Profe. Ake Rasmuson
Research Interests
<< The research is primarily focused on crystallization of pharmaceutical molecules. The work includes the fundamentals of nucleation and growth kinetics, polymorphs and cocrystals, and agglomeration. The work also includes manufacturing of nanocrystals, tailoring of crystal size distributions, influence of impurities and purification, population balance modelling, determination and prediction of solubilities and separation of enantiomers. Further areas of interest includes the hydrodynamics of agitated tanks, separation and utilization of biogas, and recovery of rare earth elements (REE) from industrial waste and spent consumer products.Peer Reviewed Journals
Investigating the Role of Solvent-Solute Interaction in Crystal Nucleation of Salicylic Acid from Organic Solvents
Khamar, D,Zeglinski, J,Mealey, D,Rasmuson, AC (2014) Investigating the Role of Solvent-Solute Interaction in Crystal Nucleation of Salicylic Acid from Organic Solvents. Journal of the American Chemical Society :11664-11673
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Investigating the dissolution of the metastable triclinic polymorph of carbamazepine using in situ microscopy
O'Mahony, M,Seaton, CC,Croker, DM,Veesler, S,Rasmuson, AC,Hodnett, BK (2014) Investigating the dissolution of the metastable triclinic polymorph of carbamazepine using in situ microscopy. Crystengcomm :4133-4141
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Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents
Maher, A,Croker, DM,Seaton, CC,Rasmuson, AC,Hodnett, BK (2014) Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents. Crystal Growth & Design :3967-3974
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Measuring the Solubility of a Quickly Transforming Metastable Polymorph of Carbamazepine
O'Mahony, MA,Croker, DM,Rasmuson, AC,Veesler, S,Hodnett, BK (2013) Measuring the Solubility of a Quickly Transforming Metastable Polymorph of Carbamazepine. Organic Process Research & Development :512-518
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Solid-State Transformations of Sulfathiazole Polymorphs: The Effects of Milling and Humidity
Hu, Y,Erxleben, A,Hodnett, BK,Li, BY,McArdle, P,Rasmuson, AC,Ryder, AG (2013) Solid-State Transformations of Sulfathiazole Polymorphs: The Effects of Milling and Humidity. Crystal Growth & Design :3404-3413
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Investigation into the Mechanism of Solution-Mediated Transformation from FI to FIII Carbamazepine: The Role of Dissolution and the Interaction between Polymorph Surfaces
O'Mahony, MA,Seaton, CC,Croker, DM,Veesler, S,Rasmuson, AC,Hodnett, BK (2013) Investigation into the Mechanism of Solution-Mediated Transformation from FI to FIII Carbamazepine: The Role of Dissolution and the Interaction between Polymorph Surfaces. Crystal Growth & Design :1861-1871
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m-Hydroxybenzoic Acid: Quantifying Thermodynamic Stability and Influence of Solvent on the Nucleation of a Polymorphic System
Svard, M; Rasmuson, AC (2013) m-Hydroxybenzoic Acid: Quantifying Thermodynamic Stability and Influence of Solvent on the Nucleation of a Polymorphic System. Crystal Growth & Design :1140-1152
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Primary nucleation of salicylamide: the influence of process conditions and solvent on the metastable zone width
Nordstrom, FL; Svard, M; Rasmuson, AC (2013) Primary nucleation of salicylamide: the influence of process conditions and solvent on the metastable zone width. Crystengcomm :7285-7297
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Influence of Solution Thermal and Structural History on the Nucleation of m-Hydroxybenzoic Acid Polymorphs
Nordstrom, FL;Svard, M;Malmberg, B;Rasmuson, AC (2012) Influence of Solution Thermal and Structural History on the Nucleation of m-Hydroxybenzoic Acid Polymorphs. Crystal Growth & Design :4340-4348
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Examining Solution and Solid State Composition for the Solution-Mediated Polymorphic Transformation of Carbamazepine and Piracetam
O'Mahony, MA,Maher, A,Croker, DM,Rasmuson, AC,Hodnett, BK (2012) Examining Solution and Solid State Composition for the Solution-Mediated Polymorphic Transformation of Carbamazepine and Piracetam. Crystal Growth & Design :1925-1932
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Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram
Croker, DM,Foreman, ME,Hogan, BN,Maguire, NM,Elcoate, CJ,Hodnett, BK,Maguire, AR,Rasmuson, AC,Lawrence, SE (2012) Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram. Crystal Growth & Design :869-875
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Selective desorption of carbon dioxide from sewage sludge for in-situ methane enrichment: Enrichment experiments in pilot scale
Nordberg, A,Edstrom, M,Uusi-Penttila, M,Rasmuson, AC (2012) Selective desorption of carbon dioxide from sewage sludge for in-situ methane enrichment: Enrichment experiments in pilot scale. Biomass & Bioenergy :196-204
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Crystallization of metal fluoride hydrates from mixed hydrofluoric and nitric acid solutions, part II: Iron (III) and nickel (II)
Forsberg, KM; Rasmuson, AC (2010) Crystallization of metal fluoride hydrates from mixed hydrofluoric and nitric acid solutions, part II: Iron (III) and nickel (II). Journal Of Crystal Growth :2358-2362
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Crystallization of metal fluoride hydrates from mixed hydrofluoric and nitric acid solutions, Part I, Iron (III) and Chromium (III)
Forsberg, KM; Rasmuson, AC (2010) Crystallization of metal fluoride hydrates from mixed hydrofluoric and nitric acid solutions, Part I, Iron (III) and Chromium (III). Journal Of Crystal Growth :2351-2357
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Solubility of Butyl Paraben in Methanol, Ethanol, Propanol, Ethyl Acetate, Acetone, and Acetonitrile
Yang, HY; Rasmuson, AC (2010) Solubility of Butyl Paraben in Methanol, Ethanol, Propanol, Ethyl Acetate, Acetone, and Acetonitrile. Journal Of Chemical And Engineering Data :5091-5093
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Prediction of solubility curves and melting properties of organic and pharmaceutical compounds
Nordstrom, F. L.,Rasmuson, A. C. (2009) Prediction of solubility curves and melting properties of organic and pharmaceutical compounds. European Journal Of Pharmaceutical Scienceseuropean Journal Of Pharmaceutical Sciences :330-344
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Effect of preparation method on compactability of paracetamol granules and agglomerates
Fichtner, F.,Rasmuson, A. C.,Alander, E. M.,Alderborn, G. (2007) Effect of preparation method on compactability of paracetamol granules and agglomerates. International Journal Of Pharmaceuticsinternational Journal Of Pharmaceutics :148-158
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Selective desorption of carbon dioxide from sewage sludge for in situ methane enrichment - Part II: Modelling and evaluation of experiments
Lindberg, A.,Rasmuson, A. C. (2007) Selective desorption of carbon dioxide from sewage sludge for in situ methane enrichment - Part II: Modelling and evaluation of experiments. Biotechnology And Bioengineeringbiotechnology And Bioengineering :1039-1052
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Oiling out or molten hydrate-liquid-liquid phase separation in the system vanillin-water
Svard, M.,Gracin, S.,Rasmuson, A. C. (2007) Oiling out or molten hydrate-liquid-liquid phase separation in the system vanillin-water. Journal Of Pharmaceutical Sciencesjournal Of Pharmaceutical Sciences :2390-2398
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Selective desorption of carbon dioxide from sewage sludge for in situ methane enrichment - Part 1: Pilot-plant experiments
Lindberg, A.,Rasmuson, A. C. (2006) Selective desorption of carbon dioxide from sewage sludge for in situ methane enrichment - Part 1: Pilot-plant experiments. Biotechnology And Bioengineeringbiotechnology And Bioengineering :794-803
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Solubility of beta-FeF3 center dot 3H(2)O in mixtures of nitric and hydrofluoric acid
Osterdahl, K. M.,Rasmuson, A. C. (2006) Solubility of beta-FeF3 center dot 3H(2)O in mixtures of nitric and hydrofluoric acid. Journal Of Chemical And Engineering Datajournal Of Chemical And Engineering Data :223-229
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Particle size distribution and evolution in tablet structure during and after compaction
Fichtner, F.,Rasmuson, A.,Alderborn, G. (2005) Particle size distribution and evolution in tablet structure during and after compaction. International Journal Of Pharmaceuticsinternational Journal Of Pharmaceutics :211-225
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Nucleation of calcium carbonate in presence of citric acid, DTPA, EDTA and pyromellitic acid
Westin, K. J.,Rasmuson, A. C. (2005) Nucleation of calcium carbonate in presence of citric acid, DTPA, EDTA and pyromellitic acid. Journal Of Colloid And Interface Sciencejournal Of Colloid And Interface Science :370-379
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Mechanisms of crystal agglomeration of paracetamol in acetone-water mixtures
Alander, E. M.,Rasmuson, A. C. (2005) Mechanisms of crystal agglomeration of paracetamol in acetone-water mixtures. Industrial & Engineering Chemistry Researchindustrial & Engineering Chemistry Research :5788-5794
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Crystal growth of aragonite and calcite in presence of citric acid, DTPA, EDTA and pyromellitic acid
Westin, K.,Rasmuson, A. C. (2005) Crystal growth of aragonite and calcite in presence of citric acid, DTPA, EDTA and pyromellitic acid. Journal Of Colloid And Interface Sciencejournal Of Colloid And Interface Science :359-369
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Influence of solvent and the operating conditions on the crystallization of racemic mandelic acid
Profir, V. M.,Rasmuson, A. C. (2004) Influence of solvent and the operating conditions on the crystallization of racemic mandelic acid. Crystal Growth & Designcrystal Growth & Design :315-323
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Agglomeration of paracetamol during crystallization in pure and mixed solvents
Alander, E. M.,Uusi-Penttila, M. S.,Rasmuson, A. C. (2004) Agglomeration of paracetamol during crystallization in pure and mixed solvents. Industrial & Engineering Chemistry Researchindustrial & Engineering Chemistry Research :629-637
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Influence of additives on nucleation of vanillin: Experiments and introductory molecular simulations
Pino-Garcia, O.,Rasmuson, A. C. (2004) Influence of additives on nucleation of vanillin: Experiments and introductory molecular simulations. Crystal Growth & Designcrystal Growth & Design :1025-1037
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Analysis of solution nonideality of a pseudomorphic drug system through a comprehensive thermodynamic framework for the design of a crystallization process
Nordstrom, F. L.,Rasmuson, A.,Sheikh, A. Y. (2004) Analysis of solution nonideality of a pseudomorphic drug system through a comprehensive thermodynamic framework for the design of a crystallization process. Journal Of Pharmaceutical Sciencesjournal Of Pharmaceutical Sciences :995-1004
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Experimental study for agglomeration behaviour of paracetamol in acetone-toluene-water systems
Uus-Penttila, M. S.,Rasmuson, A. C. (2003) Experimental study for agglomeration behaviour of paracetamol in acetone-toluene-water systems. Chemical Engineering Research & Designchemical Engineering Research & Design :489-495
Read moreSolubility of phenylacetic acid, p-hydroxyphenylacetic acid, p-aminophenylacetic acid, p-hydroxybenzoic acid, and ibuprofen in pure solvents
Gracin, S.,Rasmuson, A. C. (2002) Solubility of phenylacetic acid, p-hydroxyphenylacetic acid, p-aminophenylacetic acid, p-hydroxybenzoic acid, and ibuprofen in pure solvents. Journal Of Chemical And Engineering Datajournal Of Chemical And Engineering Data :1379-1383
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Prediction of solubility of solid organic compounds in solvents by UNIFAC
Gracin, S.,Brinck, T.,Rasmuson, A. C. (2002) Prediction of solubility of solid organic compounds in solvents by UNIFAC. Industrial & Engineering Chemistry Researchindustrial & Engineering Chemistry Research :5114-5124
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Study of the crystallization of mandelic acid in water using in situ ATR-IR spectroscopy
Profir, V. M.,Furusjo, E.,Danielsson, L. G.,Rasmuson, A. C. (2002) Study of the crystallization of mandelic acid in water using in situ ATR-IR spectroscopy. Crystal Growth & Designcrystal Growth & Design :273-279
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Solubility of paracetamol in binary and ternary mixtures of water plus acetone plus toluene
Granberg, R. A.,Rasmuson, A. C. (2000) Solubility of paracetamol in binary and ternary mixtures of water plus acetone plus toluene. Journal Of Chemical And Engineering Datajournal Of Chemical And Engineering Data :478-483
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Supersaturation generation at the feed point in reaction crystallization of a molecular compound
Lindberg, M.,Rasmuson, A. C. (2000) Supersaturation generation at the feed point in reaction crystallization of a molecular compound. Chemical Engineering Sciencechemical Engineering Science :1735-1746
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Projected area of measurement volume in phase-Doppler anemometry and application for velocity bias correction and particle concentration estimation
Yu, Z.,Rasmuson, A. C. (1999) Projected area of measurement volume in phase-Doppler anemometry and application for velocity bias correction and particle concentration estimation. Experiments In Fluidsexperiments In Fluids :189-198
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Application of three-dimensional phase-Doppler anemometry to mechanically agitated crystallizers
Pettersson, M.,Rasmuson, A. C. (1997) Application of three-dimensional phase-Doppler anemometry to mechanically agitated crystallizers. Chemical Engineering Research & Designchemical Engineering Research & Design :132-141
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THE FORMATION OF SUBMICRON ORGANIC PARTICLES BY PRECIPITATION IN AN EMULSION
Sjostrom, B.,Bergenstahl, B.,Lindberg, M.,Rasmuson, A. C. (1994) THE FORMATION OF SUBMICRON ORGANIC PARTICLES BY PRECIPITATION IN AN EMULSION. Journal Of Dispersion Science And Technologyjournal Of Dispersion Science And Technology :89-117
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SEMIBATCH REACTION CRYSTALLIZATION OF BENZOIC-ACID
Aslund, B. L.,Rasmuson, A. C. (1992) SEMIBATCH REACTION CRYSTALLIZATION OF BENZOIC-ACID. Aiche Journalaiche Journal :328-342
Read moreAPPLICATION OF CONTROLLED COOLING AND SEEDING IN BATCH CRYSTALLIZATION
Bohlin, M.,Rasmuson, A. C. (1992) APPLICATION OF CONTROLLED COOLING AND SEEDING IN BATCH CRYSTALLIZATION. Canadian Journal Of Chemical Engineeringcanadian Journal Of Chemical Engineering :120-126
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Characterization and rotation symmetry of the impeller region in baffled agitated suspensions. 10th European Conference on Mixing
Yu, Z. Y.,Rasmuson, A. (2000) Characterization and rotation symmetry of the impeller region in baffled agitated suspensions. 10th European Conference on Mixing. 10th European Conference on Mixing10th European Conference on Mixing :423-430
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