Biography

Catríona received a BSc (education) and a research MSc in animal physiology at the University of Limerick. In 2012, Catríona secured a scholarship from the Irish Cancer Society to pursue a PhD in cancer biology at the University of Limerick. During this time, Catríona received an international mobility grant from the Irish Cancer Society to carry out a research in University of California San Diego. Following her PhD, Catríona undertook post-doctoral work at the Royal College of Surgeons in Ireland, during which time she secured independent fellowships from the Irish Research Council and Marie Skłodowska-Curie Action Global Fellowship. Subsequently, Catríona spent two years at the Perlmutter Cancer Centre at the NYU Langone Health in New York. In 2020, Catríona joined the School of Medicine as a Lecturer in Biomedical Sciences. Catríona's current research interests are focused around manipulating the intrinsic metabolic rewiring in lung cancer cells to enhance anti-tumor immunity.

Academic Qualifications: BSc, MSc, PhD

Peer Reviewed Journals

2021

Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer

Catríona M. Dowling;Kate E. R. Hollinshead;Alessandra Di Grande;Justin Pritchard;Hua Zhang;Eugene T. Dillon;Kathryn Haley;Eleni Papadopoulos;Anita K. Mehta;Rachel Bleach;Andreas U. Lindner;Brian Mooney;Heiko Düssmann;Darran O’Connor;Jochen H. M. Prehn;Kieran Wynne;Michael Hemann;James E. Bradner;Alec C. Kimmelman;Jennifer L. Guerriero;Gerard Cagney;Kwok-Kin Wong;Anthony G. Letai;Tríona Ní Chonghaile; (2021) Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. Science Advances

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2021

Targeting the Atf7ipâ€'Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity

Hai Hu;Alireza Khodadadi-Jamayran;Igor Dolgalev;Hyunwoo Cho;Sana Badri;Luis A. Chiriboga;Briana Zeck;Miguel Lopez De Rodas Gregorio;Catríona M. Dowling;Kristen Labbe;Jiehui Deng;Ting Chen;Hua Zhang;Paul Zappile;Ze Chen;Beatrix Ueberheide;Angeliki Karatza;Han Han;Michela Ranieri;Sittinon Tang;George Jour;Iman Osman;Antje Sucker;Dirk Schadendorf;Aristotelis Tsirigos;Kurt A. Schalper;Vamsidhar Velcheti;Hsin-yi Huang;Yujuan Jin;Hongbin Ji;John T. Poirier;Fei Li;Kwok-Kin Wong; (2021) Targeting the Atf7ipâ€'Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity. Cancer immunology research

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2020

Generation of genetically engineered mouse lung organoid models for squamous cell lung cancers allows for the study of combinatorial immunotherapy

Josephine Hai;Hua Zhang;Jin Zhou;Zhong Wu;Ting Chen;Eleni Papadopoulos;Catríona M Dowling;Val Pyon;Yuanwang Pan;Jie B. Liu;Roderick T. Bronson;Heather Silver;Patrick H. Lizotte;Jiehui Deng;Joshua D. Campbell;Lynette M. Sholl;Christine Ng;Ming-Sound Tsao;Cassandra Thakurdin;Adam J. Bass;Kwok-Kin Wong; (2020) Generation of genetically engineered mouse lung organoid models for squamous cell lung cancers allows for the study of combinatorial immunotherapy. Clinical Cancer Research

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2020

Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Nonâ€'Small Cell Lung Cancer

Fei Li;Wai-Lung Ng;Troy A. Luster;Hai Hu;Vladislav O. Sviderskiy;Catríona M. Dowling;Kate E.R. Hollinshead;Paula Zouitine;Hua Zhang;Qingyuan Huang;Michela Ranieri;Wei Wang;Zhaoyuan Fang;Ting Chen;Jiehui Deng;Kai Zhao;Hon-Cheong So;Alireza Khodadadi-Jamayran;Mousheng Xu;Angeliki Karatza;Val Pyon;Shuai Li;Yuanwang Pan;Kristen Labbe;Christina Almonte;John T. Poirier;George Miller;Richard Possemato;Jun Qi;Kwok-Kin Wong; (2020) Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Nonâ€'Small Cell Lung Cancer. Cancer Research

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2020

Shining a light on metabolic vulnerabilities in non-small cell lung cancer.

Dowling CM;Zhang H;Chonghaile TN;kwok kin wong; (2020) Shining a light on metabolic vulnerabilities in non-small cell lung cancer.. Biochimica Et Biophysica Acta-Reviews On Cancer

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2019

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer.

Zhang H;Christensen CL;Dries R;Oser MG;Jiehui Deng;Diskin B;Li F;Pan Y;Zhang X;Yin Y;Papadopoulos E;Pyon V;Thakurdin C;Kwiatkowski N;Jani K;Rabin AR;Castro DM;ting chen;Silver H;Huang Q;Mirna Bulatović;Dowling CM;Sundberg B;Leggett A;Michela Ranieri;Han H;Li S;Yang A;Labbe KE;Almonte C;Vladislav Sviderskiy;Quinn M;Donaghue J;Wang ES;Zhang T;He Z;Velcheti V;Hammerman PS;Freeman GJ;Bonneau R;Kaelin WG Jr;Sutherland KD;Kersbergen A;Aguirre AJ;Yuan GC;Eli Rothenberg;Miller G;Gray NS;kwok kin wong; (2019) CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer.. Cancer Cell

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2019

BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer.

Walsh L;Kathryn Haley;Bruce Moran;Mooney B;Tarrant F;Stephen Madden;Di Grande A;Fan Y;Das S;Oscar M Rueda;Dowling CM;Damir Vareslija;Chin SF;Linn S;Young LS;Jirström K;John Crown;Bernards R;Carlos Caldas;Gallagher WM;O'Connor DP;Triona Ni Chonghaile; (2019) BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer.. Clinical cancer research : an official journal of the American Association for Cancer Research

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2019

In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras Mutant Lung Adenocarcinoma.

Huang Q;Luster TA;Hu H;Zhang H;Wai-Lung Ng;Alireza Khodadadi-Jamayran;Wang W;Ting Chen;ting chen;Jiehui Deng;Michela Ranieri;Fang Z;Pyon V;Dowling CM;Bagdatlioglu E;Almonte C;Labbe K;Silver H;Rabin AR;Jani K;Aristotelis Tsirigos;Papagiannakopoulos T;Hammerman PS;Velcheti V;Freeman GJ;Qi J;Miller G;kwok kin wong; (2019) In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras Mutant Lung Adenocarcinoma.. Cancer Discovery

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2018

HDAC1 interacts with the p50 NF-?B subunit via its nuclear localization sequence to constrain inflammatory gene expression.

Tyrell Cartwright;Julie Worrell;Letizia Marchetti;Dowling CM;Knox A;Kiely P;Mann J;Mann DA;Wilson CL; (2018) HDAC1 interacts with the p50 NF-?B subunit via its nuclear localization sequence to constrain inflammatory gene expression.. Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms

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2016

The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue.

Dowling CM;Dara Walsh;Coffey JC;Kiely PA; (2016) The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue.. F1000research

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2016

Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.

Dowling CM;James J. Phelan;Callender JA;Cathcart MC;Brian J Mehigan;Paul mccormick;Dalton T;Coffey JC;Newton AC;Jacintha O'Sullivan;Kiely PA; (2016) Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.. Oncotarget

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2014

Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells.

Dowling CM;Herranz Ors C;Kiely PA; (2014) Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells. . Bioscience reports

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