Biography
Research Interests
The research focus of my group is in three interrelated areas:
1. Polar lipids and human health
2. Food security
3. Emerging hazards in water and food and how they are linked to inflammation
In the 1st area, we are interested in isolating and identifying functional polar lipids of food origin that have strong anti-inflammatory activities, i.e. the potential to stop the onset of inflammation and thus the development of CardioVascular Diseases (CVDs). These lipids can be further exploited in various ways, ranging from developing novel health claims (according to EFSA EU guidelines) for foods till producing novel neutraceuticals and pharmaceuticals.
(Lordan and Zabetakis 2017; Megalemou et al. 2017; Sioriki et al. 2016)
In the 2nd area, we work with Fish feeds and animal feeds.
For fish feeds, we study ways how to increase food security by decreasing our dependency on fish oil (FO). The sustainability of FO is a threat for aquaculture and there is a worldwide search for alternative sources of lipids that can used in fish feeds.
For animal feeds, we evaluate different ways of how to exploit by products of olive industry, brewing and distilling processes and use these by-products to enrich fish feeds. Our ultimate scope is to develop sustainable manufacturing processes of novel animal and fish feeds and also final products (fish; pig; chicken etc) with improved cardioprotective properties. (Nasopoulou et al. 2014) (Nasopoulou et al 2018 / Patents)
In the 3rd area, the interest is in studying the effect of anthropogenic pollution on food chain and how these pollutants (focusing to Cr and Ni) can be uptaken by food tubers. We are now investigating the role of these heavy metals in (promoting) inflammation and thus their link to the onset of a plethora of inflammation-triggered diseases. (Stasinos et al. 2014; Stoikou et al. 2017).
Teaching Interests
1. Food Chemistry
2. Food Functionality
3. Problem Based Learning in Food Science
Professional Activities
Patent
- 2014 WO2014122571 (A1) ― 2014-08-14 - PRODUCTION METHOD OF FISH FEED ENRICHED WITH POLAR LIPIDS AND METHOD TO ENRICH FARMED FISHES
Language
- Greek
- English
- French
Publications
Book
The impact of nutrition and statins on cardiovascular diseases
Zabetakis I.;Lordan R.;Tsoupras A.
The Impact of Nutrition and Statins on Cardiovascular Diseases
DOI: 10.1016/C2017-0-00506-2
Marine Oils (from sea to pharmaceuticals)
Zabetakis, Ioannis (Editor)
Book Chapter
Inflammation and cardiovascular diseases
Lordan R.;Tsoupras A.;Zabetakis I.
The Impact of Nutrition and Statins on Cardiovascular Diseases
DOI: 10.1016/B978-0-12-813792-5.00003-3
Nutrition versus statins in primary prevention: Where do we stand now?
Zabetakis I.;Lordan R.;Tsoupras A.
The Impact of Nutrition and Statins on Cardiovascular Diseases
DOI: 10.1016/B978-0-12-813792-5.00009-4
Cardiovascular risk: Assumptions, limitations, and research
Tsoupras A.;Lordan R.;Zabetakis I.
The Impact of Nutrition and Statins on Cardiovascular Diseases
DOI: 10.1016/B978-0-12-813792-5.00007-0
Cholesterol in atherosclerosis and cardiovascular disease: The role of specific dietary and lifestyle patterns
Tsoupras A.;Lordan R.;Zabetakis I.
The Impact of Nutrition and Statins on Cardiovascular Diseases
DOI: 10.1016/B978-0-12-813792-5.00005-7
The lipid hypothesis and the seven countries study
Lordan R.;Tsoupras A.;Zabetakis I.
The Impact of Nutrition and Statins on Cardiovascular Diseases
DOI: 10.1016/B978-0-12-813792-5.00004-5
The origin of chronic diseases with respect to cardiovascular disease
Lordan R.;Tsoupras A.;Zabetakis I.
The Impact of Nutrition and Statins on Cardiovascular Diseases
DOI: 10.1016/B978-0-12-813792-5.00001-X
Statins: Rationale, mode of action, and side effects
Sultan S.;D’Souza A.;Zabetakis I.;Lordan R.;Tsoupras A.;Kavanagh E.P.;Hynes N.
The Impact of Nutrition and Statins on Cardiovascular Diseases
DOI: 10.1016/B978-0-12-813792-5.00006-9
Diet and cardiovascular disease: The mediterranean diet
Tierney A.;Lordan R.;Tsoupras A.;Zabetakis I.
The Impact of Nutrition and Statins on Cardiovascular Diseases
DOI: 10.1016/B978-0-12-813792-5.00008-2
Inflammation
Lordan R.;Tsoupras A.;Zabetakis I.
The Impact of Nutrition and Statins on Cardiovascular Diseases
DOI: 10.1016/B978-0-12-813792-5.00002-1
The Anti-inflammatory Properties of Food Polar Lipids
Lordan R., Nasopoulou C., Tsoupras A., Zabetakis I.
Bioactive Molecules in Food
DOI: https://doi.org/10.1007/978-3-319-54528-8_95-1
Other Publication
COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation
Zabetakis I.;Lordan R.;Norton C.;Tsoupras A.
Nutrients
DOI: 10.3390/nu12051466
Inflammation and cardiovascular disease: are marine phospholipids the answer?
Lordan R.;Redfern S.;Tsoupras A.;Zabetakis I.
Food & Function
DOI: 10.1039/c9fo01742a
Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents
Lordan R.;Tsoupras A.;Zabetakis I.
Blood Reviews
DOI: 10.1016/j.blre.2020.100694
Forty years since the structural elucidation of platelet-activating factor (PAF): Historical, current, and future research perspectives
Lordan R.;Tsoupras A.;Zabetakis I.;Demopoulos C.
Molecules
DOI: 10.3390/molecules24234414
Changing the Irish dietary guidelines to incorporate the principles of the Mediterranean diet: Proposing the MedÉire diet
Tierney A.;Zabetakis I.
Public Health Nutrition
DOI: 10.1017/S136898001800246X
Dairy Fats and Cardiovascular Disease: Do We Really Need to Be Concerned?
Lordan, R;Tsoupras, A;Mitra, B;Zabetakis, I
Foods
DOI: 10.3390/foods7030029
Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties
Lordan, R,Tsoupras, A,Zabetakis, I
Molecules
DOI: 10.3390/molecules22111964
The anti-inflammatory properties of dairy lipids
Lordan, R,Zabetakis, I
Journal Of Dairy Science
DOI: 10.3168/jds.2016-12224
Lipids and cardiovascular disease: where does dietary intervention sit alongside statin therapy?
Megson, IL,Whitfield, PD,Zabetakis, I
Food & Function
DOI: 10.1039/c6fo00024j
Peer Reviewed Journal
Yoghurt fermentation alters the composition and antiplatelet properties of milk polar lipids
Lordan R.;Vidal N.P.;Huong Pham T.;Tsoupras A.;Thomas R.H.;Zabetakis I.
Food chemistry
DOI: 10.1016/j.foodchem.2020.127384
The Effects of Oxidation on the Antithrombotic Properties of Tea Lipids Against PAF, Thrombin, Collagen, and ADP.
Tsoupras A;Lordan R;Harrington J;Pienaar R;Devaney K;Heaney S;Koidis A;Zabetakis I;
Foods
DOI: 10.3390/foods9040385
Total, neutral, and polar lipids of brewing ingredients, by-products and beer: Evaluation of antithrombotic activities
Lordan R.;O’Keeffe E.;Tsoupras A.;Zabetakis I.
Inform
Caprine milk fermentation enhances the antithrombotic properties of cheese polar lipids
Lordan R.;Walsh A.;Crispie F.;Finnegan L.;Demuru M.;Tsoupras A.;Cotter P.;Zabetakis I.
Journal Of Functional Foods
DOI: 10.1016/j.jff.2019.103507
The effect of ovine milk fermentation on the antithrombotic properties of polar lipids
Lordan R.;Walsh A.;Crispie F.;Finnegan L.;Cotter P.;Zabetakis I.
Journal Of Functional Foods
DOI: 10.1016/j.jff.2019.01.029
The in vitro antithrombotic properties of ale, lager, and stout beers
Lordan R.;O'Keeffe E.;Dowling D.;Mullally M.;Heffernan H.;Tsoupras A.;Zabetakis I.
Food Bioscience
DOI: 10.1016/j.fbio.2019.01.012
Bioprospecting for antithrombotic polar lipids from salmon, herring, and boarfish by-products
Tsoupras A.;O’Keeffe E.;Lordan R.;Redfern S.;Zabetakis I.
Foods
DOI: 10.3390/foods8090416
Total, neutral, and polar lipids of brewing ingredients, by-products and beer: Evaluation of antithrombotic activities
Lordan R.;O'Keeffe E.;Tsoupras A.;Zabetakis I.
Foods
DOI: 10.3390/foods8050171
The Potential Role of Dietary Platelet-Activating Factor Inhibitors in Cancer Prevention and Treatment
Lordan R.;Tsoupras A.;Zabetakis I.
Advances In Nutrition (Bethesda, Md.)
DOI: 10.1093/advances/nmy090
In Vitro Antithrombotic Properties of Salmon (Salmo salar) Phospholipids in a Novel Food-Grade Extract
Tsoupras, A;Lordan, R;Shiels, K;Saha, SK;Nasopoulou, C;Zabetakis, I
Marine Drugs
DOI: 10.3390/md17010062
Platelet aggregometry assay for evaluating the effects of platelet agonists and antiplatelet compounds on platelet function in vitro
Tsoupras A.;Zabetakis I.;Lordan R.
Methodsx
DOI: 10.1016/j.mex.2018.12.012
Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives.
Lordan R;Tsoupras A;Zabetakis I;Demopoulos CA;
Molecules
DOI: 10.3390/molecules24234414
Dairy Fats and Cardiovascular Disease: Do We Really Need to Be Concerned?
Lordan, R; Tsoupras, A; Mitra, B; Zabetakis, I
Foods
Dairy Fats and Cardiovascular Disease: Do We Really Need to be Concerned?
Lordan R;Tsoupras A;Mitra B;Zabetakis I;
Foods
DOI: 10.3390/foods7030029
In vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds
Sioriki, E;Lordan, R;Nahra, F;van Hecke, K;Zabetakis, I;Nolan, SP
Chemmedchem
DOI: 10.1002/cmdc.201800601
Evaluation of Olive Pomace in the Production of Novel Broilers With Enhanced In Vitro Antithrombotic Properties
Nasopoulou, C,Lytoudi, K,Zabetakis, I
European Journal Of Lipid Science And Technology
DOI: 10.1002/ejlt.201700290
Inflammation, not Cholesterol, Is a Cause of Chronic Disease
Tsoupras, A;Lordan, R;Zabetakis, I
Nutrients
DOI: 10.3390/nu10050604
Evaluation of olive pomace in the production of novel broilers with enhanced in vitro antithrombotic properties
Nasopoulou, C; Lutoudi, K; Zabetakis I
European Journal Of Lipid Science And Technology
DOI: 10.1002/ejlt.201700290
Structural Elucidation of Irish Organic Farmed Salmon (Salmo salar) Polar Lipids with Antithrombotic Activities
Tsoupras, A;Lordan, R;Demuru, M;Shiels, K;Saha, SK;Nasopoulou, C;Zabetakis, I
Marine Drugs
DOI: 10.3390/md16060176
Phospholipids of goat and sheep origin: Structural and functional studies
Poutzalis, S;Lordan, R;Nasopoulou, C;Zabetakis, I
Small Ruminant Research
DOI: 10.1016/j.smallrumres.2018.07.015
Metal Uptake by Sunflower (Helianthus annuus) Irrigated withWater Polluted with Chromium and Nickel
Stoikou, V,Andrianos, V,Stasinos, S,Kostakis, MG,Attiti, S,Thomaidis, NS,Zabetakis, I
Foods
DOI: 10.3390/foods6070051
Fatty acid profile and assessment of heavy metals content of Sardina pilchardus captured in the Algerian coast
Benguendouz A.;Bouderoua K.;Bouterfa A.;Belabes M.;Bekada A.;Sioriki E.;Zabetakis I.
Iranian Journal Of Fisheries Sciences
Evaluation of sensory and in vitro anti-thrombotic properties of traditional Greek yogurts derived from different types of milk
Megalemou, K; Sioriki, E.; Lordan, R.; Dermiki, M.; Nasopoulou, C.; Zabetakis, I.
Elsevier
DOI: 10.1016/j.heliyon.2016.e00227
Fatty acid profile and assessment of heavy metals content of Sardina pilchardus captured in the Algerian coast
Benguendouz, A,Bouderoua, K,Bouterfa, A,Belabes, M,Bekada, A,Sioriki, E,Zabetakis, I
Iranian Journal Of Fisheries Sciences
Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties
Lordan, R; Tsoupras, A; Zabetakis, I
Molecules
Invited review: The anti-inflammatory properties of dairy lipids.
Lordan R; Zabetakis I
Journal Of Dairy Science
DOI: https://www.ncbi.nlm.nih.gov/pubmed/28342603
Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties.
Lordan R;Tsoupras A;Zabetakis I;
Molecules
DOI: 10.3390/molecules22111964
Structure and cardioprotective activities of polar lipids of olive pomace, olive pomace-enriched fish feed and olive pomace fed gilthead sea bream (Sparus aurata)
Sioriki, E,Smith, TK,Demopoulos, CA,Zabetakis, I
Food Research International
DOI: 10.1016/j.foodres.2016.03.015
Structure and cardioprotective activities of polar lipids of olive pomace, olive pomace-enriched fish feed and olive pomace fed gilthead sea bream (Sparus aurata)
Sioriki, E; Smith, TK; Demopoulos, CA; Zabetakis I.
Food Research International
DOI: 10.1016/j.foodres.2016.03.015
Lipids and cardiovascular disease: where does dietary intervention sit alongside statin therapy?
Megson, IL; Whitfield PD; Zabetakis, I
Food & Function
DOI: 10.1039/C6FO00024J
Carotenoids and Antioxidant Enzymes as Biomarkers of the Impact of Heavy Metals in food Chain
Andrianos, V;Stoikou, V;Tsikrika, K;Lamprou, D;Stasinos, S;Proestos, C;Zabetakis, I
Current Research In Nutrition And Food Science
DOI: 10.12944/CRNFSJ.4.Special-Issue1.02
Comparison of Sensory and Cardioprotective Properties of Olive-Pomace Enriched and Conventional Gilthead Sea Bream (Sparus aurata): The Effect of Grilling
Sioriki, Eleni,Nasopoulou, Constantina,Demopoulos, Constantinos A.,Zabetakis, Ioannis
Journal Of Aquatic Food Product Technology
DOI: 10.1080/10498850.2013.813100
Assessment of the in Vitro Antithrombotic Properties of Sardine (Sardina pilchardus) Fillet Lipids and Cod Liver Oil
Morphis, Gregory,Kyriazopoulou, Aggeliki,Nasopoulou, Constantina,Sioriki, Eleni,Demopoulos, Constantinos,Zabetakis, Ioannis
Fishes
Evaluation of the in vitro anti-atherogenic activities of goat milk and goat dairy products
Poutzalis, Stylianos,Anastasiadou, Areti,Nasopoulou, Constantina,Megalemou, Kalliopi,Sioriki, Eleni,Zabetakis, Ioannis
Dairy Science & Technology
DOI: 10.1007/s13594-015-0266-x
The Urgent Need to Re-Think Outside the Omega-3 Pufas Box
Zabetakis, Ioannis
Journal of Aquaculture Research & Development
Structural elucidation of olive pomace fed sea bass (Dicentrarchus labrax) polar lipids with cardioprotective activities
Nasopoulou, Constantina,Smith, Terry,Detopoulou, Maria,Tsikrika, Constantina,Papaharisis, Leonidas,Barkas, Dimitris,Zabetakis, Ioannis
Food Chemistry
DOI: http://dx.doi.org/10.1016/j.foodchem.2013.08.091
Localization of strawberry (Fragaria x ananassa) and Methylobacterium extorquens genes of strawberry flavor biosynthesis in strawberry tissue by in situ hybridization
Nasopoulou, Constantina,Pohjanen, Johanna,Koskimäki, Janne J.,Zabetakis, Ioannis,Pirttilä, Anna Maria
Journal Of Plant Physiology
DOI: http://dx.doi.org/10.1016/j.jplph.2014.03.018
Irrigating Onions and Potatoes with Chromium and Nickel: Its Effects on Catalase and Peroxidase Activities and the Cross-Contamination of Plants
Stasinos, Sotiris,Kostakis, Marios,Thomaidis, Nikolaos,Zabetakis, Ioannis
Water, Air And Soil Pollution
DOI: 10.1007/s11270-014-2142-3
The Bioaccumulation and Physiological Effects of Heavy Metals in Carrots, Onions, and Potatoes and Dietary Implications for Cr and Ni: A Review
Stasinos, Sotiris,Nasopoulou, Constantina,Tsikrika, Constantina,Zabetakis, Ioannis
Journal Of Food Science
DOI: 10.1111/1750-3841.12433
In vitro anti-atherogenic properties of traditional Greek cheese lipid fractions
Tsorotioti, S. E.,Nasopoulou, C.,Detopoulou, M.,Sioriki, E.,Demopoulos, C. A.,Zabetakis, I.
Dairy Science & Technology
DOI: 10.1007/s13594-014-0161-x
Exploiting the anti-inflammatory properties of olive (Olea europaea) in the sustainable production of functional food and neutraceuticals
Nasopoulou, Constantina,Karantonis, HaralabosC,Detopoulou, Maria,Demopoulos, ConstantinosA,Zabetakis, Ioannis
Phytochemistry Reviews
DOI: 10.1007/s11101-014-9350-8
Food security and cardioprotection: the polar lipid link.
Ioannis Zabetakis
Journal Of Food Science
Evaluation of Sensory and <i>in Vitro</i> Cardio Protective Properties of Sardine (<i>Sardina pilchardus</i>): The Effect of Grilling and Brining
Constantina Nasopoulou,Evangelia Psani,Eleni Sioriki,Constantinos A. Demopoulos,Ioannis Zabetakis
Food and Nutrition Sciences
DOI: 10.4236/fns.2013.49122
Agricultural and aquacultural potential of olive pomace. A review.
Constantina Nasopoulou and Ioannis Zabetakis
Journal Of Agricultural Science
DOI: http://www.ccsenet.org/journal/index.php/jas/article/view/26875
The uptake of nickel and chromium from irrigation water by potatoes, carrots and onions
Stasinos, Sotiris,Zabetakis, Ioannis
Ecotoxicology And Environmental Safety
DOI: http://dx.doi.org/10.1016/j.ecoenv.2013.01.023
Hen egg yolk lipid fractions with antiatherogenic properties
Nasopoulou, Constantina,Gogaki, Vassiliki,Panagopoulou, Eleanna,Demopoulos, Constantinos,Zabetakis, Ioannis
Animal Science Journal
DOI: 10.1111/j.1740-0929.2012.01067.x
Fish polar lipids retard atherosclerosis in rabbits by down-regulating PAF biosynthesis and up-regulating PAF catabolism.
Nasopoulou C;Tsoupras AB;Karantonis HC;Demopoulos CA;Zabetakis I;
Lipids In Health And Disease
DOI: 10.1186/1476-511X-10-213