Prof. Aedin Culhane
Biography
Aedín Culhane is a Director of the Limerick Digital Cancer Research Centre and is a Professor of Biomedical Sciences (Cancer Genomics) in the UL School of Medicine. She is a computational oncologist with expertise in multi-omics data integration, statistical genomics, clinical bioinformatics and genomics in oncology. She has over 20 years' experience in cancer genomics, of which over 15 years were in the Dana-Farber Cancer Institute and Harvard TH Chan School of Public Health in Boston, USA. Her recent research focuses on algorithm development and integrative data of single cell molecular data in cancer to identify molecules that regulate and can be targeted during tumour development, progression, drug response and resistance. She is a leader in the Bioconductor (www.bioconductor.org) community, a global open source, open development software in R for genomics and an advocate for open source science. She is PI of the all-island eHealth- Hub for Cancer funded under the HEA North-South program in partnership with Prof Mark Lawler, Queens University Belfast. She is a member of the Ireland 1+ million genome program and is a PI in the Genomic Data Infrastructure that will be an important step toward realising 1+MG.Google Scholar: https://scholar.google.com/citations?user=O8OszPcAAAAJ
LinkedIn Profile https://www.linkedin.com/in/aedinculhane/
ORC ID https://orcid.org/my-orcid?orcid=0000-0002-1395-9734
eHealth Hub for Cancer https://ehealth4cancer.org/
Research Interests
Cancer Computational Genomics & Digital HealthDirector of the Limerick Digital Cancer Center
Lead the all-island eHealth-Hub for Cancer
Member, All-Ireland Cancer Institute Steering Group
Open Science: Bioconductor, ELIXIR, OHDSI
- Single Cell Genomics methods for the Human Cell Atlas Program
- Spatial Biology Methods development for the National Spatial Profiling Platform
- Cancer genomics, clinical cancer research, translational oncology
- Latent Space and Matrix Factorisation and Cancer Genomics algorithm development
- Immune-Oncology, Tumor Microenvironment
- European 1+ Million Genomes Program GDI
- Real world evidence
Specialties: Bioconductor, R, bioinformatics, genomics, multivariate analysis, multi-omics, biostatistician, transcriptomics, proteomics, epigenomics, computational biology, mathematical oncology, tumor microenvironment, tumor immunology, neuro-immunology, kidney cancer, breast cancer, ovarian cancer, electronic health records, data harmonisation, genomics, real world data, real world evidence, data standards, open science, FAIR data
Professional Activities
Committee
- 2023 1 Million Genomes (1+MG) Working groups 3 and 9, Irish mirror group,
- 2023 Single Cell Network, ELIXIR,
- 2022 EHS Research Committee,
- 2020 Bioconductor Community Advisory Board,
- 2014 Bioconductor Technical Advisory Board,
Association
- 2023 Board Member, Irish Association for Cancer Research (IACR)
- 2021 Board of Directors, Massive Analysis and Quality Control Society (MAQC) Society
- 2021 Member, European Association for Cancer Research (EACR)
- 2007 Member, American Association for Cancer Research (AACR)
- 2000 Member, The International Society for Computational Biology (ISCB)
Employment
- 2021 University of Limerick - Professor
- 2006 Dana Farber Cancer Institute -
- 2005 Harvard T.H. Chan School of Public Health -
Award
- 2021 - Bioconductor Community Award
Education
- 2005 University College Dublin -
- 2003 University College Cork -
- 2000 University of Manchester -
Research Collaborators
- Professor Mark Lawler - Funding Award - Queen's University Belfast -Northern Ireland -NI Partner in the eHealth-Hub For Cancer
- Prof Wayne Marasco and Dr Yufei Wang - Funding Award - Harvard Medical School -USA -Optimizing 2nd Generation Dual-Targeted Fine-tuned Immune-Restoring (DFIR) CAR T Cells to Improve Cures of Advanced clear cell Renal Cell Carcinoma (Dana-Farber Cancer Institute)
- Prof Constantine Mitsiades - Joint Publication - Harvard Medical School -USA
Peer Reviewed Journals
Curated single cell multimodal landmark datasets for R/Bioconductor.
Eckenrode KB;Righelli D;Ramos M;Argelaguet R;Vanderaa C;Geistlinger L;Culhane AC;Gatto L;Carey V;Morgan M;Risso D;Waldron L; (2023) Curated single cell multimodal landmark datasets for R/Bioconductor.. Plos Computational Biology
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Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias
de Matos Simoes R.;Shirasaki R.;Downey-Kopyscinski S.L.;Matthews G.M.;Barwick B.G.;Gupta V.A.;Dupéré-Richer D.;Yamano S.;Hu Y.;Sheffer M.;Dhimolea E.;Dashevsky O.;Gandolfi S.;Ishiguro K.;Meyers R.M.;Bryan J.G.;Dharia N.V.;Hengeveld P.J.;Brüggenthies J.B.;Tang H.;Aguirre A.J.;Sievers Q.L.;Ebert B.L.;Glassner B.J.;Ott C.J.;Bradner J.E.;Kwiatkowski N.P.;Auclair D.;Levy J.;Keats J.J.;Groen R.W.J.;Gray N.S.;Culhane A.C.;McFarland J.M.;Dempster J.M.;Licht J.D.;Boise L.H.;Hahn W.C.;Vazquez F.;Tsherniak A.;Mitsiades C.S. (2023) Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias. Nature Cancer :754-773
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Multi-omic spatial profiling reveals the unique virus-driven immune landscape of COVID-19 placentitis
Matthew Pugh,Éanna Fennell,Ciara I Leahy,Tracey Perry,Beata Hargitai,Tamas Marton,Kelly J. Hunter,Graham Halford,Hale Onder Yilmaz,Zania Stamataki,Gary Reynolds,Harriet J. Hill,Benjamin E. Willcox,Neil Steven,Catherine A. Thornton,Stefan D. Dojcinov,Aedin Culhane,Paul G. Murray,Graham S. Taylor (2022) Multi-omic spatial profiling reveals the unique virus-driven immune landscape of COVID-19 placentitis. bioRxiv
Read moreAnti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model
Wang Y.;Buck A.;Grimaud M.;Culhane A.C.;Kodangattil S.;Razimbaud C.;Bonal D.M.;Nguyen Q.D.;Zhu Z.;Wei K.;O'Donnell M.L.;Huang Y.;Signoretti S.;Choueiri T.K.;Freeman G.J.;Zhu Q.;Marasco W.A. (2022) Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model. Molecular Therapy Oncolytics :385-399
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Community-wide hackathons to identify central themes in single-cell multi-omics
Cao, Kim-Anh Le;Abadi, Al J.;Davis-Marcisak, Emily F.;Hsu, Lauren;Arora, Arshi;Coullomb, Alexis;Deshpande, Atul;Feng, Yuzhou;Jeganathan, Pratheepa;Loth, Melanie;Meng, Chen;Mu, Wancen;Pancaldi, Vera;Sankaran, Kris;Singh, Amrit;Sodicoff, Joshua S.;Stein-O'Brien, Genevieve L.;Subramanian, Ayshwarya;Welch, Joshua D.;You, Yue;Argelaguet, Ricard;Carey, Vincent J.;Dries, Ruben;Greene, Casey S.;Holmes, Susan;Love, Michael, I;Ritchie, Matthew E.;Yuan, Guo-Cheng;Culhane, Aedin C.;Fertig, Elana; (2021) Community-wide hackathons to identify central themes in single-cell multi-omics. Genome Biology
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Development of dual-targeted fine-tuned immune restoring (DFIR) CAR T cell therapy for clear cell renal cell carcinoma (ccRCC)
Wang, Yufei;Buck, Alicia;Grimaud, Marion;Kodangattil, Sreekumar;Razimbaud, Cecile;Fayed, Atef;Chang, Matthew;Culhane, Aedin;Braun, David A.;Choueiri, Toni K.;Wu, Catherine J.;Wei, Kevin S.;Chan, Leo L.;Piel, Brandon P.;Ivanova, Elena V.;Paweletz, Cloud P.;Barbie, David A.;Jennings, Rebecca;Ficial, Miriam;Sticco-Ivins, Maura Aliezah;Signoretti, Sabina;Freeman, Gordon J.;Zhu, Quan K.;Marasco, Wayne A.; (2021) Development of dual-targeted fine-tuned immune restoring (DFIR) CAR T cell therapy for clear cell renal cell carcinoma (ccRCC). Cancer Research
Read moreCommunity-wide hackathons to identify central themes in single-cell multi-omics (vol 22, 220, 2021)
Cao, Kim-Anh Le;Abadi, Al J.;Davis-Marcisak, Emily F.;Hsu, Lauren;Arora, Arshi;Coullomb, Alexis;Deshpande, Atul;Feng, Yuzhou;Jeganathan, Pratheepa;Loth, Melanie;Meng, Chen;Mu, Wancen;Pancaldi, Vera;Sankaran, Kris;Righelli, Dario;Singh, Amrit;Sodicoff, Joshua S.;Stein-O'Brien, Genevieve L.;Subramanian, Ayshwarya;Welch, Joshua D.;You, Yue;Argelaguet, Ricard;Carey, Vincent J.;Dries, Ruben;Greene, Casey S.;Holmes, Susan;Love, Michael I.;Ritchie, Matthew E.;Yuan, Guo-Cheng;Culhane, Aedin C.;Fertig, Elana; (2021) Community-wide hackathons to identify central themes in single-cell multi-omics (vol 22, 220, 2021). Genome Biology
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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
Shirasaki, Ryosuke;Matthews, Geoffrey M.;Gandolfi, Sara;Simoes, Ricardo de Matos;Buckley, Dennis L.;Vora, Joseline Raja;Sievers, Quinlan L.;Bruggenthies, Johanna B.;Dashevsky, Olga;Poarch, Haley;Tang, Huihui;Bariteau, Megan A.;Sheffer, Michal;Hu, Yiguo;Downey-Kopyscinski, Sondra L.;Hengeveld, Paul J.;Glassner, Brian J.;Dhimolea, Eugen;Ott, Christopher J.;Zhang, Tinghu;Kwiatkowski, Nicholas P.;Laubach, Jacob P.;Schlossman, Robert L.;Richardson, Paul G.;Culhane, Aedin C.;Groen, Richard W. J.;Fischer, Eric S.;Vazquez, Francisca;Tsherniak, Aviad;Hahn, William C.;Levy, Joan;Auclair, Daniel;Licht, Jonathan D.;Keats, Jonathan J.;Boise, Lawrence H.;Ebert, Benjamin L.;Bradner, James E.;Gray, Nathanael S.;Mitsiades, Constantine S.; (2021) Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Cell Reports
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Landscape of molecular events regulating tumor cell responses to natural killer cells
Sheffer, Michal;Lowry, Emily;Beelen, Nicky;Borah, Minasri;Naffar-Abu Amara, Suha;Mader, Chris C.;Roth, Jennifer;Tsherniak, Aviad;Dashevsky, Olga;Gandolfi, Sara;Bender, Samantha;Bryan, Jordan;Zhu, Cong;Wang, Li;Simoes, Ricardo De-Matos;Yu, Channing;Hu, Yiguo;Dufva, Olli;Giannakis, Marios;Golub, Todd;Romee, Rizwan;Mustjoki, Satu;Culhane, Aedin C.;Wieten, Lotte;Mitsiades, Constantine S.; (2021) Landscape of molecular events regulating tumor cell responses to natural killer cells. Cancer immunology research
Read moreTreatment persistence of residual breast tumors through an embryonic diapause-like cancer cell state with suppressed myc activity
Dhimolea, Eugen;Simoes, Ricardo De Matos;Kansara, Dhvanir;Bouyssou, Juliette;Roth, Jennifer;Sheffer, Michal;Jeselsohn, Rinath;Gray, Nathanael;Steidl, Ulrich;Bartholdy, Boris;Brown, Myles;Culhane, Aedin;Mitsiades, Constantine; (2021) Treatment persistence of residual breast tumors through an embryonic diapause-like cancer cell state with suppressed myc activity. Cancer Research
Read moreCurated Single Cell Multimodal Landmark Datasets for R/Bioconductor
Kelly B. Eckenrode;Dario Righelli;Marcel Ramos;Ricard Argelaguet;Christophe Vanderaa;Ludwig Geistlinger;Aedin Culhane;Laurent Gatto;Vincent Carey;Martin Morgan;Davide Risso;Levi Waldron; (2021) Curated Single Cell Multimodal Landmark Datasets for R/Bioconductor. Biorxiv : The Preprint Server For Biology
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An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence
Dhimolea, Eugen;Simoes, Ricardo de Matos;Kansara, Dhvanir;Al'Khafaji, Aziz;Bouyssou, Juliette;Weng, Xiang;Sharma, Shruti;Raja, Joseline;Awate, Pallavi;Shirasaki, Ryosuke;Tang, Huihui;Glassner, Brian J.;Liu, Zhiyi;Gao, Dong;Bryan, Jordan;Bender, Samantha;Roth, Jennifer;Scheffer, Michal;Jeselsohn, Rinath;Gray, Nathanael S.;Georgakoudi, Irene;Vazquez, Francisca;Tsherniak, Aviad;Chen, Yu;Welm, Alana;Duy, Cihangir;Melnick, Ari;Bartholdy, Boris;Brown, Myles;Culhane, Aedin C.;Mitsiades, Constantine S.; (2021) An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence. Cancer Cell
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ACHIEVE CLEAR CELL RENAL CELL CARCINOMA (CCRCC) CURES THROUGH DUAL-TARGETED FINE-TUNED IMMUNE RESTORING (DFIR) CAR-T CELL THERAPY
Wang, Y.;Buck, A.;Grimaud, M.;Kodangattil, S.;Razimbaud, C.;Fayed, A.;Chang, M. R.;Culhane, A.;Braun, D.;Choueiri, T. K.;Wu, C.;Wei, K.;Chan, L. L.;Piel, B. P.;Ivanova, E.;Paweletz, C. P.;Barbie, D.;Jenning, R.;Ficial, M.;Sticco-Ivins, M.;Signoretti, S.;Freeman, G. J.;Zhu, Q.;Marasco, W.; (2021) ACHIEVE CLEAR CELL RENAL CELL CARCINOMA (CCRCC) CURES THROUGH DUAL-TARGETED FINE-TUNED IMMUNE RESTORING (DFIR) CAR-T CELL THERAPY. Cytotherapy
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Genome-scale screens identify factors regulating tumor cell responses to natural killer cells
Sheffer, Michal;Lowry, Emily;Beelen, Nicky;Borah, Minasri;Naffar-Abu Amara, Suha;Mader, Chris C.;Roth, Jennifer A.;Tsherniak, Aviad;Freeman, Samuel S.;Dashevsky, Olga;Gandolfi, Sara;Bender, Samantha;Bryan, Jordan G.;Zhu, Cong;Wang, Li;Tariq, Ifrah;Kamath, Govinda M.;Simoes, Ricardo De Matos;Dhimolea, Eugen;Yu, Channing;Hu, Yiguo;Dufva, Olli;Giannakis, Marios;Syrgkanis, Vasilis;Fraenkel, Ernest;Golub, Todd;Romee, Rizwan;Mustjoki, Satu;Culhane, Aedin C.;Wieten, Lotte;Mitsiades, Constantine S.; (2021) Genome-scale screens identify factors regulating tumor cell responses to natural killer cells. Nature Genetics
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Treatment-induced embryonic diapause-like adaptation through suppression of Myc activity as mediator of drug persistence in cancer
Dhimolea, Eugen;Simoes, Ricardo De Matos;Kansara, Dhvanir;Vilas, Caroline;Al'Khafaji, Aziz;Bouyssou, Juliette;Culhane, Aedin;Mitsiades, Constantine S.; (2021) Treatment-induced embryonic diapause-like adaptation through suppression of Myc activity as mediator of drug persistence in cancer. Cancer Research
Read moreCorrespondence analysis for dimension reduction, batch integration, and visualization of single-cell RNA-seq data
Lauren L. Hsu; Aedin C. Culhane; (2021) Correspondence analysis for dimension reduction, batch integration, and visualization of single-cell RNA-seq data. Biorxiv : The Preprint Server For Biology
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Use of Olfactory Receptor Genes As Controls for Genome-Scale CRISPR Functional Genomic Studies to Define Treatment Resistance Mechanisms
Dashevsky, Olga;Simoes, Ricardo De Matos;Shirasaki, Ryosuke;Sheffer, Michal;Dhimolea, Eugen;Gandolfi, Sara;Tang, Huihui;Downey-Kopyscinski, Sondra L.;Bariteau, Megan;Sorrell, Jeffrey;Glassner, Brian;Doench, John;Boise, Larry H.;Licht, Jonathan D.;Culhane, Aedin;Hahn, William C.;Vazquez, Francisca;Tsherniak, Aviad;Mitsiades, Constantine S.; (2020) Use of Olfactory Receptor Genes As Controls for Genome-Scale CRISPR Functional Genomic Studies to Define Treatment Resistance Mechanisms. Blood
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POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma
Simoes, Ricardo De Matos;Shirasaki, Ryosuke;Tang, Huihui;Yamano, Shizuka;Barwick, Benjamin G.;Gandolfi, Sara;Dhimolea, Eugen;Downey-Kopyscinski, Sondra L.;Dashevsky, Olga;Glassner, Brian;Sheffer, Michal;Kansara, Dhvanir;Bariteau, Megan;Sorrell, Jeffrey;Gupta, Vikas;Culhane, Aedin;Tsherniak, Aviad;Vazquez, Francisca;Boise, Larry H.;Licht, Jonathan D.;Mitsiades, Constantine S.; (2020) POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma. Blood
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Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study
Lane, J.C.E.;Weaver, J.;Kostka, K.;Duarte-Salles, T.;Abrahao, M.T.F.;Alghoul, H.;Alser, O.;Alshammari, T.M.;Biedermann, P.;Banda, J.M.;Burn, E.;Casajust, P.;Conover, M.M.;Culhane, A.C.;Davydov, A.;DuVall, S.L.;Dymshyts, D.;Fernandez-Bertolin, S.;Fišter, K.;Hardin, J.;Hester, L.;Hripcsak, G.;Kaas-Hansen, B.S.;Kent, S.;Khosla, S.;Kolovos, S.;Lambert, C.G.;van der Lei, J.;Lynch, K.E.;Makadia, R.;Margulis, A.V.;Matheny, M.E.;Mehta, P.;Morales, D.R.;Morgan-Stewart, H.;Mosseveld, M.;Newby, D.;Nyberg, F.;Ostropolets, A.;Park, R.W.;Prats-Uribe, A.;Rao, G.A.;Reich, C.;Reps, J.;Rijnbeek, P.;Sathappan, S.M.K.;Schuemie, M.;Seager, S.;Sena, A.G.;Shoaibi, A.;Spotnitz, M.;Suchard, M.A.;Torre, C.O.;Vizcaya, D.;Wen, H.;de Wilde, M.;Xie, J.;You, S.C.;Zhang, L.;Zhuk, O.;Ryan, P.;Prieto-Alhambra, D.; (2020) Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study. The Lancet Rheumatology
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Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study
Burn, E.;You, S.C.;Sena, A.G.;Kostka, K.;Abedtash, H.;Abrahão, M.T.F.;Alberga, A.;Alghoul, H.;Alser, O.;Alshammari, T.M.;Aragon, M.;Areia, C.;Banda, J.M.;Cho, J.;Culhane, A.C.;Davydov, A.;DeFalco, F.J.;Duarte-Salles, T.;DuVall, S.;Falconer, T.;Fernandez-Bertolin, S.;Gao, W.;Golozar, A.;Hardin, J.;Hripcsak, G.;Huser, V.;Jeon, H.;Jing, Y.;Jung, C.Y.;Kaas-Hansen, B.S.;Kaduk, D.;Kent, S.;Kim, Y.;Kolovos, S.;Lane, J.C.E.;Lee, H.;Lynch, K.E.;Makadia, R.;Matheny, M.E.;Mehta, P.P.;Morales, D.R.;Natarajan, K.;Nyberg, F.;Ostropolets, A.;Park, R.W.;Park, J.;Posada, J.D.;Prats-Uribe, A.;Rao, G.;Reich, C.;Rho, Y.;Rijnbeek, P.;Schilling, L.M.;Schuemie, M.;Shah, N.H.;Shoaibi, A.;Song, S.;Spotnitz, M.;Suchard, M.A.;Swerdel, J.N.;Vizcaya, D.;Volpe, S.;Wen, H.;Williams, A.E.;Yimer, B.B.;Zhang, L.;Zhuk, O.;Prieto-Alhambra, D.;Ryan, P.; (2020) Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study. Nature Communications
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The impact of stroma admixture on molecular subtypes and prognostic gene signatures in serous ovarian cancer
Schwede, M.;Waldron, L.;Mok, S.C.;Wei, W.;Basunia, A.;Merritt, M.A.;Mitsiades, C.S.;Parmigiani, G.;Harrington, D.P.;Quackenbush, J.;Birrer, M.J.;Culhane, A.C.; (2020) The impact of stroma admixture on molecular subtypes and prognostic gene signatures in serous ovarian cancer. Cancer Epidemiology Biomarkers & Prevention
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Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma
Simoes, Ricardo De Matos;Shirasaki, Ryosuke;Downey-Kopyscinski, Sondra L.;Matthews, Geoffrey;Yiguo, Hu;Sheffer, Michal;Dhimolea, Eugen;Dashevsky, Olga;Gandolfi, Sara;Dempster, Joshua;Meyers, Robin M.;Bryan, Jordan;McFarland, James M.;Brueggenthies, Johanna;Tang, Huihui;Bariteau, Megan;Borah, Minasri;Sievers, Quinlan L.;Ebert, Benjamin;Glassner, Brian;Ott, Christopher J.;Kwiatkowski, Nicholas P.;Doench, John G.;Auclair, Daniel;Levy, Joan;Boise, Lawrence H.;Keats, Jonathan J.;Licht, Jonathan D.;Groen, Richard;Gray, Nathanael;Culhane, Aedin;Hahn, William C.;Vazquez, Francisca;Tsherniak, Aviad;Mitsiades, Constantine S.; (2019) Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma. Blood
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Erratum: The Immune Landscape of Cancer (Immunity (2018) 48(4) (812â'830.e14), (S1074761318301213), (10.1016/j.immuni.2018.03.023))
Thorsson, V.;Gibbs, D.L.;Brown, S.D.;Wolf, D.;Bortone, D.S.;Ou Yang, T.-H.;Porta-Pardo, E.;Gao, G.F.;Plaisier, C.L.;Eddy, J.A.;Ziv, E.;Culhane, A.C.;Paull, E.O.;Sivakumar, I.K.A.;Gentles, A.J.;Malhotra, R.;Farshidfar, F.;Colaprico, A.;Parker, J.S.;Mose, L.E.;Vo, N.S.;Liu, J.;Liu, Y.;Rader, J.;Dhankani, V.;Reynolds, S.M.;Bowlby, R.;Califano, A.;Cherniack, A.D.;Anastassiou, D.;Bedognetti, D.;Mokrab, Y.;Newman, A.M.;Rao, A.;Chen, K.;Krasnitz, A.;Hu, H.;Malta, T.M.;Noushmehr, H.;Pedamallu, C.S.;Bullman, S.;Ojesina, A.I.;Lamb, A.;Zhou, W.;Shen, H.;Choueiri, T.K.;Weinstein, J.N.;Guinney, J.;Saltz, J.;Holt, R.A.;Rabkin, C.S.;Caesar-Johnson, S.J.;Demchok, J.A.;Felau, I.;Kasapi, M.;Ferguson, M.L.;Hutter, C.M.;Sofia, H.J.;Tarnuzzer, R.;Wang, Z.;Yang, L.;Zenklusen, J.C.;Zhang, J.J.;Chudamani, S.;Liu, J.;Lolla, L.;Naresh, R.;Pihl, T.;Sun, Q.;Wan, Y.;Wu, Y.;Cho, J.;DeFreitas, T.;Frazer, S.;Gehlenborg, N.;Getz, G.;Heiman, D.I.;Kim, J.;Lawrence, M.S.;Lin, P.;Meier, S.;Noble, M.S.;Saksena, G.;Voet, D.;Zhang, H.;Bernard, B.;Chambwe, N.;Knijnenburg, T.;Kramer, R.;Leinonen, K.;Miller, M.;Reynolds, S.;Shmulevich, I.;Thorsson, V.;Zhang, W.;Akbani, R.;Broom, B.M.;Hegde, A.M.;Ju, Z.;Kanchi, R.S.;Korkut, A.;Li, J.;Liang, H.;Ling, S.;Liu, W.;Lu, Y.;Mills, G.B.;Ng, K.-S.;Ryan, M.;Wang, J.;Zhang, J.;Abeshouse, A.;Armenia, J.;Chakravarty, D.;Chatila, W.K.;de Bruijn, I.;Gao, J.;Gross, B.E.;Heins, Z.J.;Kundra, R.;La, K.;Ladanyi, M.;Luna, A.;Nissan, M.G.;Ochoa, A.;Phillips, S.M.;Reznik, E.;Sanchez-Vega, F.;Sander, C.;Schultz, N.;Sheridan, R.;Sumer, S.O.;Sun, Y.;Taylor, B.S.;Wang, J.;Zhang, H.;Anur, P.;Peto, M.;Spellman, P.;Benz, C.;Stuart, J.M.;Wong, C.K.;Yau, C.;Hayes, D.N.;Wilkerson, M.D.;Ally, A.;Balasundaram, M.;Brooks, D.;Carlsen, R.;Chuah, E.;Dhalla, N.;Holt, R.;Jones, S.J.M.;Kasaian, K.;Lee, D.;Ma, Y.;Marra, M.A.;Mayo, M.;Moore, R.A.;Mungall, A.J.;Mungall, K.;Robertson, A.G.;Sadeghi, S.;Schein, J.E.;Sipahimalani, P.;Tam, A.;Thiessen, N.;Tse, K.;Wong, T.;Berger, A.C.;Beroukhim, R.;Cibulskis, C.;Gabriel, S.B.;Ha, G.;Meyerson, M.;Schumacher, S.E.;Shih, J.;Kucherlapati, M.H.;Kucherlapati, R.S.;Baylin, S.;Cope, L.;Danilova, L.;Bootwalla, M.S.;Lai, P.H.;Maglinte, D.T.;Van Den Berg, D.J.;Weisenberger, D.J.;Auman, J.T.;Balu, S.;Bodenheimer, T.;Fan, C.;Hoadley, K.A.;Hoyle, A.P.;Jefferys, S.R.;Jones, C.D.;Meng, S.;Mieczkowski, P.A.;Perou, A.H.;Perou, C.M.;Roach, J.;Shi, Y.;Simons, J.V.;Skelly, T.;Soloway, M.G.;Tan, D.;Veluvolu, U.;Fan, H.;Hinoue, T.;Laird, P.W.;Bellair, M.;Chang, K.;Covington, K.;Creighton, C.J.;Dinh, H.;Doddapaneni, H.;Donehower, L.A.;Drummond, J.;Gibbs, R.A.;Glenn, R.;Hale, W.;Han, Y.;Hu, J.;Korchina, V.;Lee, S.;Lewis, L.;Li, W.;Liu, X.;Morgan, M.;Morton, D.;Muzny, D.;Santibanez, J.;Sheth, M.;Shinbrot, E.;Wang, L.;Wang, M.;Wheeler, D.A.;Xi, L.;Zhao, F.;Hess, J.;Appelbaum, E.L.;Bailey, M.;Cordes, M.G.;Ding, L.;Fronick, C.C.;Fulton, L.A.;Fulton, R.S.;Kandoth, C.;Mardis, E.R.;McLellan, M.D.;Miller, C.A.;Schmidt, H.K.;Wilson, R.K.;Crain, D.;Curley, E.;Gardner, J.;Lau, K.;Mallery, D.;Morris, S.;Paulauskis, J.;Penny, R.;Shelton, C.;Shelton, T.;Sherman, M.;Thompson, E.;Yena, P.;Bowen, J.;Gastier-Foster, J.M.;Gerken, M.;Leraas, K.M.;Lichtenberg, T.M.;Ramirez, N.C.;Wise, L.;Zmuda, E.;Corcoran, N.;Costello, T.;Hovens, C.;Carvalho, A.L.;de Carvalho, A.C.;Fregnani, J.H.;Longatto-Filho, A.;Reis, R.M.;Scapulatempo-Neto, C.;Silveira, H.C.S.;Vidal, D.O.;Burnette, A.;Eschbacher, J.;Hermes, B.;Noss, A.;Singh, R.;Anderson, M.L.;Castro, P.D.;Ittmann, M.;Huntsman, D.;Kohl, B.;Le, X.;Thorp, R.;Andry, C.;Duffy, E.R.;Lyadov, V.;Paklina, O.;Setdikova, G.;Shabunin, A.;Tavobilov, M.;McPherson, C.;Warnick, R.;Berkowitz, R.;Cramer, D.;Feltmate, C.;Horowitz, N.;Kibel, A.;Muto, M.;Raut, C.P.;Malykh, A.;Barnholtz-Sloan, J.S.;Barrett, W.;Devine, K.;Fulop, J.;Ostrom, Q.T.;Shimmel, K.;Wolinsky, Y.;Sloan, A.E.;De Rose, A.;Giuliante, F.;Goodman, M.;Karlan, B.Y.;Hagedorn, C.H.;Eckman, J.;Harr, J.;Myers, J.;Tucker, K.;Zach, L.A.;Deyarmin, B.;Kvecher, L.;Larson, C.;Mural, R.J.; (2019) Erratum: The Immune Landscape of Cancer (Immunity (2018) 48(4) (812â'830.e14), (S1074761318301213), (10.1016/j.immuni.2018.03.023)). Immunity
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CRISPR-based functional genomics landscape of genes recurrently mutated in MM
Simoes, Ricardo de Matos;Shirasaki, Ryosuke;Tang, Huihui;Sheffer, Michal;Dashevsky, Olga;Downey-Kopyscinski, Sondra;Dhimolea, Eugen;Bariteau, Megan;Licht, Jonathan;Glassner, Brian J.;Levy, Joan;Auclair, Daniel;Vazquez, Francisca;Tsherniak, Aviad;Hahn, William;Culhane, Aedin;Mitsiades, Constantine; (2019) CRISPR-based functional genomics landscape of genes recurrently mutated in MM. Clinical Lymphoma Myeloma And Leukemia
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Molecular markers of myeloma cell sensitivity vs. resistance to heterobifunctional degraders of oncoproteins: therapeutic implications
Shirasaki, Ryosuke;Simoes, Ricardo de Matos;Gandolfi, Sara;Matthews, Geoffrey;Buckley, Dennis;Raja, Joseline;Sievers, Quinlan;Bruggenthies, Johanna;Dashevsky, Olga;Poarch, Haley;Tang, Huihui;Bariteau, Megan;Sheffer, Michal;Hu, Yiguo;Downey-Kopyscinski, Sondra;Hengeveld, Paul;Glassner, Brian J.;Dhimolea, Eugen;Ott, Christopher;Zhang, Tinghu;Kwiatkowski, Nicholas;Laubach, Jacob;Schlossman, Robert;Culhane, Aedin;Richardson, Paul G.;Groen, Richard;Fischer, Eric;Vazquez, Francisca;Tsherniak, Aviad;Hahn, William;Levy, Joan;Auclair, Daniel;Licht, Jonathan;Keats, Jonathan;Boise, Lawrence;Ebert, Benjamin;Bradner, James;Gray, Nathanael;Mitsiades, Constantine; (2019) Molecular markers of myeloma cell sensitivity vs. resistance to heterobifunctional degraders of oncoproteins: therapeutic implications. Clinical Lymphoma Myeloma And Leukemia
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CRISPR studies identify genes preferentially essential for myeloma cells vs. other neoplasias: implications for future therapies selective against MM
Shirasaki, Ryosuke;Simoes, Ricardo de Matos;Downey-Kopyscinski, Sondra;Matthews, Geoffrey;Hu, Yiguo;Sheffer, Michal;Dhimolea, Eugen;Dashevsky, Olga;Gandolfi, Sara;Hengeveld, Paul;Dempster, Joshua;Meyers, Robin;Bryan, Jordan;Dharia, Neekesh;McFarland, James;Sarkar, Subhashis;Bruggenthies, Johanna;Tang, Huihui;Bariteau, Megan;Aguirre, Andrew;Borah, Minasri;Sievers, Quinlan;Ebert, Benjamin;Raja, Joseline;Glassner, Brian J.;Ott, Christopher;Bradner, James;Kwiatkowski, Nicholas;Auclair, Daniel;Levy, Joan;Poarch, Haley;Zhang, Tinghu;Laubach, Jacob;Buckley, Dennis;Schlossman, Robert;Groen, Richard;Fischer, Eric;Richardson, Paul G.;Keats, Jonathan;Boise, Lawrence;Licht, Jonathan;Culhane, Aedin;Gray, Nathanael;Hahn, William;Vazquez, Francisca;Tsherniak, Aviad;Mitsiades, Constantine; (2019) CRISPR studies identify genes preferentially essential for myeloma cells vs. other neoplasias: implications for future therapies selective against MM. Clinical Lymphoma Myeloma And Leukemia
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Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins
Shirasaki, Ryosuke;Gandolfi, Sara;Simoes, Ricardo De Matos;Matthews, Geoffrey M.;Buckley, Dennis;Raja, Joseline;Sievers, Quinlan L.;Dashevsky, Olga;Poarch, Haley;Tang, Huihui;Bariteau, Megan;Sheffer, Michal;Downey-Kopyscinski, Sondra L.;Hengeveld, Paul;Glassner, Brian;Dhimolea, Eugen;Ott, Christopher J.;Zhang, Tinghu;Kwiatkowski, Nicholas P.;Laubach, Jacob P.;Schlossman, Robert L.;Richardson, Paul G.;Culhane, Aedin;Groen, Richard W. J.;Fischer, Eric;Ebert, Benjamin L.;Vazquez, Francisca;Tsherniak, Aviad;Hahn, William C.;Levy, Joan;Auclair, Daniel;Licht, Jonathan D.;Keats, Jonathan J.;Boise, Lawrence H.;Bradner, James;Gray, Nathanael;Mitsiades, Constantine S.; (2019) Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins. Blood
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BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
Li, A.G.;Murphy, E.C.;Culhane, A.C.;Powell, E.;Wang, H.;Bronson, R.T.;Von, T.;Giobbie-Hurder, A.;Gelman, R.S.;Briggs, K.J.;Piwnica-Worms, H.;Zhao, J.J.;Kung, A.L.;Kaelin, W.G.;Livingston, D.M.; (2018) BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation. Proceedings of the National Academy of Sciences of the United States of America
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CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias
Shirasaki, Ryosuke;Gandolfi, Sara;Simoes, Ricardo De Matos;Matthews, Geoffrey;Buckley, Dennis;Dashevsky, Olga;Downey-Kopyscinski, Sondra L.;Tang, Huihui;Sheffer, Michal;Dhimolea, Eugen;Glassner, Brian;Bariteau, Megan;Sorrell, Jeffrey;Bruggenthies, Johanna B.;Sievers, Quinlan;Poarch, Haley;Kwiatkowski, Nicholas P.;Zhang, Tinghu;Laubach, Jacob;Schlossman, Robert L.;Richardson, Paul;Culhane, Aedin;Groen, Richard W. J.;Fischer, Eric S.;Vazquez, Francisca;Tsherniak, Aviad;Hahn, William C.;Levy, Joan;Auclair, Daniel;Licht, Jonathan D.;Keats, Jonathan J.;Boise, Lawrence H.;Ebert, Benjamin L.;Bradner, James;Gray, Nathanae;Mitsiades, Constantine S.; (2018) CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias. Blood
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Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma
Simoes, Ricardo De Matos;Shirasaki, Ryosuke;Tang, Huihui;Sheffer, Michal;Dashevsky, Olga;Gandolfi, Sara;Dhimolea, Eugen;Bariteau, Megan;Licht, Jonathan D.;Glassner, Brian;Groen, Richard W. J.;Levy, Joan;Auclair, Daniel;Vazquez, Francisca;Tsherniak, Aviad;Hahn, William C.;Culhane, Aedin;Mitsiades, Constantine S.; (2018) Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma. Blood
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Enter the Matrix: Factorization Uncovers Knowledge from Omics
Stein-O'Brien, G.L.;Arora, R.;Culhane, A.C.;Favorov, A.V.;Garmire, L.X.;Greene, C.S.;Goff, L.A.;Li, Y.;Ngom, A.;Ochs, M.F.;Xu, Y.;Fertig, E.J.; (2018) Enter the Matrix: Factorization Uncovers Knowledge from Omics. Trends In Genetics
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High-throughput pharmacogenomic platform to functionally probe breast cancer vulnerabilities in the context of the 3-dimensional tumor microenvironment
Dhimolea, E.;Simoes, R. De Matos;Awate, P.;Tang, H.;Culhane, A.;Mitsiades, C.; (2017) High-throughput pharmacogenomic platform to functionally probe breast cancer vulnerabilities in the context of the 3-dimensional tumor microenvironment. Cancer Research
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Software for the Integration of Multiomics Experiments in Bioconductor.
Ramos M;Schiffer L;Re A;Azhar R;Basunia A;Rodriguez C;Chan T;Chapman P;Davis SR;Gomez-Cabrero D;Culhane AC;Haibe-Kains B;Hansen KD;Waldron L; (2017) Software for the Integration of Multiomics Experiments in Bioconductor.. Cancer Research
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Molecular Subtypes Improve Prognostic Value of International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Model.
de Velasco G;Culhane AC;Fay AP;Hakimi AA;Voss MH;Tannir NM;Tamboli P;Appleman LJ;Bellmunt J;Kimryn Rathmell W;Albiges L;Hsieh JJ;Heng DY;Choueiri TK; (2017) Molecular Subtypes Improve Prognostic Value of International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Model.. Oncologist
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Characterization of lineage vs. context-dependent essential genes in multiple myeloma using CRISPR-Cas9 genome editing
Matthews, Geoffrey M.;Simoes, Ricardo de Matos;Hu, Yiguo;Sheffer, Michal;Dashevsky, Olga;Dhimolea, Eugen;Hengeveld, Paul J.;Glassner, Brian J.;Gandolfi, Sara;Bariteau, Megan A.;Sievers, Quinlan;Ebert, Benjamin L.;Vazquez, Franciska;Culhane, Aedin;Mitsiades, Constantine S.; (2017) Characterization of lineage vs. context-dependent essential genes in multiple myeloma using CRISPR-Cas9 genome editing. Cancer Research
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Enter the matrix: factorization uncovers knowledge from omics Names/Affiliations
Genevieve L. Stein-OâBrien;Raman Arora;Aedin C. Culhane;Alexander V. Favorov;Lana X. Garmire;Casey S. Greene;Loyal A. Goff;Yifeng Li;Aloune Ngom;Michael F. Ochs;Yanxun Xu;Elana J. Fertig; (2017) Enter the matrix: factorization uncovers knowledge from omics Names/Affiliations.
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Pilot study of zirconium-89 bevacizumab positron emission tomography for imaging angiogenesis in patients with inflammatory breast carcinoma receiving preoperative chemotherapy
Jacene, H. A.;Overmoyer, B.;Schlosnagle, E. J.;Abbott, A.;Yeh, E.;Paolino, J.;Goel, S.;Culhane, A.;Bellon, J. R.;Nakhlis, F.;Hirshfield-Bartek, J.;Van den Abbeele, A.; (2017) Pilot study of zirconium-89 bevacizumab positron emission tomography for imaging angiogenesis in patients with inflammatory breast carcinoma receiving preoperative chemotherapy. Cancer Research
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High-throughput patient-derived 3-dimensional organoid cultures as personalized models to assess drug response and post-treatment residual disease
Dhimolea, Eugen;Simoes, Ricardo De Matos;DeRose, Yoko;Awate, Pallavi;Weng, Xiang;Tang, Huihui;Culhane, Aedin;Welm, Alana;Mitsiades, Constantine; (2017) High-throughput patient-derived 3-dimensional organoid cultures as personalized models to assess drug response and post-treatment residual disease. Cancer Research
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In Vivo Validation of Essential Genes for Myeloma Cells By CRISPR/Cas9 Studies in a Scaffold-Based System Engineered to Establish a "Humanized" Bone Marrow-like Microenvironment
Shirasaki, Ryosuke;Tamas, Csikos;Matthews, Geoffrey;Simoes, Ricardo De Matos;Sarkar, Subhashis;Dashevsky, Olga;Hu Yiguo;Sorrell, Jeffrey;Sheffer, Michal;Dhimolea, Eugen;Bariteau, Megan;Glassner, Brian;Culhane, Aedin;Groen, Richard W. J.;Mitsiades, Constantine S.; (2017) In Vivo Validation of Essential Genes for Myeloma Cells By CRISPR/Cas9 Studies in a Scaffold-Based System Engineered to Establish a "Humanized" Bone Marrow-like Microenvironment. Blood
Read moreIntegration of Functional Dependencies and Molecular Alterations of Myeloma Cells
Simoes, Ricardo De Matos;Matthews, Geoffrey;Shirasaki, Ryosuke;Hu Yiguo;Sheffer, Michal;Dashevsky, Olga;Gandolfi, Sara;Hengeveld, Paul;Bruggenthies, Johanna;Dhimolea, Eugen;Tang, Huihui;Bariteau, Megan;Aguirre, Andrew;Sievers, Quinlan;Ebert, Benjamin L.;Glassner, Brian;Ott, Christopher J.;Buckley, Dennis;Kwiatkowski, Nicholas P.;Licht, Jonathan D.;Gray, Nathanael;Dempster, Joshua;Groen, Richard W. J.;Vazquez, Francisca;Tsherniak, Aviad;Hahn, William C.;Culhane, Aedin;Mitsiades, Constantine S.; (2017) Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells. Blood
Read moreFunctional Genomic Landscape of Epigenetic Dependencies in Myeloma
Simoes, Ricardo De Matos;Matthews, Geoffrey;Richer, Daphne Dupere;Shirasaki, Ryosuke;Sheffer, Michal;Dashevsky, Olga;Gandolfi, Sara;Dhimolea, Eugen;Glassner, Brian;Groen, Richard W. J.;Vazquez, Franciska;Dempster, Joshua;Tsherniak, Aviad;Hahn, William C.;Culhane, Aedin;Licht, Jonathan D.;Mitsiades, Constantine S.; (2017) Functional Genomic Landscape of Epigenetic Dependencies in Myeloma. Blood
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Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing
Matthews, Geoffrey M.;Simoes, Ricardo De Matos;Hu, Yiguo;Sheffer, Michal;Dhimolea, Eugen;Hengeveld, Paul J.;Bariteau, Megan A.;Glassner, Brian;Sievers, Quinlan;Ebert, Benjamin L.;Gandolfi, Sara;Awate, Pallavi;Tang, Huihui;Vazquez, Franciska;Culhane, Aedin;Mitsiades, Constantine S.; (2016) Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing. Blood
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BRCA2, and not BRCA1, dependent crosstalk between replication stress suppression and nucleotide excision repair - Clinical implications
Pathania, Shailja;Reed, Rachel;Duan, Haohui;Culhane, Aedin;Garber, Judy; (2016) BRCA2, and not BRCA1, dependent crosstalk between replication stress suppression and nucleotide excision repair - Clinical implications. Cancer Research
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MECP2 is a frequently amplified oncogene with a novel epigenetic mechanism that mimics the role of activated RAS in malignancy
Neupane, M.;Clark, A.P.;Landini, S.;Birkbak, N.J.;Eklund, A.C.;Lim, E.;Culhane, A.C.;Barry, W.T.;Schumacher, S.E.;Beroukhim, R.;Szallasi, Z.;Vidal, M.;Hill, D.E.;Silver, D.P.; (2016) MECP2 is a frequently amplified oncogene with a novel epigenetic mechanism that mimics the role of activated RAS in malignancy. Cancer Discovery
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Abstract B54: Non-malignant cells from metastatic niches induce estrogen receptor-positive breast cancer cell resistance to therapy
Eugen Dhimolea;Richard Groen;Culhane Aedin;Mitsiades Nicholas;Polyak Kornelia;Mitsiades Constantine; (2015) Abstract B54: Non-malignant cells from metastatic niches induce estrogen receptor-positive breast cancer cell resistance to therapy. Cell Interactions In The Tumor Microenvironment
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Prognostic value of genomic signatures in metastatic Clear Cell Renal Cell Carcinoma (mRCC) using The Cancer Genome Atlas (TCGA) data
de Velasco, Guillermo;Fay, Andre Poisl;Culhane, Aedin;Hakimi, A. Ari;Voss, Martin Henner;Tannir, Nizar M.;Tamboli, Pheroze;Appleman, Leonard Joseph;Bellmunt, Joaquim;Rathmell, Kimryn;Albiges, Laurence K.;Hsieh, James;Heng, Daniel Yick Chin;Signoretti, Sabina;Choueiri, Toni K.; (2015) Prognostic value of genomic signatures in metastatic Clear Cell Renal Cell Carcinoma (mRCC) using The Cancer Genome Atlas (TCGA) data. Clinical Oncology
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RelA-induced interferon response negatively regulates proliferation
Kochupurakkal, B.S.;Wang, Z.C.;Hua, T.;Culhane, A.C.;Rodig, S.J.;Rajkovic-Molek, K.;Lazaro, J.-B.;Richardson, A.L.;Biswas, D.K.;Iglehart, J.D.; (2015) RelA-induced interferon response negatively regulates proliferation. Plos One
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Comparative meta-analysis of prognostic gene signatures for late-stage ovarian cancer.
Waldron, L.;Haibe-Kains, B.;Culhane, A.C.;Riester, M.;Ding, J.;Wang, X.V.;Ahmadifar, M.;Tyekucheva, S.;Bernau, C.;Risch, T.;Ganzfried, B.F.;Huttenhower, C.;Birrer, M.;Parmigiani, G.; (2014) Comparative meta-analysis of prognostic gene signatures for late-stage ovarian cancer.. Journal Of The National Cancer Institute
Read moreRisk prediction for late-stage ovarian cancer by meta-analysis of 1,525 patient samples
Riester, Markus;Wei, Wei;Culhane, Aedin C.;Trippa, Lorenzo;Michor, Franziska;Huttenhower, Curtis;Parmigiani, Giovanni;Birrer, Michael; (2014) Risk prediction for late-stage ovarian cancer by meta-analysis of 1,525 patient samples. Cancer Research
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Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samples.
Riester, M.;Wei, W.;Waldron, L.;Culhane, A.C.;Trippa, L.;Oliva, E.;Kim, S.H.;Michor, F.;Huttenhower, C.;Parmigiani, G.;Birrer, M.J.; (2014) Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samples.. Journal Of The National Cancer Institute
Read moreMeta-analysis of public microarray databases for prognostic and predictive gene signatures of late-stage ovarian cancer
Birrer, Michael J.;Riester, Markus;Wei, Wei;Waldron, Levi;Culhane, Aedin;Trippa, Lorenzo;Oliva, Esther;Kim, Sunghoon;Michor, Franziska;Huttenhower, Curtis;Parmigiani, Giovanni; (2014) Meta-analysis of public microarray databases for prognostic and predictive gene signatures of late-stage ovarian cancer. Clinical Oncology
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Taxonomy of breast cancer based on normal cell phenotype predicts outcome
Santagata, S.;Thakkar, A.;Ergonul, A.;Wang, B.;Woo, T.;Hu, R.;Harrell, J.C.;McNamara, G.;Schwede, M.;Culhane, A.C.;Kindelberger, D.;Rodig, S.;Richardson, A.;Schnitt, S.J.;Tamimi, R.M.;Ince, T.A.; (2014) Taxonomy of breast cancer based on normal cell phenotype predicts outcome. Journal Of Clinical Investigation
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Stem Cell-Like Gene Expression in Ovarian Cancer Predicts Type II Subtype and Prognosis
Schwede, M.;Spentzos, D.;Bentink, S.;Hofmann, O.;Haibe-Kains, B.;Harrington, D.;Quackenbush, J.;Culhane, A.C.; (2013) Stem Cell-Like Gene Expression in Ovarian Cancer Predicts Type II Subtype and Prognosis. Plos One
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MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32
Kelly, A.D.;Haibe-Kains, B.;Janeway, K.A.;Hill, K.E.;Howe, E.;Goldsmith, J.;Kurek, K.;Perez-Atayde, A.R.;Francoeur, N.;Fan, J.-B.;April, C.;Schneider, H.;Gebhardt, M.C.;Culhane, A.;Quackenbush, J.;Spentzos, D.; (2013) MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32. Genome Medicine
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Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer
Bowman-Colin, C.;Xia, B.;Bunting, S.;Klijn, C.;Drost, R.;Bouwman, P.;Fineman, L.;Chen, X.;Culhane, A.C.;Cai, H.;Rodig, S.J.;Bronson, R.T.;Jonkers, J.;Nussenzweig, A.;Kanellopoulou, C.;Livingston, D.M.; (2013) Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proceedings of the National Academy of Sciences of the United States of America
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Identification of transcription factors associated with castration-resistance: Is the serum responsive factor a potential therapeutic target?
Prencipe, M.;Madden, S.F.;O'Neill, A.;O'Hurley, G.;Culhane, A.;O'Connor, D.;Klocker, H.;Kay, E.W.;Gallagher, W.M.;Watson, W.R.; (2013) Identification of transcription factors associated with castration-resistance: Is the serum responsive factor a potential therapeutic target?. Prostate
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Taxonomy of breast cancer based on normal cell phenotype and ontology
Thakkar, Ankita;Santagata, Sandro;Ergonul, Ayse;Wang, Bin;Woo, Terri;Hu, Rong;Harrell, J. Chuck;McNamara, George;Schwede, Matthew;Culhane, Aedin C.;Kindelberger, David;Rodig, Scott;Richardson, Andrea;Schnitt, Stuart J.;Tamimi, Rulla M.;Ince, Tan A.; (2013) Taxonomy of breast cancer based on normal cell phenotype and ontology. Molecular Cancer Research
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GeneSigDB: A manually curated database and resource for analysis of gene expression signatures
Culhane, A.C.;Schröder, M.S.;Sultana, R.;Picard, S.C.;Martinelli, E.N.;Kelly, C.;Haibe-Kains, B.;Kapushesky, M.;St Pierre, A.-A.;Flahive, W.;Picard, K.C.;Gusenleitner, D.;Papenhausen, G.;O'Connor, N.;Correll, M.;Quackenbush, J.; (2012) GeneSigDB: A manually curated database and resource for analysis of gene expression signatures. Nucleic Acids Research
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Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome
Wang, Z.C.;Birkbak, N.J.;Culhane, A.C.;Drapkin, R.;Fatima, A.;Tian, R.;Schwede, M.;Alsop, K.;Daniels, K.E.;Piao, H.;Liu, J.;Etemadmoghadam, D.;Miron, A.;Salvesen, H.B.;Mitchell, G.;DeFazio, A.;Quackenbush, J.;Berkowitz, R.S.;Iglehart, J.D.;Bowtell, D.D.L.;Matulonis, U.A.; (2012) Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome. Clinical Cancer Research
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A three-gene model to robustly identify breast cancer molecular subtypes
Haibe-Kains, B.;Desmedt, C.;Loi, S.;Culhane, A.C.;Bontempi, G.;Quackenbush, J.;Sotiriou, C.; (2012) A three-gene model to robustly identify breast cancer molecular subtypes. Journal Of The National Cancer Institute
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Gene Expression Atlas update - Value-added database of microarray and sequencing-based functional genomics experiments
Kapushesky, M.;Adamusiak, T.;Burdett, T.;Culhane, A.;Farne, A.;Filippov, A.;Holloway, E.;Klebanov, A.;Kryvych, N.;Kurbatova, N.;Kurnosov, P.;Malone, J.;Melnichuk, O.;Petryszak, R.;Pultsin, N.;Rustici, G.;Tikhonov, A.;Travillian, R.S.;Williams, E.;Zorin, A.;Parkinson, H.;Brazma, A.; (2012) Gene Expression Atlas update - Value-added database of microarray and sequencing-based functional genomics experiments. Nucleic Acids Research
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Angiogenic mRNA and microRNA gene expression signature predicts a novel subtype of serous ovarian cancer
Bentink, S.;Haibe-Kains, B.;Risch, T.;Fan, J.-B.;Hirsch, M.S.;Holton, K.;Rubio, R.;April, C.;Chen, J.;Wickham-Garcia, E.;Liu, J.;Culhane, A.;Drapkin, R.;Quackenbush, J.;Matulonis, U.A.; (2012) Angiogenic mRNA and microRNA gene expression signature predicts a novel subtype of serous ovarian cancer. Plos One
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The cocaine-and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer
Brennan, D.J.;O'connor, D.P.;Laursen, H.;Mcgee, S.F.;Mccarthy, S.;Zagozdzon, R.;Rexhepaj, E.;Culhane, A.C.;Martin, F.M.;Duffy, M.J.;Landberg, G.;Ryden, L.;Hewitt, S.M.;Kuhar, M.J.;Bernards, R.;Millikan, R.C.;Crown, J.P.;Jirström, K.;Gallagher, W.M.; (2012) The cocaine-and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer. Oncogene
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The prognostic value of the cocaine and amphetamine-regulated transcript (CART) in breast cancer (BC).
(2011) The prognostic value of the cocaine and amphetamine-regulated transcript (CART) in breast cancer (BC).. Clinical Oncology
Read moreIntegrated analysis of multiple microarray datasets identifies a reproducible survival predictor in ovarian cancer
Konstantinopoulos, P.A.;Cannistra, S.A.;Fountzilas, H.;Culhane, A.;Pillay, K.;Rueda, B.;Cramer, D.;Seiden, M.;Birrer, M.;Coukos, G.;Zhang, L.;Quackenbush, J.;Spentzos, D.; (2011) Integrated analysis of multiple microarray datasets identifies a reproducible survival predictor in ovarian cancer. Plos One
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Transcriptomic profiling of castrate resistant prostate cancer cells: identification of transcription factors associated with androgen resistance
Prencipe, Maria;Madden, Stephen;O'Neill, Amanda;Culhane, Aedin;O'Connor, Darran;Klocker, Helmut;Gallagher, William M.;Watson, William; (2011) Transcriptomic profiling of castrate resistant prostate cancer cells: identification of transcription factors associated with androgen resistance. Cancer Research
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Robustness of breast cancer molecular subtypes identification
(2010) Robustness of breast cancer molecular subtypes identification. Ann Oncol
Read moreProliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue
Chen, D.-T.;Nasir, A.;Culhane, A.;Venkataramu, C.;Fulp, W.;Rubio, R.;Wang, T.;Agrawal, D.;McCarthy, S.M.;Gruidl, M.;Bloom, G.;Anderson, T.;White, J.;Quackenbush, J.;Yeatman, T.; (2010) Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue. Breast Cancer Research And Treatment
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Genetic relationships between ovarian and breast cancers
Wang, Zhigang C.;Culhane, Aedin;Drapkin, Ronny;Fatima, Aquila;Tian, Ruiyang;Daniels, Kathryn E.;Kantoff, Emily;Liu, Joyce;Quackenbush, John;Richardson, Andrea L.;Berkowitz, Ross S.;Iglehart, J. Dirk;Matulonis, Ursula A.; (2010) Genetic relationships between ovarian and breast cancers. Cancer Research
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Therapeutic implications of GIPC1 silencing in cancer
Chittenden, T.W.;Pak, J.;Rubio, R.;Cheng, H.;Holton, K.;Prendergast, N.;Glinskii, V.;Cai, Y.;Culhane, A.;Bentink, S.;Schwede, M.;Mar, J.C.;Howe, E.A.;Aryee, M.;Sultana, R.;Lanahan, A.A.;Taylor, J.M.;Holmes, C.;Hahn, W.C.;Zhao, J.J.;Iglehart, J.D.;Quackenbush, J.; (2010) Therapeutic implications of GIPC1 silencing in cancer. Plos One
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Repeatability of published microarray gene expression analyses
Ioannidis, J.P.A.;Allison, D.B.;Ball, C.A.;Coulibaly, I.;Cui, X.;Culhane, A.C.;Falchi, M.;Furlanello, C.;Game, L.;Jurman, G.;Mangion, J.;Mehta, T.;Nitzberg, M.;Page, G.P.;Petretto, E.;Van Noort, V.; (2009) Repeatability of published microarray gene expression analyses. Nature Genetics
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A 19-Gene Classifier Distinguishes Invasive Ductal and Classic Lobular Breast Carcinomas: Amplification of Chromosome 8q Characterizes Ductal While Estrogen-Related EGR-1 Characterizes Lobular Cancers
Culhane, A. C.;Nasir, A.;Chen, D. T.;Venkataramu, C.;White, J.;Andersson, T.;Gruidl, M.;Bloom, G.;Rubio, R.;Centeno, B. A.;Quackenbush, J.;Yeatman, T. J.; (2009) A 19-Gene Classifier Distinguishes Invasive Ductal and Classic Lobular Breast Carcinomas: Amplification of Chromosome 8q Characterizes Ductal While Estrogen-Related EGR-1 Characterizes Lobular Cancers. Laboratory Investigation
Read moreAnalysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification
Smith, M.J.;Culhane, A.C.;Donovan, M.;Coffey, J.C.;Barry, B.D.;Kelly, M.A.;Higgins, D.G.;Wang, J.H.;Kirwan, W.O.;Cotter, T.G.;Redmond, H.P.; (2009) Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification. British Journal Of Cancer
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A 19-Gene Classifier Distinguishes Invasive Ductal and Classic Lobular Breast Carcinomas: Amplification of Chromosome 8q Characterizes Ductal While Estrogen-Related EGR-1 Characterizes Lobular Cancers
Culhane, A. C.;Nastr, A.;Chen, D. T.;Venkataramu, C.;White, J.;Anderson, T.;Gruidl, M.;Bloom, G.;Rubio, R.;Centeno, B. A.;Quackenbush, J.;Yeatman, T. J.; (2009) A 19-Gene Classifier Distinguishes Invasive Ductal and Classic Lobular Breast Carcinomas: Amplification of Chromosome 8q Characterizes Ductal While Estrogen-Related EGR-1 Characterizes Lobular Cancers. Modern Pathology
Read moreMolecular classification of serous ovarian cancer subtypes
Quackenbush, John;Fan, Jian-Bing;Hirsch, Michelle;Mar, Jessica;Howe, Eleanor;Holton, Kristina;Rubio, Renee;April, Craig;Chen, Jing;Wickham-Garcia, Eliza;Liu, Joyce;Culhane, Aedin;Drapkin, Ronny;Matulonis, Ursula; (2009) Molecular classification of serous ovarian cancer subtypes. Cancer Research
Read moreGeneSigDB-A curated database of gene expression signatures
Culhane, A.C.;Schwarzl, T.;Sultana, R.;Picard, K.C.;Picard, S.C.;Lu, T.H.;Franklin, K.R.;French, S.J.;Papenhausen, G.;Correll, M.;Quackenbush, J.; (2009) GeneSigDB-A curated database of gene expression signatures. Nucleic Acids Research
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Immunohistochemical Validation of Topoisomerase 2 alpha and BubR1 as Novel Breast Cancer Risk Genes in Benign Breast Tissue
Nasir, A.;Chen, D. T.;Culhane, A. C.;Gruidl, M.;McCarthy, S. M.;Venkataramu, C.;Quackenbush, J.;Yeatman, T. J.; (2009) Immunohistochemical Validation of Topoisomerase 2 alpha and BubR1 as Novel Breast Cancer Risk Genes in Benign Breast Tissue. Laboratory Investigation
Read moreIdentification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer
Speers, C.;Tsimelzon, A.;Sexton, K.;Herrick, A.M.;Gutierrez, C.;Culhane, A.;Quackenbush, J.;Hilsenbeck, S.;Chang, J.;Brown, P.; (2009) Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer. Clinical Cancer Research
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Immunohistochemical Validation of Topoisomerase 2 alpha and BubR1 as Novel Breast Cancer Risk Genes in Benign Breast Tissue
Nasir, A.;Chen, D. T.;Culhane, A. C.;Gruidl, M.;McCarthy, S. M.;Venkataramu, C.;Quackenbush, J.;Yeatman, T. J.; (2009) Immunohistochemical Validation of Topoisomerase 2 alpha and BubR1 as Novel Breast Cancer Risk Genes in Benign Breast Tissue. Modern Pathology
Read moreMechanisms driving local breast cancer recurrence in a model of breast-conserving surgery
Smith, M.J.;Culhane, A.C.;Killeen, S.;Kelly, M.A.;Wang, J.H.;Cotter, T.G.;Redmond, H.P.; (2008) Mechanisms driving local breast cancer recurrence in a model of breast-conserving surgery. Annals Of Surgical Oncology
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Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer
Brennan, D.J.;Rexhepaj, E.;O'Brien, S.L.;McSherry, E.;O'Connor, D.P.;Fagan, A.I.;Culhane, A.C.;Higgins, D.G.;Jirstrom, K.;Millikan, R.C.;Landberg, G.;Duffy, M.J.;Hewitt, S.M.;Gallagher, W.M.; (2008) Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer. Clinical Cancer Research
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Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome
Cheng, A.S.L.;Culhane, A.C.;Chan, M.W.Y.;Venkataramu, C.R.;Ehrich, M.;Nasir, A.;Rodriguez, B.A.T.;Liu, J.;Yan, P.S.;Quackenbush, J.;Nephew, K.P.;Yeatman, T.J.;Huang, T.H.-M.; (2008) Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome. Cancer Research
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Systematic validation of novel breast cancer progression-associated biomarkers via high-throughput antibody generation and application of tissue microarray technology
Penny, S. A.;Kelly, C. M.;Brennan, D. J.;Culhane, A. C.;Higgins, D. G.;Dervan, P. A.;Jirstrom, K.;Ponten, F.;Uhlen, M.;Gallagher, W. M.; (2008) Systematic validation of novel breast cancer progression-associated biomarkers via high-throughput antibody generation and application of tissue microarray technology. European Journal Of Cancer, Supplement
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Systematic validation of novel breast cancer progression-associated biomarkers via high-throughput antibody generation and application of tissue microarray technology: an initial report
(2008) Systematic validation of novel breast cancer progression-associated biomarkers via high-throughput antibody generation and application of tissue microarray technology: an initial report. Clinical Oncology
Read moreFunctional classification analysis of somatically mutated genes in human breast and colorectal cancers
Chittenden, T.W.;Howe, E.A.;Culhane, A.C.;Sultana, R.;Taylor, J.M.;Holmes, C.;Quackenbush, J.; (2008) Functional classification analysis of somatically mutated genes in human breast and colorectal cancers. Genomics
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Integrating transcription factor binding site information with gene expression datasets
Jeffery, I.B.;Madden, S.F.;McGettigan, P.A.;Perrière, G.;Culhane, A.C.;Higgins, D.G.; (2007) Integrating transcription factor binding site information with gene expression datasets. Bioinformatics
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Gene expression profiling of malignant melanoma: Application of TaqMan technology for high-throughput downstream validation of transcriptomic studies
Rafferty, Mairin;Donoghue, Stephen;Faller, William J.;Nolan, Ilse-Maria;Culhane, Aedin C.;Moss, Catherine;McCormick, Janet;Easty, David J.;Dervan, Peter A.;Gallagher, William M.; (2007) Gene expression profiling of malignant melanoma: Application of TaqMan technology for high-throughput downstream validation of transcriptomic studies. Anticancer Research
Read moreCENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer
O'Brien, S.L.;Fagan, A.;Fox, E.J.P.;Millikan, R.C.;Culhane, A.C.;Brennan, D.J.;McCann, A.H.;Hegarty, S.;Moyna, S.;Duffy, M.J.;Higgins, D.G.;Jirström, K.;Landberg, G.;Gallagher, W.M.; (2007) CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer. International Journal Of Cancer
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A Multivariate Approach to Integrating Datasets using made4 and ade4
(2006) A Multivariate Approach to Integrating Datasets using made4 and ade4. The Newsletter Of The R Project Volume 6/5, December 2006
Read moreDifferential Gene Expression of Clinically Resected Colorectal Cancer and Flow Cytometrically Sorted Tumour Cells
(2006) Differential Gene Expression of Clinically Resected Colorectal Cancer and Flow Cytometrically Sorted Tumour Cells. Endoscopy
Read moreComparison and evaluation of methods for generating differentially expressed gene lists from microarray data
Jeffery, I.B.;Higgins, D.G.;Culhane, A.C.; (2006) Comparison and evaluation of methods for generating differentially expressed gene lists from microarray data. Bmc Bioinformatics
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Upregulation of the receptor tyrosine kinase Ddr1 may induce Akt activation in a model of local breast cancer recurrence
(2005) Upregulation of the receptor tyrosine kinase Ddr1 may induce Akt activation in a model of local breast cancer recurrence. The British journal of surgery
Read moreAdministration of a perioperative multiple heat shock protein dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo
Smith, MJ;Shilling, DA;Kelly, MA;England, KE;Culhane, A;Wang, JH;O'Mahony, L;Cotter, TG;Redmond, HP; (2005) Administration of a perioperative multiple heat shock protein dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo. Annals Of Surgical Oncology
Read moreApplication of DNA microarray technology in determining breast cancer prognosis and therapeutic response
Brennan, D.J.;O'Brien, S.L.;Fagan, A.;Culhane, A.C.;Higgins, D.G.;Duffy, M.J.;Gallagher, W.M.; (2005) Application of DNA microarray technology in determining breast cancer prognosis and therapeutic response. Expert Opinion On Biological Therapy
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DNA microarray-based gene expression profiling in cancer: Aiding cancer diagnosis, assessing prognosis and predicting response to therapy
Duffy, M.J.;Kelly, Z.D.;Culhane, A.C.;O'Brien, S.L.;Gallagher, W.M.; (2005) DNA microarray-based gene expression profiling in cancer: Aiding cancer diagnosis, assessing prognosis and predicting response to therapy. Current Pharmacogenomics
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Optimized between-group classification: A new jackknife-based gene selection procedure for genome-wide expression data
Baty, F.;Bihl, M.P.;Perrière, G.;Culhane, A.C.;Brutsche, M.H.; (2005) Optimized between-group classification: A new jackknife-based gene selection procedure for genome-wide expression data. Bmc Bioinformatics
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Multiple markers for melanoma progression regulated by DNA methylation: Insights from transcriptomic studies
Gallagher, W.M.;Rafferty, M.;Kelly, Z.D.;Nolan, I.-M.;Fox, E.J.P.;Culhane, A.C.;McArdle, L.;Fraga, M.F.;Hughes, L.;Currid, C.A.;O'Mahony, F.;Byrne, A.;Murphy, A.A.;Moss, C.;McDonnell, S.;Stallings, R.L.;Plumb, J.A.;Esteller, M.;Brown, R.;Dervan, P.A.;Easty, D.J.; (2005) Multiple markers for melanoma progression regulated by DNA methylation: Insights from transcriptomic studies. Carcinogenesis
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Oligonucleotide microarray analysis of gene expression in neuroblastoma displaying loss of chromosome 11q
McArdle, L.;McDermott, M.;Purcell, R.;Grehan, D.;O'Meara, A.;Breatnach, F.;Catchpoole, D.;Culhane, A.C.;Jeffery, I.;Gallagher, W.M.;Stallings, R.L.; (2004) Oligonucleotide microarray analysis of gene expression in neuroblastoma displaying loss of chromosome 11q. Carcinogenesis
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Expression profiler: Next generation - An online platform for analysis of microarray data
Kapushesky, M.;Kemmeren, P.;Culhane, A.C.;Durinck, S.;Ihmels, J.;Körner, C.;Kull, M.;Torrente, A.;Sarkans, U.;Vilo, J.;Brazma, A.; (2004) Expression profiler: Next generation - An online platform for analysis of microarray data. Nucleic Acids Research
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Algorithms for gene expression analysis
(2004) Algorithms for gene expression analysis. Encyclopedia Of Genetics, Genomics, Proteomics And Bioinformatics
Read moreUse of competitive pcr to monitor expression of the bcl-2. bcl-x. mcl-1. box. bak and bfl-1 genes during the induction of apoptosis in human haematopoietic cell lines
Smith, C.A.;Ganderton, S.K.;Culhane, A.C.;Leite, P.S.;Williams, G.T.; (1996) Use of competitive pcr to monitor expression of the bcl-2. bcl-x. mcl-1. box. bak and bfl-1 genes during the induction of apoptosis in human haematopoietic cell lines. Biochemical Society Transactions
Read moreApoptosis: Molecular regulation of cell death (vol 236, pg 6, 1996)
Hale, AJ;Smith, CA;Satherland, LC;Stoneman, VEA;Longthorne, V;Culhane, AC;Williams, GT; (1996) Apoptosis: Molecular regulation of cell death (vol 236, pg 6, 1996). European Journal Of Biochemistry
Read moreApoptosis: molecular regulation of cell death.
Hale AJ;Smith CA;Sutherland LC;Stoneman VE;Longthorne V;Culhane AC;Williams GT; (1996) Apoptosis: molecular regulation of cell death.. European Journal Of Biochemistry
Read moreErratum: Molecular regulation of cell death (Eur. J. Biochem. 236, No. 1 (6))
Hale, A.J.;Smith, C.A.;Sutherland, L.C.;Stoneman, V.E.A.;Longthorne, V.;Culhane, A.C.;Williams, G.T.; (1996) Erratum: Molecular regulation of cell death (Eur. J. Biochem. 236, No. 1 (6)). European Journal Of Biochemistry
Read moreBooks
Topological pathway enrichment analysis of gene expression in high grade serous ovarian cancer reveals tumor-stoma cross-talk
Zeleznik, O.A.;Thallinger, G.G.;Platig, J.;Culhane, A.C.; (2017) Topological pathway enrichment analysis of gene expression in high grade serous ovarian cancer reveals tumor-stoma cross-talk. Trends in Mathematics
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Book Chapters
Al Methods for Analyzing Microarray Data
(2009) Al Methods for Analyzing Microarray Data. Encyclopedia of artificial intelligence
Read moreMining of Gene-Expression Data
(2006) Mining of Gene-Expression Data. In silico technologies in drug target identification and validation
Read moreOptimization of Between Group Analysis of gene expression disease class prediction
(2006) Optimization of Between Group Analysis of gene expression disease class prediction. BIOMAT 2005
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