M., Wilkinson, M., O'Callaghan, D.M., and Fitzgerald, R.J. (1995) 4th Moorepark Cheese Symposium. :68-71

Conference Contributions

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Published Reports

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Editorials

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Book Reviews

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Other Publications