Biography

Dr. Sinéad O'Keeffe is a Royal Society – Science Foundation Ireland University Research Fellow at the OFSRC. She graduated with BE (hons) in Electronic Engineering from the University of Limerick in 2003 and received her PhD in 2006 from the same institute, for the development of polymer optical fibre sensors for the sterilization industry. On completion of her PhD, she worked as a Marie Curie Research Fellow in the General Engineering Research Institute at Liverpool John Moores University, developing optical fibre sensors for monitoring UV and Ozone. She returned to the Optical Fibre Sensors Research Centre at the University of Limerick in 2008 and was awarded an FP7 Marie Curie Research Fellowship developing radiation dosimeters for monitoring patient doses received during radiotherapy for cancer treatment. She was Chair of the highly successful and recently completed COST Action TD1001 aimed at developing fibre optic sensor systems for reliable use in safety and security relevant applications in society. She is Member-at-Large of the IEEE Sensors Council for 2017-2020 and Chair of the IEEE Sensors Council Women in Sensors Committee 2019-2020.

Research Interests

Project: Advancing Photonics for RadiotherapyFunded by The Royal Society – Science Foundation Ireland University Research FellowshipThis project addresses the challenges of delivering effective and optimal radiation treatment for oncology, with specific focus on Low Dose Rate Brachytherapy for treating prostate cancer. It focuses on the need for personalised real-time radiation monitoring during advanced cancer treatments by proposing advances in photonics technology applicable to radiotherapy. It focuses on the development of highly innovative optical fibre based technology to create in-vivo devices for the diagnosis, assessment and radiotherapy treatment of prostate cancer tumours. Specialist micro-machining techniques, based on femto-second laser and ultra-precision diamond tooling, will allow for miniaturised sensor tips to be incorporated at the end of an optical fibre. The small geometries of optical fibres, coupled with the novel and innovative use of micro-machining technologies, facilitates in-vivo placement of the sensors at the tumour site or nearby critical structures requiring monitoring. Furthermore the development of a fully integrated sensor system, in close consultation with leading clinicians and radiotherapy physicists, will ensure the sensors can be incorporated within current clinical environments in a minimally invasive means. The measurement of oxygen concentration, coupled with the in-vivo radiation dose measurement, constitutes a powerful combination of leading-edge optical fibre based measurement techniques, providing potential solutions to as yet unresolved problems (reliable and repeatable measurements during the treatment of hypoxic tumours). This opens up the possibility of adapting the radiation dose delivered during the course of the radiotherapy treatment, with a consecutive impact on improving patient outcomes.

Project: Optical Fibre Dose Imaging for Adaptive Brachytherapy [EU H2020 - ICT-05-2019 - Application driven photonics components]ORIGIN aims to deliver more effective, photonics-enabled, brachytherapy for cancer treatment through advanced real-time radiation dose imaging and source localisation. This will be achieved by the development of a new optical fibre based sensor system to support diagnostics-driven therapy through enhanced adaptive brachytherapy. A 16-point optical fibre sensors system will be developed, for Low Dose Rate (LDR) and High Dose Rate (HDR) Brachytherapy, with sensitivity of 150 counts/Gy for LDR- and 2500 counts/mGy for HDR- BT alongside a dedicated data acquisition system providing a dose mapping system with a spatial resolution of 0.5mm (HDR) and 3mm (LDR) and time resolution of 0.1s (HDR) and 0.5s (LDR), with 5% uncertainty. This is a 50% improvement in uncertainty over existing systems. Further interrogation of the optical signal will provide real-time monitoring of the radiation source location during treatment. The ORIGIN system will be integrated into existing clinical brachytherapy treatment planning and delivery systems to confirm that the dose prescribed to the tumour is achieved, whilst ensuring the dose to organs at risk (OARs) is within acceptable limits. This will provide for optimised dose-led, patient-oriented, personalised treatment plans leading to improved patient outcomes and prevention of treatment errors, with the potential to reduce the overall risk of treatment error by 55%. The optical fibre radiation dosimeters will be further optimised for improved optical signal collection efficiency, higher signal-to-noise ratio (SNR) and repeatable high volume fabrication. Taking manufacturability into consideration from the outset will ensure that ORIGIN establishes Europe at the fore of brachytherapy system development and photonics manufacturing.

Books

This author has not written any publications of this type yet.

Book Chapters

Optical fibers and optical fiber sensors used in radiation monitoring

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2012
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Optical Fibres for Radiation Dosimetry

Dr. Sinead O'Keeffe
2017
Switzerland
Springer
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Edited Books

This author has not written any publications of this type yet.

Peer Reviewed Journals

Compact and Low-Cost Optical Fiber Respiratory Monitoring Sensor Based on Intensity Interrogation

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
Dr. Kieran O'Sullivan
2017
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Optical Fibers and Optical Fiber Sensors Used in Radiation Monitoring

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2012
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Highly Sensitive Extrinsic X-Ray Polymer Optical Fiber Sensors Based on Fiber Tip Modification

Dr. Sinead O'Keeffe
2017
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Mote interface for fibre optic spectral sensing with real-time monitoring of the marine environment

Dr. Eoin O'Connell
Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2013
New York
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Optical Fibre Bending Sensor With Automatic Intensity Compensation

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2015
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Plastic Optical Fibre Sensor for Spine Bending Monitoring with Power Fluctuation Compensation

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2013
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Characterization of a Terbium Activated Gadolinium Oxysulfide Plastic Optical Fibre Sensor in Photons and Protons

Dr. Sinead O'Keeffe
2017
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A Lightweight Classification Algorithm for External Sources of Interference in IEEE 802.15.4-Based Wireless Sensor Networks Operating at the 2.4 GHz

Assoc. Prof. Elfed Lewis
Dr. Thomas Newe
Dr. Sinead O'Keeffe
2014
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Intensity-modulated fiber optic sensor for health monitoring applications: a comparative review

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2013
Bingley, UK
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Ozone measurement in visible region: an optical fibre sensor system

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2005
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Multidisciplinary evaluation of X-ray optical fibre sensors

Dr. Sinead O'Keeffe
2014
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A Lightweight Classification Algorithm for External Sources of Interference in IEEE 802.15.4-based Wireless Sensor Networks operating at the 2.4 GHz

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2014
USA
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A review of optical fibre radiation dosimeters

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2008
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Cross-sensitivity evaluation for ammonia sensing using absorption spectroscopy in the UV region

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2011
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Characterization of Scintillating X-ray Optical Fiber Sensors

Dr. Sinead O'Keeffe
2014
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An Extrinsic Optical Fiber Bending Sensor: A Theoretical Investigation and Validation

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2015
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An Optical Fibre-Based Sensor for Real-Time Monitoring of Clinical Linear Accelerator Radiotherapy Delivery

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2016
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Polymer optical fibre for in situ monitoring of gamma radiation processes

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2009
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Experimental investigations of microwave plasma UV lamp for food applications.

Dr. Sinead O'Keeffe
2008
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Radiation Dosimeter Using an Extrinsic Fiber Optic Sensor

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2014
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Real-time gamma dosimetry using PMMA optical fibres for applications in the sterilization industry

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2007
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An optical fibre based ultra violet and visible absorption spectroscopy system for ozone concentration monitoring

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2007
Read more

Low cost portable 3-D printed optical fiber sensor for real-time monitoring of lower back bending

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
Dr. Kieran O'Sullivan
2017
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A review of recent advances in optical fibre sensors for in vivo dosimetry during radiotherapy

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
Gabriel Leen
2015
Read more

Real-time fibre optic radiation dosimeters for nuclear environment monitoring around thermonuclear reactors

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2008
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Multidisciplinary evaluation of X-ray optical fiber sensors

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2014
Read more

Characterization of Scintillating X-ray Optical Fiber Sensors

Assoc. Prof. Elfed Lewis
Dr. Sinead O'Keeffe
2014
Read more

Highly sensitive extrinsic X-ray polymer optical fiber sensors based on fiber tip modification

Dr. Sinead O'Keeffe
2017
Read more

Other Journals

Novel optical fibre dosimeters and their applications in radiotherapy: A Monte Carlo study

Dr. Sinead O'Keeffe
2017
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Optical fibre sensor for the online monitoring of gamma radiation doses

Dr. Sinead O'Keeffe
2007
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U-bend fibre optic pH sensors using layer-by-layer electrostatic self-assembly technique

Dr. Sinead O'Keeffe
2009
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Optical fibre sensor for the online monitoring of gamma radiation doses

Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2007
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Conference Publications

IEEE Sensors 2011

Dr. Eoin O'Connell
Dr. Thomas Newe
Dr. Sinead O'Keeffe
2011
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ICWMC 2012. The Eighth International Conference on Wireless and Mobile Communications

Dr. Thomas Newe
Dr. Sinead O'Keeffe
2012
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Optical fibre sensors for the monitoring of a microwave plasma UV lamp and ozone generation system

Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2008
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Comparisons between Novel Approaches in Silica Optical Fibre and Plastic Fibre for Use in Clinical in-vivo Dosimetry

Dr. Sinead O'Keeffe
2016
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Optical Fiber Sensors Conference (OFS), 2017 25th

Dr. Sinead O'Keeffe
2017
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Fifth European Workshop on Optical Fibre Sensors

Dr. Sinead O'Keeffe
2013
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Sensors, 2009 IEEE

Dr. Sinead O'Keeffe
2009
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Sensors & their Applications XIII

Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2005
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13th International Conference on Polymer Optical Fibre.

Dr. Sinead O'Keeffe
2004
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Optical fibre multi-parameter sensing with secure cloud based signal capture and processing

Dr. Eoin O'Connell
Dr. Thomas Newe
Dr. Sinead O'Keeffe
Gabriel Leen
2016
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Proceedings of IEEE Sensors

Dr. Eoin O'Connell
Dr. Thomas Newe
Dr. Sinead O'Keeffe
2009
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SENSORNETS 2012. 1st international Conference on Sensor Networks

Dr. Thomas Newe
Dr. Sinead O'Keeffe
2012
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Characterisation of radioluminesence based optical fibre dosimeter in radiotherapy beam applications

Dr. Sinead O'Keeffe
2014
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Effects of Magnetic Field on an Optical Fibre Radiation Dosimeter

Dr. Sinead O'Keeffe
2016
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24TH INTERNATIONAL CONFERENCE ON OPTICAL FIBRE SENSORS

Dr. Sinead O'Keeffe
2015
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Sensors, 2013 IEEE

Dr. Sinead O'Keeffe
2013
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Sensors, 2010 IEEE

Dr. Sinead O'Keeffe
Gabriel Leen
2010
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4th International Symposium on Automatic Control

Dr. Sinead O'Keeffe
2005
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Proceedings of SPIE - The International Society for Optical Engineering

Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2008
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22ND INTERNATIONAL CONFERENCE ON OPTICAL FIBER SENSORS, PTS 1-3

Dr. Eoin O'Connell
Dr. Thomas Newe
Dr. Sinead O'Keeffe
2012
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EOS Topical Meeting on "Blue" Photonics - Optics in the Sea

Dr. Daniel Toal
Dr. Thomas Newe
Dr. Sinead O'Keeffe
2009
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EUROSENSORS XXV

Dr. Sinead O'Keeffe
2011
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Optical Fibre Luminescence Sensor for Real-time LDR Brachytherapy Dosimetry

Dr. Sinead O'Keeffe
2016
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Compensated Intensity-Modulated Optical Fibre Bending Sensor based on Tilt Angle Loss Measurement

Dr. Sinead O'Keeffe
2014
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22ND INTERNATIONAL CONFERENCE ON OPTICAL FIBER SENSORS, PTS 1-3

Dr. Sinead O'Keeffe
2012
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Sensors, 2009 IEEE

Dr. Sinead O'Keeffe
2009
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Sensors, 2009 IEEE

Dr. Sinead O'Keeffe
2009
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14th International Conference on Polymer Optical Fibres (POF 2005).

Dr. Sinead O'Keeffe
2005
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2010 IEEE Sensors Applications Symposium, SAS 2010 - Proceedings

Dr. Sinead O'Keeffe
2010
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2011 IEEE SENSORS

Dr. Eoin O'Connell
Dr. Thomas Newe
Dr. Sinead O'Keeffe
2011
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2012 12TH INTERNATIONAL CONFERENCE ON ITS TELECOMMUNICATIONS (ITST-2012)

Dr. Thomas Newe
Dr. Sinead O'Keeffe
2012
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U-bend fibre optic pH sensors using layer-by-layer electrostatic self-assembly technique

Dr. Sinead O'Keeffe
2009
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OPTICAL SENSING AND DETECTION III

Dr. Sinead O'Keeffe
2014
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Radioluminescence based optical fibre sensor for radiation monitoring during brachytherapy

Dr. Sinead O'Keeffe
2015
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Photonics (ICP), 2013 IEEE 4th International Conference on

Dr. Sinead O'Keeffe
2013
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Sensor Technologies and Applications, 2009. SENSORCOMM'09. Third International Conference on

Dr. Sinead O'Keeffe
2009
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Sensors, 2011 IEEE

Dr. Sinead O'Keeffe
2011
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4th IEEE Sensors Conference

Dr. Sinead O'Keeffe
2005
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Proceedings of IEEE Sensors

Dr. Sinead O'Keeffe
2009
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8th International Conference on Sensing Technology (ICST 2014)

Dr. Eoin O'Connell
Dr. Thomas Newe
Dr. Sinead O'Keeffe
2014
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2012 IEEE SENSORS PROCEEDINGS

Dr. Thomas Newe
Dr. Sinead O'Keeffe
2012
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SENSORS & THEIR APPLICATIONS XVI

Dr. Sinead O'Keeffe
2011
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FIFTH EUROPEAN WORKSHOP ON OPTICAL FIBRE SENSORS

Dr. Sinead O'Keeffe
2013
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Extrinsic Optical Fibre Bending Sensor for Spine Monitoring

Dr. Sinead O'Keeffe
2015
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BioPhotonics, 2011 International Workshop on

Dr. Sinead O'Keeffe
Gabriel Leen
2011
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Optical Fiber Sensors

Dr. Sinead O'Keeffe
2006
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Sensors, 2005 IEEE

Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2005
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13th International Plastic Optical Fibres Conference

Dr. Sinead O'Keeffe
2005
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Proceedings of IEEE Sensors

Dr. Sinead O'Keeffe
2009
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Sensors, 2009 IEEE

Dr. Eoin O'Connell
Dr. Thomas Newe
Dr. Sinead O'Keeffe
2009
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Sensors, 2012 IEEE

Dr. Thomas Newe
Dr. Sinead O'Keeffe
2012
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SENSORS & THEIR APPLICATIONS XVII

Dr. Sinead O'Keeffe
2013
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23RD INTERNATIONAL CONFERENCE ON OPTICAL FIBRE SENSORS

Dr. Sinead O'Keeffe
2014
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2012 IEEE SENSORS PROCEEDINGS

Dr. Sinead O'Keeffe
2012
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Photonics (ICP), 2013 IEEE 4th International Conference on

Dr. Sinead O'Keeffe
2013
Read more

Sensors, 2009 IEEE

Dr. Sinead O'Keeffe
2009
Read more

Sensors Applications Symposium, 2009. SAS 2009. IEEE

Dr. Sinead O'Keeffe
2009
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Sensors & their Applications XIII.

Dr. Sinead O'Keeffe
2005
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SAS 2009 - IEEE Sensors Applications Symposium Proceedings

Dr. Sinead O'Keeffe
2009
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Sensors, 2011 IEEE

Dr. Eoin O'Connell
Dr. Thomas Newe
Dr. Sinead O'Keeffe
2011
Read more

ICWMC 2012, The Eighth International Conference on Wireless and Mobile Communications

Dr. Thomas Newe
Dr. Sinead O'Keeffe
2012
Read more

Fabry-Perot based refractive index optical fiber sensor for measurement of oxygen concentration levels in hypoxic tumors during radiotherapy treatment

Dr. Sinead O'Keeffe
2017
Read more

2011 IEEE SENSORS

Dr. Sinead O'Keeffe
2011
Read more

UV LED-based Fiber Coupled Optical Sensor for Detection of Ozone in the ppm and ppb Range

Dr. Sinead O'Keeffe
2009
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Sensors, 2011 IEEE

Dr. Sinead O'Keeffe
2011
Read more

Sensors, 2010 IEEE

Dr. Sinead O'Keeffe
2010
Read more

14th International Conference on Polymer Optical Fibres POF 2005

Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2005
Read more

IEEE Sensors 2011 Conference

Dr. Sinead O'Keeffe
2011
Read more

Proceedings of IEEE Sensors

Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2008
Read more

The Eighth IEEE Conference on Sensors (IEEE Sensors Conference)

Dr. Eoin O'Connell
Dr. Thomas Newe
Dr. Sinead O'Keeffe
2009
Read more

12th International Conference on ITS Telecommunications (ITST 2012).

Dr. Thomas Newe
Dr. Sinead O'Keeffe
2012
Read more

A comparison of clinic based dosimeters based on silica optical fibre and plastic optical fibre for in-vivo dosimetry

Dr. Sinead O'Keeffe
2017
Read more

2011 IEEE SENSORS

Dr. Sinead O'Keeffe
2011
Read more

Optical Fiber Sensors Conference (OFS), 2017 25th

Dr. Sinead O'Keeffe
2017
Read more

Sensors Applications Symposium (SAS), 2010 IEEE

Dr. Sinead O'Keeffe
2010
Read more

Sensors, 2008 IEEE

Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2008
Read more

18th International Optical Fiber Sensors Conference

Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2006
Read more

IEEE Sensors 2011 Conference.

Dr. Sinead O'Keeffe
2011
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Proceedings of SPIE - The International Society for Optical Engineering

Dr. Sinead O'Keeffe
Dr. Colin Fitzpatrick
2005
Read more

Conference Contributions

This author has not written any publications of this type yet.

Published Reports

This author has not written any publications of this type yet.

Editorials

This author has not written any publications of this type yet.

Book Reviews

This author has not written any publications of this type yet.

Other Publications

A review of recent advances in optical fibre sensors for in vivo dosimetry during radiotherapy.

Dr. Sinead O'Keeffe
Gabriel Leen
2015
Read more

Spectroscopic Sensing Techniques Using Polymer Optical Fibres for Applications in the Sterilisation Industry

Dr. Sinead O'Keeffe
2006
Read more