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Dr. Luis Padrela

Biography

Luis Padrela is a lecturer in Industrial Biochemistry within the Department of Chemical Sciences and a Researcher at the Synthesis and Solid State Pharmaceutical Centre (SSPC) within the Bernal Institute. Luis studied Biochemistry at undergraduate level before obtaining his PhD in Chemical Engineering at the University of Lisbon (Portugal). Following his PhD, Luis worked in the pharmaceutical industry for almost 2 years (Hovione FarmaCiência, Portugal) before joining SSPC in UL as a postdoctoral researcher and as a senior research fellow later on.

Luis worked on different research projects in different institutions (academia and industry) and countries (Ireland, Portugal and Sweden) focusing his research on Particle Engineering Technologies, Continuous Nanocrystallization and (Bio)Pharmaceutical Processing. He has developed industrial expertise in Quality by Design, scale-up methods and particle engineering technologies for small and large molecule APIs with particular emphasis to spray drying of biopharmaceuticals. Luis has worked within the highest standards of quality (GLP, GMP) in the industry and participated in the development of several spray drying and nanosizing processes for oral and parenteral dosage forms.

Research Interests

IMS Health reports show the global pharmaceutical industry is a $1 trillion dollar sales business, representing more than €30 billion in exports for Ireland. Particularly, the Biopharmaceutical Industry has made in the last decade a capital investment of approximately $8 billion in new facilities in Ireland, presenting significant challenges and opportunities to advance bioprocess development.

Meanwhile drugs which are worth more than $65 billion are wasted every year due to poor solubility, poor bioavailability and the lack of efficient manufacturing and formulation approaches to consistently improve their bioavailability. The manufacture of drug nanoparticles with enhanced properties (e.g. solubility, stability, bioavailability, drug specificity) provides the opportunity to bring new medicines to market. However, pharmaceutical companies have been facing considerable challenges to successfully overcome engineering and manufacturing (e.g. scale-up) hurdles associated with nano-processes.

My research interests are primarily focused in the development of particle engineering technologies for small and large molecule APIs (Active Pharmaceutical Ingredients), with a particular emphasis in (bio)pharmaceutical nanomanufacturing, which includes:

  • Pharmaceutical processing for large molecule APIs (biopharmaceuticals):
    - Isolation and stabilization of biopharmaceuticals using spray drying and freeze drying
    -
    Engineering and manufacturing of biopharmaceutical nanoparticles
  • Pharmaceutical processing for small molecule APIs (pharmaceuticals):
    - Continuous crystallization and drying of drug nanoparticles
    - Supercritical Co2 processing for polymorphic control
    - (Co)Crystal engineering

Teaching Interests

I am teaching within the Bsc Industrial Biochemistry with responsibility for:
Bioprocess Engineering 1
Bioprocess Engineering for Biochemists
Immunology and DNA Diagnostic Techniques

Professional Activities

Award

  • 2021 - Bernal Mid-Career Researcher of the Year 2020
  • 2020 - SFI Frontiers for the Future project
  • 2020 - Laboratory Staff Member of the Year
  • 2019 - Laboratory Staff Member of the Year
  • 2019 - H2020 Marie Curie Innovative Training Network (MSCA-ITN-2019) European Industrial Doctorate (EID)
  • 2018 - Continuous Manufacturing of drug Nano-particles (CM-NANO)
  • 2017 - SFI/NSF I-Corps@SFI Entrepreneurial Programme - 'Continuous Manufacturing Method for the Production of Pharmaceutical Drug Nanoparticles'
  • 2016 - US-Ireland R&D Partnership Programme – ‘Partnership in continuous manufacturing for nano-based drug products'
  • 2008 - Design and Processing of Pharmaceutical Cocrystals using Supercritical Fluid Technology

Association

  • 2018 Associated Member, IChemE
  • 2018 Member, EUFEPS

Consultancy

  • 2018 Pfizer Ireland Pharmaceuticals - Consultancy services in a API-DP interface event

Employment

  • 2017 University of Limerick - Lecturer
  • 2016 Synthesis and Solid State Pharmaceutical Centre (SSPC), University of Limerick - Senior Research Fellow
  • 2014 Synthesis and Solid State Pharmaceutical Centre (SSPC), University of Limerick - Postdoctoral Researcher
  • 2013 Instituto Superior Técnico, University of Lisbon - Research Fellow
  • 2012 Hovione FarmaCiencia SA - Process Development Scientist
  • 2006 Instituto Superior Técnico, Universidade de Lisboa - Assistant Research Fellow

Patent

  • 2015 WO2015036799 A1 - Synthesis and particle engineering of cocrystals
  • 2013 WO2013129953 A1 - Vaccine against strangles of the Equidae
  • 2013 WO2013095169 A1 - Crystalline minocycline thermo-resistant obtained by recrystallization with carbon dioxide

Education

  • 2012 Instituto Superior Técnico, University of Lisbon - PhD
  • 2006 Faculty of Sciences, University of Lisbon - BSc (Hons)

Other

  • Invited speaker for a seminar to the NUIG Society of Chemistry (02 May 2018) Title of presentation: "Batch and continuous particle engineering processes for (bio)pharmaceuticals"
  • Speaker in a Masterclass in Process Development and Scale-Up at NUIG (April 26-27, 2018) Title of presentation: "Solid state properties of APIs"
  • Invited speaker at the 5th Annual Formulation & Drug Delivery Congress (London, UK) organized by Oxford Global (29-30 April 2019). Title of presentation: "Supercritical CO2-Assisted Spray Drying For The Generation Of Tailored API Nanoparticles "
  • Webinar on QbD for Process Development & Nanoparticle CMC Considerations: https://www.oxfordglobal.co.uk/formulation-series/webinar-recordings/

Outreach

Research Collaborators

  • Gavin Andrews - Funding Award - Queen's University Belfast -Northern Ireland
  • Miguel Rodrigues - Joint Publication - Instituto Superior Tecnico -Portugal
  • Rohit Ramachandran - Funding Award - Rutgers State University -USA
  • Hermínio Sousa - Joint Publication -Portugal -University of Coimbra

Publications

Peer Reviewed Journals

2021

Generation and physicochemical characterization of posaconazole cocrystals using Gas Antisolvent (GAS) and Supercritical Solvent (CSS) methods
Long B.;Verma V.;Ryan K.M.;Padrela L.
(2021) Generation and physicochemical characterization of posaconazole cocrystals using Gas Antisolvent (GAS) and Supercritical Solvent (CSS) methods
In Journal Of Supercritical Fluids;
DOI: 10.1016/j.supflu.2020.105134

2020

Pharmaceutical Nanoparticle Isolation Using CO2-Assisted Dynamic Bed Coating.
Verma V;Ryan KM;Padrela L;
(2020) Pharmaceutical Nanoparticle Isolation Using CO2-Assisted Dynamic Bed Coating.
In International journal of pharmaceutics;
DOI: 10.1016/j.ijpharm.2020.120032

2020

Solubility and thermodynamic analysis of ketoprofen in organic solvents
Soto R.;Svärd M.;Verma V.;Padrela L.;Ryan K.;Rasmuson Å.C.
(2020) Solubility and thermodynamic analysis of ketoprofen in organic solvents
In International journal of pharmaceutics;
DOI: 10.1016/j.ijpharm.2020.119686

2020

Cortisone and Cortisol Break H-bonding Rules toMake a Drug-Prodrug Solid Solution
Verma, Vivek,Bordignon, Simone,Chierotti, Michele R.,Lestari, Monica ,Lyons, Keiran,Padrela, Luis,Ryan, Kevin M. ,Lusi, Matteo
(2020) Cortisone and Cortisol Break H-bonding Rules toMake a Drug-Prodrug Solid Solution
In Iucrjiucrj;
DOI: 10.1107/S2052252520013263

2020

Development and validation of a two-dimensional population balance model for a supercritical CO<inf>2</inf> antisolvent batch crystallization process
Muthancheri I.;Long B.;Ryan K.M.;Padrela L.;Ramachandran R.
(2020) Development and validation of a two-dimensional population balance model for a supercritical CO<inf>2</inf> antisolvent batch crystallization process
In Advanced Powder Technology;
DOI: 10.1016/j.apt.2020.06.008

2020

Investigating Process Variables and Additive Selection to Optimize Polymorphic Control of Carbamazepine in a CO<inf>2</inf>Antisolvent Crystallization Process
Long B.;Ryan K.M.;Padrela L.
(2020) Investigating Process Variables and Additive Selection to Optimize Polymorphic Control of Carbamazepine in a CO<inf>2</inf>Antisolvent Crystallization Process
In Organic Process Research &Amp; Development; pp. 1006-1017
DOI: 10.1021/acs.oprd.9b00545

2020

A rational approach towards spray drying of biopharmaceuticals: The case of lysozyme
Ziaee A.;Albadarin A.B.;Padrela L.;Ung M.T.;Femmer T.;Walker G.;O'Reilly E.
(2020) A rational approach towards spray drying of biopharmaceuticals: The case of lysozyme
In Powder Technology; pp. 206-215
DOI: 10.1016/j.powtec.2020.02.057

2019

From batch to continuous — New opportunities for supercritical CO2 technology in pharmaceutical manufacturing
B. Long, K. M. Ryan, L. Padrela
(2019) From batch to continuous — New opportunities for supercritical CO2 technology in pharmaceutical manufacturing
In European Journal Of Pharmaceutical Sciences;
DOI: https://doi.org/10.1016/j.ejps.2019.104971

2019

Co-crystal Polymorphic Control by Nanodroplet and Electrical Confinement
L. M. Padrela, B. Castro.dominguez, A. Ziaee, B. Long, K. M. Ryan, G. Walker, E. J. O'Reilly
(2019) Co-crystal Polymorphic Control by Nanodroplet and Electrical Confinement
In Crystengcomm;
DOI: 10.1039/C9CE00060G

2019

Controlling Polymorphism of Carbamazepine Nanoparticles in a Continuous Supercritical CO2-Assisted Spray Drying Process
B. Long, G. M. Walker, K. M. Ryan, L. Padrela
(2019) Controlling Polymorphism of Carbamazepine Nanoparticles in a Continuous Supercritical CO2-Assisted Spray Drying Process
In Crystal Growth & Design; pp. ---
DOI: doi.org/10.1021/acs.cgd.9b00154
[ULIR]

2019

Amorphous Solid Dispersion of Ibuprofen: A Comparative Study on the Effect of Solution Based Techniques
Ahmad Ziaee, Stephen O'Dea, Aoise Howard-Hildige, Luis Padrela, Catherine Potter, Javed Iqbal, Ahmad B. Albadarin, Gavin Walker, Emmet J. O'Reilly
(2019) Amorphous Solid Dispersion of Ibuprofen: A Comparative Study on the Effect of Solution Based Techniques
In International Journal Of Pharmaceutics; pp. 118816-
DOI: 10.1016/j.ijpharm.2019.118816

2018

Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches.
Ziaee A;Albadarin AB;Padrela L;Femmer T;O'Reilly E;Walker G;
(2018) Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches.
In European Journal Of Pharmaceutical Sciences : Official Journal Of The European Federation For Pharmaceutical Sciences;
DOI: 10.1016/j.ejps.2018.10.026

2018

Unraveling the Link between Solvent-Mediated Proton Transfer and the Salt Formation of Saccharin and Sulfamethazine
Luis Padrela, Jacek Zeglinski, Kevin M Ryan
(2018) Unraveling the Link between Solvent-Mediated Proton Transfer and the Salt Formation of Saccharin and Sulfamethazine
In Crystal Growth & Design;
DOI: 10.1021/acs.cgd.8b01015

2018

Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals - A comprehensive review.
Luis Padrela, Miguel A.Rodrigues, Andreia Duarte, Ana M.A.Dias, Mara E.M.Braga, Hermínio C.de Sousa
(2018) Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals - A comprehensive review.
In Advanced Drug Delivery Reviews;
DOI: 10.1016/j.addr.2018.07.010

2018

Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications
Karimi-Jafari, M;Padrela, L;Walker, GM;Croker, DM
(2018) Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications
In Crystal Growth & Design; WASHINGTON : pp. 6370-6387
DOI: 10.1021/acs.cgd.8b00933
[ULIR]

2017

Spray Drying Ternary Amorphous Solid Dispersions of Ibuprofen – An Investigation into Critical Formulation and Processing Parameters
Ahmad Ziaee, Ahmad B. Albadarin, Luis Padrela, Alexandra Faucher, Emmet O'Reilly, GavinWalker
(2017) Spray Drying Ternary Amorphous Solid Dispersions of Ibuprofen – An Investigation into Critical Formulation and Processing Parameters
In European Journal Of Pharmaceutics And Biopharmaceutics; pp. 43-51
DOI: https://doi.org/10.1016/j.ejpb.2017.08.005

2017

Insight into the Role of Additives in Controlling Polymorphic Outcome: A CO2-Antisolvent Crystallization Process of Carbamazepine
Luis Padrela, Jacek Zeglinski, Kevin M. Ryan
(2017) Insight into the Role of Additives in Controlling Polymorphic Outcome: A CO2-Antisolvent Crystallization Process of Carbamazepine
In Crystal Growth & Design; pp. 4544-4553
DOI: http://dx.doi.org/10.1021/acs.cgd.7b00163

2015

Insight into the Mechanisms of Cocrystallization of Pharmaceuticals in Supercritical Solvents
Padrela L., Rodrigues M.A., Tiago J., Velaga S.P., Matos H.A., Azevedo E.G.
(2015) Insight into the Mechanisms of Cocrystallization of Pharmaceuticals in Supercritical Solvents
In Crystal Growth & Design; pp. 3175-3181
DOI: https://doi.org/10.1021/acs.cgd.5b00200

2014

Tuning physicochemical properties of theophylline by cocrystallization using the supercritical fluid enhanced atomization technique
Padrela L., Rodrigues M.A., Tiago J., Velaga S.P., Matos H.A., Azevedo E.G.
(2014) Tuning physicochemical properties of theophylline by cocrystallization using the supercritical fluid enhanced atomization technique
In Journal Of Supercritical Fluids; pp. 129-136
DOI: https://doi.org/10.1016/j.supflu.2013.12.011

2014

New Thermoresistant Polymorph from CO2 Recrystallization of Minocycline Hydrochloride
Rodrigues M.A., Tiago J.M., Padrela L., Matos H.A., Nunes T.G., Pinheiro L., Almeida A.J., Azevedo E.G.
(2014) New Thermoresistant Polymorph from CO2 Recrystallization of Minocycline Hydrochloride
In Pharmaceutical Research; pp. 3136-3149
DOI: https://doi.org/10.1007/s11095-014-1406-3

2013

Single-step co-crystallization and lipid dispersion by supercritical enhanced atomization
Tiago J., Padrela L., Rodrigues M.A., Matos H.A., Almeida A.J., Azevedo E.G.
(2013) Single-step co-crystallization and lipid dispersion by supercritical enhanced atomization
In Crystal Growth & Design; pp. 4940-4947
DOI: https://doi.org/10.1021/cg401131x

2012

Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model
Rodrigues M.A., Figueiredo L., Padrela L., Cadete A., Tiago J., Matos H.A., Azevedo E.G., Florindo H.F., Gonçalves L.M.D., Almeida A.J.
(2012) Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model
In European Journal Of Pharmaceutics And Biopharmaceutics; pp. 392-400
DOI: https://doi.org/10.1016/j.ejpb.2012.07.005

2011

Theophylline polymorphs by atomization of supercritical antisolvent induced suspensions
Rodrigues M.A., Padrela L., Geraldes V., Santos J., Matos H.A., Azevedo E.G.
(2011) Theophylline polymorphs by atomization of supercritical antisolvent induced suspensions
In Journal Of Supercritical Fluids; pp. 303-312
DOI: https://doi.org/10.1016/j.supflu.2011.05.012

2011

Powder X-ray diffraction method for the quantification of cocrystals in the crystallization mixture
Padrela L. , Azevedo E.G., Velaga E.G.
(2011) Powder X-ray diffraction method for the quantification of cocrystals in the crystallization mixture
In Drug Development And Industrial Pharmacy; pp. 923-929
DOI: https://doi.org/10.3109/03639045.2011.633263

2010

Antibacterial activity of tigecycline micro/nanoparticles under supercritical fluids conditions
Pinheiro L., Matos A., Crespo J., Padrela L., Rodrigues M.A., Matos H.A., Castro M., Duarte A., Almeida A.J., Bettencourt A.
(2010) Antibacterial activity of tigecycline micro/nanoparticles under supercritical fluids conditions
In European Cells & Materials;

2010

Screening for pharmaceutical cocrystals using the supercritical fluid enhanced atomization process
Padrela L., Rodrigues M.A., Velaga S.P., Fernandes A.C., Matos H.A., Azevedo E.G.
(2010) Screening for pharmaceutical cocrystals using the supercritical fluid enhanced atomization process
In Journal Of Supercritical Fluids; pp. 156-164
DOI: https://doi.org/10.1016/j.supflu.2010.01.010

2009

Formation of indomethacin-saccharin cocrystals using supercritical fluid technology
Padrela L., Rodrigues M.A., Velaga S.P., Matos H.A., Azevedo E.G.
(2009) Formation of indomethacin-saccharin cocrystals using supercritical fluid technology
In European Journal Of Pharmaceutical Sciences; pp. 9-17
DOI: https://doi.org/10.1016/j.ejps.2009.05.010

2009

Anti-solvent effect in the production of lysozyme nanoparticles by supercritical fluid-assisted atomization processes
Rodrigues M.A., Li J., Padrela L., Almeida A., Matos H.A., Azevedo E.G.
(2009) Anti-solvent effect in the production of lysozyme nanoparticles by supercritical fluid-assisted atomization processes
In Journal Of Supercritical Fluids; pp. 253-260
DOI: https://doi.org/10.1016/j.supflu.2008.06.006

Conference Contributions

2018

ECO-BIO2018
Ahmad Ziaee, Ahmad B. Albadarin, Luis Padrela, Emmet O'Rielly, Gavin Walker
(2018) ECO-BIO2018
Dublin, Ireland

2018

EuPAT9 - Ninth pan-European Conference on PAT and QbD Sciences
Barry Long, Luis Padrela, Kevin M Ryan
(2018) EuPAT9 - Ninth pan-European Conference on PAT and QbD Sciences
Manchester (UK)

2018

EuPAT9 - Ninth pan-European Conference on PAT and QbD Sciences
Luis Padrela, Barry Long, Kevin M Ryan
(2018) EuPAT9 - Ninth pan-European Conference on PAT and QbD Sciences
Manchester (UK)

2018

EuPAT9 - Ninth pan-European Conference on PAT and QbD Sciences
Ahmad Ziaee, Luis Padrela, Ahmad Albadarin, Emmet O'Reilly, Gavin Walker
(2018) EuPAT9 - Ninth pan-European Conference on PAT and QbD Sciences
Manchester (UK)

2017

10th World Congress of Chemical Engineering
Ahmad Ziaee, Ahmad B. Albadarin, Luis Padrela, Emmet O'Rielly, Gavin Walker
(2017) 10th World Congress of Chemical Engineering
Barcelona, Spain

2017

NUIG-UL Alliance 7th Postgraduate Research Day
Ahmad Ziaee, Ahmad B. Albadarin, Luis Padrela, Emmet O'Rielly, Gavin Walker
(2017) NUIG-UL Alliance 7th Postgraduate Research Day
Galway, Ireland

2017

10th World Congress of Chemical Engineering
B. Castro Dominguez, B. Schaller, P. Cronin, K. Moroney, A. Ziaee, M. Pishnamazi, A. Albadarin, L. Padrela, G. Walker
(2017) 10th World Congress of Chemical Engineering
Barcelona (Spain)

2017

10th World Congress of Chemical Engineering
Luis Padrela, Ahmad Ziaee, Barbara Schaller, Bernardo Castro-Dominguez, Patrick Cronin, Kevin Moroney, Mahboubeh Pishnamazi, Ahmad Albadarin, Emmet O'Reilly, Gavin Walker
(2017) 10th World Congress of Chemical Engineering
Barcelona, Spain

2017

10th World Congress of Chemical Engineering
A. Ziaee, L. Padrela, A. B. Albadarin, B. Castro- Dominguez, B. Schaller, P. Cronin, K. Moroney, M. Pishnamazi, E. O'Reilly, G. Walker
(2017) 10th World Congress of Chemical Engineering
Barcelona (Spain)

2017

2017 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition
Luis Padrela, Ahmad Ziaee, Maryam Karimijafari, Ahmad Alabadarin, Emmet O'Reilly, Gavin Walker
(2017) 2017 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition
San Diego, USA

2017

10th World Congress of Chemical Engineering
M. Pishnamazi, B. C. Dominguez, P. Cronin, B. Schaller, K. Moroney, A. Ziaee, L. Padrela, A. B. Albadarin, M. N. Collins, G. M. Walker
(2017) 10th World Congress of Chemical Engineering
Barcelona (Spain)

2017

2017 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition
Luis Padrela
(2017) 2017 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition
San Diego (USA)

2016

ISPE Ireland Affiliate Seminar - Continuous Manufacturing
Luis Padrela
(2016) ISPE Ireland Affiliate Seminar - Continuous Manufacturing
Fota Island Hotel, Cork, Ireland

2016

CGOM12 / BACG 2016 - Crystal Growth Joint Conference
Luis Padrela, Jacek Zeglinski, Åke Rasmuson, Kevin M Ryan
(2016) CGOM12 / BACG 2016 - Crystal Growth Joint Conference
University of Leeds, Leeds, UK

2016

CGOM12 / BACG 2016 - Crystal Growth Joint Conference
Luis Padrela, Jacek Zeglinski, Åke Rasmuson, Kevin M Ryan
(2016) CGOM12 / BACG 2016 - Crystal Growth Joint Conference
University of Leeds, Leeds, UK

2016

2016 AIChE Annual Meeting
Luis Padrela, Barry Long, Miguel Rodrigues, Kevin M Ryan
(2016) 2016 AIChE Annual Meeting
San Francisco, USA

2016

2016 AIChE Annual Meeting
Luis Padrela, Barry Long, Kevin M. Ryan
(2016) 2016 AIChE Annual Meeting
San Francisco, USA