Biography

CAREER PROFILE
Education
  • 2000-2005 TU Munich, Germany, Diploma in Biology, Major: Genetics, Minor: Neurobiology and Zoology
  • 2005-2009 University Ulm, Germany, PhD, international PhD program in molecular medicine

Employment
  • 2009-2011 Postdoctoral fellow, Stanford University, USA, Dept. of Psychiatry and Behavioral Sciences, Stanford School of Medicine
  • 2011-2016 Assistant Professor, University Ulm, Germany, Dept. of Neurology
  • 2011-2016 Executive Director of the Neurocenter of Ulm University
  • 2017- Lecturer in Cell Biology, University of Limerick, Ireland, Dept. of Biological Sciences, School of Natural Sciences

Scientific Activities - My research focuses on synaptopathies as a key feature of neurodevelopmental diseases. Disruptions in synaptic structure leading to abnormal circuit formation and function are potentially the major determinant of such brain diseases. My work aims to understand how genetic and non-genetic factors contribute to neuronal dysfunction and to develop novel research and treatment strategies using nanotechnology.

Research Interests

My research is interested in the underlying components able to modify synaptic plasticity and transmission in the Central Nervous System (CNS) in health and disease. Thereby, synaptopathy defines key features of neurodegenerative and psychiatric diseases. It implies that disruptions in synaptic structure and function are potentially the major determinant of such brain diseases. Using a combination of biochemical, cellular, molecular and behavioral approaches, we have investigated proteins of excitatory postsynapses focusing on their deregulation in neurodevelopmental and neuropsychiatric disorders such as Autism Spectrum Disorders, Alzheimer's disease and Schizophrenia. We are especially interested in the functional interaction of biometals and synaptic proteins in mechanisms such as synapse formation and maturation in health and disease. Given that dysregulation of trace metals is reported in many brain disorders, their role in the modification of synaptic function needs to be investigated in more detail. Especially since many brain disorders seem to not only have a genetic but also an environmental component triggering the disease. To investigate the role of biometals in disorders of the CNS, we use several approaches. For example, targeted manipulation of biometal levels in animal models and cells derived from human induced pluripotent stem cells is a major goal in our research. To that end, the development of novel drug carriers (i.e. Nanoparticles) and assays designed to evaluate their potency to influence synapse formation, maturation and plasticity has become an important part of our research. On the other hand, we investigate human patients with selected disorders and perform a state of the art assessment of their trace metal status and clinical phenotype to define subgroups with biometal abnormalities, which can be associated with specific clinical presentations. Understanding how environmental and genetic factors contribute to synaptic function will hopefully allow the development of research strategies to normalize function in individuals with synaptopathies.

Professional Activities

Association

  • 2012 Member, International Society for Zinc Biology
  • 2007 Member, Society for Neuroscience

Language

  • German
  • English

Peer Reviewed Journals

2022

Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders

Sauer, AK;Malijauskaite, S;Meleady, P;Boeckers, TM;McGourty, K;Grabrucker, AM (2022) Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders. BASEL : SPRINGER BASEL AG Cellular And Molecular Life Sciences

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2022

Identification of the common neurobiological process disturbed in genetic and non-genetic models for autism spectrum disorders

Malijauskaite S.;Sauer A.K.;Hickey S.E.;Franzoni M.;Grabrucker A.M.;McGourty K. (2022) Identification of the common neurobiological process disturbed in genetic and non-genetic models for autism spectrum disorders. Cellular And Molecular Life Sciences

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2022

Prevalence of low dietary zinc intake in women and pregnant women in Ireland

De Benedictis C.A.;Trame S.;Rink L.;Grabrucker A.M. (2022) Prevalence of low dietary zinc intake in women and pregnant women in Ireland. Irish journal of medical science

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2022

Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments

Duskey J.T.;Rinaldi A.;Ottonelli I.;Caraffi R.;De Benedictis C.A.;Sauer A.K.;Tosi G.;Vandelli M.A.;Ruozi B.;Grabrucker A.M. (2022) Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments. Pharmaceutics

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2022

Zinc Supplementation in Health and Disease

Hans S.;Stanton J.E.;O’Connor E.M.;Grabrucker A.M. (2022) Zinc Supplementation in Health and Disease. Trace Metals: Sources, Applications And Environmental Implications :1-29

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2021

Altered gut-brain signaling in autism spectrum disorders-from biomarkers to possible intervention strategies

Sauer A.K.;Dooley L.;Vaughan A.;Grabrucker A.M. (2021) Altered gut-brain signaling in autism spectrum disorders-from biomarkers to possible intervention strategies. Neural Engineering Techniques For Autism Spectrum Disorder: Volume 1: Imaging And Signal Analysis :127-149

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2021

IPSC-derived intestinal organoids and current 3D intestinal scaffolds

Malijauskaite S.;Mulvihill J.J.E.;Grabrucker A.M.;McGourty K. (2021) IPSC-derived intestinal organoids and current 3D intestinal scaffolds. Ipscs In Tissue Engineering :293-327

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2021

Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.

Grabrucker S;Pagano J;Schweizer J;Urrutia-Ruiz C;Schön M;Thome K;Ehret G;Grabrucker AM;Zhang R;Hengerer B;Bockmann J;Verpelli C;Sala C;Boeckers TM; (2021) Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.. Embo Journal

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2021

S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis

Daini, E;Hagmeyer, S;De Benedictis, CA;Cristovao, JS;Bodria, M;Ross, AM;Raab, A;Boeckers, TM;Feldmann, J;Gomes, CM;Zoli, M;Vilella, A;Grabrucker, AM (2021) S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis. LONDON : SPRINGERNATURE Translational Psychiatry

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2021

Sperm selection by rheotaxis improves sperm quality and early embryo development

Romero-Aguirregomezcorta, J;Laguna-Barraza, R;Fernandez-Gonzalez, R;Stiavnicka, M;Ward, F;Cloherty, J;McAuliffe, D;Larsen, PB;Grabrucker, AM;Gutierrez-Adan, A;Newport, D;Fair, S (2021) Sperm selection by rheotaxis improves sperm quality and early embryo development. BRISTOL : BIOSCIENTIFICA LTD Reproduction :343-352

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2021

Expression Analysis of Zinc Transporters in Nervous Tissue Cells Reveals Neuronal and Synaptic Localization of ZIP4

De Benedictis, CA;Haffke, C;Hagmeyer, S;Sauer, AK;Grabrucker, AM (2021) Expression Analysis of Zinc Transporters in Nervous Tissue Cells Reveals Neuronal and Synaptic Localization of ZIP4. BASEL : MDPI International Journal Of Molecular Sciences

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2021

The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders

Stanton JE; Malijauskaite S; McGourty K; Grabrucker AM (2021) The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders. n/a Frontiers In Molecular Neuroscience :n/a-n/a

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2021

Localizing therapeutics to the brain

Hans S.;McNamara K.;Cunnane E.;Ross A.M.;Milane L.S.;Mulvihill J.J.E.;Grabrucker A.M. (2021) Localizing therapeutics to the brain. Organelle And Molecular Targeting :207-225

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2020

Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties

Ross A.M.;Kennedy T.;McNulty D.;Leahy C.I.;Walsh D.R.;Murray P.;Grabrucker A.M.;Mulvihill J.J.E. (2020) Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties. Materials Science & Engineering C-Materials For Biological Applications

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2020

Metallic-based nanocarriers: methods employed in nanoparticle characterization and assessing the interaction with the blood–brain barrier

Ross A.M.;Grabrucker A.M.;McGourty K.D.;Mulvihill J.J.E. (2020) Metallic-based nanocarriers: methods employed in nanoparticle characterization and assessing the interaction with the blood–brain barrier. Advances And Avenues In The Development Of Novel Carriers For Bioactives And Biological Agents :255-282

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2020

Concentrations of Essential Trace Metals in the Brain of Animal Species-A Comparative Study.

DeBenedictis CA;Raab A;Ducie E;Howley S;Feldmann J;Grabrucker AM; (2020) Concentrations of Essential Trace Metals in the Brain of Animal Species-A Comparative Study.. Brain Sciences

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2020

Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles.

Lutz AK;Pfaender S;Incearap B;Ioannidis V;Ottonelli I;Föhr KJ;Cammerer J;Zoller M;Higelin J;Giona F;Stetter M;Stoecker N;Alami NO;Schön M;Orth M;Liebau S;Barbi G;Grabrucker AM;Delorme R;Fauler M;Mayer B;Jesse S;Roselli F;Ludolph AC;Bourgeron T;Verpelli C;Demestre M;Boeckers TM; (2020) Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles.. Science Translational Medicine

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2020

Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal- Melphalan Prodrug for Glioblastoma Treatment

Oddone N, Boury F, Garcion E, Grabrucker AM, Del Carmen Martinez M, Da F, Janaszewska A, Forni F, Vandelli MA, Tosi G, Ruozi B, Duskey JT (2020) Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal- Melphalan Prodrug for Glioblastoma Treatment. Frontiers In Pharmacology

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2020

Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers

Mulvihill J.;Cunnane E.;Ross A.;Duskey J.;Tosi G.;Grabrucker A. (2020) Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers. Nanomedicine (London, England) :205-214

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2019

Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI

Schoen M.;Asoglu H.;Bauer H.;Müller H.;Abaei A.;Sauer A.;Zhang R.;Song T.;Bockmann J.;Kassubek J.;Rasche V.;Grabrucker A.;Boeckers T. (2019) Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI. Frontiers In Neural Circuits :-6

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2019

Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice

Sauer A.;Grabrucker A. (2019) Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice. Frontiers In Neuroscience

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2019

Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery: In vitro evidence

Pederzoli F.;Ruozi B.;Duskey J.;Hagmeyer S.;Sauer A.;Grabrucker S.;Coelho R.;Oddone N.;Ottonelli I.;Daini E.;Zoli M.;Vandelli M.;Tosi G.;Grabrucker A. (2019) Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery: In vitro evidence. Pharmaceutics

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2019

Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer’s disease model mice

Hagmeyer S.;Romão M.;Cristóvão J.;Vilella A.;Zoli M.;Gomes C.;Grabrucker A. (2019) Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer’s disease model mice. Frontiers In Neuroscience

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2019

Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model

Sauer A.;Bockmann J.;Steinestel K.;Boeckers T.;Grabrucker A. (2019) Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model. International Journal Of Molecular Sciences

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2019

ROS-responsive “smart” polymeric conjugate: Synthesis, characterization and proof-of-concept study

Oddone N.;Pederzoli F.;Duskey J.;De Benedictis C.;Grabrucker A.;Forni F.;Angela Vandelli M.;Ruozi B.;Tosi G. (2019) ROS-responsive “smart” polymeric conjugate: Synthesis, characterization and proof-of-concept study. International journal of pharmaceutics

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2019

Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives.

Ross AM;Mc Nulty D;O'Dwyer C;Grabrucker AM;Cronin P;Mulvihill JJE; (2019) Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives.. Journal Of Controlled Release

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2018

Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain

Hagmeyer, S,Cristovao, JS,Mulvihill, JJE,Boeckers, TM,Gomes, CM,Grabrucker, AM (2018) Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain. Frontiers In Molecular Neuroscience

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2018

Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome.

Hagmeyer S;Sauer AK;Grabrucker AM; (2018) Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome.. Frontiers In Synaptic Neuroscience

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2018

Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain

Belletti, D; Grabrucker, AM; Pederzoli, F; Menrath, I; Vandelli, MA; Tosi, G; Duskey, TJ; Forni, F; Ruozi, B; (2018) Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain. International journal of pharmaceutics :300-310

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2018

Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder

Grabrucker, S,Haderspeck, JC,Sauer, AK,Kittelberger, N,Asoglu, H,Abaei, A,Rasche, V,Schon, M,Boeckers, TM,Grabrucker, AM (2018) Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder. Frontiers In Molecular Neuroscience

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2017

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability

Küry, S; van Woerden, GM; Besnard, T; Proietti Onori, M; Latypova, X; Towne, MC; Cho, MT; Prescott, TE; Ploeg, MA; Sanders, S; Stessman, HAF; Pujol, A; Distel, B; Robak, LA; Bernstein, JA; Denommé-Pichon, AS; Lesca, G; Sellars, EA; Berg, J; Carré, W; Busk, ØL; van Bon, BWM; Waugh, JL; Deardorff, M; Hoganson, GE; Bosanko, KB; Johnson, DS; Dabir, T; Holla, ØL; Sarkar, A; Tveten, K; de Bellescize, J; Braathen, GJ; Terhal, PA; Grange, DK; van Haeringen, A; Lam, C; Mirzaa, G; Burton, J; Bhoj, EJ; Douglas, J; Santani, AB; Nesbitt, AI; Helbig, KL; Andrews, MV; Begtrup, A; Tang, S; van Gassen, KLI; Juusola, J; Foss, K; Enns, GM; Moog, U; Hinderhofer, K; Paramasivam, N; Lincoln, S; Kusako, BH; Lindenbaum, P; Charpentier, E; Nowak, CB; Cherot, E; Simonet, T; Ruivenkamp, CAL; Hahn, S; Brownstein, CA; Xia, F; Schmitt, S; Deb, W; Bonneau, D; Nizon, M; Quinquis, D; Chelly, J; Rudolf, G; Sanlaville, D; Parent, P; Gilbert-Dussardier, B; Toutain, A; Sutton, VR; Thies, J; Peart-Vissers, LELM; Boisseau, P; Vincent, M; Grabrucker, AM; Dubourg, C; Tan, WH; Verbeek, NE; Granzow, M; Santen, GWE; Shendure, J; Isidor, B; Pasquier, L; Redon, R; Yang, Y; State, MW; Kleefstra, T; Cogné, B; Petrovski, S; Retterer, K; Eichler, EE; Rosenfeld, JA; Agrawal, PB; Bézieau, S; Odent, S; Elgersma, Y; Mercier, S (2017) De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. American Journal Of Human Genetics :768-788

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2017

Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer's disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery.

Vilella, A; Belletti, D; Sauer, AK; Hagmeyer, S; Sarowar, T; Masoni, M; Stasiak, N; Mulvihill, JJE; Ruozi, B; Forni, F; Vandelli, MA; Tosi, G; Zoli, M; Grabrucker, AM (2017) Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer's disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery.. Journal Of Trace Elements In Experimental Medicine

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2017

Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2

Sarowar, T; Grabrucker, S; Boeckers, TM; Grabrucker, AM (2017) Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2. Frontiers In Neuroscience

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2017

Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC

Sauer, AK,Pfaender, S,Hagmeyer, S,Tarana, L,Mattes, AK,Briel, F,Kury, S,Boeckers, TM,Grabrucker, AM (2017) Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC. Biometals :643-661

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2017

Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates

Ruozi, B; Belletti, D; Pederzoli, F; Masoni, M; Keller, J; Ballestrazzi, A; Vandelli, MA; Tosi, G; Grabrucker, AM (2017) Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates. International Journal Of Pharmaceutics

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2017

Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3

Pfaender, S; Sauer, AK; Hagmeyer, S; Mangus, K; Linta, L; Liebau, S; Bockmann, J; Huguet, G; Bourgeron, T; Boeckers, TM; Grabrucker, AM (2017) Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3. Scientific Reports

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2016

Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells

Pfaender, S; Föhr, K; Lutz, AK; Putz, S; Achberger, K; Linta, L; Liebau, S; Boeckers, TM; Grabrucker, AM (2016) Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells. Neural plasticity

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2016

Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency

Grabrucker, S; Boeckers, TM; Grabrucker, AM (2016) Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency. Frontiers In Behavioral Neuroscience

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2016

Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies

Sarowar, T; Grabrucker, AM (2016) Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies. Neural plasticity

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2016

Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2

Sarowar, T; Grabrucker, S; Föhr, K; Mangus, K; Eckert, M; Bockmann, J; Boeckers, TM; Grabrucker, AM (2016) Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2. Molecular Brain

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2016

Activity and circadian rhythm influence synaptic Shank3 protein levels in mice

Sarowar, T; Chhabra, R; Vilella, A; Boeckers, TM; Zoli, M; Grabrucker, AM (2016) Activity and circadian rhythm influence synaptic Shank3 protein levels in mice. Journal Of Neurochemistry :887-895

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2016

EXPLOITING THE VERSATILITY OF CHOLESTEROL IN NANOPARTICLES FORMULATION

Belletti, D; Grabrucker, AM; Pederzoli, F; Menrath, I; Cappello, V; Vandelli, MA; Forni, F; Tosi, G; Ruozi, B (2016) EXPLOITING THE VERSATILITY OF CHOLESTEROL IN NANOPARTICLES FORMULATION. International Journal Of Pharmaceutics :331-340

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2015

N-Cadherin-mediated cell adhesion is regulated by extracellular Zn(2+)

Heiliger, E; Osmanagic, A; Haase, H; Golenhofen, N; Grabrucker, AM; Weth, A; Baumgartner, W (2015) N-Cadherin-mediated cell adhesion is regulated by extracellular Zn(2+). Metallomics :355-362

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2015

Effects of trace metal profiles characteristic for autism on synapses in cultured neurons

Hagmeyer, S; Mangusm K; Boeckers, TM; Grabrucker, AM (2015) Effects of trace metal profiles characteristic for autism on synapses in cultured neurons. Neural plasticity

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2015

Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo

Chhabra, R; Ruozi, B; Vilella, A; Belletti, D; Mangus, K; Pfaender, S; Sarowar, T; Boeckers, TM; Zoli, M; Forni, F; Vandelli, MA; Tosi, G; Grabrucker, AM (2015) Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo. Cns & Neurological Disorders-Drug Targets :1041-1053

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2015

Zinc in gut-brain interaction in autism and neurological disorders

Vela, G; Stark, P; Socha, M; Sauer, AK; Hagmeyer, S; Grabrucker, AM (2015) Zinc in gut-brain interaction in autism and neurological disorders. Neural plasticity

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2015

Emerging Use of Nanotechnology in the Treatment of Neurological Disorders

Chhabra, R; Tosi, G; Grabrucker, AM (2015) Emerging Use of Nanotechnology in the Treatment of Neurological Disorders. Current Pharmaceutical Design :3111-3130

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2014

Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders

Grabrucker, S; Jannetti, L; Eckert, M; Gaub, S; Chhabra, R; Pfaender, S; Mangus, K; Reddy, PP; Rankovic, V; Schmeisser, MJ; Kreutz, MR; Ehret, G; Boeckers, TM; Grabrucker, AM (2014) Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders. Brain :137-152

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2014

Characterization of biometal profiles in neurological disorders

Pfaender, S; Grabrucker, AM (2014) Characterization of biometal profiles in neurological disorders. Metallomics :960-977

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2014

Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution

Vilella, A; Tosi, G; Grabrucker, AM; Ruozi, B; Belletti, D; Vandelli, MA; Boeckers, TM; Forni, F; Zoli, M (2014) Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution. Journal Of Controlled Release :195-201

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2014

Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport

Tosi, G; Vilella, A; Chhabra, R; Schmeisser, MJ; Boeckers, TM; Ruozi, B; Vandelli, MA; Forni, F; Zoli, M; Grabrucker, AM (2014) Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport. Journal Of Controlled Release :90-107

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2014

Behavioral impairments in animal models for zinc deficiency

Hagmeyer, S; Haderspeck, JC; Grabrucker, AM (2014) Behavioral impairments in animal models for zinc deficiency. Frontiers In Behavioral Neuroscience

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2014

The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation

Grabrucker, S; Proepper, C; Mangus, K; Eckert, M; Chhabra, R; Schmeisser, MJ; Boeckers, TM; Grabrucker, AM. (2014) The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation. Experimental Neurology :126-137

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2014

Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses

Baecker, T; Mangus, K; Pfaender, S; Chhabra, R; Boeckers, TM; Grabrucker, AM (2014) Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses. Biometals :715-730

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2014

Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release

Chhabra, R; Grabrucker, AM; Veratti, P; Belletti, D; Boeckers, TM; Vandelli, MA; Forni, F; Tosi, G; Ruozi, B (2014) Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release. International Journal Of Pharmaceutics :349-357

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2013

The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons

Schmeisser, MJ; Kühl, SJ; Schoen, M; Beth, NH; Weis, TM; Grabrucker, AM; Kühl, M; Boeckers, TM (2013) The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons. Neural Development

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2012

Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling

Arons, MH; Thynne, CJ; Grabrucker, AM; Li, D; Schoen, M; Cheyne, JE; Boeckers, TM; Montgomery, JM; Garner, CC (2012) Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling. Journal Of Neuroscience :14966-14978

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2012

Grabrucker AM. Environmental factors in autism

Grabrucker, AM (2012) Grabrucker AM. Environmental factors in autism. Frontiers in psychiatry

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2012

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

Schmeisser, MJ; Ey, E; Wegener, S; Bockmann, J; Stempel, AV; Kuebler, A; Janssen, AL; Udvardi, PT; Shiban, E; Spilker, C; Balschun, D; Skryabin, BV; Dieck, St; Smalla, KH; Montag, D; Leblond, CS; Faure, P; Torquet, N; Le Sourd, AM; Toro, R; Grabrucker, AM; Shoichet, SA; Schmitz, D; Kreutz, MR; Bourgeron, T; Gundelfinger, ED; Boeckers, TM (2012) Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature :256-260

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2011

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

Grabrucker, AM; Schmeisser, MJ; Schoen, M; Boeckers, TM (2011) Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies. Trends In Cell Biology :594-603

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2011

Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation

Grabrucker, AM; Knight, MJ; Proepper, C; Bockmann, J; Joubert, M; Rowan, M; Nienhaus, GU; Garner, CC; Bowie, JU; Kreutz, MR; Gundelfinger, ED; Boeckers, TM (2011) Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. Embo Journal :569-581

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2011

Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences

Grabrucker, AM; Garner, CC; Boeckers, TM; Bondioli, L; Ruozi, B; Forni, F; Vandelli, MA; Tosi, G (2011) Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences. Plos One :e17851-

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2011

Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold

Grabrucker, AM; Schmeisser, MJ; Udvardi, PT; Arons, M; Schoen, M; Woodling, NS; Andreasson, KI; Hof, PR; Buxbaum, JD; Garner, CC; Boeckers, TM (2011) Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold. Molecular Neurodegeneration

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2009

Synaptogenesis of hippocampal neurons in primary cell culture

Grabrucker, A; Vaida, B; Bockmann, J; Boeckers, TM (2009) Synaptogenesis of hippocampal neurons in primary cell culture. Cell And Tissue Research :333-341

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2009

ynaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses

Schmeisser, MJ; Grabrucker, AM; Bockmann, J; Boeckers, TM (2009) ynaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses. Journal Of Biological Chemistry :29146-29157

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2009

Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system

Grabrucker, AM; Vaida, B; Bockmann, J; Boeckers, TM (2009) Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system. Journal Of Neuroscience Methods :227-234

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2009

Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma

Vellanki, SH; Grabrucker, A; Liebau, S; Proepper, C; Eramo, A; Braun, V; Boeckers, T; Debatin, KM; Fulda, S (2009) Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma. Neoplasia :743-752

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Books

2020

Biometals in Autism Spectrum Disorders

Andreas M. Grabrucker (2020) Biometals in Autism Spectrum Disorders . Cambridge, MA, USA : Academic Press / Elsevier

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2019

Eco-Neurobiology and how the environment shapes our brain

Andreas M. Grabrucker (2019) Eco-Neurobiology and how the environment shapes our brain. Newcastle upon Tyne, UK : Cambridge Scholars

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Book Chapters

2021

Chapter 7 - Altered gut–brain signaling in autism spectrum disorders—from biomarkers to possible intervention strategies

Sauer AK; Dooley L; Vaughan A; Grabrucker AM (2021) Chapter 7 - Altered gut–brain signaling in autism spectrum disorders—from biomarkers to possible intervention strategies. Cambridge, MA, USA : Academic Press / Elsevier Neural Engineering Techniques for Autism Spectrum Disorder :127-149

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2020

Biometals and nutrition in autism spectrum disorders

(2020) Biometals and nutrition in autism spectrum disorders. Biometals in Autism Spectrum Disorders

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2020

Introduction to metallomics: the science of biometals

(2020) Introduction to metallomics: the science of biometals. Biometals in Autism Spectrum Disorders

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2020

Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases

Cristovao, JS;Moreira, GG;Grabrucker, AM;Gomes, CM (2020) Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases. LONDON : ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD PROTEIN HOMEOSTASIS DISEASES :181-195

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2020

Extracerebral biometals in autism spectrum disorders: the gutâ€'brain axis

(2020) Extracerebral biometals in autism spectrum disorders: the gutâ€'brain axis. Biometals in Autism Spectrum Disorders

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2020

Targeting Metal Homeostasis as a Therapeutic Strategy for Alzheimer's Disease

Antonietta Vilella, Eleonora Daini, Chiara A. De Benedictis, Andreas M. Grabrucker. (2020) Targeting Metal Homeostasis as a Therapeutic Strategy for Alzheimer's Disease. Brisbane (AU) : Exon Publications Alzheimer's Disease: Drug Discovery

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2020

The specific role of zinc in autism spectrum disorders

(2020) The specific role of zinc in autism spectrum disorders. Biometals in Autism Spectrum Disorders

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2020

Future perspectives: autism, a disorder of biometal imbalance?

(2020) Future perspectives: autism, a disorder of biometal imbalance?. Biometals in Autism Spectrum Disorders

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2020

Nonessential metals and their brain pathology

(2020) Nonessential metals and their brain pathology. Biometals in Autism Spectrum Disorders

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2020

Human stem cell models linking biometal abnormalities and autism

(2020) Human stem cell models linking biometal abnormalities and autism. Biometals in Autism Spectrum Disorders

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2020

Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr

Ross, AM; Grabrucker, AM; McGourty, KD; Mulvihill, JE (2020) Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr. Cambridge, Massachusetts, United States : Academic Press Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents 1st Edition.

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2020

The history of metals in autism spectrum disorders

(2020) The history of metals in autism spectrum disorders. Biometals in Autism Spectrum Disorders

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2020

Animal models for autismâ€'links to biometal abnormalities

(2020) Animal models for autismâ€'links to biometal abnormalities. Biometals in Autism Spectrum Disorders

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2020

Biometal homeostasis as a therapeutic strategy in autism spectrum disorders

(2020) Biometal homeostasis as a therapeutic strategy in autism spectrum disorders. Biometals in Autism Spectrum Disorders

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2020

Measuring biometals

(2020) Measuring biometals. Biometals in Autism Spectrum Disorders

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2020

Linking trace metal abnormalities to autismâ€'insights from epidemiological studies

(2020) Linking trace metal abnormalities to autismâ€'insights from epidemiological studies. Biometals in Autism Spectrum Disorders

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2020

Essential trace metals and their function in brain development

(2020) Essential trace metals and their function in brain development. Biometals in Autism Spectrum Disorders

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2020

Animal models for trace metal abnormalitiesâ€'links to autism

(2020) Animal models for trace metal abnormalitiesâ€'links to autism. Biometals in Autism Spectrum Disorders

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2019

The Role of Trace Metals in Alzheimer's Disease

Chiara A. De Benedictis, Antonietta Vilella, Andreas M. Grabrucker (2019) The Role of Trace Metals in Alzheimer's Disease. Brisbane, Australia : Codon Publications Alzheimer's Disease :85-106

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2017

Zinc and autism

Grabrucker, S; Grabrucker AM (2017) Zinc and autism. Netherlands : Elsevier Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics

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2017

Animal models of ASD – Extracerebral dysfunction

Hill-Yardin, EL; McKeown, SJ; Novarino, G; Grabrucker, AM (2017) Animal models of ASD – Extracerebral dysfunction. Germany : Springer Nature Advances in Anatomy, Embryology and Cell Biology, Translational anatomy and cell biology of autism spectrum disorders

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2017

Neurodegenerative Diseases: Anatomy and Pathology

Sarowar, T; Grabrucker, AM (2017) Neurodegenerative Diseases: Anatomy and Pathology. Sharjah : Bentham Science Publishers Frontiers in Nanomedicine: Nanomedicine and Neuroscience. :3-64

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2016

Zinc in the developing brain

Grabrucker, AM (2016) Zinc in the developing brain. USA : CRC Press Nutrition and the developing brain :143-168

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2016

Zinc Deficiency

Sauer, AK; Hagmeyer, S; Grabrucker, AM (2016) Zinc Deficiency. Croatia : InTech Nutritional Deficiency :23-46

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2014

Ursachen

Grabrucker, AM; Schmeisser, MJ (2014) Ursachen. Germany : Kohlhammer Handlexikon Autismus-Spektrum: Schlüsselbegriffe aus Forschung, Theorie, Praxis und Betroffenen-Sicht :382-392

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2013

Nanoparticles as Blood–Brain Barrier Permeable CNS Targeted Drug Delivery Systems

Grabrucker, AM; Chhabra, R; Belletti, D; Forni, F; Vandelli, MA; Ruozi, B; Tosi,G (2013) Nanoparticles as Blood–Brain Barrier Permeable CNS Targeted Drug Delivery Systems. Germany : Springer Topics in Medicinal Chemistry :71-89

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Edited Books

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Other Journals

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Conference Publications

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Conference Contributions

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Published Reports

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Editorials

2022

Editorial: Autism Spectrum Disorders and Metal Dyshomeostasis

Pandey, MK;Grabrucker, AM;Mehta, SQ;Harvey, RJ (2022) Editorial: Autism Spectrum Disorders and Metal Dyshomeostasis. LAUSANNE : FRONTIERS MEDIA SA Frontiers In Molecular Neuroscience

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2022

Non-Genetic Modifiers of Synaptic Plasticity and Neurotransmission in the Central Nervous System (CNS) in Health and Disease

Grabrucker A.M. (2022) Non-Genetic Modifiers of Synaptic Plasticity and Neurotransmission in the Central Nervous System (CNS) in Health and Disease. International Journal Of Molecular Sciences

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2021

Editorial: Interactions of the Nervous System With Bacteria

Hill-Yardin, EL;Grabrucker, AM;Franks, AE;Luna, RA;Monif, M (2021) Editorial: Interactions of the Nervous System With Bacteria. LAUSANNE : FRONTIERS MEDIA SA Frontiers In Neuroscience

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2017

Molecular and Cellular Mechanisms of Synaptopathies

Ardiles, AO; Grabrucker, AM; Scholl, FG; Rudenko, G; Borsello, T (2017) Molecular and Cellular Mechanisms of Synaptopathies. Neural Plasticity :1-3

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Book Reviews

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Other Publications

2022

Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients

Harishkumar R.;Hans S.;Stanton J.E.;Grabrucker A.M.;Lordan R.;Zabetakis I. (2022) Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients. Nutrients

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2022

Editorial: Autism Spectrum Disorders and Metal Dyshomeostasis

Pandey, MK;Grabrucker, AM;Mehta, SQ;Harvey, RJ (2022) Editorial: Autism Spectrum Disorders and Metal Dyshomeostasis. LAUSANNE : FRONTIERS MEDIA SA Frontiers In Molecular Neuroscience

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2022

Atherosclerosis fate in the era of tailored functional foods: Evidence-based guidelines elicited from structure- and ligand-based approaches

Azevedo L.;Serafim M.S.M.;Maltarollo V.G.;Grabrucker A.M.;Granato D. (2022) Atherosclerosis fate in the era of tailored functional foods: Evidence-based guidelines elicited from structure- and ligand-based approaches. Trends In Food Science & Technology :75-89

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2022

Prenatal Zinc Deficient Mice as a Model for Autism Spectrum Disorders

Sauer A.K.;Hagmeyer S.;Grabrucker A.M. (2022) Prenatal Zinc Deficient Mice as a Model for Autism Spectrum Disorders. International Journal Of Molecular Sciences

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2022

Non-Genetic Modifiers of Synaptic Plasticity and Neurotransmission in the Central Nervous System (CNS) in Health and Disease

Grabrucker A.M. (2022) Non-Genetic Modifiers of Synaptic Plasticity and Neurotransmission in the Central Nervous System (CNS) in Health and Disease. International Journal Of Molecular Sciences

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2021

Editorial: Interactions of the Nervous System With Bacteria

Hill-Yardin, EL;Grabrucker, AM;Franks, AE;Luna, RA;Monif, M (2021) Editorial: Interactions of the Nervous System With Bacteria. LAUSANNE : FRONTIERS MEDIA SA Frontiers In Neuroscience

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2021

The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders

Stanton, JE;Malijauskaite, S;McGourty, K;Grabrucker, AM (2021) The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders. LAUSANNE : FRONTIERS MEDIA SA Frontiers In Molecular Neuroscience

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2020

Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders

Sauer A.K.;Vela H.;Vela G.;Stark P.;Barrera-Juarez E.;Grabrucker A.M. (2020) Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders. Frontiers In Oncology

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2020

Rho GTPases in the Amygdala-A Switch for Fears?

Sarowar T.;Grabrucker A.M. (2020) Rho GTPases in the Amygdala-A Switch for Fears?. Cells

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2017

Molecular and Cellular Mechanisms of Synaptopathies

Ardiles, AO; Grabrucker, AM; Scholl, FG; Rudenko, G; Borsello, T (2017) Molecular and Cellular Mechanisms of Synaptopathies. Neural Plasticity :1-3

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