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Dr. Luis Padrela

Biography

Luis Padrela is a lecturer in Industrial Biochemistry within the Department of Chemical Sciences and a Researcher at the Synthesis and Solid State Pharmaceutical Centre (SSPC) within the Bernal Institute. Luis studied Biochemistry at undergraduate level before obtaining his PhD in Chemical Engineering at the University of Lisbon (Portugal). Following his PhD, Luis worked in the pharmaceutical industry for almost 2 years (Hovione FarmaCiência, Portugal) before joining SSPC in UL as a postdoctoral researcher and as a senior research fellow later on.

Luis worked on different research projects in different institutions (academia and industry) and countries (Ireland, Portugal and Sweden) focusing his research on Particle Engineering Technologies, Continuous Nanocrystallization and (Bio)Pharmaceutical Processing. He has developed industrial expertise in Quality by Design, scale-up methods and particle engineering technologies for small and large molecule APIs with particular emphasis to spray drying of biopharmaceuticals. Luis has worked within the highest standards of quality (GLP, GMP) in the industry and participated in the development of several spray drying and nanosizing processes for oral and parenteral dosage forms.

Teaching Interests

I am teaching within the Bsc Industrial Biochemistry with responsibility for:
Bioprocess Engineering 1
Bioprocess Engineering 2
Bioprocess Engineering for Biochemists
Immunology and DNA Diagnostic Techniques
Microbial Technology 2

Professional Activities

Award

  • 2019 - Laboratory Staff Member of the Year
  • 2019 - H2020 Marie Curie Innovative Training Network (MSCA-ITN-2019) European Industrial Doctorate (EID)
  • 2018 - Continuous Manufacturing of drug Nano-particles (CM-NANO)
  • 2017 - SFI/NSF I-Corps@SFI Entrepreneurial Programme - 'Continuous Manufacturing Method for the Production of Pharmaceutical Drug Nanoparticles'
  • 2016 - US-Ireland R&D Partnership Programme – ‘Partnership in continuous manufacturing for nano-based drug products’
  • 2008 - Design and Processing of Pharmaceutical Cocrystals using Supercritical Fluid Technology

Association

  • 2018 Associated Member, IChemE
  • 2018 Member, EUFEPS

Consultancy

  • 2018 Pfizer Ireland Pharmaceuticals - Consultancy services in a API-DP interface event

Employment

  • 2017 University of Limerick - Lecturer
  • 2016 Synthesis and Solid State Pharmaceutical Centre (SSPC), University of Limerick - Senior Research Fellow
  • 2014 Synthesis and Solid State Pharmaceutical Centre (SSPC), University of Limerick - Postdoctoral Researcher
  • 2013 Instituto Superior Técnico, University of Lisbon - Research Fellow
  • 2012 Hovione FarmaCiencia SA - Process Development Scientist
  • 2006 Instituto Superior Técnico, Universidade de Lisboa - Assistant Research Fellow

Patent

  • 2015 WO2015036799 A1 - Synthesis and particle engineering of cocrystals
  • 2013 WO2013129953 A1 - Vaccine against strangles of the Equidae
  • 2013 WO2013095169 A1 - Crystalline minocycline thermo-resistant obtained by recrystallization with carbon dioxide

Education

  • 2012 Instituto Superior Técnico, University of Lisbon - PhD
  • 2006 Faculty of Sciences, University of Lisbon - BSc (Hons)

Other

  • Webinar on QbD for Process Development & Nanoparticle CMC Considerations: https://www.oxfordglobal.co.uk/formulation-series/webinar-recordings/
  • Invited speaker at the 5th Annual Formulation & Drug Delivery Congress (London, UK) organized by Oxford Global (29-30 April 2019). Title of presentation: "Supercritical CO2-Assisted Spray Drying For The Generation Of Tailored API Nanoparticles "
  • Invited speaker for a seminar to the NUIG Society of Chemistry (02 May 2018) Title of presentation: "Batch and continuous particle engineering processes for (bio)pharmaceuticals"
  • Speaker in a Masterclass in Process Development and Scale-Up at NUIG (April 26-27, 2018) Title of presentation: "Solid state properties of APIs"

Outreach

Research Collaborators

  • Gavin Andrews - Funding Award - Queen's University Belfast -Northern Ireland
  • Miguel Rodrigues - Joint Publication - Instituto Superior Tecnico -Portugal
  • Rohit Ramachandran - Funding Award - Rutgers State University -USA
  • Hermínio Sousa - Joint Publication -Portugal -University of Coimbra

Publications

Conference Contribution

2018

EuPAT9 - Ninth pan-European Conference on PAT and QbD Sciences
Ahmad Ziaee, Luis Padrela, Ahmad Albadarin, Emmet O'Reilly, Gavin Walker

2018

ECO-BIO2018
Ahmad Ziaee, Ahmad B. Albadarin, Luis Padrela, Emmet O’Rielly, Gavin Walker

2018
2018
2017

10th World Congress of Chemical Engineering
A. Ziaee, L. Padrela, A. B. Albadarin, B. Castro- Dominguez, B. Schaller, P. Cronin, K. Moroney, M. Pishnamazi, E. O’Reilly, G. Walker

2017

2017 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition
Luis Padrela, Ahmad Ziaee, Maryam Karimijafari, Ahmad Alabadarin, Emmet O’Reilly, Gavin Walker

2017

10th World Congress of Chemical Engineering
M. Pishnamazi, B. C. Dominguez, P. Cronin, B. Schaller, K. Moroney, A. Ziaee, L. Padrela, A. B. Albadarin, M. N. Collins, G. M. Walker

2017

10th World Congress of Chemical Engineering
Ahmad Ziaee, Ahmad B. Albadarin, Luis Padrela, Emmet O’Rielly, Gavin Walker

2017

NUIG-UL Alliance 7th Postgraduate Research Day
Ahmad Ziaee, Ahmad B. Albadarin, Luis Padrela, Emmet O’Rielly, Gavin Walker

2017

10th World Congress of Chemical Engineering
B. Castro Dominguez, B. Schaller, P. Cronin, K. Moroney, A. Ziaee, M. Pishnamazi, A. Albadarin, L. Padrela, G. Walker

2017

10th World Congress of Chemical Engineering
Luis Padrela, Ahmad Ziaee, Barbara Schaller, Bernardo Castro-Dominguez, Patrick Cronin, Kevin Moroney, Mahboubeh Pishnamazi, Ahmad Albadarin, Emmet O’Reilly, Gavin Walker

2016

2016 AIChE Annual Meeting
Luis Padrela, Barry Long, Miguel Rodrigues, Kevin M Ryan

2016

2016 AIChE Annual Meeting
Luis Padrela, Barry Long, Kevin M. Ryan

2016

CGOM12 / BACG 2016 - Crystal Growth Joint Conference
Luis Padrela, Jacek Zeglinski, Åke Rasmuson, Kevin M Ryan

2016

CGOM12 / BACG 2016 - Crystal Growth Joint Conference
Luis Padrela, Jacek Zeglinski, Åke Rasmuson, Kevin M Ryan

Peer Reviewed Journal

2020

A rational approach towards spray drying of biopharmaceuticals: The case of lysozyme
Ziaee A.;Albadarin A.B.;Padrela L.;Ung M.T.;Femmer T.;Walker G.;O'Reilly E.
Powder Technology DOI: 10.1016/j.powtec.2020.02.057

2020

Solubility and thermodynamic analysis of ketoprofen in organic solvents
Soto R.;Svärd M.;Verma V.;Padrela L.;Ryan K.;Rasmuson Å.C.
International journal of pharmaceutics DOI: 10.1016/j.ijpharm.2020.119686

2019

Amorphous Solid Dispersion of Ibuprofen: A Comparative Study on the Effect of Solution Based Techniques
Ahmad Ziaee, Stephen O'Dea, Aoise Howard-Hildige, Luis Padrela, Catherine Potter, Javed Iqbal, Ahmad B. Albadarin, Gavin Walker, Emmet J. O'Reilly
International Journal Of Pharmaceutics DOI: 10.1016/j.ijpharm.2019.118816

2019

Co-crystal Polymorphic Control by Nanodroplet and Electrical Confinement
L. M. Padrela, B. Castro.dominguez, A. Ziaee, B. Long, K. M. Ryan, G. Walker, E. J. O'Reilly
Crystengcomm DOI: 10.1039/C9CE00060G

2018

Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches.
Ziaee A;Albadarin AB;Padrela L;Femmer T;O'Reilly E;Walker G;
European Journal Of Pharmaceutical Sciences : Official Journal Of The European Federation For Pharmaceutical Sciences DOI: 10.1016/j.ejps.2018.10.026

2018

Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications
Karimi-Jafari, M;Padrela, L;Walker, GM;Croker, DM
Crystal Growth & Design DOI: 10.1021/acs.cgd.8b00933

2018

Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals - A comprehensive review.
Luis Padrela, Miguel A.Rodrigues, Andreia Duarte, Ana M.A.Dias, Mara E.M.Braga, Hermínio C.de Sousa
Advanced Drug Delivery Reviews DOI: 10.1016/j.addr.2018.07.010

2017

Spray Drying Ternary Amorphous Solid Dispersions of Ibuprofen – An Investigation into Critical Formulation and Processing Parameters
Ahmad Ziaee, Ahmad B. Albadarin, Luis Padrela, Alexandra Faucher, Emmet O'Reilly, GavinWalker
European Journal Of Pharmaceutics And Biopharmaceutics DOI: https://doi.org/10.1016/j.ejpb.2017.08.005

2015

Insight into the Mechanisms of Cocrystallization of Pharmaceuticals in Supercritical Solvents
Padrela L., Rodrigues M.A., Tiago J., Velaga S.P., Matos H.A., Azevedo E.G.
Crystal Growth & Design DOI: https://doi.org/10.1021/acs.cgd.5b00200

2014
2014

New Thermoresistant Polymorph from CO2 Recrystallization of Minocycline Hydrochloride
Rodrigues M.A., Tiago J.M., Padrela L., Matos H.A., Nunes T.G., Pinheiro L., Almeida A.J., Azevedo E.G.
Pharmaceutical Research DOI: https://doi.org/10.1007/s11095-014-1406-3

2013

Single-step co-crystallization and lipid dispersion by supercritical enhanced atomization
Tiago J., Padrela L., Rodrigues M.A., Matos H.A., Almeida A.J., Azevedo E.G.
Crystal Growth & Design DOI: https://doi.org/10.1021/cg401131x

2012

Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model
Rodrigues M.A., Figueiredo L., Padrela L., Cadete A., Tiago J., Matos H.A., Azevedo E.G., Florindo H.F., Gonçalves L.M.D., Almeida A.J.
European Journal Of Pharmaceutics And Biopharmaceutics DOI: https://doi.org/10.1016/j.ejpb.2012.07.005

2011

Theophylline polymorphs by atomization of supercritical antisolvent induced suspensions
Rodrigues M.A., Padrela L., Geraldes V., Santos J., Matos H.A., Azevedo E.G.
Journal Of Supercritical Fluids DOI: https://doi.org/10.1016/j.supflu.2011.05.012

2010

Screening for pharmaceutical cocrystals using the supercritical fluid enhanced atomization process
Padrela L., Rodrigues M.A., Velaga S.P., Fernandes A.C., Matos H.A., Azevedo E.G.
Journal Of Supercritical Fluids DOI: https://doi.org/10.1016/j.supflu.2010.01.010

2010

Antibacterial activity of tigecycline micro/nanoparticles under supercritical fluids conditions
Pinheiro L., Matos A., Crespo J., Padrela L., Rodrigues M.A., Matos H.A., Castro M., Duarte A., Almeida A.J., Bettencourt A.
European Cells & Materials

2009

Anti-solvent effect in the production of lysozyme nanoparticles by supercritical fluid-assisted atomization processes
Rodrigues M.A., Li J., Padrela L., Almeida A., Matos H.A., Azevedo E.G.
Journal Of Supercritical Fluids DOI: https://doi.org/10.1016/j.supflu.2008.06.006

2009

Formation of indomethacin-saccharin cocrystals using supercritical fluid technology
Padrela L., Rodrigues M.A., Velaga S.P., Matos H.A., Azevedo E.G.
European Journal Of Pharmaceutical Sciences DOI: https://doi.org/10.1016/j.ejps.2009.05.010