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Dr. Denise Croker

Biography

Industrial chemist turned chemical engineer, my career to-date has been earned between industry and academia. My PhD was an industrially based reseach project at the alumina refinery Aughinish Alumina in Askeaton, Co. Limerick. I investigated a unit operation at this site, mimicing the plant reaction in a lab-scale autocalve at in-situ synchrotron facility. I subsequently joined the company for a period as a process engineer. I returned to UL as a post doctorate researcher with the Solid State Pharmaceutical Cluster. This involved managing the day-day activities of a group of post-graduate research student, and conducting research around crystallization and associated phenomena. I became very interested in the pahramceutical industry and moved to the real world of pharma in a transition to MSD (Merck, Sharpe & Dohme) as a project engineer, where I worked mainly on the commercialization of new products.
I have just recently returned to UL as a lecturer for the BEng Chemical & Biochemical Engineering program and look forward to teaching and informing students, while establishing research activities and remaining connected to industry.

Research Interests

Crystal engineering - cocrystallization

Crystallization processes

Use of process analytical technologies

Process Optimisation

Industrial crystallization

Academic-industrial collaborations

Teaching Interests

I will be teaching within the BEng Chemical & Biochemical Engineering
with initial responsibility for:
Bioprocess Engineering 1
Bioprocess Engineering 2

Professional Activities

Association

  • 2013 Chartered Member, Institution of Chemical Engineers
  • 2013 Chartered Engineer, Engineering Council

Employment

  • 2011 MSD Ballydine - Project Engineer
  • 2009 Solid State Pharmaceutical Cluster - Post Doctorate Researcher
  • 2007 Aughinish Alumina - Process Engineer

Education

  • 2007 University of Limerick - PhD
  • 2004 University of Limerick - BSc (Hons)

Publications

Peer Reviewed Journals

2013

Nucleation in the p-Toluenesulfonamide/Triphenylphosphine Oxide Co-crystal System
Croker, Denise M and Davey, Roger J and Rasmuson, AAke C and Seaton, Colin C
(2013) Nucleation in the p-Toluenesulfonamide/Triphenylphosphine Oxide Co-crystal System
In Crystal Growth & Design; pp. 3754-3762
DOI: 10.1021/cg400780e

2013

Solution mediated phase transformations between co-crystals
Croker, Denise M and Davey, Roger J and Rasmuson, AAke C and Seaton, Colin C
(2013) Solution mediated phase transformations between co-crystals
In CrystEngComm; pp. 2044-2047
DOI: 10.1039/c2ce26801a

2013

Investigation into the Mechanism of Solution-Mediated Transformation from FI to FIII Carbamazepine: The Role of Dissolution and the Interaction between Polymorph Surfaces
O’Mahony, Marcus A and Seaton, Colin C and Croker, Denise M and Veesler, Stéphane and Rasmuson, AAke C and Hodnett, Benjamin K
(2013) Investigation into the Mechanism of Solution-Mediated Transformation from FI to FIII Carbamazepine: The Role of Dissolution and the Interaction between Polymorph Surfaces
In Crystal Growth & Design; pp. 1861-1871
DOI: 10.1021/cg301456m

2012

A comparative study of the use of powder X-ray diffraction, Raman and near infrared spectroscopy for quantification of binary polymorphic mixtures of piracetam
Croker, Denise M and Hennigan, Michelle C and Maher, Anthony and Hu, Yun and Ryder, Alan G and Hodnett, Benjamin K
(2012) A comparative study of the use of powder X-ray diffraction, Raman and near infrared spectroscopy for quantification of binary polymorphic mixtures of piracetam
In Journal of pharmaceutical and biomedical analysis; pp. 80-86
DOI: 10.1016/j.jpba.2012.01.013

2012

Solution mediated polymorphic transformation: form II to form III piracetam in ethanol
Maher, Anthony and Croker, Denise M and Rasmuson, AAke C and Hodnett, Benjamin K
(2012) Solution mediated polymorphic transformation: form II to form III piracetam in ethanol
In Crystal Growth & Design; pp. 6151-6157
DOI: 10.1021/cg301290z

2012

Relative Stabilities of the Five Polymorphs of Sulfathiazole
Munroe, Áine and Rasmuson, AAke C and Hodnett, B Kieran and Croker, Denise M
(2012) Relative Stabilities of the Five Polymorphs of Sulfathiazole
In Crystal Growth & Design; pp. 2825-2835
DOI: 10.1021/cg2016419

2012

Examining solution and solid state composition for the solution-mediated polymorphic transformation of carbamazepine and piracetam
O’Mahony, Marcus A and Maher, Anthony and Croker, Denise M and Rasmuson, AAke C and Hodnett, Benjamin K
(2012) Examining solution and solid state composition for the solution-mediated polymorphic transformation of carbamazepine and piracetam
In Crystal Growth & Design; pp. 1925-1932
DOI: 10.1021/cg201665z

2012

Investigation of the Solid-State Polymorphic Transformations of Piracetam
Maher, Anthony and Seaton, Colin C and Hudson, Sarah and Croker, Denise M and Rasmuson, AAke C and Hodnett, Benjamin K
(2012) Investigation of the Solid-State Polymorphic Transformations of Piracetam
In Crystal Growth & Design; pp. 6223-6233
DOI: 10.1021/cg301418c

2012

Solubility of the Metastable Polymorph of Piracetam (Form II) in a Range of Solvents
Maher, Anthony and Rasmuson, AAke C and Croker, Denise M and Hodnett, Benjamin K
(2012) Solubility of the Metastable Polymorph of Piracetam (Form II) in a Range of Solvents
In Journal of Chemical & Engineering Data; pp. 3525-3531
DOI: 10.1021/je300711r

2012

Examining solution and solid state composition for the solution mediated polymorphic transformation of carbamazepine and piracetam
O' Mahony, M; Maher, A; Croker, D, Rasmuson, A C; Hodnett, B K;
(2012) Examining solution and solid state composition for the solution mediated polymorphic transformation of carbamazepine and piracetam
In Crystal Growth & Design;

2012

Measuring the Solubility of a Quickly Transforming Metastable Polymorph of Carbamazepine
O’Mahony, Marcus A and Croker, Denise M and Rasmuson, AAke C and Veesler, Stéphane and Hodnett, Benjamin K
(2012) Measuring the Solubility of a Quickly Transforming Metastable Polymorph of Carbamazepine
In Organic Process Research & Development; pp. 512-518
DOI: 10.1021/op300228g

2011

Analysis of FII crystals of sulfathiazole: epitaxial growth of FII on FIV
Munroe, Aine and Croker, Denise and Rasmuson, AAke C and Hodnett, BK
(2011) Analysis of FII crystals of sulfathiazole: epitaxial growth of FII on FIV
In CrystEngComm; pp. 831-834
DOI: 10.1039/c0ce00221f

2011

Epitaxial growth of polymorphic systems: The case of sulfathiazole
Munroe, 'Aine and Croker, Denise and Hodnett, B Kieran and Seaton, Colin C
(2011) Epitaxial growth of polymorphic systems: The case of sulfathiazole
In CrystEngComm; pp. 5903-5907
DOI: 10.1039/c1ce05585b

2011

In situ monitoring of supersaturation and polymorphic form of piracetam during batch cooling crystallization
Barrett, Mark and Hao, Hongxun and Maher, Anthony and Hodnett, Kieran and Glennon, Brian and Croker, Denise
(2011) In situ monitoring of supersaturation and polymorphic form of piracetam during batch cooling crystallization
In Organic Process Research & Development; pp. 681-687
DOI: 10.1021/op2000628

2011

Understanding the p-toluenesulfonamide/triphenylphosphine oxide crystal chemistry: a new 1: 1 cocrystal and ternary phase diagram
Croker, Denise M and Foreman, Michael E and Hogan, Bridget N and Maguire, Nuala M and Elcoate, Curtis J and Hodnett, Benjamin K and Maguire, Anita R and Rasmuson, AAke C and Lawrence, Simon E
(2011) Understanding the p-toluenesulfonamide/triphenylphosphine oxide crystal chemistry: a new 1: 1 cocrystal and ternary phase diagram
In Crystal Growth & Design; pp. 869-875

2010

Solubility of Form III piracetam in a range of solvents
Maher, A; Croker, D; Rasmuson, A C; Hodnett, B K;
(2010) Solubility of Form III piracetam in a range of solvents
In Journal Of Chemical And Engineering Data;
DOI: 10.1021/je1003934

2010

Mechanistic features of polymorphic transformations: the role of surfaces
Croker, D and Hodnett, BK
(2010) Mechanistic features of polymorphic transformations: the role of surfaces
In Crystal Growth & Design; pp. 2806-2816
DOI: 10.1021/cg901594c

2009

Kinetics and mechanisms of the hydrothermal crystallization of calcium titanate species
Croker, D; Loan, M; Hodnett, B K
(2009) Kinetics and mechanisms of the hydrothermal crystallization of calcium titanate species
In Crystal Growth & Design;
DOI: 10.1021/cg8009223

2008

Desilication reactions at digestion conditions: An in-situ X-ray diffraction study
Croker, D; Loan, M; Hodnett, B K;
(2008) Desilication reactions at digestion conditions: An in-situ X-ray diffraction study
In Crystal Growth & Design;

Conference Papers

2005

In situ time-resolved synchrotron diffraction studies of high temperature Bayer digestion. Proceedings of the 7th International Alumina Quality Workshop, AQW Inc., Perth, Australia
Loan, M,Loughlin, B,Haines, J,Croker, D,Fennell, M,Hodnett, BK
(2005) In situ time-resolved synchrotron diffraction studies of high temperature Bayer digestion. Proceedings of the 7th International Alumina Quality Workshop, AQW Inc., Perth, Australia
In Proceedings of the 7th International Alumina Quality Workshop, AQW Inc., Perth, AustraliaProceedings of the 7th International Alumina Quality Workshop, AQW Inc., Perth, Australia; pp. 117-122