Prof. Michael Walsh

Faculty Of Science & Engineering

Mechanical Aeronautical & Biomedical Eng

School Of Engineering

Email: michael.walsh@ul.ie

Biography

My research activity focuses on an improved understanding of the host response to the treatment of vascular diseases. My primary area of research is focused on vascular disease properties and how such properties can be leveraged for improved medical device design. My secondary area of research investigates how disease caused by vascular surgical interventions (intimal hyperplasia) is instigated/mediated by hemodynamics. Elucidating the role of diseased tissue in device performance is a crucial step towards the understanding of how surgical treatments lead to disease formation and also how treatments can be improved to minimise intimal hyperplasia. My former post-doctoral researchers are all working in Irish industry as are 13 of 20 PhD graduates. Five other PhD graduates are all pursuing academic careers at institutions such as Georgia Institute of Technology, Edinburgh University, University of Pittsburgh, Erasmus Medical Centre, Rotterdam and the University of Limerick. I have published 74 peer-reviewed journal papers and 8 book chapters. I have 4 granted patents, 2 in review and a spin-out company, Class Medical, established in 2014.My research activity focuses on an improved understanding of the host response to the treatment of vascular diseases. My primary area of research is focused on vascular disease properties and how such properties can be leveraged for improved medical device design. My secondary area of research investigates how disease caused by vascular surgical interventions (intimal hyperplasia) is instigated/mediated by hemodynamics. Elucidating the role of diseased tissue in device performance is a crucial step towards the understanding of how surgical treatments lead to disease formation and also how treatments can be improved to minimise intimal hyperplasia. My former post-doctoral researchers are all working in Irish industry as are 13 of 20 PhD graduates. Five other PhD graduates are all pursuing academic careers at institutions such as Georgia Institute of Technology, Edinburgh University, University of Pittsburgh, Erasmus Medical Centre, Rotterdam and the University of Limerick. I have published 74 peer-reviewed journal papers and 8 book chapters. I have 4 granted patents, 2 in review and a spin-out company, Class Medical, established in 2014.

Research Interests

Research Interests: Cardiovascular Hemodynamics, Arteriovenous Access, Human diseased soft tissue characterisation

Professional Activities

Committee

2007 Biomedical Engineering Division, Engineers Ireland,
2006 American Society of Mechanical Engineers,

Employment

2007 University of Limerick - Course Director, Biomedical Engineering

Association

2006 Member, American Society of Mechanical Engineers
2005 Member, Engineers Ireland

Education

2001 University of Limerick - Ph.D.
1996 University of Limerick - B.Eng.

Patent

- The Prolong Graft for peripheral bypass surgery
- The Prolong II graft
- The Isolator Graft for Abdominal Aortic Aneurysms

Peer Reviewed Journals

2014

On the potential of hydrated storage for naturally derived ECMs and associated effects on mechanical and cellular performance

Davis, LM,Callanan, A,Carroll, GT,Doyle, BJ,Walsh, MT,McGloughlin, TM (2014) On the potential of hydrated storage for naturally derived ECMs and associated effects on mechanical and cellular performance. Journal Of Biomedical Materials Research Part B-Applied Biomaterials :89-97

Biography

Research Interests

Professional Activities

Committee

Employment

Association

Education

Patent

Publications

Peer Reviewed Journals

On the potential of hydrated storage for naturally derived ECMs and associated effects on mechanical and cellular performance

Numerical modelling of mass transport in an arterial wall with anisotropic transport properties

The mesocolon  a histological and electron microscopic characterisation of the mesenteric attachment of the colon prior to and after surgical mobilization.

An Analysis of Three Dimensional Diffusion in a Representative Arterial Wall Mass Transport Model

On the mechanical behaviour of carotid artery plaques: the influence of curve-fitting experimental data on numerical model results

Influence of implant design on the method of failure for three implants designed for use in the treatment of intertrochanteric fractures: the dynamic hip screw (DHS), DHS blade and X-BOLT

Variability of Computational Fluid Dynamics Solutions for Pressure and Flow in a Giant Aneurysm: The ASME 2012 Summer Bioengineering Conference CFD Challenge

Mechanical, biological and structural characterization of in vitro ruptured human carotid plaque tissue

Wrist postures in the general population of computer users during a computer task

Mechanical, biological and structural characterisation of in vitro ruptured human carotid plaque tissue.

Mechanical characterisation of unidirectional and cross-directional multilayered urinary bladder matrix (UBM) scaffolds

Spherical indentation of free-standing acellular extracellular matrix membranes

Second Level Education and the Decline in Popularity of Engineering within an Irish Context

Dynamic hip screw versus DHS blade A BIOMECHANICAL COMPARISON OF THE FIXATION ACHIEVED BY EACH IMPLANT IN BONE

Wall Shear Stresses Remain Elevated in Mature Arteriovenous Fistulas: A Case Study

Experimental determination of circumferential properties of fresh carotid artery plaques

Identification of rupture locations in patient-specific abdominal aortic aneurysms using experimental and computational techniques

A Computational Study of the Magnitude and Direction of Migration Forces in Patient-specific Abdominal Aortic Aneurysm Stent-Grafts

Demonstrating the Influence of Compression on Artery Wall Mass Transport

Experimental validation of convection-diffusion discretisation scheme employed for computational modelling of biological mass transport

Engineering Silicone Rubbers for In Vitro Studies: Creating AAA Models and ILT Analogues With Physiological Properties

Vessel asymmetry as an additional diagnostic tool in the assessment of abdominal aortic aneurysms

Improved assessment and treatment of abdominal aortic aneurysms: the use of 3D reconstructions as a surgical guidance tool in endovascular repair

Experimental modelling of aortic aneurysms: Novel applications of silicone rubbers

Fluid-structure interaction of a patient-specific abdominal aortic aneurysm treated with an endovascular stent-graft

Extracellular matrices as advanced scaffolds for vascular tissue engineering

Fluid-structure interaction of a patient-specific abdominal aortic aneurysm treated with an endovascular stent-graft.

An Experimental and Numerical Comparison of the Rupture Locations of an Abdominal Aortic Aneurysm

Realistic Temporal Variations of Shear Stress Modulate MMP-2 and MCP-1 Expression in Arteriovenous Vascular Access

In Vitro modelling of an abdominal aortic aneurysm to determine rupture location

Investigation of a glottal related harmonics-to-noise ratio and spectral tilt as indicators of glottal noise in synthesized and human voice signals

Geometrical Enhancements for Abdominal Aortic Stent-Grafts

The Surgical Feasibility of a Novel Vascular Graft developed for the Treatment of Peripheral Arterial Disease using In Vitro Experimental Design Techniques

Effects of flat, parabolic and realistic steady flow inlet profiles on idealised and realistic stent graft fits through Abdominal Aortic Aneurysms (AAA)

Effects of flat, parabolic and realistic steady flow inlet profiles on idealised and realistic stent graft fits through Abdominal Aortic Aneurysms (AAA)

Altering end-to-side anastomosis junction hemodynamics: The effects of flow-splitting

Numerical modelling of Newtonian and non-Newtonian representation of blood in a distal end-to-side vascular bypass graft anastomosis

That hemodynamics and not material mismatch is of primary concern in bypass graft failure: An experimental argument

Computational investigations of a new prosthetic femoral-popliteal bypass graft design

3-D numerical simulation of blood flow through models of the human aorta

A New Approach to Peripheral Bypass Graft Design.

On reducing abnormal hemodynamics in the femoral end-to-side anastomosis: The influence of mechanical factors

On reducing hemodynamic factors in the femoral end-to side anastomosis: the influence of mechanical factors

Mass transport disturbances in the distal graft/artery junction of a peripheral bypass graft

Injection-moulded models of major and minor arteries: the variability of model wall thickness owing to casting technique

A mathematical model to predict the in vivo pulsatile drag forces acting on bifurcated stent grafts used in endovascular treatment of abdominal aortic aneurysms (AAA)

An evolutionary approach to wall shear stress prediction in a grafted artery

A mathematical model to predict in vivo distraction forces acting on bifurcated stent grafts used in endovascular treatment of Abdominal Aortic Aneurysms (AAA)

An evolutionary approach to Wall Shear Stress prediction in a grafted artery

On using experimentally estimated wall shear stresses to validate numerically predicted results

On the existence of an optimum end-to-side junctional geometry in peripheral bypass surgery - A computer generated study

The Effects of Arterial Wall Remodelling on the Wall Shear Stress Distributions in Vascular Bypass Grafts ESEM Belfast May 3-5th 2001

An investigation into the hemodynamic behaviour of vascular bypass grafts witha nd without the use of vein cuffs 23rd Sir peter Freyer Surgical Symposium

Books

Book Chapters

Numerical and Experimental Techniques for the Study of Biomechanics in the Arterial System

Validated Numerical Simulations of Blood Flow Through Idealised and Realistic Graft/Artery Junctions

Comparative Analysis of Finite Element and Finite Volume Methods for Blood Flow Through a Graft-Artery Junction

Edited Books

Other Journals

Are we educating our students out of engineering?

Conference Publications

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, 2010

IFMBE Proceedings

IFMBE Proceedings

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B

Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B

Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009

Proceedings of the ASME Summer Bioengineering Conference, SBC2008

The mesocolon a histological and electron microscopic characterisation of the mesenteric attachment of the colon prior to and after surgical mobilization.