I am a Lecturer in Immunology in the Department of Biological Sciences. My research focuses on understanding the role of human myeloid cells in controlling inflammation. I am particularly interested in how these important immune cells might be manipulated by the local tissue environment in diseases such as Inflammatory Bowel Disease and Colorectal Cancer.
Amodio G, Cichy J, Conde P, Matteoli G, Moreau A, Ochando J, Oral BH, Pekarova M, Ryan EJ, Roth J, Sohrabi Y, Cuturi MC, Gregori S. Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation. Cancer Immunol Immunother. 2019 Apr;68(4):661-672. DOI: 10.1007/s00262-018-2264-3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447499/
Elliott LA, Doherty GA, Sheahan K, Ryan EJ. Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity. Front Immunol. 2017 Feb 6;8:86. DOI: 10.3389/fimmu.2017.00086. https://www.frontiersin.org/articles/10.3389/fimmu.2017.00086/full
Kelly A, Robinson MW, Roche G, Biron CA, O'Farrelly C, Ryan EJ. Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway. J Interferon Cytokine Res. 2016 Dec;36(12):671-680.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165669/
Gibson DJ, Elliott L, McDermott E, Tosetto M, Keegan D, Byrne K, Martin ST, Rispens T, Cullen G, Mulcahy HE, Cheifetz AS, Moss AC, Robson SC, Doherty GA, Ryan EJ. Heightened Expression of CD39 by Regulatory T Lymphocytes Is Associated with Therapeutic Remission in Inflammatory Bowel Disease.Inflamm Bowel Dis. 2015 Dec;21(12):2806-14. DOI: 10.1097/MIB.0000000000000566. https://academic.oup.com/ibdjournal/article-abstract/21/12/2806/4579186?redirectedFrom=fulltext
O'Toole A, Michielsen AJ, Nolan B, Tosetto M, Sheahan K, Mulcahy HE, Winter DC, Hyland JM, O'Connell PR, Fennelly D, O'Donoghue D, O'Sullivan J, Doherty GA, Ryan EJ. Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive. Br J Cancer. 2014 Aug 26;111(5):927-32. DOI: 10.1038/bjc.2014.367. https://www.nature.com/articles/bjc2014367