Research Interests
Enzyme biotechnology: The development of renewable sources of liquid fuels as an alternative to fossil fuels is receiving increasing global attention due environmental, economic and energy security concerns. The production of bioethanol from cellulose-based raw materials (e.g. grass, straw & wood) is at the forefront of this technology, but a major stumbling block is how to effectively degrade the cellulose to its glucose building blocks (the glucose is then fermented to ethanol, basically by brewing technology). A major ongoing focus of my research group is the identification and use of enzymes (proteins that speed up chemical reactions) derived from thermoacidophilic bacteria (bugs that grow best in boiling acid) to more efficiently achieve cellulose degradation (a process that currently usually entails the use of boiling acid). These enzymes are also academically interesting because they work best under such extreme conditions. An additional focus of my research group is to identify selected enzymes produced by acidophilic bugs which can be used as digestive supplements in humans or animals (working in the acidic environs of the stomach). For example, the identification of acid-active lactase' enzymes to degrade milk lactose in the stomach, thereby alleviating lactose intolerance (which effects up to 75% of the world's adult population).
Curriculum design.
Curriculum design and development, particularly with reference to pharmaceutical biotechnology/ protein biotechnology.
Professional Activities
Education
- 2009 University of Limerick - Graduate Diploma in Academic Practice
- 1989 University College Galway - Ph.D.
- 1986 University College Galway - B.Sc.
Award
- 2006 - Special achievement in research award
- 2003 - University of Limerick excellence in teaching award
Committee
- 2004 International advisory committee, Pharma BioTec Europe 2004 conference,
- 2002 Board of governors and executive committee, European Association of Pharma Biotechnology,
- 2002 Scientific secretary, European Association of Pharma Biotechnology,
Employment
- 1994 CES dept, UL. - Assistant lecturer
- 1992 Alltech European Biosciences Research Centre - Senior research scientist
- 1990 Vetrepharm Ireland - Production manager
- 1989 Olympus diagnostics, Tulla. - Research scientist
Publications
Book
Medical Product Regulatory Affairs
Tobin, J.J. and Walsh, G.
Teaching at college and university: effective strategies and key principles
Moore, S; Walsh, G; Risquez, A
Directory of approved biopharmaceutical products
Spada, S; Walsh, G
Protein Biotechnology
Walsh, G; Headon, D
Book Chapter
Posttranslational modifications to improve biopharmaceuticals
Walsh, G
Modern Biopharmaceuticals: recent success stories
DOI: 10.1002/9783527669417.ch20
Drug approval in the European Union and United States
Walsh, G
Pharmaceutical Biotechnology
DOI: 10.1002/9783527632909.ch11
Drug approval in the European Union and the United States
Walsh, G
An introduction to molecular biotechnology, second edition
Drug approval in the European Union and the United States
Walsh, G
Applications of pharmaceutical biotechnology
Biopharmaceutical regulatory affairs
Walsh, G
Biopharmaceuticals, an industrial perspective
Biopharmaceuticals; an overview
Walsh, G
Biopharmaceuticals, an industrial perspective
In-feed assay of enzymes by radial enzyme diffusion, recent developments and application to analysis in pelleted feed
Walsh, G
Biotechnology in the feed industry
Registration of enzymes and biological products around the world; current analytical methods for feed enzymes and future developments
Power, RF; Walsh, G
Biotechnology in the feed industry
Biological control of pollution
Headon, DR; Walsh, G
Principles of pig science
Industrial enzyme applications; matching enzyme to substrate in animal feed
Sears, A; Walsh, G
Biotechnology in the feed industry
Conference Publication
Environ 2014
Boyce, A. and Walsh, G.
4th international congress on Green Process Engineering
Boyce, A. and Walsh, G.
Environ 2014
Ryan, M. and Walsh, G.
BIO World Congress on Industrial Biotechnology & Bioprocessing
Boyce, A. and Walsh, G.
Proceedings of the 5th international conference on sustainable energy and environmental protection
McKevitt, K. and Walsh, G.
Environ 2012
Boyce, A. and Walsh, G.
20th European Biomass Conference
Boyce, A. and Walsh, G.
Pharmaceutical Regulatory Affairs
Walsh, G.
Biotrends
Walsh, G.
Third Brazilian Biotechnology Congress
Walsh, G.
EPA National Research Conference 2010
Walsh, G.
EPA National Research Conference 2010
Boyce, A. ans Walsh, G.
Environ 2010
Boyce, A. and Walsh, G.
Third Annual Biosimilars conference
Walsh, G
Environ 2009
Boyce, A. and Walsh, G.
42nd IUPAC Congress
Boyce, A., Piterina, A. and Walsh, G.
Edited Book
Post-translational Modification of Protein Biopharmaceuticals
Directory of Therapeutic Enzymes
Peer Reviewed Journal
Milestones and Moderate Progress in 2012 Drug Approvals
Walsh, G
Biopharm International
A 25-year retrospective on the public's perception of the biopharmaceutical and biotech industry
Walsh, G and Ultee, M.
Biopharm International
New Biopharmaceuticals
Walsh, G
Biopharm International
Stabilization of a supplemental digestive enzyme by post-translational engineering using chemically-activated polyethylene glycol
Turner, KM; Pasut, G; Veronese, FM; Boyce, A; Walsh, G
Biotechnology Letters
DOI: 10.1007/s10529-010-0474-7
Post-translational modifications of therapeutic proteins
Walsh, G
Drug Discovery Today
DOI: 10.1016/j.drudis.2010.06.009
Assessment of the potential suitability of selected commercially available enzymes for cleaning-in-place (CIP) in the dairy industry.
Boyce A., Piterina A.V., Walsh G.
Biofouling
DOI: 10.1080/08927014.2010.522705
Biopharmaceutical Approval Trends in 2009
Walsh, G
Biopharm International
The importance of and an approach to comprehensive reflective practice
Walsh, G.
Biochemistry And Molecular Biology Education
DOI: 10.1002/bmb.20370
Biopharmaceutical benchmarks 2010
Walsh, G
Nature Biotechnology
DOI: 10.1038/nbt0910-917
A novel acid-stable, acid-active beta-galactosidase potentially suited to the alleviation of lactose intolerance
O'Connell, S; Walsh, G
Applied Microbiology And Biotechnology
DOI: 10.1007/s00253-009-2270-7
Engineering of a fungal beta-galactosidase to remove product inhibition by galactose
Hu, XJ; Robin, S; O'Connell, S; Walsh, G; Wall, JG
Applied Microbiology And Biotechnology
DOI: 10.1007/s00253-010-2662-8
Biopharmaceuticals: Approval Trends in 2008
Walsh, G
Biopharm International
Biopharmaceuticals: Approval Trends in 2007
Walsh, G
Biopharm International
Application relevant studies of fungal beta-galactosidases with potential application in the alleviation of lactose intolerance
O'Connell, S; Walsh, G
Applied Biochemistry And Biotechnology
DOI: 10.1007/s12010-007-8098-7
Engineering biopharmaceuticals
Walsh, G
Biopharm International
Production, purification and application-relevant characterisation of an endo-1,3(4)-beta-glucanase from Rhizomucor miehei
Boyce, A; Walsh, G
Applied Microbiology And Biotechnology
DOI: 10.1007/s00253-007-1058-x
The pharmaceutical biotechnology content of pharmacy programs within Europe: A survey
Walsh G., Muller R.
Pharmacy Education
DOI: 10.1080/15602210601084366
Protein engineering - Case studies of commercialized engineered products
Walsh, G
Biochemistry And Molecular Biology Education
DOI: 10.1002/bmb.21
Purification and characterisation of an acid phosphatase with phytase activity from Mucor hiemalis Wehmer
Boyce, A; Walsh, G
Journal Of Biotechnology
DOI: 10.1016/j.jbiotec.2007.08.028
Approval trends in 2006
Walsh, G
Biopharm International
Purification and properties of a beta-galactosidase with potential application as a digestive supplement
O'Connell, S; Walsh, G
Applied Biochemistry And Biotechnology
DOI: 10.1007/s12010-007-9206-4
Protein post translatioal modification in the context of biopharmaceuticals
Walsh, G and Jefferis, R.
Nature Biotechnology
Comparison of selected physicochemical characteristics of commercial phytases relevant to their application in phosphate pollution abatement
Boyce, A; Walsh, G
Journal Of Environmental Science And Health Part A-Toxic/Hazardous Substances & Environmental Engineering
DOI: 10.1080/10934520600614397
Physicochemical characteristics of commercial lactases relevant to their application in the alleviation of lactose intolerance
O'Connell, S; Walsh, G
Applied Biochemistry And Biotechnology
DOI: 10.1385/ABAB:134:2:179
Biopharmaceuticals: Approval trends in 2005
Walsh, G
Biopharm International
Biopharmaceutical benchmarks 2006
Walsh, G
Nature Biotechnology
DOI: 10.1038/nbt0706-769
Scaling the biobusiness information mountain
Williams, G; Walsh, G
Nature Biotechnology
DOI: 10.1038/bioent836
Therapeutic insulins and their large scale manufacture
Walsh, G
Applied Microbiology And Biotechnology
Biopharmaceuticals: Approvals and approval trends in 2004
Walsh, G
Biopharm International
Quantification of supplemental enzymes in animal feedingstuffs by radial enzyme diffusion
Walsh, G; Murphy, RA; Killeen, GF; Power, RF
Applied Microbiology And Biotechnology
DOI: 10.1007/s00253-004-1826-9
A series of enzymology-based experiments designed to mimic an applied research project
Boyce, A; Walsh, G
Biochemistry And Molecular Biology Education
DOI: 10.1002/bmb.2005.49403306420
Biopharmaceuticals: recent trends and likely directions
Walsh, G
Trends In Biotechnology
The use of proteases to remove protein-based residues from solid surfaces
Turner, K; Serantoni, M; Boyce, A; Walsh, G
Process Biochemistry
DOI: 10.1016/j.procbio.2005.03.040
Thermostable phytase enzyme
Walsh G.
Industrial Bioprocessing
Second generation biopharmaceuticals
Walsh, G
European J. Pharmaceutics & Biopharmaceutics
Modern antibody-based therapeutics
Walsh, G
Biopharm International
Identification and characterization of a phytase of potential commercial interest
Casey, A; Walsh, G
Journal Of Biotechnology
DOI: 10.1016/j.jbiotec.2004.03.001
A phytase enzyme-based biochemistry practical particularly suited to students undertaking courses in biotechnology and environmental science
Boyce, A; Casey, A; Walsh, G
Biochemistry And Molecular Biology Education
DOI: 10.1002/bmb.2004.494032050392
Pharmaceutical biotechnology products approved within the European Union
Walsh, G
European J. Pharmaceutics & Biopharmaceutics
Biopharmaceutical benchmarks - 2003
Walsh, G
Nature Biotechnology
DOI: 10.1038/nbt0803-865
Purification and characterization of extracellular phytase from Aspergillus niger ATCC 9142
Casey, A; Walsh, G
Bioresource Technology
DOI: 10.1016/S0960-8524(02)00145-1
Purification and characterization of an extracellular phytase from Aspergillus niger ATCC 9142
Casey, A; Walsh, G
Bioresource Technology
Biopharmaceuticals and biotechnology medicines; an issue of nomenclature
Walsh, G
European J. Pharmaceutical Sciences
Eine neue generation von biopharmazeutika
Walsh, G
Labor Praxis
Biopharmaceuticals first versus second-generation products
Walsh, G
New Drugs
Monoclonal antibody based therapeutics
Walsh, G
Pharmaceutical Technology Europe
Core concepts suitable for education and training for the biopharmaceutical industry
Walsh, G
Drug Information Journal
Biopharmaceuticals
Walsh, G
New Drugs
Biopharmaceutical benchmarks
Walsh, G
Nature Biotechnology
DOI: 10.1038/78720
A suggested postgraduate curriculum for education and training for the biopharmaceutical industry
Murphy, DB; Walsh, G
Drug Information Journal
Drug approval in Europe - The EMEA gets good grades, but has room for improvement
Walsh, G
Nature Biotechnology
DOI: 10.1038/6977
Antimicrobial Saponins of Yucca schidigera and the Implications of Their in Vitro Properties for Their in Vivo Impact
Killeen G.F., Madigan C.A., Connolly C.R., Walsh G.A., Clark C., Hynes M.J., Timmins B.F., James P., Headon D.R., Power R.F.
Journal Of Agricultural And Food Chemistry
A simple immunoassay-based system capable of detecting antibody raised against human IgG
Walsh, G; O'Shaughnessy, B; Shanley, N; Tobin, JJ
Biochemical Education
DOI: 10.1016/S0307-4412(98)00049-1
Biopharmaceuticals, the future
Walsh, G
The Biologist
Enzymes, the workhorses of biotechnology
Walsh, G; Adley, C; Pembroke, JT
The Biologist
Technical note: detection and quantification of supplemental beta glucanase activity in animal feed.
Walsh, G., Murphy, R., Killeen, G., Headon, D. and Power, R.
Journal Of Animal Science
Nervous excitement over neurotrophic factors
Walsh G.
Nature Biotechnology
Biopharmaceuticals, the bodie's own drugs
Walsh, G.
The Biologist
Recombinant reproduction
DeKoning, W., Walsh, G., Wrenn, A., and Headon, D.
Nature Biotechnology
Influence of Yucca Shidigera preparations on the activity of urease from Bacillus pasteurii
Killeen, G., Buggle, K. Hynes. M., Walsh, G. Power, R. and Headon, D
Journal Of The Science Of Food And Agriculture
The industrial production of enzymes.
Headon, D. and Walsh, G.
Biotechnology Advances
Enzymes in the animal feed industry
Walsh, G. Power, R. and Headon, D.
Trends In Food Science & Technology
An ultrafuiltration method for the removal of interfering agents and its application to the determination of free ammonia in solutons of oxystarch by the berthelot method
Killeen, J., Hynes, M., Power, R., Walsh, G and Headon, D.
Analytical Biochemistry
Enzymes in the animal feed industry
walsh, G. Power, R. and Headon, D.
Trends In Biotechnology