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Prof. Andreas Grabrucker

Biography

CAREER PROFILE


Education
  • 2000-2005 TU Munich, Germany, Diploma in Biology, Major: Genetics, Minor: Neurobiology and Zoology
  • 2005-2009 University Ulm, Germany, PhD, international PhD program in molecular medicine

Employment
  • 2009-2011 Postdoctoral fellow, Stanford University, USA, Dept. of Psychiatry and Behavioral Sciences, Stanford School of Medicine
  • 2011-2016 Assistant Professor, University Ulm, Germany, Dept. of Neurology
  • 2011-2016 Executive Director of the Neurocenter of Ulm University
  • 2017- Lecturer in Cell Biology, University of Limerick, Ireland, Dept. of Biological Sciences, School of Natural Sciences

Scientific Activities - My research focuses on synaptopathies as a key feature of neurodevelopmental diseases. Disruptions in synaptic structure leading to abnormal circuit formation and function are potentially the major determinant of such brain diseases. My work aims to understand how genetic and non-genetic factors contribute to neuronal dysfunction and to develop novel research and treatment strategies using nanotechnology.

Research Interests

My research is interested in the underlying components able to modify synaptic plasticity and transmission in the Central Nervous System (CNS) in health and disease. Thereby, synaptopathy defines key features of neurodegenerative and psychiatric diseases. It implies that disruptions in synaptic structure and function are potentially the major determinant of such brain diseases.

Using a combination of biochemical, cellular, molecular and behavioral approaches, we have investigated proteins of excitatory postsynapses focusing on their deregulation in neurodevelopmental and neuropsychiatric disorders such as Autism Spectrum Disorders, Alzheimer's disease and Schizophrenia. We are especially interested in the functional interaction of biometals and synaptic proteins in mechanisms such as synapse formation and maturation in health and disease. Given that dysregulation of trace metals is reported in many brain disorders, their role in the modification of synaptic function needs to be investigated in more detail. Especially since many brain disorders seem to not only have a genetic but also an environmental component triggering the disease. To investigate the role of biometals in disorders of the CNS, we use several approaches. For example, targeted manipulation of biometal levels in animal models and cells derived from human induced pluripotent stem cells is a major goal in our research. To that end, the development of novel drug carriers (i.e. Nanoparticles) and assays designed to evaluate their potency to influence synapse formation, maturation and plasticity has become an important part of our research. On the other hand, we investigate human patients with selected disorders and perform a state of the art assessment of their trace metal status and clinical phenotype to define subgroups with biometal abnormalities, which can be associated with specific clinical presentations. Understanding how environmental and genetic factors contribute to synaptic function will hopefully allow the development of research strategies to normalize function in individuals with synaptopathies.

Professional Activities

Association

  • 2012 Member, International Society for Zinc Biology
  • 2007 Member, Society for Neuroscience

Language

  • German
  • English

Publications

Books

2020

Biometals in Autism Spectrum Disorders
Andreas M. Grabrucker
(2020) Biometals in Autism Spectrum Disorders
Cambridge, MA, USA : Academic Press / Elsevier
DOI: https://doi.org/10.1016/C2019-0-01808-0

2019

Eco-Neurobiology and how the environment shapes our brain
Andreas M. Grabrucker
(2019) Eco-Neurobiology and how the environment shapes our brain
Andreas M. Grabrucker(Ed.) Newcastle upon Tyne, UK : Cambridge Scholars

Book Chapters

2020

Animal models for trace metal abnormalitiesâ€'links to autism
(2020) Animal models for trace metal abnormalitiesâ€'links to autism
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00009-4

2020

Human stem cell models linking biometal abnormalities and autism
(2020) Human stem cell models linking biometal abnormalities and autism
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00011-2

2020

Targeting Metal Homeostasis as a Therapeutic Strategy for Alzheimer's Disease
Antonietta Vilella, Eleonora Daini, Chiara A. De Benedictis, Andreas M. Grabrucker.
(2020) Targeting Metal Homeostasis as a Therapeutic Strategy for Alzheimer's Disease
In Alzheimer's Disease: Drug Discovery; Huang X(Ed.) Brisbane (AU) : Exon Publications
DOI: 10.36255/exonpublications.alzheimersdisease.2020.ch5

2020

The history of metals in autism spectrum disorders
(2020) The history of metals in autism spectrum disorders
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00003-3

2020

Biometals and nutrition in autism spectrum disorders
(2020) Biometals and nutrition in autism spectrum disorders
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00006-9

2020

Animal models for autismâ€'links to biometal abnormalities
(2020) Animal models for autismâ€'links to biometal abnormalities
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00010-0

2020

Biometal homeostasis as a therapeutic strategy in autism spectrum disorders
(2020) Biometal homeostasis as a therapeutic strategy in autism spectrum disorders
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00013-6

2020

Introduction to metallomics: the science of biometals
(2020) Introduction to metallomics: the science of biometals
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00001-x

2020

Measuring biometals
(2020) Measuring biometals
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00002-1

2020

Extracerebral biometals in autism spectrum disorders: the gutâ€'brain axis
(2020) Extracerebral biometals in autism spectrum disorders: the gutâ€'brain axis
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00012-4

2020

Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases
Joana S. Cristóvão, Guilherme G. Moreira, Andreas M. Grabrucker, Cláudio M. Gomes
(2020) Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases
In Protein Homeostasis Diseases. ; Angel L. Pey(Ed.) Amsterdam, NL : Elsevier pp. 181-195
DOI: 10.1016/B978-0-12-819132-3.00009-9

2020

Linking trace metal abnormalities to autismâ€'insights from epidemiological studies
(2020) Linking trace metal abnormalities to autismâ€'insights from epidemiological studies
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00007-0

2020

The specific role of zinc in autism spectrum disorders
(2020) The specific role of zinc in autism spectrum disorders
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00008-2

2020

Future perspectives: autism, a disorder of biometal imbalance?
(2020) Future perspectives: autism, a disorder of biometal imbalance?
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00014-8

2020

Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr
Ross, AM; Grabrucker, AM; McGourty, KD; Mulvihill, JE
(2020) Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr
In Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents 1st Edition.; Sigh RW, Singh D, Kanwar J, Singh Chauha N(Ed.) Cambridge, Massachusetts, United States : Academic Press

2020

Essential trace metals and their function in brain development
(2020) Essential trace metals and their function in brain development
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00004-5

2020

Nonessential metals and their brain pathology
(2020) Nonessential metals and their brain pathology
In Biometals in Autism Spectrum Disorders;
DOI: 10.1016/b978-0-12-821132-8.00005-7

2019

The Role of Trace Metals in Alzheimer's Disease
Chiara A. De Benedictis, Antonietta Vilella, Andreas M. Grabrucker
(2019) The Role of Trace Metals in Alzheimer's Disease
In Alzheimer's Disease; Thomas Wisniewski(Ed.) Brisbane, Australia : Codon Publications pp. 85-106
DOI: 10.15586/alzheimersdisease.2019

2017

Neurodegenerative Diseases: Anatomy and Pathology
Sarowar, T; Grabrucker, AM
(2017) Neurodegenerative Diseases: Anatomy and Pathology
In Frontiers in Nanomedicine: Nanomedicine and Neuroscience.; Sharjah : Bentham Science Publishers pp. 3-64

2017

Zinc and autism
Grabrucker, S; Grabrucker AM
(2017) Zinc and autism
In Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics; Netherlands : Elsevier

2017

Animal models of ASD – Extracerebral dysfunction
Hill-Yardin, EL; McKeown, SJ; Novarino, G; Grabrucker, AM
(2017) Animal models of ASD – Extracerebral dysfunction
In Advances in Anatomy, Embryology and Cell Biology, Translational anatomy and cell biology of autism spectrum disorders; Germany : Springer Nature
DOI: 10.1007/978-3-319-52498-6_9

2016

Zinc in the developing brain
Grabrucker, AM
(2016) Zinc in the developing brain
In Nutrition and the developing brain; USA : CRC Press pp. 143-168

2016

Zinc Deficiency
Sauer, AK; Hagmeyer, S; Grabrucker, AM
(2016) Zinc Deficiency
In Nutritional Deficiency; Croatia : InTech pp. 23-46
DOI: 10.5772/63203

2014

Ursachen
Grabrucker, AM; Schmeisser, MJ
(2014) Ursachen
In Handlexikon Autismus-Spektrum: Schlüsselbegriffe aus Forschung, Theorie, Praxis und Betroffenen-Sicht; Germany : Kohlhammer pp. 382-392

2013

Nanoparticles as Blood–Brain Barrier Permeable CNS Targeted Drug Delivery Systems
Grabrucker, AM; Chhabra, R; Belletti, D; Forni, F; Vandelli, MA; Ruozi, B; Tosi,G
(2013) Nanoparticles as Blood–Brain Barrier Permeable CNS Targeted Drug Delivery Systems
In Topics in Medicinal Chemistry; Germany : Springer pp. 71-89
DOI: 10.1007/7355_2013_22

Peer Reviewed Journals

2021

Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.
Grabrucker S;Pagano J;Schweizer J;Urrutia-Ruiz C;Schön M;Thome K;Ehret G;Grabrucker AM;Zhang R;Hengerer B;Bockmann J;Verpelli C;Sala C;Boeckers TM;
(2021) Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.
In Embo Journal;
DOI: 10.15252/embj.2019104267

2020

Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties
Ross A.M.;Kennedy T.;McNulty D.;Leahy C.I.;Walsh D.R.;Murray P.;Grabrucker A.M.;Mulvihill J.J.E.
(2020) Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties
In Materials Science & Engineering C-Materials For Biological Applications;
DOI: 10.1016/j.msec.2020.110985
[ULIR]

2020

Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles.
Lutz AK;Pfaender S;Incearap B;Ioannidis V;Ottonelli I;Föhr KJ;Cammerer J;Zoller M;Higelin J;Giona F;Stetter M;Stoecker N;Alami NO;Schön M;Orth M;Liebau S;Barbi G;Grabrucker AM;Delorme R;Fauler M;Mayer B;Jesse S;Roselli F;Ludolph AC;Bourgeron T;Verpelli C;Demestre M;Boeckers TM;
(2020) Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles.
In Science Translational Medicine;
DOI: 10.1126/scitranslmed.aaz3267

2020

Concentrations of Essential Trace Metals in the Brain of Animal Species-A Comparative Study.
DeBenedictis CA;Raab A;Ducie E;Howley S;Feldmann J;Grabrucker AM;
(2020) Concentrations of Essential Trace Metals in the Brain of Animal Species-A Comparative Study.
In Brain Sciences;
DOI: 10.3390/brainsci10070460

2020

Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal- Melphalan Prodrug for Glioblastoma Treatment
Oddone N, Boury F, Garcion E, Grabrucker AM, Del Carmen Martinez M, Da F, Janaszewska A, Forni F, Vandelli MA, Tosi G, Ruozi B, Duskey JT
(2020) Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal- Melphalan Prodrug for Glioblastoma Treatment
In Frontiers In Pharmacology;
DOI: 10.3389/fphar.2020.00574

2020

Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers
Mulvihill J.;Cunnane E.;Ross A.;Duskey J.;Tosi G.;Grabrucker A.
(2020) Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers
In Nanomedicine (London, England); pp. 205-214
DOI: 10.2217/nnm-2019-0367
[ULIR]

2019

Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer’s disease model mice
Hagmeyer S.;Romão M.;Cristóvão J.;Vilella A.;Zoli M.;Gomes C.;Grabrucker A.
(2019) Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer’s disease model mice
In Frontiers In Neuroscience;
DOI: 10.3389/fnins.2019.00640

2019

Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model
Sauer A.;Bockmann J.;Steinestel K.;Boeckers T.;Grabrucker A.
(2019) Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model
In International Journal Of Molecular Sciences;
DOI: 10.3390/ijms20092134

2019

Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI
Schoen M.;Asoglu H.;Bauer H.;Müller H.;Abaei A.;Sauer A.;Zhang R.;Song T.;Bockmann J.;Kassubek J.;Rasche V.;Grabrucker A.;Boeckers T.
(2019) Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI
In Frontiers In Neural Circuits; pp. -6
DOI: 10.3389/fncir.2019.00006
[ULIR]

2019

ROS-responsive “smart” polymeric conjugate: Synthesis, characterization and proof-of-concept study
Oddone N.;Pederzoli F.;Duskey J.;De Benedictis C.;Grabrucker A.;Forni F.;Angela Vandelli M.;Ruozi B.;Tosi G.
(2019) ROS-responsive “smart” polymeric conjugate: Synthesis, characterization and proof-of-concept study
In International journal of pharmaceutics;
DOI: 10.1016/j.ijpharm.2019.118655

2019

Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery: In vitro evidence
Pederzoli F.;Ruozi B.;Duskey J.;Hagmeyer S.;Sauer A.;Grabrucker S.;Coelho R.;Oddone N.;Ottonelli I.;Daini E.;Zoli M.;Vandelli M.;Tosi G.;Grabrucker A.
(2019) Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery: In vitro evidence
In Pharmaceutics;
DOI: 10.3390/pharmaceutics11110572

2019

Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice
Sauer A.;Grabrucker A.
(2019) Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice
In Frontiers In Neuroscience;
DOI: 10.3389/fnins.2019.01295

2019

Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives.
Ross AM;Mc Nulty D;O'Dwyer C;Grabrucker AM;Cronin P;Mulvihill JJE;
(2019) Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives.
In Journal Of Controlled Release;
DOI: 10.1016/j.jconrel.2019.01.022
[ULIR]

2018

Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain
Hagmeyer, S,Cristovao, JS,Mulvihill, JJE,Boeckers, TM,Gomes, CM,Grabrucker, AM
(2018) Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain
In Frontiers In Molecular Neuroscience;
DOI: 10.3389/fnmol.2017.00456
[ULIR]

2018

Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome.
Hagmeyer S;Sauer AK;Grabrucker AM;
(2018) Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome.
In Frontiers In Synaptic Neuroscience;
DOI: 10.3389/fnsyn.2018.00011
[ULIR]

2018

Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain
Belletti, D; Grabrucker, AM; Pederzoli, F; Menrath, I; Vandelli, MA; Tosi, G; Duskey, TJ; Forni, F; Ruozi, B;
(2018) Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain
In International journal of pharmaceutics; pp. 300-310
DOI: 10.1016/j.ijpharm.2018.03.061
[ULIR]

2018

Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder
Grabrucker, S,Haderspeck, JC,Sauer, AK,Kittelberger, N,Asoglu, H,Abaei, A,Rasche, V,Schon, M,Boeckers, TM,Grabrucker, AM
(2018) Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder
In Frontiers In Molecular Neuroscience;
DOI: 10.3389/fnmol.2017.00450
[ULIR]

2017

Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2
Sarowar, T; Grabrucker, S; Boeckers, TM; Grabrucker, AM
(2017) Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2
In Frontiers In Neuroscience;
DOI: 10.3389/fnmol.2017.00180
[ULIR]

2017

Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC
Sauer, AK,Pfaender, S,Hagmeyer, S,Tarana, L,Mattes, AK,Briel, F,Kury, S,Boeckers, TM,Grabrucker, AM
(2017) Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC
In Biometals; pp. 643-661
DOI: 10.1007/s10534-017-0033-y

2017

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability
Küry, S; van Woerden, GM; Besnard, T; Proietti Onori, M; Latypova, X; Towne, MC; Cho, MT; Prescott, TE; Ploeg, MA; Sanders, S; Stessman, HAF; Pujol, A; Distel, B; Robak, LA; Bernstein, JA; Denommé-Pichon, AS; Lesca, G; Sellars, EA; Berg, J; Carré, W; Busk, ØL; van Bon, BWM; Waugh, JL; Deardorff, M; Hoganson, GE; Bosanko, KB; Johnson, DS; Dabir, T; Holla, ØL; Sarkar, A; Tveten, K; de Bellescize, J; Braathen, GJ; Terhal, PA; Grange, DK; van Haeringen, A; Lam, C; Mirzaa, G; Burton, J; Bhoj, EJ; Douglas, J; Santani, AB; Nesbitt, AI; Helbig, KL; Andrews, MV; Begtrup, A; Tang, S; van Gassen, KLI; Juusola, J; Foss, K; Enns, GM; Moog, U; Hinderhofer, K; Paramasivam, N; Lincoln, S; Kusako, BH; Lindenbaum, P; Charpentier, E; Nowak, CB; Cherot, E; Simonet, T; Ruivenkamp, CAL; Hahn, S; Brownstein, CA; Xia, F; Schmitt, S; Deb, W; Bonneau, D; Nizon, M; Quinquis, D; Chelly, J; Rudolf, G; Sanlaville, D; Parent, P; Gilbert-Dussardier, B; Toutain, A; Sutton, VR; Thies, J; Peart-Vissers, LELM; Boisseau, P; Vincent, M; Grabrucker, AM; Dubourg, C; Tan, WH; Verbeek, NE; Granzow, M; Santen, GWE; Shendure, J; Isidor, B; Pasquier, L; Redon, R; Yang, Y; State, MW; Kleefstra, T; Cogné, B; Petrovski, S; Retterer, K; Eichler, EE; Rosenfeld, JA; Agrawal, PB; Bézieau, S; Odent, S; Elgersma, Y; Mercier, S
(2017) De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability
In American Journal Of Human Genetics; pp. 768-788
DOI: http://dx.doi.org/10.1016/j.ajhg.2017.10.003

2017

Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer's disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery.
Vilella, A; Belletti, D; Sauer, AK; Hagmeyer, S; Sarowar, T; Masoni, M; Stasiak, N; Mulvihill, JJE; Ruozi, B; Forni, F; Vandelli, MA; Tosi, G; Zoli, M; Grabrucker, AM
(2017) Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer's disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery.
In Journal Of Trace Elements In Experimental Medicine;
DOI: 10.1016/j.jtemb.2017.12.006

2017

Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates
Ruozi, B; Belletti, D; Pederzoli, F; Masoni, M; Keller, J; Ballestrazzi, A; Vandelli, MA; Tosi, G; Grabrucker, AM
(2017) Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates
In International Journal Of Pharmaceutics;
DOI: 10.1016/j.ijpharm.2017.05.015
[ULIR]

2017

Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3
Pfaender, S; Sauer, AK; Hagmeyer, S; Mangus, K; Linta, L; Liebau, S; Bockmann, J; Huguet, G; Bourgeron, T; Boeckers, TM; Grabrucker, AM
(2017) Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3
In Scientific Reports;
DOI: 10.1038/srep45190
[ULIR]

2016

Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells
Pfaender, S; Föhr, K; Lutz, AK; Putz, S; Achberger, K; Linta, L; Liebau, S; Boeckers, TM; Grabrucker, AM
(2016) Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells
In Neural plasticity;
DOI: 10.1155/2016/3760702
[ULIR]

2016

Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies
Sarowar, T; Grabrucker, AM
(2016) Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies
In Neural plasticity;
DOI: 10.1155/2016/8051861
[ULIR]

2016

EXPLOITING THE VERSATILITY OF CHOLESTEROL IN NANOPARTICLES FORMULATION
Belletti, D; Grabrucker, AM; Pederzoli, F; Menrath, I; Cappello, V; Vandelli, MA; Forni, F; Tosi, G; Ruozi, B
(2016) EXPLOITING THE VERSATILITY OF CHOLESTEROL IN NANOPARTICLES FORMULATION
In International Journal Of Pharmaceutics; pp. 331-340
DOI: 10.1016/j.ijpharm.2016.07.022

2016

Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2
Sarowar, T; Grabrucker, S; Föhr, K; Mangus, K; Eckert, M; Bockmann, J; Boeckers, TM; Grabrucker, AM
(2016) Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2
In Molecular Brain;
DOI: 10.1186/s13041-016-0206-6
[ULIR]

2016

Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency
Grabrucker, S; Boeckers, TM; Grabrucker, AM
(2016) Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency
In Frontiers In Behavioral Neuroscience;
DOI: 10.3389/fnbeh.2016.00037
[ULIR]

2016

Activity and circadian rhythm influence synaptic Shank3 protein levels in mice
Sarowar, T; Chhabra, R; Vilella, A; Boeckers, TM; Zoli, M; Grabrucker, AM
(2016) Activity and circadian rhythm influence synaptic Shank3 protein levels in mice
In Journal Of Neurochemistry; pp. 887-895
DOI: 10.1111/jnc.13709

2015

Emerging Use of Nanotechnology in the Treatment of Neurological Disorders
Chhabra, R; Tosi, G; Grabrucker, AM
(2015) Emerging Use of Nanotechnology in the Treatment of Neurological Disorders
In Current Pharmaceutical Design; pp. 3111-3130

2015

N-Cadherin-mediated cell adhesion is regulated by extracellular Zn(2+)
Heiliger, E; Osmanagic, A; Haase, H; Golenhofen, N; Grabrucker, AM; Weth, A; Baumgartner, W
(2015) N-Cadherin-mediated cell adhesion is regulated by extracellular Zn(2+)
In Metallomics; pp. 355-362
DOI: 10.1039/c4mt00300d

2015

Effects of trace metal profiles characteristic for autism on synapses in cultured neurons
Hagmeyer, S; Mangusm K; Boeckers, TM; Grabrucker, AM
(2015) Effects of trace metal profiles characteristic for autism on synapses in cultured neurons
In Neural plasticity;
DOI: 10.1155/2015/985083

2015

Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo
Chhabra, R; Ruozi, B; Vilella, A; Belletti, D; Mangus, K; Pfaender, S; Sarowar, T; Boeckers, TM; Zoli, M; Forni, F; Vandelli, MA; Tosi, G; Grabrucker, AM
(2015) Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo
In Cns & Neurological Disorders-Drug Targets; pp. 1041-1053

2015

Zinc in gut-brain interaction in autism and neurological disorders
Vela, G; Stark, P; Socha, M; Sauer, AK; Hagmeyer, S; Grabrucker, AM
(2015) Zinc in gut-brain interaction in autism and neurological disorders
In Neural plasticity;
DOI: 10.1155/2015/972791

2014

Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release
Chhabra, R; Grabrucker, AM; Veratti, P; Belletti, D; Boeckers, TM; Vandelli, MA; Forni, F; Tosi, G; Ruozi, B
(2014) Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release
In International Journal Of Pharmaceutics; pp. 349-357
DOI: 10.1016/j.ijpharm.2014.05.054

2014

Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution
Vilella, A; Tosi, G; Grabrucker, AM; Ruozi, B; Belletti, D; Vandelli, MA; Boeckers, TM; Forni, F; Zoli, M
(2014) Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution
In Journal Of Controlled Release; pp. 195-201
DOI: 10.1016/j.jconrel.2013.11.023

2014

Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport
Tosi, G; Vilella, A; Chhabra, R; Schmeisser, MJ; Boeckers, TM; Ruozi, B; Vandelli, MA; Forni, F; Zoli, M; Grabrucker, AM
(2014) Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport
In Journal Of Controlled Release; pp. 90-107
DOI: 10.1016/j.jconrel.2014.01.004

2014

Behavioral impairments in animal models for zinc deficiency
Hagmeyer, S; Haderspeck, JC; Grabrucker, AM
(2014) Behavioral impairments in animal models for zinc deficiency
In Frontiers In Behavioral Neuroscience;
DOI: 10.3389/fnbeh.2014.00443

2014

Characterization of biometal profiles in neurological disorders
Pfaender, S; Grabrucker, AM
(2014) Characterization of biometal profiles in neurological disorders
In Metallomics; pp. 960-977
DOI: 10.1039/c4mt00008k

2014

The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation
Grabrucker, S; Proepper, C; Mangus, K; Eckert, M; Chhabra, R; Schmeisser, MJ; Boeckers, TM; Grabrucker, AM.
(2014) The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation
In Experimental Neurology; pp. 126-137
DOI: 10.1016/j.expneurol.2013.12.015

2014

Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses
Baecker, T; Mangus, K; Pfaender, S; Chhabra, R; Boeckers, TM; Grabrucker, AM
(2014) Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses
In Biometals; pp. 715-730
DOI: 10.1007/s10534-014-9764-1

2014

Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders
Grabrucker, S; Jannetti, L; Eckert, M; Gaub, S; Chhabra, R; Pfaender, S; Mangus, K; Reddy, PP; Rankovic, V; Schmeisser, MJ; Kreutz, MR; Ehret, G; Boeckers, TM; Grabrucker, AM
(2014) Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders
In Brain; pp. 137-152
DOI: 10.1093/brain/awt303

2013

The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons
Schmeisser, MJ; Kühl, SJ; Schoen, M; Beth, NH; Weis, TM; Grabrucker, AM; Kühl, M; Boeckers, TM
(2013) The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons
In Neural Development;
DOI: 10.1186/1749-8104-8-18

2012

Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling
Arons, MH; Thynne, CJ; Grabrucker, AM; Li, D; Schoen, M; Cheyne, JE; Boeckers, TM; Montgomery, JM; Garner, CC
(2012) Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling
In Journal Of Neuroscience; pp. 14966-14978
DOI: 10.1523/JNEUROSCI.2215-12.2012

2012

Grabrucker AM. Environmental factors in autism
Grabrucker, AM
(2012) Grabrucker AM. Environmental factors in autism
In Frontiers in psychiatry;
DOI: 10.3389/fpsyt.2012.00118

2012

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
Schmeisser, MJ; Ey, E; Wegener, S; Bockmann, J; Stempel, AV; Kuebler, A; Janssen, AL; Udvardi, PT; Shiban, E; Spilker, C; Balschun, D; Skryabin, BV; Dieck, St; Smalla, KH; Montag, D; Leblond, CS; Faure, P; Torquet, N; Le Sourd, AM; Toro, R; Grabrucker, AM; Shoichet, SA; Schmitz, D; Kreutz, MR; Bourgeron, T; Gundelfinger, ED; Boeckers, TM
(2012) Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
In Nature; pp. 256-260
DOI: 10.1038/nature11015

2011

Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
Grabrucker, AM; Schmeisser, MJ; Udvardi, PT; Arons, M; Schoen, M; Woodling, NS; Andreasson, KI; Hof, PR; Buxbaum, JD; Garner, CC; Boeckers, TM
(2011) Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
In Molecular Neurodegeneration;
DOI: 10.1186/1750-1326-6-65

2011

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies
Grabrucker, AM; Schmeisser, MJ; Schoen, M; Boeckers, TM
(2011) Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies
In Trends In Cell Biology; pp. 594-603
DOI: 10.1016/j.tcb.2011.07.003

2011

Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences
Grabrucker, AM; Garner, CC; Boeckers, TM; Bondioli, L; Ruozi, B; Forni, F; Vandelli, MA; Tosi, G
(2011) Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences
In Plos One; pp. e17851-
DOI: 10.1371/journal.pone.0017851

2011

Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
Grabrucker, AM; Knight, MJ; Proepper, C; Bockmann, J; Joubert, M; Rowan, M; Nienhaus, GU; Garner, CC; Bowie, JU; Kreutz, MR; Gundelfinger, ED; Boeckers, TM
(2011) Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
In Embo Journal; pp. 569-581
DOI: 10.1038/emboj.2010.336

2009

Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system
Grabrucker, AM; Vaida, B; Bockmann, J; Boeckers, TM
(2009) Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system
In Journal Of Neuroscience Methods; pp. 227-234
DOI: 10.1016/j.jneumeth.2009.05.008

2009

Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma
Vellanki, SH; Grabrucker, A; Liebau, S; Proepper, C; Eramo, A; Braun, V; Boeckers, T; Debatin, KM; Fulda, S
(2009) Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma
In Neoplasia; pp. 743-752

2009

ynaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses
Schmeisser, MJ; Grabrucker, AM; Bockmann, J; Boeckers, TM
(2009) ynaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses
In Journal Of Biological Chemistry; pp. 29146-29157
DOI: 10.1074/jbc.M109.020628

2009

Synaptogenesis of hippocampal neurons in primary cell culture
Grabrucker, A; Vaida, B; Bockmann, J; Boeckers, TM
(2009) Synaptogenesis of hippocampal neurons in primary cell culture
In Cell And Tissue Research; pp. 333-341
DOI: 10.1007/s00441-009-0881-z

Other Publications

2020

Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders
Sauer A.K.;Vela H.;Vela G.;Stark P.;Barrera-Juarez E.;Grabrucker A.M.
(2020) Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders
In Frontiers In Oncology;
DOI: 10.3389/fonc.2020.01293

2020

Rho GTPases in the Amygdala-A Switch for Fears?
Sarowar T.;Grabrucker A.M.
(2020) Rho GTPases in the Amygdala-A Switch for Fears?
In Cells;
DOI: 10.3390/cells9091972

2017

Molecular and Cellular Mechanisms of Synaptopathies
Ardiles, AO; Grabrucker, AM; Scholl, FG; Rudenko, G; Borsello, T
(2017) Molecular and Cellular Mechanisms of Synaptopathies
In Neural Plasticity; pp. 1-3
DOI: 10.1155/2017/2643943