Sarah studied Chemistry in Trinity College Dublin were she was a Trinity Foundation Scholar and where she did a research masters on the synthesis of a family of Re (I) metal complexes and a study of their photophysical properties with Prof John Kelly. Her PhD in the University of Limerick focussed on the immobilization of enzymes onto novel mesoporous supports and their catalytic properties with Prof Edmond Magner, Prof Kieran Hodnett and Dr Jakki Cooney. She secured a Marie Curie Outgoing International Fellowship to work with Prof Robert Langer in MIT, USA. There she developed in situ crosslinkable hydrogel systems for cartilage regeneration and drug delivery and she also studied the biocompatibility (in vivo and in vitro) of micro- and nano- mesoporous silica particles. After this fellowship, Sarah worked in Waterford Institute of Technology on the identification of the mechanisms and causes of tablet splitting within the Genzyme Ireland facility. Since November 2011, Sarah has been a lecturer in Chemistry in the Department of Chemical Sciences and a researcher in the Bernal Institute in the University of Limerick. She is a funded investigator in the Synthesis and Solid State Pharmaceutical Research Centre (SSPC) since 2013.
The Hudson group focuses on the manipulation of the physicochemical properties of small and large active molecules to improve their stability, solubility and dissolution rates with the ultimate goal of improving the bioavailability of active pharmaceutical ingredients. They explore the solution and solid state behaviour of these molecules both during formulation/manufacture into medicines and in biorelevant environments. Their research focuses on the thermodynamics behind aggregation, crystallisation and precipitation in a range of solvents and bio relevant media and develops formulations and structures to control this solution/solid state behaviour.
Current Postdoctoral researchers:
Dr Edel Durack (SFI CDA)
Current PhD students:
Ajay Kumar (SFI, SSPC)
James Flynn (SFI, CDA)
Sally Ryan (SFI, Curam)
Michele Dully (IRC, COOK Medical)
Miriama Ceresnakova (IRC, COOK Medical)
Aoibhin Ryan (IRC)
Current MSc students:
Tracey Carroll (Sanofi Genzyme)
Former PhD students:
Dr Teresa Tierney (IRCSET, SSPC)
Dr Raquel Arribas Bueno (SFI SSPC)
Dr Pauric Bannigan (SFI CDA)
Dr Vivek Verma (SFI SSPC)
Dr Katalin Bodnar (SFI SSPC)
Former Masters students:
Sarah Mallen (SFI CDA)
Sarah is a lecturer in Physical and General Chemistry to undergraduate chemistry students. She also is coordinator for the core chemistry curriculum for training second level chemistry teachers, including chemistry pedagogy. She has engaged in peer observation exercises with colleagues from the Civil and Mechanical engineering departments and have worked on integrating their suggestions for problem based and self directed learning into her own teaching style. She engages with technology during lectures, where advantageous and appropriate, e.g. using clicker quizzes to motivate student participation and promote class discussion on topics. Her ambition is to stimulate a passion, or at least a curiosity, in her students and strives to do this by emphasizing the importance and relevance of each topic for life and their education.
- 2014 Member, Marie Curie Alumni Association
- 2013 - MSSI Innovation Award
- 2013 - PI in the Synthesis and Solid State Pharmaceutical Centre
- 2013 - Academic Partner in Enterprise Ireland Commercialisation Grant
- 2012 - Principal Supervisor of an IRCSET Student
- 2012 - Fast Moving Front paper
- 2007 - Best Post-graduate Web of Science Journal Publication
- 2006 - Marie Curie Outgoing International Fellowship
- 2005 - BOC Gases Post Graduate Bursary
- 1997 - Foundation Scholar of Trinity College Dublin
- 2013 University of Limerick - Diploma
- 2006 University of Limerick - PhD
- 2000 Trinity College Dublin - Masters by research
- 1999 Trinity College Dublin - BA (Mod)
- Volunteered at the St Vincent de Paul grind school in Moyross 2011-2012
- School placement tutor for training education students 2012-present
33rd Annual MSI Meeting
Tanner D. A. Nakahara S. Hudson S. Magner E. Redington W. Hodnett K.
8th International Symposium on Biocatalysis and Biotransformations
Hudson, S., J. Cooney, B. K. Hodnett and E. Magner.
Bionanotechnology session, American Institute of Chemical Engineering 2007 Annual Meeting,
Hudson, S. and E. Magner.
Europacat-VII, Seventh European Congree on Catalysis
Hudson S., Magner E., Cooney J. and B.K. Hodnett
Microscopical Society of Ireland 29th Annual Symposium
Hudson S., Tanner D.A., Redington W., Magner E, Hodnett, K. and Nakahara S.
Hudson, S., Hodnett, B.K., Cooney, J., and Magner, E.
Biotrans 2005 7th International Symposium on Biocatalysis and Biotransformations
Hudson, S., Hodnett, B.K., Cooney, J., Magner, E.
Biotrans 2005 Symposium, The key to Industrial Biotechnology
Hudson S., Goradia D., White S., Cooney J., Hodnett B.K. and E. Magner
nanoSMat2005, International conference on Surfaces, Coatings and Nanostructured Material
Hudson S., Magner E., Cooney J. and Hodnett, B.K.
Peer Reviewed Journal
Mesoporous matrices for the delivery of the broad spectrum bacteriocin, nisin A
Flynn, J;Mallen, S;Durack, E;O'Connor, PM;Hudson, SP
Journal of colloid and interface science DOI: 10.1016/j.jcis.2018.11.037
Promotion of Mefenamic Acid Nucleation by a Surfactant Additive, Docusate Sodium
Bodnár K.;Hudson S.;Rasmuson Å.
Crystal Growth & Design DOI: 10.1021/acs.cgd.8b00995
Protecting bactofencin A to enable its antimicrobial activity using mesoporous matrices
Durack, E;Mallen, S;O'Connor, PM;Rea, MC;Ross, RP;Hill, C;Hudson, S
International journal of pharmaceutics DOI: 10.1016/j.ijpharm.2018.12.035
Overcoming the Common Ion Effect for Weakly Basic Drugs: Inhibiting the Crystallization of Clofazimine Hydrochloride in Simulated Gastrointestinal Media
Bannigan P.;Verma V.;Hudson S.
Crystal Growth & Design DOI: 10.1021/acs.cgd.8b01365
Nitrogen and sulfur co-doped carbon nanodots toward bovine hemoglobin: A fluorescence quenching mechanism investigation
Wang J.;Xiang X.;Milcovich G.;Chen J.;Chen C.;Feng J.;Hudson S.;Weng X.;Ruan Y.
Journal Of Molecular Recognition DOI: 10.1002/jmr.2761
Delivery of a hydrophobic drug into the lower gastrointestinal system via an endogenous enzyme-mediated carrier mechanism: An in vitro study
Bannigan, P;Durack, E;Mathur, H;Rea, MC;Ross, RP;Hudson, SP
European Journal Of Pharmaceutics And Biopharmaceutics DOI: 10.1016/j.ejpb.2018.09.019
Investigating the effects of amphipathic gastrointestinal compounds on the solution behaviour of salt and free base forms of clofazimine: An in vitro evaluation
Bannigan, P;Stokes, K;Kumar, A;Madden, C;Hudson, SP
International journal of pharmaceutics DOI: 10.1016/j.ijpharm.2018.09.012
Co-reductive fabrication of carbon nanodots with high quantum yield for bioimaging of bacteria
Wang, JJ,Liu, X,Milcovich, G,Chen, TY,Durack, E,Mallen, S,Ruan, YM,Weng, XX,Hudson, SP
Beilstein Journal Of Nanotechnology DOI: 10.3762/bjnano.9.16
Size and Shape Control of Micron-Sized Salicylic Acid Crystals during Antisolvent Crystallization
Tierney, TB,Rasmuson, AC,Hudson, SP
Organic Process Research & Development DOI: 10.1021/acs.oprd.7b00181
Preparation and characterization of amorphous ciprofloxacin-amino acid salts
Mesallati, H,Conroy, D,Hudson, S,Tajber, L
European Journal Of Pharmaceutics And Biopharmaceutics DOI: 10.1016/j.ejpb.2017.09.009
Stepwise Use of Additives for Improved Control over Formation and Stability of Mefenamic Acid Nanocrystals Produced by Antisolvent Precipitation
Bodnar, K,Hudson, SP,Rasmuson, AC
Crystal Growth & Design DOI: 10.1021/acs.cgd.6b01256
Carrier particle design for stabilization and isolation of drug nanoparticles
Tierney, T,Bodnar, K,Rasmuson, A,Hudson, S
International journal of pharmaceutics DOI: 10.1016/j.ijpharm.2016.11.045
Role of Biorelevant Dissolution Media in the Selection of Optimal Salt Forms of Oral Drugs: Maximizing the Gastrointestinal Solubility and in Vitro Activity of the Antimicrobial Molecule, Clofazimine
Bannigan, P,Durack, E,Madden, C,Lusi, M,Hudson, SP
Acs Omega DOI: 10.1021/acsomega.7b01454
Recyclable SERS substrates based on Fe2O3-Ag hybrid hollow microspheres with crumpled surfaces
Weng, XX,Feng, ZL,Guo, YN,Feng, JJ,Hudson, SP,Zheng, JF,Ruan, YM,Laffir, F,Pita, I
New Journal Of Chemistry DOI: 10.1039/c6nj00473c
Investigation into the Solid and Solution Properties of Known and Novel Polymorphs of the Antimicrobial Molecule Clofazimine
Bannigan, P,Zeglinski, J,Lusi, M,O'Brien, J,Hudson, SP
Crystal Growth & Design DOI: 10.1021/acs.cgd.6b01411
Investigation of the Particle Growth of Fenofibrate following Antisolvent Precipitation and Freeze-Drying
Tierney, TB,Guo, YN,Beloshapkin, S,Rasmuson, AC,Hudson, SP
Crystal Growth & Design DOI: 10.1021/acs.cgd.5b00662
Investigating the solubility and cytocompatibility of CaO-Na2O-SiO2/TiO2 bioactive glasses
Wren, AW,Coughlan, A,Smith, CM,Hudson, SP,Laffir, FR,Towler, MR
Journal Of Biomedical Materials Research Part A DOI: 10.1002/jbm.a.35223
Enhancement and restriction of chain motion in polymer networks
Hudson, SP,Owens, E,Hughes, H,McLoughlin, P
International Journal Of Pharmaceutics DOI: 10.1016/j.ijpharm.2012.03.045
Enhancement and restriction of chain motion in polymer networks.
Hudson SP, Owens E, Hughes H, McLoughlin P
International journal of pharmaceutics DOI: 10.1016/j.ijpharm.2012.03.045
Injectable in situ cross-linking hydrogels for local antifungal therapy
Hudson, SP; Langer, R; Fink, GR; Kohane, DS
Biomaterials DOI: 10.1016/j.biomaterials.2009.11.016
Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D.
Yang F, Cho SW, Son SM, Hudson SP, Bogatyrev S, Keung L, Kohane DS, Langer R, Anderson DG
Biomacromolecules DOI: 10.1021/bm100357t
A mesoporous reactor for high throughput proteolysis.
Qiao L; Liu, Y; Hudson, S; Yang, P; Magner, E; Liu, B
Chemistry A European Journal
Solvent dependent photophysics of fac-[Re(CO)(3)(11,12-X(2)dppz)(py)](+)(X = H, F or Me).
Dyer J, Creely CM, Penedo JC, Grills DC, Hudson S, Matousek P, Parker AW, Towrie M, Kelly JM, George MW
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology DOI: 10.1039/b618651c
The photophysics of fac-[Re(CO)3(dppz)(py)]+ in CH3CN: a comparative picosecond flash photolysis, transient infrared, transient resonance Raman and density functional theoretical study.
Dyer J, Blau WJ, Coates CG, Creely CM, Gavey JD, George MW, Grills DC, Hudson S, Kelly JM, Matousek P, McGarvey JJ, McMaster J, Parker AW, Towrie M, Weinstein JA
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology