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Dr Sinead O'Keeffe

Biography

Dr. Sinéad O'Keeffe is a Royal Society – Science Foundation Ireland University Research Fellow at the OFSRC. She graduated with BE (hons) in Electronic Engineering from the University of Limerick in 2003 and received her PhD in 2006 from the same institute, for the development of polymer optical fibre sensors for the sterilization industry. On completion of her PhD, she worked as a Marie Curie Research Fellow in the General Engineering Research Institute at Liverpool John Moores University, developing optical fibre sensors for monitoring UV and Ozone. She returned to the Optical Fibre Sensors Research Centre at the University of Limerick in 2008 and was awarded an FP7 Marie Curie Research Fellowship developing radiation dosimeters for monitoring patient doses received during radiotherapy for cancer treatment. She was Chair of the highly successful and recently completed COST Action TD1001 aimed at developing fibre optic sensor systems for reliable use in safety and security relevant applications in society. She is Member-at-Large of the IEEE Sensors Council for 2017-2020 and Chair of the IEEE Sensors Council Women in Sensors Committee 2019-2020.

Research Interests

Project: Advancing Photonics for RadiotherapyFunded by The Royal Society – Science Foundation Ireland University Research FellowshipThis project addresses the challenges of delivering effective and optimal radiation treatment for oncology, with specific focus on Low Dose Rate Brachytherapy for treating prostate cancer. It focuses on the need for personalised real-time radiation monitoring during advanced cancer treatments by proposing advances in photonics technology applicable to radiotherapy. It focuses on the development of highly innovative optical fibre based technology to create in-vivo devices for the diagnosis, assessment and radiotherapy treatment of prostate cancer tumours. Specialist micro-machining techniques, based on femto-second laser and ultra-precision diamond tooling, will allow for miniaturised sensor tips to be incorporated at the end of an optical fibre. The small geometries of optical fibres, coupled with the novel and innovative use of micro-machining technologies, facilitates in-vivo placement of the sensors at the tumour site or nearby critical structures requiring monitoring. Furthermore the development of a fully integrated sensor system, in close consultation with leading clinicians and radiotherapy physicists, will ensure the sensors can be incorporated within current clinical environments in a minimally invasive means. The measurement of oxygen concentration, coupled with the in-vivo radiation dose measurement, constitutes a powerful combination of leading-edge optical fibre based measurement techniques, providing potential solutions to as yet unresolved problems (reliable and repeatable measurements during the treatment of hypoxic tumours). This opens up the possibility of adapting the radiation dose delivered during the course of the radiotherapy treatment, with a consecutive impact on improving patient outcomes.

Project: Optical Fibre Dose Imaging for Adaptive Brachytherapy [EU H2020 - ICT-05-2019 - Application driven photonics components]

ORIGIN aims to deliver more effective, photonics-enabled, brachytherapy for cancer treatment through advanced real-time radiation dose imaging and source localisation. This will be achieved by the development of a new optical fibre based sensor system to support diagnostics-driven therapy through enhanced adaptive brachytherapy. A 16-point optical fibre sensors system will be developed, for Low Dose Rate (LDR) and High Dose Rate (HDR) Brachytherapy, with sensitivity of 150 counts/Gy for LDR- and 2500 counts/mGy for HDR- BT alongside a dedicated data acquisition system providing a dose mapping system with a spatial resolution of 0.5mm (HDR) and 3mm (LDR) and time resolution of 0.1s (HDR) and 0.5s (LDR), with 5% uncertainty. This is a 50% improvement in uncertainty over existing systems. Further interrogation of the optical signal will provide real-time monitoring of the radiation source location during treatment. The ORIGIN system will be integrated into existing clinical brachytherapy treatment planning and delivery systems to confirm that the dose prescribed to the tumour is achieved, whilst ensuring the dose to organs at risk (OARs) is within acceptable limits. This will provide for optimised dose-led, patient-oriented, personalised treatment plans leading to improved patient outcomes and prevention of treatment errors, with the potential to reduce the overall risk of treatment error by 55%. The optical fibre radiation dosimeters will be further optimised for improved optical signal collection efficiency, higher signal-to-noise ratio (SNR) and repeatable high volume fabrication. Taking manufacturability into consideration from the outset will ensure that ORIGIN establishes Europe at the fore of brachytherapy system development and photonics manufacturing.

Publications

Book Chapter

2017

Optical Fibres for Radiation Dosimetry
O'Keeffe, S,
Fiber Optic Sensors: Current Status and Future Possibilities DOI: 10.1007/978-3-319-42625-9_7

Conference Publication

2017

A comparison of clinic based dosimeters based on silica optical fibre and plastic optical fibre for in-vivo dosimetry
Chen, LX,O'Keeffe, S,Woulfe, P,Lewis, E,
Optical Coherence Tomography And Coherence Techniques V DOI: 10.1117/12.2265032

2017

Optical Fiber Sensors Conference (OFS), 2017 25th
Chen, Lingxia and O'Keeffe, Sinead and Woulfe, Peter and Lewis, Elfed

2017

Optical Fiber Sensors Conference (OFS), 2017 25th
Viphavakit, Charusluk and Duraibabu, DineshBabu and O'Keeffe, Sinead and Lewis, Elfed

2017

Fabry-Perot based refractive index optical fiber sensor for measurement of oxygen concentration levels in hypoxic tumors during radiotherapy treatment
Viphavakit, C,Duraibabu, D,O'Keeffe, S,Lewis, E,
Optical Coherence Tomography And Coherence Techniques V DOI: 10.1117/12.2265084

2016
2016

Optical Fibre Luminescence Sensor for Real-time LDR Brachytherapy Dosimetry
Woulfe, P,Sullivan, FJ,O'Keeffe, S,Lewis, E
Optical Coherence Tomography And Coherence Techniques V

2016

Effects of Magnetic Field on an Optical Fibre Radiation Dosimeter
O'Keeffe, S,Chen, L,Lewis, E,Grattan, M,Hounsell, A,Whitten, G,Schettino, G,
2012 Ieee Sensors Proceedings

2015

Radioluminescence based optical fibre sensor for radiation monitoring during brachytherapy
O'Keeffe, S,Woulfe, P,Sullivan, FJ,
2012 Ieee Sensors Proceedings

2015

24TH INTERNATIONAL CONFERENCE ON OPTICAL FIBRE SENSORS
Woulfe, P,Sullivan, FJ,Lewis, E,O'Keeffe, S.
DOI: 10.1117/12.2195213

2015

Extrinsic Optical Fibre Bending Sensor for Spine Monitoring
Zawawi, MA,O'Keeffe, S,Lewis, E,O'Sullivan, K,
2012 Ieee Sensors Proceedings

2014

Characterisation of radioluminesence based optical fibre dosimeter in radiotherapy beam applications
Woulfe, P,O'Keeffe, S,McCarthy, D,Grattan, M,Hounsell, A,Cronin, J,Lewis, E,LopezHiguera, JM,Jones, J,LopezAmo, M,Santos, JL
Optical Coherence Tomography And Coherence Techniques V DOI: 10.1117/12.2059389

2014

OPTICAL SENSING AND DETECTION III
Lewis, E,O'Keeffe, S,Grattan, M,Hounsell, A,McCarthy, D,Woulfe, P,Cronin, J,Mihai, L,Sporea, D,Santhanam, A,Agazaryan, N,Berghmans, F,Mignani, AG,DeMoor, P
Optical Coherence Tomography And Coherence Techniques V DOI: 10.1117/12.2058572

2014

Compensated Intensity-Modulated Optical Fibre Bending Sensor based on Tilt Angle Loss Measurement
Zawawi, MA,O'Keeffe, S,Lewis, E,
2012 Ieee Sensors Proceedings

2014

23RD INTERNATIONAL CONFERENCE ON OPTICAL FIBRE SENSORS
Zawawi, MA,O'Keeffe, S,Lewis, E,LopezHiguera, JM,Jones, J,LopezAmo, M,Santos, JL
Optical Coherence Tomography And Coherence Techniques V DOI: 10.1117/12.2058933

2013

Photonics (ICP), 2013 IEEE 4th International Conference on
Zawawi, MA and O'Keeffe, S and Lewis, E

2013

Photonics (ICP), 2013 IEEE 4th International Conference on
Zawawi, MA and O'Keeffe, S and Lewis, E

2013

SENSORS & THEIR APPLICATIONS XVII
Zawawi, MA,O'Keeffe, S,Lewis, E,Bilas V,McConnell, G,Kyriacou, P
Eurotherm Seminar 102: Thermal Management Of Electronic Systems DOI: 10.1088/1742-6596/450/1/012004

2013

Sensors, 2013 IEEE
Woulfe, P and O'Keeffe, S and McCarthy, D and Grattan, M and Hounsell, A and Cronin, J and Lewis, E
DOI: 10.1109/ICSENS.2013.6688478

2013

FIFTH EUROPEAN WORKSHOP ON OPTICAL FIBRE SENSORS
O'Keeffe, S,Grattan, M,Hounsell, A,McCarthy, D,Woulfe, P,Cronin, J,Lewis, E,Jaroszewicz, LR
Optical Coherence Tomography And Coherence Techniques V DOI: 10.1117/12.2025864

2013

Fifth European Workshop on Optical Fibre Sensors
O'Keeffe, S and Grattan, M and Hounsell, A and McCarthy, D and Woulfe, P and Cronin, J and Lewis, E

2012

2012 IEEE SENSORS PROCEEDINGS
McCarthy, D,O'Keeffe, S,Lewis, E,Sporea, D,Sporea, A,Tiseanu, I,Woulfe, P,Cronin, J,
2012 Ieee Sensors Proceedings

2012

22ND INTERNATIONAL CONFERENCE ON OPTICAL FIBER SENSORS, PTS 1-3
McCarthy, D,O'Keeffe, S,Woulfe, P,Cronin, J,Lewis, E,
DOI: 10.1117/12.975240

2011

EUROSENSORS XXV
Dooly, G,Manap, H,O'Keeffe, S,Lewis, E,Kaltsas, G,Tsamis, C
Engineering Of Sport 8: Engineering Emotion - 8th Conference Of The International Sports Engineering Association (Isea) DOI: 10.1016/j.proeng.2011.12.274

2011

2011 IEEE SENSORS
McCarthy, D,O'Keeffe, S,Lewis, E,Sporea, D,Sporea, A,Tiseanu, I,
2011 Ieee Sensors

2011

Sensors, 2011 IEEE
McCarthy, Denis and O'Keeffe, Sinead and Lewis, Elfed and Sporea, Dan and Sporea, Adelina and Tiseanu, Ion

2011

2011 IEEE SENSORS
Dooly, G,Manap, H,O'Keeffe, S,Lewis, E,
2011 Ieee Sensors

2011

SENSORS & THEIR APPLICATIONS XVI
Dooly, G,Manap, H,O'Keeffe, S,Lewis, E,Kyriacou, PA,O'Riordan, A,McConnell, G
Eurotherm Seminar 102: Thermal Management Of Electronic Systems DOI: 10.1088/1742-6596/307/1/012058

2011

Sensors, 2011 IEEE
Dooly, G and Manap, H and O'Keeffe, S and Lewis, E

2011

IEEE Sensors 2011 Conference
Dooly G., Manap H., O'Keeffe S. and Lewis E.

2011

IEEE Sensors 2011 Conference.
McCarthy, D., O'Keeffe,S., Lewis,E., Sporea, D., Sporea,A., Tiseanu,I.

2010

Sensors Applications Symposium (SAS), 2010 IEEE
McCarthy, D and O'Keeffe, S and Lewis, E

2010

Sensors, 2010 IEEE
O'Keeffe, S and Manap, H and Dooly, G and Lewis, E

2009

Sensor Technologies and Applications, 2009. SENSORCOMM'09. Third International Conference on
Manap, Hadi and Dooly, Gerald and Muda, Razali and O'Keeffe, Sinead and Lewis, Elfed

2009

Sensors, 2009 IEEE
O'Keeffe, S and Lewis, E and Santhanam, A and Winningham, A and Rolland, JP

2009

U-bend fibre optic pH sensors using layer-by-layer electrostatic self-assembly technique
Surre, F,Lyons, WB,Sun, T,Grattan, KTV,O'Keeffe, S,Lewis, E,Elosua, C,Hernaez, M,Barian, C,Augousti, AT,McConnell, G
Eurotherm Seminar 102: Thermal Management Of Electronic Systems DOI: 10.1088/1742-6596/178/1/012046

2009

Proceedings of IEEE Sensors
O'Keeffe S., Lewis E., Santhanam A., Winningham A., Rolland J.P.
DOI: 10.1109/ICSENS.2009.5398516

2009

Sensors Applications Symposium, 2009. SAS 2009. IEEE
Korostynska, O and Arshak, A and Creedon, P and Arshak, K and Wendling, L and Al-Shamma'a, AI and O'Keeffe, S

2009

Proceedings of IEEE Sensors
Degner M., Damaschke N., Ewald H., O'Keeffe S., Lewis E.
DOI: 10.1109/ICSENS.2009.5398230

2009

Sensors, 2009 IEEE
Degner, M and Damaschke, N and Ewald, H and O'Keeffe, S and Lewis, E

2009

UV LED-based Fiber Coupled Optical Sensor for Detection of Ozone in the ppm and ppb Range
Degner, M,Damaschke, N,Ewald, H,O'Keeffe, S,Lewis, E,
2009 Ieee Sensors, Vols 1-3

2009

SAS 2009 - IEEE Sensors Applications Symposium Proceedings
Korostynska O., Arshak A., Creedon P., Arshak K., Wendling L., Al-Shamma'a A.I., O'keeffe S.
DOI: 10.1109/SAS.2009.4801772

2009

Sensors, 2009 IEEE
O'Keeffe, S and Lewis, E and Santhanam, A and Rolland, JP

2009

Sensors, 2009 IEEE
Manap, Hadi and Dooly, Gerald and O'Keeffe, Sinead and Lewis, Elfed

2006

Optical Fiber Sensors
O'Keeffe, Sinead and Fernandez Fernandez, Alberto and Fitzpatrick, Colin and Brichard, Beno^it and Lewis, Elfed

2005

4th IEEE Sensors Conference
O¿Keeffe, S., C. Fitzpatrick and E. Lewis.

2005

13th International Plastic Optical Fibres Conference
O¿Keeffe, S., C. Fitzpatrick, A. Fernandez Fernandez, B. Brichard, F. Berghmans and E. Lewis.

2005

Sensors & their Applications XIII.
O'Keeffe, S., G. Dooly, C. Fitzpatrick and E. Lewis

2005

4th International Symposium on Automatic Control
O¿Keeffe, S., C. Fitzpatrick and E. Lewis.

2005

14th International Conference on Polymer Optical Fibres (POF 2005).
O¿Keeffe, S., C. Fitzpatrick and E. Lewis.

2004

13th International Conference on Polymer Optical Fibre.
O'Keeffe S., C. Fitzpatrick, A. Fernandez Fernandez, B. Brichard, F. Bergmans and E. Lewis,

Other Journal

2017

Novel optical fibre dosimeters and their applications in radiotherapy: A Monte Carlo study
Alharbi, Majed and Martyn, Michael and Woulfe, Peter and Chen, Lingxia and O’Keeffe, Sinead and Foley, Mark
Physica Medica: European Journal of Medical Physics

2009

U-bend fibre optic pH sensors using layer-by-layer electrostatic self-assembly technique
Surre F., Lyons B., Sun T., Grattan V., O'Keeffe S., Lewis E., Elosua C., Hernaez M., Barian C.
Journal of Physics: Conference Series DOI: 10.1088/1742-6596/178/1/012046

2007

Optical fibre sensor for the online monitoring of gamma radiation doses
O'Keeffe, S and Fitzpatrick, C and Fernandez, A Fernandez and Lewis, E and Al-Shamma'a, Ai
Journal of Physics: Conference Series

Other Publication

Peer Reviewed Journal

2017

Highly sensitive extrinsic X-ray polymer optical fiber sensors based on fiber tip modification
de Andr'es, Ana I and O’Keeffe, Sinead and Chen, Lingxia and Esteban, 'Oscar
Ieee Sensors Journal

2017

Characterization of a Terbium Activated Gadolinium Oxysulfide Plastic Optical Fibre Sensor in Photons and Protons
Penner, C and Hoehr, C and O’Keeffe, S and Woulfe, P and Duzenli, C
IEEE Sensors Journal

2017
2014

Multidisciplinary evaluation of X-ray optical fibre sensors
Sporea, Dan and Mihai, Laura and Tiseanu, Ion and V^actua
Sensors and Actuators A: Physical DOI: 10.1016/j.sna.2014.03.038

2014

Characterization of Scintillating X-ray Optical Fiber Sensors
Sporea, Dan and Mihai, Laura and V^actua
Sensors DOI: 10.3390/s140203445

2008

Experimental investigations of microwave plasma UV lamp for food applications.
Ortoneda, Montserrat and O'Keeffe, Sinead and Cullen, Jeff D and Al-Shamma'a, Ahmed I and Phipps, David A
Journal of Microwave Power & Electromagnetic Energy