Biography

Former Senior Lecturer and REF 5* Wellcome, Leverhulme and Sir Jules Thorn Trust Project Grant funded researcher, University of Birmingham, UK. Moved to the University of Limerick, Ireland in 1995-6 as Professor and HOD of the Physical Education and Sports Sciences Department (PESS) to establish an exercise science teaching and research base. The research focus is the study of human physiology and biochemistry of exercise, investigating change(s) in the human phenotype in response to exercise and exercise x nutrient interaction. Translational work relates to neuromuscular disease, osteoporosis, insulin resistance, obesity and age-related sarcopenia. https://www.podomatic.com/podcasts/universitylimerick/episodes/2018-04-09T08_19_29-07_00
A foundation PI of the Health Research Institute and Centre for Interventions in Inflammation, Infection and Immunity, the current research staff are supported by Programme Grants under the auspices of the National Technology Centre, Food for Health Ireland, Enterprise Ireland Innovation Partnership Projects and DAFF/FIRM Project Grant Awards.
Lead PI to Food for Health @ UL and the UL Body Composition research programme (ULBC )

Research Interests

Human Exercise Science; Biochemistry of Exercise; Growth Factors; Bone Turnover; Muscle Adaptation; Nutrition and metabolism. Research interests focus on the perturbation invoked by physical exercise as a vehicle to study the regulatory and adaptive processes of human metabolism in selected populations of human subjects. Founded on project grant funding from the Wellcome Trust (UK), the Leverhulme Trust (UK) and the Sir Jules Thorne Trust (UK) and recent funding from Enterprise Ireland and Industry, the Human Science Research Unit (HSRU) was formed in 2004 and is equipped to undertake metabolic studies in humans. Recent acquisitions include dual X-ray absorptiometry DXA and isotope-ratio mass spectrometry (combustible-IRMS). Collaboration with faculty from the new Medical School @ UL is currently exploring the application of in-vivo microdialysis to human metabolic and exercise studies within the HRSU. External funding has been awarded to undertake project research housed within environment-controlled laboratories. Current funding and projects include;
  1. Human body composition/Anthropometric phenotyping in health and disease by Dual Energy X-ray Absorptiometry (DXA) and Bioelectric Impedence Analysis (BIA) www.ul.ie/bodycompositionstudy ;
  2. Human energy expenditure and metabolic studies of endogenous and exogenous substrate, metabolic flexibility and studies of human energy expenditure and exercise metabolism by indirect calorimetry and on-line metabolic measurement (www.FHI.ie)
  3. Discovery and in vitro evaluation of bioatives in foods that confer in vivo anti-inflammatory effect in humans (DAFM/FIRM)
  4. Nutrient interaction with physical activity specialising in the preservation of musculoskeletal health and reducing the incidence of osteopenia and sarcopenia in older adults (www.FHI.ie)
  5. Invasive investigation via venous cannulation, skeletal muscle and adipose tissue percutaneous biopsy and in vivo microdialysis (www.FHI.ie)
  6. Simulated altitude training (normobaric hypoxia) www.ul.ie/altitude and hypoxic pre-operative conditioning.
Current Grant Funding by project Funding BodyAmount as PI Period
Nutrient support for age-related sarcopeniaEnterprise Ireland (FHI) €371,131 01/10/10 to 30/09/13
Total Grant of €454,400 as Lead PI No: CC20080001
Antioxidant and Anti-inflammatory Ingredients DAFM (FIRM) €55,200 01/06/13 to 30/09/15
Total Grant of €495,472 as co-PINo: 11/F/63
Nutrient Support to Healthy Ageing Enterprise Ireland (FHI)€1,961,086 01/09/13 to 30/06/18
Total Grant of €1,961,086 as Lead PINo: TC20130001
Validation of Antioxidant Ingredients DAFM (FIRM) €58,400 01/11/13 to 31/12/16
Total Grant of €495,919 as co-PI No: 11/F/64












Professional Activities

Award

  • 2022 - Fellow of The Physiological Society

Committee

  • 2019 Life and Medical Sciences Committee of the Royal Irish Academy, The Life and Medical Sciences Committee of the RIA, under the chairmanship of Mark Crowe, continue to advance the Symposium: 'Importance of Fundamental Biomedical Research'
  • 2012 Medical Research Council/Wellcome Trust UK Biobank Imaging Enhancement,
  • 2004 Programmatic Review Peer Group Panel, Department of Applied Biology and Chemistry, Carlow Institute of Technology,
  • 2002 Food Safety Promotion Board (FSPB) Expert Committee: Stimulant Drinks,
  • 1899 Medical Research Council (U.K.),
  • 1899 Wellcome Trust (U.K.),
  • 1899 Leverhulme Trust (U.K.),

Patent

  • 2019 US 10,455,853 B2 - Nutritional supplement composition suitable for improving lean tissue mass status in an adult human

Consultancy

  • 2014 Siel Bleu - Member of Board of Directors consisting of people with the appropriate mix of skills, knowledge and experience to support Siel Bleu Ireland. The Board is responsible for the overall governance and strategic direction of Siel Bleu Ireland with progress and goals reviewed at each Board Meeting.
  • - Member, Scientific Advisory Group, Glanbia Nutritionals
  • - Member, Glanbia Scientfic Advisory Group. Advisory body to Glanbia Nutritionals

Association

  • 2009 Professional Member, American College of Sports medicine
  • 2006 Fellow Council Member, Biomedical Sciences Section, Royal Academy of Medicine in Ireland
  • 2005 Professional Member Reviewer, European College of Sport sciences
  • 1984 Professional Member, Member Human Physiology Interest Group, Physiological Society
  • 1975 Member Council Member, Irish Section Local Ambassador (LA) to Biochemistry Society in Ireland, Biochemical Society

Employment

  • 1995 University of Limerick - Professor (FULL)
  • 1994 University of Birmingham - Senior Lecturer
  • 1990 University of Birmingham - Lecturer
  • 1989 Manchester Metropolitan University - Principal Lecturer/Reader
  • 1987 Manchester Metropolitan University - Senior Lecturer
  • 1984 Manchester Metropolitan University - Lecturer
  • 1981 University of Salford, Manchester, UK - Reserach Fellow

Education

  • 1984 University of Salford - Ph.D.
  • 1978 University of Manchester - MSc
  • 1975 University of Salford - B.Sc.

Outreach

  • A social enterprise and a non for profit organisation who transform lives through exercise! We work with older adults, patient groups, community organisations, people living with physical and intellectual disabilities.

Other

  • Established and set governance for professional society of Sport and Exercise Scientists in Ireland

Research Collaborators

  • Basant Puri - Joint Publication - Hammersmith Hospital -England
  • Basant Puri - Joint Publication - Hammersmith Hospital -England
  • Ivana Sestak - Joint Publication - Queen Mary University of London -England
  • Janet Walton - Joint Publication - Kellogg¿s Co. Ltd -England
  • Jill Pell - Other - University of Glasgow -Scotland
  • John Griffiths - Funding Award - University of Oxford -England
  • Peter Francis - Joint Publication - Leeds Beckett University -England
  • Peter Francis - Joint Publication - Leeds Beckett University -England
  • Richard Bracken - External Examiner - Swansea University -Wales
  • Richard Bracken - External Examiner - Swansea University -Wales
  • Thomas Smith - Funding Award - University of Oxford -England
  • Professor Phil Atherton - Joint Programme - University of Nottingham -England -Stable isotope research collaborative partnership on 3 grants
  • Prof Ken Smith - Joint Publication - University of Nottingham -England -Stable isotope studies on 3 research grants
  • Prof Guy Pasqui - Joint Programme - Maastricht University -Netherlands -Stable isotope studies of human energy exependiture

Publications

Peer Reviewed Journals

2023

An Investigation of the Protein Quality and Temporal Pattern of Peripheral Blood Aminoacidemia following Ingestion of 0.33 g·kg<sup>−1</sup> Body Mass Protein Isolates of Whey, Pea, and Fava Bean in Healthy, Young Adult Men

Kozior M.;Davies R.W.;Amigo-Benavent M.;Fealy C.;Jakeman P.M. (2023) An Investigation of the Protein Quality and Temporal Pattern of Peripheral Blood Aminoacidemia following Ingestion of 0.33 g·kg<sup>−1</sup> Body Mass Protein Isolates of Whey, Pea, and Fava Bean in Healthy, Young Adult Men. Nutrients

2022

Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia

Norton C.;Hettiarachchi M.;Cooke R.;Kozior M.;Kontro H.;Daniel R.;Jakeman P. (2022) Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia. Nutrients

2017

Twelve weeks' progressive resistance training combined with protein supplementation beyond habitual intakes increases upper leg lean tissue mass, muscle strength and extended gait speed in healthy older women

Francis, P and Mc Cormack, W. and Toomey, C. and Norton, C. and Saunders, J. and Kerin, E. and Lyons, M. and Jakeman, P. (2017) Twelve weeks' progressive resistance training combined with protein supplementation beyond habitual intakes increases upper leg lean tissue mass, muscle strength and extended gait speed in healthy older women. Biogerontology :881-891

2015

An in vivo microdialysis characterization of the transient changes in the interstitial dialysate concentration of metabolites and cytokines in human skeletal muscle in response to insertion of a microdialysis probe

Carson, BP,McCormack, WG,Conway, C,Cooke, J,Saunders, J,O'Connor, WT,Jakeman, PM (2015) An in vivo microdialysis characterization of the transient changes in the interstitial dialysate concentration of metabolites and cytokines in human skeletal muscle in response to insertion of a microdialysis probe. Cytokine :327-333

2015

An in vivo microdialysis characterization of the transient changes in the interstitial dialysate concentration of metabolites and cytokines in human skeletal muscle in response to insertion of a microdialysis probe

Carson, B. P. and McCormack, W. G. and Conway, C. and Cooke, J. and Saunders, J. and O'Connor, W. T. and Jakeman, P. M. (2015) An in vivo microdialysis characterization of the transient changes in the interstitial dialysate concentration of metabolites and cytokines in human skeletal muscle in response to insertion of a microdialysis probe. Cytokine :327-33

2007

Osteoporosis update 1/2007,Osteoporose-Update 1/2007

Pfeilschifter, J.;Häussler, B.;Gothe, H.;Mangiapane, S.;Glaeske, G.;Pientka, L.;Felsenberg, D.;Chen, P.;Miller, P.D.;Delmas, P.D.;Misurski, D.A.;Krege, J.H.;Gallagher, J.C.;Rapuri, P.B.;Smith, L.M.;Lewis, C.E.;Ewing, S.K.;Taylor, B.C.;Shikany, J.M.;Fink, H.A.;Ensrud, K.E.;Barrett-Connor, E.;Cummings, S.R.;Orwoll, E.;Gallacher, S.J.;Gallagher, A.P.;McQuillian, C.;Mitchell, P.J.;Dixon, T.;Nguyen, N.D.;Eisman, J.A.;Center, J.R.;Nguyen, T.V.;Towler, M.R.;Wren, A.;Rushe, N.;Saunders, J.;Cummins, N.M.;Jakeman, P.M.;Richards, J.;Leslie, W.;Joseph, L.;Siminoski, K.;Hanley, D.;Adachi, J.;Brown, J.;Morin, S.;Papaioannou, A.;Josse, R.;Prior, J.;Davison, K.;Tenenhouse, A.;Goltzman, D.;Black, D.M.;Schwartz, A.V.;Ensrud, K.E.;Cauley, J.A.;Levis, S.;Quandt, S.A.;Satterfield, S.;Wallace, R.B.;Bauer, D.C.;Palermo, L.;Wehren, L.E.;Lombardi, A.;Santora, A.C.;Cummings, S.R.;Sornay-Rendu, E.;Boutroy, S.;Munoz, F.;Delmas, P.D.; (2007) Osteoporosis update 1/2007,Osteoporose-Update 1/2007. Osteologie

2003

Commentary

Jakeman P (2003) Commentary. British Journal Of Sports Medicinebritish Journal Of Sports Medicine :1-

1995

ENDURANCE TRAINING MODIFIES THE AVAILABILITY OF CIRCULATING INSULIN-LIKE GROWTH-FACTORS BY CHANGING THE RELATIVE CONCENTRATION OF HIGH AND LOW-AFFINITY BINDING-PROTEINS AT REST AND DURING PROLONGED EXERCISE IN MAN

JAKEMAN, PM,JEAL, S,CWYFANHUGHES, S,HOLLY, JMP (1995) ENDURANCE TRAINING MODIFIES THE AVAILABILITY OF CIRCULATING INSULIN-LIKE GROWTH-FACTORS BY CHANGING THE RELATIVE CONCENTRATION OF HIGH AND LOW-AFFINITY BINDING-PROTEINS AT REST AND DURING PROLONGED EXERCISE IN MAN. Journal Of Physiology-Londonjournal Of Physiology-London

Books

Book Chapters

2023

Mesenteric Microbiology and Inflammatory Bowel Disease: Improved Understanding Due to Accelerating Innovation and Sophistication of Molecular Technology

Miranda G. Kiernan, Suzanne Shine Dunne, Kieran McDermott, Phil Jakeman, Brendan Gilmore, Thomas P. Thompson, Stephen Kelly, J. Calvin Coffey & Colum P. Dunne (2023) Mesenteric Microbiology and Inflammatory Bowel Disease: Improved Understanding Due to Accelerating Innovation and Sophistication of Molecular Technology. Switzerland : Springer Nature The Mesentery and Inflammation . Progress in Inflammation Research

1982

Factors affecting athletic performance

Jakeman, PM (1982) Factors affecting athletic performance. Oxford. : University Press, Oxford. Science and Sporting Performance: Management or manipulation? :30-43

Edited Books

This author has not written any publications of this type yet.

Other Journals

Conference Publications

2006

European Neurological Society

S. Hosback, P. Jakeman, C. Nolan, M. Doyle, O. O' Toole, G. Gorman, C. Lynch, O. Hardiman (2006) European Neurological Society. :*-*

1995

Endurance training modifies the availability of circulating insulin-like growth factors by changing the relative concentration of high and low affinity binding proteins at rest and during prolonged exercise in Man.

Jakeman, PM; Jeal, S; Cwyfan-Hughes, S; Holly, JMP (1995) Endurance training modifies the availability of circulating insulin-like growth factors by changing the relative concentration of high and low affinity binding proteins at rest and during prolonged exercise in Man.. Journal Of Physiology

Conference Contributions

2006

The Biology of Exercise

Royal Academy of Medicine in Ireland (RAMI) Biomedical Sciences (2006) The Biology of Exercise.

Published Reports

This author has not written any publications of this type yet.

Editorials

This author has not written any publications of this type yet.

Book Reviews

This author has not written any publications of this type yet.

Other Publications