Biography

CAREER PROFILE
Education
  • 2000-2005 TU Munich, Germany, Diploma in Biology, Major: Genetics, Minor: Neurobiology and Zoology
  • 2005-2009 University Ulm, Germany, PhD, international PhD program in molecular medicine

Employment
  • 2009-2011 Postdoctoral fellow, Stanford University, USA, Dept. of Psychiatry and Behavioral Sciences, Stanford School of Medicine
  • 2011-2016 Assistant Professor, University Ulm, Germany, Dept. of Neurology
  • 2011-2016 Executive Director of the Neurocenter of Ulm University
  • 2017- Lecturer in Cell Biology, University of Limerick, Ireland, Dept. of Biological Sciences, School of Natural Sciences

Scientific Activities - My research focuses on synaptopathies as a key feature of neurodevelopmental diseases. Disruptions in synaptic structure leading to abnormal circuit formation and function are potentially the major determinant of such brain diseases. My work aims to understand how genetic and non-genetic factors contribute to neuronal dysfunction and to develop novel research and treatment strategies using nanotechnology.

Research Interests

My research is interested in the underlying components able to modify synaptic plasticity and transmission in the Central Nervous System (CNS) in health and disease. Thereby, synaptopathy defines key features of neurodegenerative and psychiatric diseases. It implies that disruptions in synaptic structure and function are potentially the major determinant of such brain diseases. Using a combination of biochemical, cellular, molecular and behavioral approaches, we have investigated proteins of excitatory postsynapses focusing on their deregulation in neurodevelopmental and neuropsychiatric disorders such as Autism Spectrum Disorders, Alzheimer's disease and Schizophrenia. We are especially interested in the functional interaction of biometals and synaptic proteins in mechanisms such as synapse formation and maturation in health and disease. Given that dysregulation of trace metals is reported in many brain disorders, their role in the modification of synaptic function needs to be investigated in more detail. Especially since many brain disorders seem to not only have a genetic but also an environmental component triggering the disease. To investigate the role of biometals in disorders of the CNS, we use several approaches. For example, targeted manipulation of biometal levels in animal models and cells derived from human induced pluripotent stem cells is a major goal in our research. To that end, the development of novel drug carriers (i.e. Nanoparticles) and assays designed to evaluate their potency to influence synapse formation, maturation and plasticity has become an important part of our research. On the other hand, we investigate human patients with selected disorders and perform a state of the art assessment of their trace metal status and clinical phenotype to define subgroups with biometal abnormalities, which can be associated with specific clinical presentations. Understanding how environmental and genetic factors contribute to synaptic function will hopefully allow the development of research strategies to normalize function in individuals with synaptopathies.

Professional Activities

Association

  • 2012 Member, International Society for Zinc Biology
  • 2007 Member, Society for Neuroscience

Language

  • German
  • English

Books

Biometals in Autism Spectrum Disorders

Prof. Andreas Grabrucker
2020
Cambridge, MA, USA
Academic Press / Elsevier
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Eco-Neurobiology and how the environment shapes our brain

Prof. Andreas Grabrucker
2019
Newcastle upon Tyne, UK
Cambridge Scholars
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Book Chapters

The Role of Trace Metals in Alzheimer's Disease

Prof. Andreas Grabrucker
2019
Brisbane, Australia
Codon Publications
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Animal models of ASD – Extracerebral dysfunction

Prof. Andreas Grabrucker
2017
Germany
Springer Nature
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Essential trace metals and their function in brain development

Prof. Andreas Grabrucker
2020
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Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr

Prof. Andreas Grabrucker
Dr. Kieran McGourty
2020
Cambridge, Massachusetts, United States
Academic Press
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Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases

Prof. Andreas Grabrucker
2020
LONDON
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
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Animal models for trace metal abnormalitiesâ€'links to autism

Prof. Andreas Grabrucker
2020
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Neurodegenerative Diseases: Anatomy and Pathology

Prof. Andreas Grabrucker
2017
Sharjah
Bentham Science Publishers
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The specific role of zinc in autism spectrum disorders

Prof. Andreas Grabrucker
2020
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Biometals and nutrition in autism spectrum disorders

Prof. Andreas Grabrucker
2020
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Nanoparticles as Blood–Brain Barrier Permeable CNS Targeted Drug Delivery Systems

Prof. Andreas Grabrucker
2013
Germany
Springer
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Nonessential metals and their brain pathology

Prof. Andreas Grabrucker
2020
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Introduction to metallomics: the science of biometals

Prof. Andreas Grabrucker
2020
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Ursachen

Prof. Andreas Grabrucker
2014
Germany
Kohlhammer
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The history of metals in autism spectrum disorders

Prof. Andreas Grabrucker
2020
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Extracerebral biometals in autism spectrum disorders: the gutâ€'brain axis

Prof. Andreas Grabrucker
2020
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Zinc in the developing brain

Prof. Andreas Grabrucker
2016
USA
CRC Press
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Biometal homeostasis as a therapeutic strategy in autism spectrum disorders

Prof. Andreas Grabrucker
2020
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Future perspectives: autism, a disorder of biometal imbalance?

Prof. Andreas Grabrucker
2020
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Chapter 7 - Altered gut–brain signaling in autism spectrum disorders—from biomarkers to possible intervention strategies

Prof. Andreas Grabrucker
2021
Cambridge, MA, USA
Academic Press / Elsevier
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Zinc Deficiency

Prof. Andreas Grabrucker
2016
Croatia
InTech
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Measuring biometals

Prof. Andreas Grabrucker
2020
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Human stem cell models linking biometal abnormalities and autism

Prof. Andreas Grabrucker
2020
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Targeting Metal Homeostasis as a Therapeutic Strategy for Alzheimer's Disease

Prof. Andreas Grabrucker
2020
Brisbane (AU)
Exon Publications
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Zinc and autism

Prof. Andreas Grabrucker
2017
Netherlands
Elsevier
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Linking trace metal abnormalities to autismâ€'insights from epidemiological studies

Prof. Andreas Grabrucker
2020
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Animal models for autismâ€'links to biometal abnormalities

Prof. Andreas Grabrucker
2020
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Edited Books

This author has not written any publications of this type yet.

Peer Reviewed Journals

Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells

Prof. Andreas Grabrucker
2016
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De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability

Prof. Andreas Grabrucker
2017
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Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release

Prof. Andreas Grabrucker
2014
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Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model

Prof. Andreas Grabrucker
2019
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ynaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses

Prof. Andreas Grabrucker
2009
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Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders

Prof. Andreas Grabrucker
2022
BASEL
SPRINGER BASEL AG
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The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders

Prof. Andreas Grabrucker
2021
n/a
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Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers

Prof. Andreas Grabrucker
Dr. John Mulvihill
2020
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Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies

Prof. Andreas Grabrucker
2016
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Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.

Prof. Andreas Grabrucker
2021
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EXPLOITING THE VERSATILITY OF CHOLESTEROL IN NANOPARTICLES FORMULATION

Prof. Andreas Grabrucker
2016
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Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC

Prof. Andreas Grabrucker
2017
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Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice

Prof. Andreas Grabrucker
2019
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Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties

Prof. Andreas Grabrucker
Dr. John Mulvihill
Dr. Tadhg Kennedy
2020
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Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder

Prof. Andreas Grabrucker
2018
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Grabrucker AM. Environmental factors in autism

Prof. Andreas Grabrucker
2012
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Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation

Prof. Andreas Grabrucker
2011
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Characterization of biometal profiles in neurological disorders

Prof. Andreas Grabrucker
2014
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Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses

Prof. Andreas Grabrucker
2014
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Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer’s disease model mice

Prof. Andreas Grabrucker
2019
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Behavioral impairments in animal models for zinc deficiency

Prof. Andreas Grabrucker
2014
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Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain

Prof. Andreas Grabrucker
2018
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ROS-responsive “smart” polymeric conjugate: Synthesis, characterization and proof-of-concept study

Prof. Andreas Grabrucker
2019
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Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling

Prof. Andreas Grabrucker
2012
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N-Cadherin-mediated cell adhesion is regulated by extracellular Zn(2+)

Prof. Andreas Grabrucker
2015
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Activity and circadian rhythm influence synaptic Shank3 protein levels in mice

Prof. Andreas Grabrucker
2016
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Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2

Prof. Andreas Grabrucker
2017
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Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency

Prof. Andreas Grabrucker
2016
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Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome.

Prof. Andreas Grabrucker
2018
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Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain

Prof. Andreas Grabrucker
2018
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Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles.

Prof. Andreas Grabrucker
2020
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Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo

Prof. Andreas Grabrucker
2015
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Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives.

Prof. Andreas Grabrucker
Dr. John Mulvihill
2019
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Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system

Prof. Andreas Grabrucker
2009
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Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer's disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery.

Prof. Andreas Grabrucker
2017
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Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI

Prof. Andreas Grabrucker
2019
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Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3

Prof. Andreas Grabrucker
2017
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The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation

Prof. Andreas Grabrucker
2014
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Synaptogenesis of hippocampal neurons in primary cell culture

Prof. Andreas Grabrucker
2009
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Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution

Prof. Andreas Grabrucker
2014
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Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences

Prof. Andreas Grabrucker
2011
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Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal- Melphalan Prodrug for Glioblastoma Treatment

Prof. Andreas Grabrucker
2020
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S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis

Prof. Andreas Grabrucker
2021
LONDON
SPRINGERNATURE
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Effects of trace metal profiles characteristic for autism on synapses in cultured neurons

Prof. Andreas Grabrucker
2015
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Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold

Prof. Andreas Grabrucker
2011
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The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons

Prof. Andreas Grabrucker
2013
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Sperm selection by rheotaxis improves sperm quality and early embryo development

Prof. Andreas Grabrucker
2021
BRISTOL
BIOSCIENTIFICA LTD
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Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport

Prof. Andreas Grabrucker
2014
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Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

Prof. Andreas Grabrucker
2012
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Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2

Prof. Andreas Grabrucker
2016
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Concentrations of Essential Trace Metals in the Brain of Animal Species-A Comparative Study.

Prof. Andreas Grabrucker
2020
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Zinc in gut-brain interaction in autism and neurological disorders

Prof. Andreas Grabrucker
2015
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Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

Prof. Andreas Grabrucker
2011
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Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates

Prof. Andreas Grabrucker
2017
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Expression Analysis of Zinc Transporters in Nervous Tissue Cells Reveals Neuronal and Synaptic Localization of ZIP4

Prof. Andreas Grabrucker
2021
BASEL
MDPI
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Emerging Use of Nanotechnology in the Treatment of Neurological Disorders

Prof. Andreas Grabrucker
2015
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Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders

Prof. Andreas Grabrucker
2014
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Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma

Prof. Andreas Grabrucker
2009
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Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery: In vitro evidence

Prof. Andreas Grabrucker
2019
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Other Journals

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Conference Publications

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Conference Contributions

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Published Reports

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Editorials

Editorial: Interactions of the Nervous System With Bacteria

Prof. Andreas Grabrucker
2021
LAUSANNE
FRONTIERS MEDIA SA
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Molecular and Cellular Mechanisms of Synaptopathies

Prof. Andreas Grabrucker
2017
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Book Reviews

This author has not written any publications of this type yet.

Other Publications

Rho GTPases in the Amygdala-A Switch for Fears?

Prof. Andreas Grabrucker
2020
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The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders

Prof. Andreas Grabrucker
2021
LAUSANNE
FRONTIERS MEDIA SA
Read more

Molecular and Cellular Mechanisms of Synaptopathies

Prof. Andreas Grabrucker
2017
Read more

Editorial: Interactions of the Nervous System With Bacteria

Prof. Andreas Grabrucker
2021
LAUSANNE
FRONTIERS MEDIA SA
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Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders

Prof. Andreas Grabrucker
2020
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