Prof. Andreas Grabrucker
Biography
CAREER PROFILEEducation
- 2000-2005 TU Munich, Germany, Diploma in Biology, Major: Genetics, Minor: Neurobiology and Zoology
- 2005-2009 University Ulm, Germany, PhD, international PhD program in molecular medicine
Employment
- 2009-2011 Postdoctoral fellow, Stanford University, USA, Dept. of Psychiatry and Behavioral Sciences, Stanford School of Medicine
- 2011-2016 Assistant Professor, University Ulm, Germany, Dept. of Neurology
- 2011-2016 Executive Director of the Neurocenter of Ulm University
- 2017- Lecturer in Cell Biology, University of Limerick, Ireland, Dept. of Biological Sciences, School of Natural Sciences
Scientific Activities - My research focuses on synaptopathies as a key feature of neurodevelopmental diseases. Disruptions in synaptic structure leading to abnormal circuit formation and function are potentially the major determinant of such brain diseases. My work aims to understand how genetic and non-genetic factors contribute to neuronal dysfunction and to develop novel research and treatment strategies using nanotechnology.
Research Interests
My research is interested in the underlying components able to modify synaptic plasticity and transmission in the Central Nervous System (CNS) in health and disease. Thereby, synaptopathy defines key features of neurodegenerative and psychiatric diseases. It implies that disruptions in synaptic structure and function are potentially the major determinant of such brain diseases. Using a combination of biochemical, cellular, molecular and behavioral approaches, we have investigated proteins of excitatory postsynapses focusing on their deregulation in neurodevelopmental and neuropsychiatric disorders such as Autism Spectrum Disorders, Alzheimer's disease and Schizophrenia. We are especially interested in the functional interaction of biometals and synaptic proteins in mechanisms such as synapse formation and maturation in health and disease. Given that dysregulation of trace metals is reported in many brain disorders, their role in the modification of synaptic function needs to be investigated in more detail. Especially since many brain disorders seem to not only have a genetic but also an environmental component triggering the disease. To investigate the role of biometals in disorders of the CNS, we use several approaches. For example, targeted manipulation of biometal levels in animal models and cells derived from human induced pluripotent stem cells is a major goal in our research. To that end, the development of novel drug carriers (i.e. Nanoparticles) and assays designed to evaluate their potency to influence synapse formation, maturation and plasticity has become an important part of our research. On the other hand, we investigate human patients with selected disorders and perform a state of the art assessment of their trace metal status and clinical phenotype to define subgroups with biometal abnormalities, which can be associated with specific clinical presentations. Understanding how environmental and genetic factors contribute to synaptic function will hopefully allow the development of research strategies to normalize function in individuals with synaptopathies.Professional Activities
Association
- 2012 Member, International Society for Zinc Biology
- 2007 Member, Society for Neuroscience
Language
- German
- English
Peer Reviewed Journals
Identification of Nanoparticle Properties for Optimal Drug Delivery across a Physiological Cell Barrier
Ross A.M.;Cahalane R.M.;Walsh D.R.;Grabrucker A.M.;Marcar L.;Mulvihill J.J.E. (2023) Identification of Nanoparticle Properties for Optimal Drug Delivery across a Physiological Cell Barrier. Pharmaceutics
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Dissecting the 22q13 region to explore the genetic and phenotypic diversity of patients with Phelan-McDermid syndrome
Vitrac A.;Leblond C.S.;Rolland T.;Cliquet F.;Mathieu A.;Maruani A.;Delorme R.;Schön M.;Grabrucker A.M.;van Ravenswaaij-Arts C.;Phelan K.;Tabet A.C.;Bourgeron T. (2023) Dissecting the 22q13 region to explore the genetic and phenotypic diversity of patients with Phelan-McDermid syndrome. European Journal Of Medical Genetics
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Non-Genetic Modifiers of Synaptic Plasticity and Neurotransmission in the Central Nervous System (CNS) in Health and Disease
Grabrucker A.M. (2022) Non-Genetic Modifiers of Synaptic Plasticity and Neurotransmission in the Central Nervous System (CNS) in Health and Disease. International Journal Of Molecular Sciences
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Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients
Harishkumar R.;Hans S.;Stanton J.E.;Grabrucker A.M.;Lordan R.;Zabetakis I. (2022) Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients. Nutrients
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Identification of the common neurobiological process disturbed in genetic and non-genetic models for autism spectrum disorders
Malijauskaite S.;Sauer A.K.;Hickey S.E.;Franzoni M.;Grabrucker A.M.;McGourty K. (2022) Identification of the common neurobiological process disturbed in genetic and non-genetic models for autism spectrum disorders. Cellular And Molecular Life Sciences
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Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments
Duskey J.T.;Rinaldi A.;Ottonelli I.;Caraffi R.;De Benedictis C.A.;Sauer A.K.;Tosi G.;Vandelli M.A.;Ruozi B.;Grabrucker A.M. (2022) Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments. Pharmaceutics
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Zinc Supplementation in Health and Disease
Hans S.;Stanton J.E.;O’Connor E.M.;Grabrucker A.M. (2022) Zinc Supplementation in Health and Disease. Trace Metals: Sources, Applications And Environmental Implications :1-29
Read moreZinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders
Sauer, AK;Malijauskaite, S;Meleady, P;Boeckers, TM;McGourty, K;Grabrucker, AM (2022) Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders. BASEL : SPRINGER BASEL AG Cellular And Molecular Life Sciences
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Atherosclerosis fate in the era of tailored functional foods: Evidence-based guidelines elicited from structure- and ligand-based approaches
Azevedo L.;Serafim M.S.M.;Maltarollo V.G.;Grabrucker A.M.;Granato D. (2022) Atherosclerosis fate in the era of tailored functional foods: Evidence-based guidelines elicited from structure- and ligand-based approaches. Trends In Food Science & Technology :75-89
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Altered gut-brain signaling in autism spectrum disorders-from biomarkers to possible intervention strategies
Sauer A.K.;Dooley L.;Vaughan A.;Grabrucker A.M. (2021) Altered gut-brain signaling in autism spectrum disorders-from biomarkers to possible intervention strategies. Neural Engineering Techniques For Autism Spectrum Disorder: Volume 1: Imaging And Signal Analysis :127-149
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Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.
Grabrucker S;Pagano J;Schweizer J;Urrutia-Ruiz C;Schön M;Thome K;Ehret G;Grabrucker AM;Zhang R;Hengerer B;Bockmann J;Verpelli C;Sala C;Boeckers TM; (2021) Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.. Embo Journal
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Sperm selection by rheotaxis improves sperm quality and early embryo development
Romero-Aguirregomezcorta, J;Laguna-Barraza, R;Fernandez-Gonzalez, R;Stiavnicka, M;Ward, F;Cloherty, J;McAuliffe, D;Larsen, PB;Grabrucker, AM;Gutierrez-Adan, A;Newport, D;Fair, S (2021) Sperm selection by rheotaxis improves sperm quality and early embryo development. BRISTOL : BIOSCIENTIFICA LTD Reproduction :343-352
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S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis
Daini, E;Hagmeyer, S;De Benedictis, CA;Cristovao, JS;Bodria, M;Ross, AM;Raab, A;Boeckers, TM;Feldmann, J;Gomes, CM;Zoli, M;Vilella, A;Grabrucker, AM (2021) S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis. LONDON : SPRINGERNATURE Translational Psychiatry
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Expression Analysis of Zinc Transporters in Nervous Tissue Cells Reveals Neuronal and Synaptic Localization of ZIP4
De Benedictis, CA;Haffke, C;Hagmeyer, S;Sauer, AK;Grabrucker, AM (2021) Expression Analysis of Zinc Transporters in Nervous Tissue Cells Reveals Neuronal and Synaptic Localization of ZIP4. BASEL : MDPI International Journal Of Molecular Sciences
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Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers
Mulvihill J.;Cunnane E.;Ross A.;Duskey J.;Tosi G.;Grabrucker A. (2020) Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers. Nanomedicine (London, England) :205-214
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Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties
Ross A.M.;Kennedy T.;McNulty D.;Leahy C.I.;Walsh D.R.;Murray P.;Grabrucker A.M.;Mulvihill J.J.E. (2020) Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties. Materials Science & Engineering C-Materials For Biological Applications
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Metallic-based nanocarriers: methods employed in nanoparticle characterization and assessing the interaction with the blood–brain barrier
Ross A.M.;Grabrucker A.M.;McGourty K.D.;Mulvihill J.J.E. (2020) Metallic-based nanocarriers: methods employed in nanoparticle characterization and assessing the interaction with the blood–brain barrier. Advances And Avenues In The Development Of Novel Carriers For Bioactives And Biological Agents :255-282
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Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles.
Lutz AK;Pfaender S;Incearap B;Ioannidis V;Ottonelli I;Föhr KJ;Cammerer J;Zoller M;Higelin J;Giona F;Stetter M;Stoecker N;Alami NO;Schön M;Orth M;Liebau S;Barbi G;Grabrucker AM;Delorme R;Fauler M;Mayer B;Jesse S;Roselli F;Ludolph AC;Bourgeron T;Verpelli C;Demestre M;Boeckers TM; (2020) Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles.. Science Translational Medicine
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Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal- Melphalan Prodrug for Glioblastoma Treatment
Oddone N, Boury F, Garcion E, Grabrucker AM, Del Carmen Martinez M, Da F, Janaszewska A, Forni F, Vandelli MA, Tosi G, Ruozi B, Duskey JT (2020) Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal- Melphalan Prodrug for Glioblastoma Treatment. Frontiers In Pharmacology
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Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives.
Ross AM;Mc Nulty D;O'Dwyer C;Grabrucker AM;Cronin P;Mulvihill JJE; (2019) Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives.. Journal Of Controlled Release
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Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI
Schoen M.;Asoglu H.;Bauer H.;Müller H.;Abaei A.;Sauer A.;Zhang R.;Song T.;Bockmann J.;Kassubek J.;Rasche V.;Grabrucker A.;Boeckers T. (2019) Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI. Frontiers In Neural Circuits :-6
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Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model
Sauer A.;Bockmann J.;Steinestel K.;Boeckers T.;Grabrucker A. (2019) Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model. International Journal Of Molecular Sciences
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Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery: In vitro evidence
Pederzoli F.;Ruozi B.;Duskey J.;Hagmeyer S.;Sauer A.;Grabrucker S.;Coelho R.;Oddone N.;Ottonelli I.;Daini E.;Zoli M.;Vandelli M.;Tosi G.;Grabrucker A. (2019) Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery: In vitro evidence. Pharmaceutics
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Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer’s disease model mice
Hagmeyer S.;Romão M.;Cristóvão J.;Vilella A.;Zoli M.;Gomes C.;Grabrucker A. (2019) Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer’s disease model mice. Frontiers In Neuroscience
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ROS-responsive “smart” polymeric conjugate: Synthesis, characterization and proof-of-concept study
Oddone N.;Pederzoli F.;Duskey J.;De Benedictis C.;Grabrucker A.;Forni F.;Angela Vandelli M.;Ruozi B.;Tosi G. (2019) ROS-responsive “smart” polymeric conjugate: Synthesis, characterization and proof-of-concept study. International journal of pharmaceutics
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Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain
Belletti, D; Grabrucker, AM; Pederzoli, F; Menrath, I; Vandelli, MA; Tosi, G; Duskey, TJ; Forni, F; Ruozi, B; (2018) Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain. International journal of pharmaceutics :300-310
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Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder
Grabrucker, S,Haderspeck, JC,Sauer, AK,Kittelberger, N,Asoglu, H,Abaei, A,Rasche, V,Schon, M,Boeckers, TM,Grabrucker, AM (2018) Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder. Frontiers In Molecular Neuroscience
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Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain
Hagmeyer, S,Cristovao, JS,Mulvihill, JJE,Boeckers, TM,Gomes, CM,Grabrucker, AM (2018) Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain. Frontiers In Molecular Neuroscience
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Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome.
Hagmeyer S;Sauer AK;Grabrucker AM; (2018) Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome.. Frontiers In Synaptic Neuroscience
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Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC
Sauer, AK,Pfaender, S,Hagmeyer, S,Tarana, L,Mattes, AK,Briel, F,Kury, S,Boeckers, TM,Grabrucker, AM (2017) Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC. Biometals :643-661
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Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates
Ruozi, B; Belletti, D; Pederzoli, F; Masoni, M; Keller, J; Ballestrazzi, A; Vandelli, MA; Tosi, G; Grabrucker, AM (2017) Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates. International Journal Of Pharmaceutics
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Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3
Pfaender, S; Sauer, AK; Hagmeyer, S; Mangus, K; Linta, L; Liebau, S; Bockmann, J; Huguet, G; Bourgeron, T; Boeckers, TM; Grabrucker, AM (2017) Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3. Scientific Reports
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De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability
Küry, S; van Woerden, GM; Besnard, T; Proietti Onori, M; Latypova, X; Towne, MC; Cho, MT; Prescott, TE; Ploeg, MA; Sanders, S; Stessman, HAF; Pujol, A; Distel, B; Robak, LA; Bernstein, JA; Denommé-Pichon, AS; Lesca, G; Sellars, EA; Berg, J; Carré, W; Busk, ØL; van Bon, BWM; Waugh, JL; Deardorff, M; Hoganson, GE; Bosanko, KB; Johnson, DS; Dabir, T; Holla, ØL; Sarkar, A; Tveten, K; de Bellescize, J; Braathen, GJ; Terhal, PA; Grange, DK; van Haeringen, A; Lam, C; Mirzaa, G; Burton, J; Bhoj, EJ; Douglas, J; Santani, AB; Nesbitt, AI; Helbig, KL; Andrews, MV; Begtrup, A; Tang, S; van Gassen, KLI; Juusola, J; Foss, K; Enns, GM; Moog, U; Hinderhofer, K; Paramasivam, N; Lincoln, S; Kusako, BH; Lindenbaum, P; Charpentier, E; Nowak, CB; Cherot, E; Simonet, T; Ruivenkamp, CAL; Hahn, S; Brownstein, CA; Xia, F; Schmitt, S; Deb, W; Bonneau, D; Nizon, M; Quinquis, D; Chelly, J; Rudolf, G; Sanlaville, D; Parent, P; Gilbert-Dussardier, B; Toutain, A; Sutton, VR; Thies, J; Peart-Vissers, LELM; Boisseau, P; Vincent, M; Grabrucker, AM; Dubourg, C; Tan, WH; Verbeek, NE; Granzow, M; Santen, GWE; Shendure, J; Isidor, B; Pasquier, L; Redon, R; Yang, Y; State, MW; Kleefstra, T; Cogné, B; Petrovski, S; Retterer, K; Eichler, EE; Rosenfeld, JA; Agrawal, PB; Bézieau, S; Odent, S; Elgersma, Y; Mercier, S (2017) De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. American Journal Of Human Genetics :768-788
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Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer's disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery.
Vilella, A; Belletti, D; Sauer, AK; Hagmeyer, S; Sarowar, T; Masoni, M; Stasiak, N; Mulvihill, JJE; Ruozi, B; Forni, F; Vandelli, MA; Tosi, G; Zoli, M; Grabrucker, AM (2017) Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer's disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery.. Journal Of Trace Elements In Experimental Medicine
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Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2
Sarowar, T; Grabrucker, S; Föhr, K; Mangus, K; Eckert, M; Bockmann, J; Boeckers, TM; Grabrucker, AM (2016) Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2. Molecular Brain
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EXPLOITING THE VERSATILITY OF CHOLESTEROL IN NANOPARTICLES FORMULATION
Belletti, D; Grabrucker, AM; Pederzoli, F; Menrath, I; Cappello, V; Vandelli, MA; Forni, F; Tosi, G; Ruozi, B (2016) EXPLOITING THE VERSATILITY OF CHOLESTEROL IN NANOPARTICLES FORMULATION. International Journal Of Pharmaceutics :331-340
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Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells
Pfaender, S; Föhr, K; Lutz, AK; Putz, S; Achberger, K; Linta, L; Liebau, S; Boeckers, TM; Grabrucker, AM (2016) Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells. Neural plasticity
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Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo
Chhabra, R; Ruozi, B; Vilella, A; Belletti, D; Mangus, K; Pfaender, S; Sarowar, T; Boeckers, TM; Zoli, M; Forni, F; Vandelli, MA; Tosi, G; Grabrucker, AM (2015) Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo. Cns & Neurological Disorders-Drug Targets :1041-1053
Read moreEmerging Use of Nanotechnology in the Treatment of Neurological Disorders
Chhabra, R; Tosi, G; Grabrucker, AM (2015) Emerging Use of Nanotechnology in the Treatment of Neurological Disorders. Current Pharmaceutical Design :3111-3130
Read moreLoss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses
Baecker, T; Mangus, K; Pfaender, S; Chhabra, R; Boeckers, TM; Grabrucker, AM (2014) Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses. Biometals :715-730
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Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release
Chhabra, R; Grabrucker, AM; Veratti, P; Belletti, D; Boeckers, TM; Vandelli, MA; Forni, F; Tosi, G; Ruozi, B (2014) Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release. International Journal Of Pharmaceutics :349-357
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Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution
Vilella, A; Tosi, G; Grabrucker, AM; Ruozi, B; Belletti, D; Vandelli, MA; Boeckers, TM; Forni, F; Zoli, M (2014) Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution. Journal Of Controlled Release :195-201
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Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders
Grabrucker, S; Jannetti, L; Eckert, M; Gaub, S; Chhabra, R; Pfaender, S; Mangus, K; Reddy, PP; Rankovic, V; Schmeisser, MJ; Kreutz, MR; Ehret, G; Boeckers, TM; Grabrucker, AM (2014) Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders. Brain :137-152
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Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport
Tosi, G; Vilella, A; Chhabra, R; Schmeisser, MJ; Boeckers, TM; Ruozi, B; Vandelli, MA; Forni, F; Zoli, M; Grabrucker, AM (2014) Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport. Journal Of Controlled Release :90-107
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The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation
Grabrucker, S; Proepper, C; Mangus, K; Eckert, M; Chhabra, R; Schmeisser, MJ; Boeckers, TM; Grabrucker, AM. (2014) The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation. Experimental Neurology :126-137
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The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons
Schmeisser, MJ; Kühl, SJ; Schoen, M; Beth, NH; Weis, TM; Grabrucker, AM; Kühl, M; Boeckers, TM (2013) The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons. Neural Development
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Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
Schmeisser, MJ; Ey, E; Wegener, S; Bockmann, J; Stempel, AV; Kuebler, A; Janssen, AL; Udvardi, PT; Shiban, E; Spilker, C; Balschun, D; Skryabin, BV; Dieck, St; Smalla, KH; Montag, D; Leblond, CS; Faure, P; Torquet, N; Le Sourd, AM; Toro, R; Grabrucker, AM; Shoichet, SA; Schmitz, D; Kreutz, MR; Bourgeron, T; Gundelfinger, ED; Boeckers, TM (2012) Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature :256-260
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Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling
Arons, MH; Thynne, CJ; Grabrucker, AM; Li, D; Schoen, M; Cheyne, JE; Boeckers, TM; Montgomery, JM; Garner, CC (2012) Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling. Journal Of Neuroscience :14966-14978
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Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences
Grabrucker, AM; Garner, CC; Boeckers, TM; Bondioli, L; Ruozi, B; Forni, F; Vandelli, MA; Tosi, G (2011) Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences. Plos One :e17851-
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Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
Grabrucker, AM; Schmeisser, MJ; Udvardi, PT; Arons, M; Schoen, M; Woodling, NS; Andreasson, KI; Hof, PR; Buxbaum, JD; Garner, CC; Boeckers, TM (2011) Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold. Molecular Neurodegeneration
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Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
Grabrucker, AM; Knight, MJ; Proepper, C; Bockmann, J; Joubert, M; Rowan, M; Nienhaus, GU; Garner, CC; Bowie, JU; Kreutz, MR; Gundelfinger, ED; Boeckers, TM (2011) Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. Embo Journal :569-581
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Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system
Grabrucker, AM; Vaida, B; Bockmann, J; Boeckers, TM (2009) Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system. Journal Of Neuroscience Methods :227-234
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Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma
Vellanki, SH; Grabrucker, A; Liebau, S; Proepper, C; Eramo, A; Braun, V; Boeckers, T; Debatin, KM; Fulda, S (2009) Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma. Neoplasia :743-752
Read moreynaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses
Schmeisser, MJ; Grabrucker, AM; Bockmann, J; Boeckers, TM (2009) ynaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses. Journal Of Biological Chemistry :29146-29157
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Books
Eco-Neurobiology and how the environment shapes our brain
Andreas M. Grabrucker (2019) Eco-Neurobiology and how the environment shapes our brain. Newcastle upon Tyne, UK : Cambridge Scholars
Read moreBook Chapters
Chapter 7 - Altered gutbrain signaling in autism spectrum disordersfrom biomarkers to possible intervention strategies
Sauer AK; Dooley L; Vaughan A; Grabrucker AM (2021) Chapter 7 - Altered gutbrain signaling in autism spectrum disordersfrom biomarkers to possible intervention strategies. Cambridge, MA, USA : Academic Press / Elsevier Neural Engineering Techniques for Autism Spectrum Disorder :127-149
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Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases
Cristovao, JS;Moreira, GG;Grabrucker, AM;Gomes, CM (2020) Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases. LONDON : ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD PROTEIN HOMEOSTASIS DISEASES :181-195
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Targeting Metal Homeostasis as a Therapeutic Strategy for Alzheimer's Disease
Antonietta Vilella, Eleonora Daini, Chiara A. De Benedictis, Andreas M. Grabrucker. (2020) Targeting Metal Homeostasis as a Therapeutic Strategy for Alzheimer's Disease. Brisbane (AU) : Exon Publications Alzheimer's Disease: Drug Discovery
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Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr
Ross, AM; Grabrucker, AM; McGourty, KD; Mulvihill, JE (2020) Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr. Cambridge, Massachusetts, United States : Academic Press Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents 1st Edition.
Read moreZinc and autism
Grabrucker, S; Grabrucker AM (2017) Zinc and autism. Netherlands : Elsevier Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics
Read moreAnimal models of ASD Extracerebral dysfunction
Hill-Yardin, EL; McKeown, SJ; Novarino, G; Grabrucker, AM (2017) Animal models of ASD Extracerebral dysfunction. Germany : Springer Nature Advances in Anatomy, Embryology and Cell Biology, Translational anatomy and cell biology of autism spectrum disorders
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Neurodegenerative Diseases: Anatomy and Pathology
Sarowar, T; Grabrucker, AM (2017) Neurodegenerative Diseases: Anatomy and Pathology. Sharjah : Bentham Science Publishers Frontiers in Nanomedicine: Nanomedicine and Neuroscience. :3-64
Read moreZinc in the developing brain
Grabrucker, AM (2016) Zinc in the developing brain. USA : CRC Press Nutrition and the developing brain :143-168
Read moreUrsachen
Grabrucker, AM; Schmeisser, MJ (2014) Ursachen. Germany : Kohlhammer Handlexikon Autismus-Spektrum: Schlüsselbegriffe aus Forschung, Theorie, Praxis und Betroffenen-Sicht :382-392
Read moreNanoparticles as BloodBrain Barrier Permeable CNS Targeted Drug Delivery Systems
Grabrucker, AM; Chhabra, R; Belletti, D; Forni, F; Vandelli, MA; Ruozi, B; Tosi,G (2013) Nanoparticles as BloodBrain Barrier Permeable CNS Targeted Drug Delivery Systems. Germany : Springer Topics in Medicinal Chemistry :71-89
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Anti-inflammatory and antioxidant activities of polar lipids in vitro and implications for neurodegenerative disease
Hans, S;Grabrucker, AM;Zabetakis, I (2022) Anti-inflammatory and antioxidant activities of polar lipids in vitro and implications for neurodegenerative disease.
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The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder
Indika N.L.R.;Frye R.E.;Rossignol D.A.;Owens S.C.;Senarathne U.D.;Grabrucker A.M.;Perera R.;Engelen M.P.K.J.;Deutz N.E.P. (2023) The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder. Personalized Medicine
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The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders
Stanton, JE;Malijauskaite, S;McGourty, K;Grabrucker, AM (2021) The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders. LAUSANNE : FRONTIERS MEDIA SA Frontiers In Molecular Neuroscience
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