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Ms Sarah Hudson

BA PhD Dip MSc

Biography

Sarah studied Chemistry in Trinity College Dublin were she was a Trinity Foundation Scholar and where she did a research masters on the synthesis of a family of Re (I) metal complexes and a study of their photophysical properties with Prof John Kelly. Her PhD in the University of Limerick focussed on the immobilization of enzymes onto novel mesoporous supports and their catalytic properties with Prof Edmond Magner, Prof Kieran Hodnett and Dr Jakki Cooney. She secured a Marie Curie Outgoing International Fellowship to work with Prof Robert Langer in MIT, USA. There she developed in situ crosslinkable hydrogel systems for cartilage regeneration and drug delivery and she also studied the biocompatibility (in vivo and in vitro) of micro- and nano- mesoporous silica particles. After this fellowship, Sarah worked in Waterford Institute of Technology on the identification of the mechanisms and causes of tablet splitting within the Genzyme Ireland facility. Since November 2011, Sarah has been a lecturer in Chemistry in the Department of Chemical Sciences and a researcher in the Bernal Institute in the University of Limerick. She is a funded investigator in the Synthesis and Solid State Pharmaceutical Research Centre (SSPC) since 2013.

Research Interests


The Hudson group focuses on the manipulation of the physicochemical properties of small and large active molecules to improve their stability, solubility and dissolution rates with the ultimate goal of improving the bioavailability of active pharmaceutical ingredients. They explore the solution and solid state behaviour of these molecules both during formulation/manufacture into medicines and in biorelevant environments. Their research focuses on the thermodynamics behind aggregation, crystallisation and precipitation in a range of solvents and bio relevant media and develops formulations and structures to control this solution/solid state behaviour.

Current Postdoctoral researchers:
Dr Edel Durack (SFI CDA)

Current PhD students:
Ajay Kumar (SFI, SSPC)
James Flynn (SFI, CDA)
Sally Ryan (SFI, Curam)
Michele Dully (IRC, COOK Medical)
Miriama Ceresnakova (IRC, COOK Medical)
Aoibhin Ryan (IRC)

Current MSc students:
Tracey Carroll (Sanofi Genzyme)

Former PhD students:
Dr Teresa Tierney (IRCSET, SSPC)
Dr Raquel Arribas Bueno (SFI SSPC)
Dr Pauric Bannigan (SFI CDA)
Dr Vivek Verma (SFI SSPC)
Dr Katalin Bodnar (SFI SSPC)

Former Masters students:
Sarah Mallen (SFI CDA)



Teaching Interests

Sarah is a lecturer in Physical and General Chemistry to undergraduate chemistry students. She also is coordinator for the core chemistry curriculum for training second level chemistry teachers, including chemistry pedagogy. She has engaged in peer observation exercises with colleagues from the Civil and Mechanical engineering departments and have worked on integrating their suggestions for problem based and self directed learning into her own teaching style. She engages with technology during lectures, where advantageous and appropriate, e.g. using clicker quizzes to motivate student participation and promote class discussion on topics. Her ambition is to stimulate a passion, or at least a curiosity, in her students and strives to do this by emphasizing the importance and relevance of each topic for life and their education.

Professional Activities

Association

  • 2014 Member, Marie Curie Alumni Association

Award

  • 2013 - MSSI Innovation Award
  • 2013 - PI in the Synthesis and Solid State Pharmaceutical Centre
  • 2013 - Academic Partner in Enterprise Ireland Commercialisation Grant
  • 2012 - Principal Supervisor of an IRCSET Student
  • 2012 - Fast Moving Front paper
  • 2007 - Best Post-graduate Web of Science Journal Publication
  • 2006 - Marie Curie Outgoing International Fellowship
  • 2005 - BOC Gases Post Graduate Bursary
  • 1997 - Foundation Scholar of Trinity College Dublin

Education

  • 2013 University of Limerick - Diploma
  • 2006 University of Limerick - PhD
  • 2000 Trinity College Dublin - Masters by research
  • 1999 Trinity College Dublin - BA (Mod)

Outreach

  • Volunteered at the St Vincent de Paul grind school in Moyross 2011-2012
  • School placement tutor for training education students 2012-present

Publications

Conference Publication

2009

33rd Annual MSI Meeting
Tanner D. A. Nakahara S. Hudson S. Magner E. Redington W. Hodnett K.

2007

8th International Symposium on Biocatalysis and Biotransformations
Hudson, S., J. Cooney, B. K. Hodnett and E. Magner.

2006

COLL 488-Proteins in mesoporous silicates
Hudson, S; White, S; Essa, H; Goradia, D; Cooney, J; Hodnett, BK; Magner, E

2005

Europacat-VII, Seventh European Congree on Catalysis
Hudson S., Magner E., Cooney J. and B.K. Hodnett

2005

Microscopical Society of Ireland 29th Annual Symposium
Hudson S., Tanner D.A., Redington W., Magner E, Hodnett, K. and Nakahara S.

2005

Europacat
Hudson, S., Hodnett, B.K., Cooney, J., and Magner, E.

2005
2005

Biotrans 2005 Symposium, The key to Industrial Biotechnology
Hudson S., Goradia D., White S., Cooney J., Hodnett B.K. and E. Magner

Other Publication

2008

Proteins in Mesoporous Silicates
Hudson, S; Cooney, J; Magner, E
DOI: 10.1002/anie.200705238

Peer Reviewed Journal

2019

Carrier particle mediated stabilization and isolation of valsartan nanoparticles.
Kumar A;Davern P;Hodnett BK;Hudson SP;
Colloids and surfaces. B, Biointerfaces DOI: 10.1016/j.colsurfb.2018.12.021

2019

Protecting bactofencin A to enable its antimicrobial activity using mesoporous matrices
Durack, E;Mallen, S;O'Connor, PM;Rea, MC;Ross, RP;Hill, C;Hudson, S
International journal of pharmaceutics DOI: 10.1016/j.ijpharm.2018.12.035

2019
2019

Nitrogen and sulfur co-doped carbon nanodots toward bovine hemoglobin: A fluorescence quenching mechanism investigation
Wang J.;Xiang X.;Milcovich G.;Chen J.;Chen C.;Feng J.;Hudson S.;Weng X.;Ruan Y.
Journal Of Molecular Recognition DOI: 10.1002/jmr.2761

2019

Mesoporous matrices for the delivery of the broad spectrum bacteriocin, nisin A
Flynn, J;Mallen, S;Durack, E;O'Connor, PM;Hudson, SP
Journal of colloid and interface science DOI: 10.1016/j.jcis.2018.11.037

2018

Delivery of a hydrophobic drug into the lower gastrointestinal system via an endogenous enzyme-mediated carrier mechanism: An in vitro study
Bannigan, P;Durack, E;Mathur, H;Rea, MC;Ross, RP;Hudson, SP
European Journal Of Pharmaceutics And Biopharmaceutics DOI: 10.1016/j.ejpb.2018.09.019

2018

Dependence of Heterogeneous Nucleation on Hydrogen Bonding Lifetime and Complementarity
Verma, V;Zeglinski, J;Hudson, S;Davern, P;Hodnett, BK
Crystal Growth & Design DOI: 10.1021/acs.cgd.8b01302

2018

The heterogeneous crystallization of a novel solvate of clozapine base in the presence of excipients
Verma, V;Bannigan, P;Lusi, M;Crowley, CM;Hudson, S;Hodnett, BK;Davern, P
Crystengcomm DOI: 10.1039/c8ce00663f

2018

Heterogeneous Crystallization of Fenofibrate onto Pharmaceutical Excipients
Bueno, RA;Crowley, CM;Davern, P;Hodnett, BK;Hudson, S
Crystal Growth & Design DOI: 10.1021/acs.cgd.7b01598

2018

Co-reductive fabrication of carbon nanodots with high quantum yield for bioimaging of bacteria
Wang, JJ,Liu, X,Milcovich, G,Chen, TY,Durack, E,Mallen, S,Ruan, YM,Weng, XX,Hudson, SP
Beilstein Journal Of Nanotechnology DOI: 10.3762/bjnano.9.16

2018

The heterogeneous crystallization of a novel solvate of clozapine base in the presence of excipients
Verma, V;Bannigan, P;Lusi, M;Crowley, CM;Hudson, S;Hodnett, BK;Davern, P
Crystengcomm DOI: 10.1039/c8ce00663f

2017

Size and Shape Control of Micron-Sized Salicylic Acid Crystals during Antisolvent Crystallization
Tierney, TB,Rasmuson, AC,Hudson, SP
Organic Process Research & Development DOI: 10.1021/acs.oprd.7b00181

2017

Influence of Process Parameters on the Heterogeneous Nucleation of Active Pharmaceutical Ingredients onto Excipients
Bueno, RA,Crowley, CM,Hodnett, BK,Hudson, S,Davern, P
Organic Process Research & Development DOI: 10.1021/acs.oprd.6b00425

2017

Preparation and characterization of amorphous ciprofloxacin-amino acid salts
Mesallati, H,Conroy, D,Hudson, S,Tajber, L
European Journal Of Pharmaceutics And Biopharmaceutics DOI: 10.1016/j.ejpb.2017.09.009

2017

Carrier particle design for stabilization and isolation of drug nanoparticles
Tierney, T,Bodnar, K,Rasmuson, A,Hudson, S
International journal of pharmaceutics DOI: 10.1016/j.ijpharm.2016.11.045

2016

Recyclable SERS substrates based on Fe2O3-Ag hybrid hollow microspheres with crumpled surfaces
Weng, XX,Feng, ZL,Guo, YN,Feng, JJ,Hudson, SP,Zheng, JF,Ruan, YM,Laffir, F,Pita, I
New Journal Of Chemistry DOI: 10.1039/c6nj00473c

2015

Investigating the solubility and cytocompatibility of CaO-Na2O-SiO2/TiO2 bioactive glasses
Wren, AW,Coughlan, A,Smith, CM,Hudson, SP,Laffir, FR,Towler, MR
Journal Of Biomedical Materials Research Part A DOI: 10.1002/jbm.a.35223

2015

Investigation of the Particle Growth of Fenofibrate following Antisolvent Precipitation and Freeze-Drying
Tierney, TB,Guo, YN,Beloshapkin, S,Rasmuson, AC,Hudson, SP
Crystal Growth & Design DOI: 10.1021/acs.cgd.5b00662

2014

Thermodynamics of fenofibrate and solubility in pure organic solvents
Watterson, S,Hudson, S,Svard, M,Rasmuson, AC
Fluid Phase Equilibria DOI: 10.1016/j.fluid.2014.01.029

2012

Investigation of the Solid-State Polymorphic Transformations of Piracetam
Maher, A,Seaton, CC,Hudson, S,Croker, DM,Rasmuson, AC,Hodnett, BK
Crystal Growth & Design DOI: 10.1021/cg301418c

2012

Enhancement and restriction of chain motion in polymer networks.
Hudson SP, Owens E, Hughes H, McLoughlin P
International journal of pharmaceutics DOI: 10.1016/j.ijpharm.2012.03.045

2012

Enhancement and restriction of chain motion in polymer networks
Hudson, SP,Owens, E,Hughes, H,McLoughlin, P
International Journal Of Pharmaceutics DOI: 10.1016/j.ijpharm.2012.03.045

2011

Defocus image contrast in hexagonally-ordered mesoporous material
Nakahara, S; Tanner, DA; Hudson, S; Magner, E; Redington, W; Hodnett, K
Physical Chemistry Chemical Physics DOI: 10.1039/c0cp01141j

2011

The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications
Wren, AW; Cummins, NM; Laffir, FR; Hudson, SP; Towler, MR
Journal Of Materials Science-Materials In Medicine DOI: 10.1007/s10856-010-4184-4

2011

A Prototype Antifungal Contact Lens
Ciolino, JB; Hudson, SP; Mobbs, AN; Hoare, TR; Iwata, NG; Fink, GR; Kohane, DS
Investigative Ophthalmology & Visual Science DOI: 10.1167/iovs.10-6935

2010

Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D.
Yang F, Cho SW, Son SM, Hudson SP, Bogatyrev S, Keung L, Kohane DS, Langer R, Anderson DG
Biomacromolecules DOI: 10.1021/bm100357t

2010
2008

The biocompatibility of mesoporous silicates
Hudson, SP; Padera, RF; Langer, R; Kohane, DS
Biomaterials DOI: 10.1016/j.biomaterials.2008.07.007

2008

Proteins in mesoporous silicates.
Hudson, S; Cooney, J; Magner, E
Angewandte Chemie-International Edition In English

2008

A nanoporous reactor for efficient proteolysis
Qiao, L; Liu, Y; Hudson, SP; Yang, PY; Magner, E; Liu, BH
Chemistry-A European Journal DOI: 10.1002/chem.200701102

2008

A mesoporous reactor for high throughput proteolysis.
Qiao L; Liu, Y; Hudson, S; Yang, P; Magner, E; Liu, B
Chemistry A European Journal

2007

Chloroperoxidase on periodic mesoporous organosilanes: Immobilization and reuse
Hudson, S; Cooney, J; Hodnett, BK; Magner, E
Chemistry Of Materials DOI: 10.1021/cm070180c

2007

Solvent dependent photophysics of fac-[Re(CO)(3)(11,12-X(2)dppz)(py)](+)(X = H, F or Me).
Dyer J, Creely CM, Penedo JC, Grills DC, Hudson S, Matousek P, Parker AW, Towrie M, Kelly JM, George MW
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology DOI: 10.1039/b618651c

2006

Adsorption and activity of a domoic acid binding antibody fragment on mesoporous silicates
Hu, XJ; Spada, S; White, S; Hudson, S; Magner, E; Wall, JG
Journal Of Physical Chemistry B DOI: 10.1021/jp062423e

2006

Quantitative TEM analysis of a hexagonal mesoporous silicate structure
Hudson, S; Tanner, DA; Redington, W; Magner, E; Hodnett, K; Nakahara, S
Physical Chemistry Chemical Physics DOI: 10.1039/b605581h

2005

Methodology for the immobilization of enzymes onto mesoporous materials
Hudson, S; Magner, E; Cooney, J; Hodnett, BK
Journal Of Physical Chemistry B DOI: 10.1021/jp052102n

2003

The photophysics of fac-[Re(CO)3(dppz)(py)]+ in CH3CN: a comparative picosecond flash photolysis, transient infrared, transient resonance Raman and density functional theoretical study.
Dyer J, Blau WJ, Coates CG, Creely CM, Gavey JD, George MW, Grills DC, Hudson S, Kelly JM, Matousek P, McGarvey JJ, McMaster J, Parker AW, Towrie M, Weinstein JA
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology