Biography

Luis Padrela is a lecturer in Industrial Biochemistry within the Department of Chemical Sciences and a Researcher at the Synthesis and Solid State Pharmaceutical Centre (SSPC) within the Bernal Institute. Luis studied Biochemistry at undergraduate level before obtaining his PhD in Chemical Engineering at the University of Lisbon (Portugal). Following his PhD, Luis worked in the pharmaceutical industry for almost 2 years (Hovione FarmaCiência, Portugal) before joining SSPC in UL as a postdoctoral researcher and as a senior research fellow later on.


Luis worked on different research projects in different institutions (academia and industry) and countries (Ireland, Portugal and Sweden) focusing his research on Particle Engineering Technologies, Continuous Nanocrystallization and (Bio)Pharmaceutical Processing. He has developed industrial expertise in Quality by Design, scale-up methods and particle engineering technologies for small and large molecule APIs with particular emphasis to spray drying of biopharmaceuticals. Luis has worked within the highest standards of quality (GLP, GMP) in the industry and participated in the development of several spray drying and nanosizing processes for oral and parenteral dosage forms.

Research Interests

IMS Health reports show the global pharmaceutical industry is a $1 trillion dollar sales business, representing more than €30 billion in exports for Ireland. Particularly, the Biopharmaceutical Industry has made in the last decade a capital investment of approximately $8 billion in new facilities in Ireland, presenting significant challenges and opportunities to advance bioprocess development.

Meanwhile drugs which are worth more than $65 billion are wasted every year due to poor solubility, poor bioavailability and the lack of efficient manufacturing and formulation approaches to consistently improve their bioavailability. The manufacture of drug nanoparticles with enhanced properties (e.g. solubility, stability, bioavailability, drug specificity) provides the opportunity to bring new medicines to market. However, pharmaceutical companies have been facing considerable challenges to successfully overcome engineering and manufacturing (e.g. scale-up) hurdles associated with nano-processes.

My research interests are primarily focused in the development of particle engineering technologies for small and large molecule APIs (Active Pharmaceutical Ingredients), with a particular emphasis in (bio)pharmaceutical nanomanufacturing, which includes:

  • Pharmaceutical processing for large molecule APIs (biopharmaceuticals):
    - Isolation and stabilization of biopharmaceuticals using spray drying and freeze drying
    -
    Engineering and manufacturing of biopharmaceutical nanoparticles
  • Pharmaceutical processing for small molecule APIs (pharmaceuticals):
    - Continuous crystallization and drying of drug nanoparticles
    - Supercritical Co2 processing for polymorphic control
    - (Co)Crystal engineering

Professional Activities

Award

  • 2021 - Bernal Mid-Career Researcher of the Year 2020
  • 2020 - SFI Frontiers for the Future project
  • 2020 - Laboratory Staff Member of the Year
  • 2019 - Laboratory Staff Member of the Year
  • 2019 - H2020 Marie Curie Innovative Training Network (MSCA-ITN-2019) European Industrial Doctorate (EID)
  • 2018 - Continuous Manufacturing of drug Nano-particles (CM-NANO)
  • 2017 - SFI/NSF I-Corps@SFI Entrepreneurial Programme - 'Continuous Manufacturing Method for the Production of Pharmaceutical Drug Nanoparticles'
  • 2016 - US-Ireland R&D Partnership Programme – ‘Partnership in continuous manufacturing for nano-based drug products'
  • 2008 - Design and Processing of Pharmaceutical Cocrystals using Supercritical Fluid Technology

Association

  • 2018 Associated Member, IChemE
  • 2018 Member, EUFEPS

Consultancy

  • 2018 Pfizer Ireland Pharmaceuticals - Consultancy services in a API-DP interface event

Employment

  • 2017 University of Limerick - Lecturer
  • 2016 Synthesis and Solid State Pharmaceutical Centre (SSPC), University of Limerick - Senior Research Fellow
  • 2014 Synthesis and Solid State Pharmaceutical Centre (SSPC), University of Limerick - Postdoctoral Researcher
  • 2013 Instituto Superior Técnico, University of Lisbon - Research Fellow
  • 2012 Hovione FarmaCiencia SA - Process Development Scientist
  • 2006 Instituto Superior Técnico, Universidade de Lisboa - Assistant Research Fellow

Patent

  • 2015 WO2015036799 A1 - Synthesis and particle engineering of cocrystals
  • 2013 WO2013129953 A1 - Vaccine against strangles of the Equidae
  • 2013 WO2013095169 A1 - Crystalline minocycline thermo-resistant obtained by recrystallization with carbon dioxide

Education

  • 2012 Instituto Superior Técnico, University of Lisbon - PhD
  • 2006 Faculty of Sciences, University of Lisbon - BSc (Hons)

Other

  • Invited speaker for a seminar to the NUIG Society of Chemistry (02 May 2018) Title of presentation: "Batch and continuous particle engineering processes for (bio)pharmaceuticals"
  • Speaker in a Masterclass in Process Development and Scale-Up at NUIG (April 26-27, 2018) Title of presentation: "Solid state properties of APIs"
  • Invited speaker at the 5th Annual Formulation & Drug Delivery Congress (London, UK) organized by Oxford Global (29-30 April 2019). Title of presentation: "Supercritical CO2-Assisted Spray Drying For The Generation Of Tailored API Nanoparticles "
  • Webinar on QbD for Process Development & Nanoparticle CMC Considerations: https://www.oxfordglobal.co.uk/formulation-series/webinar-recordings/

Outreach

Research Collaborators

  • Gavin Andrews - Funding Award - Queen's University Belfast -Northern Ireland
  • Miguel Rodrigues - Joint Publication - Instituto Superior Tecnico -Portugal
  • Rohit Ramachandran - Funding Award - Rutgers State University -USA
  • Hermínio Sousa - Joint Publication -Portugal -University of Coimbra

Books

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Book Chapters

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Edited Books

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Peer Reviewed Journals

Solubility and thermodynamic analysis of ketoprofen in organic solvents

Dr. Luis Padrela
2020
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Anti-solvent effect in the production of lysozyme nanoparticles by supercritical fluid-assisted atomization processes

Dr. Luis Padrela
2009
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Controlling Polymorphism of Carbamazepine Nanoparticles in a Continuous Supercritical CO2-Assisted Spray Drying Process

Dr. Luis Padrela
2019
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Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals - A comprehensive review.

Dr. Luis Padrela
2018
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Screening for pharmaceutical cocrystals using the supercritical fluid enhanced atomization process

Dr. Luis Padrela
2010
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Unraveling the Link between Solvent-Mediated Proton Transfer and the Salt Formation of Saccharin and Sulfamethazine

Dr. Luis Padrela
2018
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Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model

Dr. Luis Padrela
2012
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Theophylline polymorphs by atomization of supercritical antisolvent induced suspensions

Dr. Luis Padrela
2011
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Single-step co-crystallization and lipid dispersion by supercritical enhanced atomization

Dr. Luis Padrela
2013
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Spray Drying Ternary Amorphous Solid Dispersions of Ibuprofen – An Investigation into Critical Formulation and Processing Parameters

Dr. Luis Padrela
2017
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Tuning physicochemical properties of theophylline by cocrystallization using the supercritical fluid enhanced atomization technique

Dr. Luis Padrela
2014
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Insight into the Mechanisms of Cocrystallization of Pharmaceuticals in Supercritical Solvents

Dr. Luis Padrela
2015
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Pharmaceutical Nanoparticle Isolation Using CO2-Assisted Dynamic Bed Coating.

Prof. Kevin M Ryan
Dr. Luis Padrela
2020
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Antibacterial activity of tigecycline micro/nanoparticles under supercritical fluids conditions

Dr. Luis Padrela
2010
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Powder X-ray diffraction method for the quantification of cocrystals in the crystallization mixture

Dr. Luis Padrela
2011
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Insight into the Role of Additives in Controlling Polymorphic Outcome: A CO2-Antisolvent Crystallization Process of Carbamazepine

Dr. Luis Padrela
2017
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Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications

Prof. Gavin Walker
Dr. Luis Padrela
2018
WASHINGTON
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New Thermoresistant Polymorph from CO2 Recrystallization of Minocycline Hydrochloride

Dr. Luis Padrela
2014
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Development and validation of a two-dimensional population balance model for a supercritical CO<inf>2</inf> antisolvent batch crystallization process

Dr. Luis Padrela
2020
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Co-crystal Polymorphic Control by Nanodroplet and Electrical Confinement

Dr. Luis Padrela
2019
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Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches.

Prof. Gavin Walker
Dr. Emmet O'Reilly
Dr. Luis Padrela
2018
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Amorphous Solid Dispersion of Ibuprofen: A Comparative Study on the Effect of Solution Based Techniques

Dr. Luis Padrela
2019
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From batch to continuous — New opportunities for supercritical CO2 technology in pharmaceutical manufacturing

Dr. Luis Padrela
2019
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Cortisone and Cortisol Break H-bonding Rules toMake a Drug-Prodrug Solid Solution

Dr. Luis Padrela
2020
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A rational approach towards spray drying of biopharmaceuticals: The case of lysozyme

Dr. Emmet O'Reilly
Dr. Luis Padrela
2020
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Generation and physicochemical characterization of posaconazole cocrystals using Gas Antisolvent (GAS) and Supercritical Solvent (CSS) methods

Dr. Luis Padrela
2021
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Formation of indomethacin-saccharin cocrystals using supercritical fluid technology

Dr. Luis Padrela
2009
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Investigating Process Variables and Additive Selection to Optimize Polymorphic Control of Carbamazepine in a CO<inf>2</inf>Antisolvent Crystallization Process

Dr. Luis Padrela
2020
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Other Journals

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Conference Publications

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Conference Contributions

10th World Congress of Chemical Engineering

Dr. Luis Padrela
2017
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10th World Congress of Chemical Engineering

Dr. Luis Padrela
2017
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10th World Congress of Chemical Engineering

Dr. Luis Padrela
2017
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NUIG-UL Alliance 7th Postgraduate Research Day

Dr. Luis Padrela
2017
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ISPE Ireland Affiliate Seminar - Continuous Manufacturing

Dr. Luis Padrela
2016
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10th World Congress of Chemical Engineering

Dr. Luis Padrela
2017
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CGOM12 / BACG 2016 - Crystal Growth Joint Conference

Dr. Luis Padrela
2016
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2017 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition

Dr. Luis Padrela
2017
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EuPAT9 - Ninth pan-European Conference on PAT and QbD Sciences

Dr. Luis Padrela
2018
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CGOM12 / BACG 2016 - Crystal Growth Joint Conference

Dr. Luis Padrela
2016
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2017 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition

Dr. Luis Padrela
2017
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EuPAT9 - Ninth pan-European Conference on PAT and QbD Sciences

Dr. Luis Padrela
2018
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2016 AIChE Annual Meeting

Dr. Luis Padrela
2016
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EuPAT9 - Ninth pan-European Conference on PAT and QbD Sciences

Dr. Luis Padrela
2018
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2016 AIChE Annual Meeting

Dr. Luis Padrela
2016
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10th World Congress of Chemical Engineering

Dr. Luis Padrela
2017
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ECO-BIO2018

Dr. Luis Padrela
2018
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Published Reports

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Editorials

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Book Reviews

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Other Publications

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