Biography


Prof. Gary Walsh is Chair of Industrial Biotechnology at the University of Limerick, Ireland. He obtained BSc & PhD degrees from the National University of Ireland at Galway in 1986 and 1989, respectively and more recently a graduate diploma in academic practice from UL in 2009. Prior to joining the university in 1994 he held the following industrial positions: Senior research scientist, Alltech Ireland Ltd., Production manager, Bioniche pharmaceuticals, Research scientist, Olympus diagnostics.

His research and scholarship interests span enzyme and pharmaceutical biotechnology as well as curriculum design and he was the recipient of the university's special achievement in research award in 2006.

His 106 ‘class 1' publications include: 9 authored books, 2 edited books, 17 book chapters and 78 journal articles. In addition he has authored 94 refereed conference proceedings, 5 book reviews and 7 reports. Three of his books are international student biotechnology textbooks that have gone to second edition and for which Chinese and Japanese foreign language editions have been published.

He has participated in research grant proposal applications which have successfully secured €3.1 million in funding, of which his personal share is €1.7 million. He has supervised/continues to supervise 22 researchers (14 postgraduate & 8 post-doctoral). He has served as a research proposal evaluator for various scientific funding bodies in Ireland, Holland, Norway and the UK.

He has presented his work at 60 international conferences, which include 33 guest/keynote presentations. He has served as session/conference chairman at 6 international conferences and as a member of the scientific advisory panel for 12 international conferences conferences.

He has acted as external examiner for 13 PhD and 4 MSc research theses in various Irish institutions, as well for Monash university in Australia. He has/continues to serve as external examiner for undergraduate taught programs in 4 Irish Institutes of Technology and 2 Irish Universities.

He teaches various biotechnology modules in Limerick and was the recipient of the university's excellence in teaching award in 2003. He has served as course director, B.Sc. industrial biochemistry for 2 terms and as the University's (acting) dean, teaching & learning from August to December 2004. He has lectured on taught courses at the University of Grenoble, France, the University of Jyvaskla, Finland and the National University of Ireland at Galway.

He chaired the University of Limerick institutional committee preparing for the 2012 institutional quality review and was the main author of the associated Institutional Self Assessment Report.

He has served as (founding) editor, biotechnology section, of the European Journal of Pharmaceutics and Biopharmaceutics and as a member of the editorial boards of Biopharm. International, New Drugs and the Encyclopaedia of Industrial Biotechnology. He has also served as scientific secretary and as a member of the board of governors of the European Association of Pharmaceutical Biotechnology and is a former Fulbright research visiting professor at the University of Georgia, in the United States.

Research Interests

Enzyme biotechnology: The development of renewable sources of liquid fuels as an alternative to fossil fuels is receiving increasing global attention due environmental, economic and energy security concerns. The production of bioethanol from cellulose-based raw materials (e.g. grass, straw & wood) is at the forefront of this technology, but a major stumbling block is how to effectively degrade the cellulose to its glucose building blocks (the glucose is then fermented to ethanol, basically by brewing technology). A major ongoing focus of my research group is the identification and use of enzymes (proteins that speed up chemical reactions) derived from thermoacidophilic bacteria (bugs that grow best in boiling acid) to more efficiently achieve cellulose degradation (a process that currently usually entails the use of boiling acid). These enzymes are also academically interesting because they work best under such extreme conditions. An additional focus of my research group is to identify selected enzymes produced by acidophilic bugs which can be used as digestive supplements in humans or animals (working in the acidic environs of the stomach). For example, the identification of acid-active ‘lactase' enzymes to degrade milk lactose in the stomach, thereby alleviating lactose intolerance (which effects up to 75% of the world's adult population).

Pharmaceutical biotechnology (Biopharmaceuticals): Biopharmaceuticals are drugs (mainly proteins such as insulin and antibodies, but also pieces of DNA called ‘gene therapy' products) that are synthesized biologically (as opposed to chemically), usually via genetic engineering. These products are at the cutting edge of the pharmaceutical sector, recording sales of €107 billion in 2011. My research in this area focuses largely upon altering the method of manufacturing (bioprocessing) of these products in order to achieve manufacturing more economically and making it more environmentally friendly in the process (green pharmaceutical manufacturing) We also work on stabilizing such proteins by attaching a chemical called PEG to them, as well as on the identification & analysis of trends/ likely future directions in biopharmaceutical production systems/ products/regulatory science.

Curriculum design.
Curriculum design and development, particularly with reference to pharmaceutical biotechnology/ protein biotechnology.

Professional Activities

Education

  • 2009 University of Limerick - Graduate Diploma in Academic Practice
  • 1989 University College Galway - Ph.D.
  • 1986 University College Galway - B.Sc.

Award

  • 2006 - Special achievement in research award
  • 2003 - University of Limerick excellence in teaching award

Committee

  • 2004 International advisory committee, Pharma BioTec Europe 2004 conference,
  • 2002 Board of governors and executive committee, European Association of Pharma Biotechnology,
  • 2002 Scientific secretary, European Association of Pharma Biotechnology,

Employment

  • 1994 CES dept, UL. - Assistant lecturer
  • 1992 Alltech European Biosciences Research Centre - Senior research scientist
  • 1990 Vetrepharm Ireland - Production manager
  • 1989 Olympus diagnostics, Tulla. - Research scientist

Books

Biopharmaceuticals; an industrial perspective

Prof. Gary Walsh
1999
Netherlands
Kluwer academic publishers
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Biopharmaceuticals: Biochemistry & Biotechnology

Prof. Gary Walsh
1998
Chichester
J. Wiley & sons
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Pharmaceutical Biotechnology. Concepts and Applications

Prof. Gary Walsh
2007
Chichester, UK
Wiley
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Proteins; biochemistry and biotechnology

Prof. Gary Walsh
2002
Chichester UK
J. Wiley & sons
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Medical Product Regulatory Affairs

Prof. Gary Walsh
2008
Weinheim, Germany
Wiley Blackwell
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Biopharmaceuticals: Biochemistry & Biotechnology

Prof. Gary Walsh
2003
Chichester
J. Wiley & sons
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Proteins. Biochemistry and Biotechnology, second edition

Prof. Gary Walsh
2014
Chichester, UK
Wiley Blackwell
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Teaching at college and university: effective strategies and key principles

Prof. Gary Walsh
2007
Maidenhead
Open University Press
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Directory of approved biopharmaceutical products

Prof. Gary Walsh
2005
USA
CRC press
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Protein Biotechnology

Prof. Gary Walsh
1994
Chichester
J. Wiley & sons
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Book Chapters

Drug approval in the European Union and the United States

Prof. Gary Walsh
2004
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Biopharmaceuticals; an overview

Prof. Gary Walsh
1999
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Posttranslational modifications to improve biopharmaceuticals

Prof. Gary Walsh
2013
Weinheim, Germany
Wiley Blackwell
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Biopharmaceutical regulatory affairs

Prof. Gary Walsh
1999
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Drug approval in the European Union and United States

Prof. Gary Walsh
2012
Weinheim, Germany
Wiley Blackwell
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Industrial enzyme applications; matching enzyme to substrate in animal feed

Prof. Gary Walsh
1993
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Drug approval in the European Union and the United States

Prof. Gary Walsh
2011
Weinheim, Germany
Wiley Blackwell
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Biological control of pollution

Prof. Gary Walsh
1994
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The Degradation of Oligonucleotide-based Pharmaceutical Products by Selected Chemical Means

Dr. Tom O'Dwyer
Prof. Gary Walsh
2010
South Africa
ATINER, SA
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Registration of enzymes and biological products around the world; current analytical methods for feed enzymes and future developments

Prof. Gary Walsh
1994
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In-feed assay of enzymes by radial enzyme diffusion, recent developments and application to analysis in pelleted feed

Prof. Gary Walsh
1995
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Edited Books

This author has not written any publications of this type yet.

Peer Reviewed Journals

Stabilization of a supplemental digestive enzyme by post-translational engineering using chemically-activated polyethylene glycol

Prof. Gary Walsh
2011
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Eine neue generation von biopharmazeutika

Prof. Gary Walsh
2002
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Biopharmaceutical benchmarks 2006

Prof. Gary Walsh
2006
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The pharmaceutical biotechnology content of pharmacy programs within Europe: A survey

Prof. Gary Walsh
2007
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Quantification of supplemental enzymes in animal feedingstuffs by radial enzyme diffusion

Prof. Gary Walsh
2005
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Biopharmaceuticals: Approval Trends in 2008

Prof. Gary Walsh
2009
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Veterinary-based biopharmaceuticals

Dr. Michael Ryan
Prof. Gary Walsh
2012
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Core concepts suitable for education and training for the biopharmaceutical industry

Prof. Gary Walsh
2001
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Utilisation of phosphorus nutrient content in industrial scale plasmid DNA production: a waste minimisation study

Dr. Tom O'Dwyer
Prof. Gary Walsh
2010
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Identification and characterization of a phytase of potential commercial interest

Prof. Gary Walsh
2004
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Drug approval in Europe - The EMEA gets good grades, but has room for improvement

Prof. Gary Walsh
1999
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Physicochemical characteristics of commercial lactases relevant to their application in the alleviation of lactose intolerance

Prof. Gary Walsh
2006
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A novel acid-stable, acid-active beta-galactosidase potentially suited to the alleviation of lactose intolerance

Prof. Gary Walsh
2010
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Biopharmaceuticals: Approvals and approval trends in 2004

Prof. Gary Walsh
2005
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Biopharmaceuticals: recent trends and likely directions

Prof. Gary Walsh
2005
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A suggested postgraduate curriculum for education and training for the biopharmaceutical industry

Prof. Gary Walsh
1999
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Life in the hot stuff: Thermophilic microorganisms

Emeritus Ap. Catherine Adley
Emeritus Prof. J Tony Pembroke
Prof. Gary Walsh
1997
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Technical note: detection and quantification of supplemental beta glucanase activity in animal feed.

Prof. Gary Walsh
1995
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Purification and characterisation of an acid phosphatase with phytase activity from Mucor hiemalis Wehmer

Prof. Gary Walsh
2007
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Scaling the biobusiness information mountain

Prof. Gary Walsh
2005
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Application relevant studies of fungal beta-galactosidases with potential application in the alleviation of lactose intolerance

Prof. Gary Walsh
2008
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Production, purification and application-relevant characterisation of an endo-1,3(4)-beta-glucanase from Rhizomucor miehei

Prof. Gary Walsh
2007
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Biopharmaceuticals: Approval trends in 2005

Prof. Gary Walsh
2006
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The use of proteases to remove protein-based residues from solid surfaces

Prof. Gary Walsh
2005
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A simple immunoassay-based system capable of detecting antibody raised against human IgG

Prof. Gary Walsh
1998
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Post-translational modifications of therapeutic proteins

Prof. Gary Walsh
2010
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Second generation biopharmaceuticals

Prof. Gary Walsh
2004
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Recombinant reproduction

Prof. Gary Walsh
1994
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Nervous excitement over neurotrophic factors

Prof. Gary Walsh
1995
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Purification and properties of a beta-galactosidase with potential application as a digestive supplement

Prof. Gary Walsh
2007
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Therapeutic insulins and their large scale manufacture

Prof. Gary Walsh
2005
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Approval trends in 2006

Prof. Gary Walsh
2007
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Monoclonal antibody based therapeutics

Prof. Gary Walsh
2001
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A suggested module detailing biopharmaceuticals suitable for inclusion in undergraduate biochemistry/applied biochemistry programmes

Prof. Gary Walsh
2000
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Identification of fungal proteases potentially suitable for environmentally friendly cleaning-in-place in the dairy industry

Prof. Gary Walsh
2012
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Pharmaceutical biotechnology products approved within the European Union

Prof. Gary Walsh
2003
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Protein post translatioal modification in the context of biopharmaceuticals

Prof. Gary Walsh
2006
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The industrial production of enzymes.

Prof. Gary Walsh
1994
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Assessment of the potential suitability of selected commercially available enzymes for cleaning-in-place (CIP) in the dairy industry.

Prof. Gary Walsh
2010
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A 25-year retrospective on the public's perception of the biopharmaceutical and biotech industry

Prof. Gary Walsh
2012
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Biopharmaceuticals: Approval Trends in 2007

Prof. Gary Walsh
2008
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The importance of and an approach to comprehensive reflective practice

Prof. Gary Walsh
2010
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Biopharmaceuticals, the bodie's own drugs

Prof. Gary Walsh
1995
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Influence of Yucca Shidigera preparations on the activity of urease from Bacillus pasteurii

Prof. Gary Walsh
1994
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Biopharmaceuticals

Prof. Gary Walsh
2001
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Biopharmaceutical benchmarks 2010

Prof. Gary Walsh
2010
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Purification and characterization of extracellular phytase from Aspergillus niger ATCC 9142

Prof. Gary Walsh
2003
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Comparison of selected physicochemical characteristics of commercial phytases relevant to their application in phosphate pollution abatement

Prof. Gary Walsh
2006
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Milestones and Moderate Progress in 2012 Drug Approvals

Prof. Gary Walsh
2013
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Biopharmaceutical Approval Trends in 2009

Prof. Gary Walsh
2010
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Protein engineering - Case studies of commercialized engineered products

Prof. Gary Walsh
2007
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Biopharmaceuticals, the future

Prof. Gary Walsh
1996
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An ultrafuiltration method for the removal of interfering agents and its application to the determination of free ammonia in solutons of oxystarch by the berthelot method

Prof. Gary Walsh
1993
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Biopharmaceuticals first versus second-generation products

Prof. Gary Walsh
2002
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Biopharmaceutical benchmarks - 2003

Prof. Gary Walsh
2003
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Purification and characterization of an extracellular phytase from Aspergillus niger ATCC 9142

Prof. Gary Walsh
2003
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Antimicrobial Saponins of Yucca schidigera and the Implications of Their in Vitro Properties for Their in Vivo Impact

Prof. Gary Walsh
1998
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New Biopharmaceuticals

Prof. Gary Walsh
2012
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Modern antibody-based therapeutics

Prof. Gary Walsh
2004
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A series of enzymology-based experiments designed to mimic an applied research project

Prof. Gary Walsh
2005
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Enzymes, the workhorses of biotechnology

Prof. Gary Walsh
1996
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Enzymes in the animal feed industry

Prof. Gary Walsh
1994
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Biopharmaceuticals and biotechnology medicines; an issue of nomenclature

Prof. Gary Walsh
2002
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Biopharmaceutical benchmarks

Prof. Gary Walsh
2000
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Thermostable phytase enzyme

Prof. Gary Walsh
2004
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Engineering of a fungal beta-galactosidase to remove product inhibition by galactose

Prof. Gary Walsh
2010
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Engineering biopharmaceuticals

Prof. Gary Walsh
2007
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Enzymes in the animal feed industry

Prof. Gary Walsh
1993
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A phytase enzyme-based biochemistry practical particularly suited to students undertaking courses in biotechnology and environmental science

Prof. Gary Walsh
2004
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Other Journals

This author has not written any publications of this type yet.

Conference Publications

Environ 2010

Dr. Tom O'Dwyer
Prof. Gary Walsh
2010
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15th International Pharmaceutical Technology Symposium

Prof. Gary Walsh
2010
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BIO World Congress on Industrial Biotechnology & Bioprocessing

Prof. Gary Walsh
2012
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4th international congress on Green Process Engineering

Prof. Gary Walsh
2014
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Third International Science to Market Conference

Prof. Gary Walsh
2010
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15th International Pharmaceutical Technology Symposium

Prof. Gary Walsh
2010
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Proceedings of the 5th international conference on sustainable energy and environmental protection

Prof. Gary Walsh
2012
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4th international congress on Green Process Engineering

Dr. Tom O'Dwyer
Prof. Gary Walsh
2014
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Third Annual Biosimilars conference

Prof. Gary Walsh
2009
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The international conference on environmental science and technology (ICEST 2010)

Dr. Tom O'Dwyer
Prof. Gary Walsh
2010
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Third Brazilian Biotechnology Congress

Prof. Gary Walsh
2010
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Proceedings of the 5th international conference on sustainable energy and environmental protection

Dr. Tom O'Dwyer
Prof. Gary Walsh
2012
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Environ 2009

Dr. Tom O'Dwyer
Prof. Gary Walsh
2009
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5th Annual International Symposium on Environment

Dr. Tom O'Dwyer
Prof. Gary Walsh
2010
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Pharmaceutical Regulatory Affairs

Prof. Gary Walsh
2011
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Proceedings of the 5th international conference on sustainable energy and environmental protection

Prof. Gary Walsh
2012
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Environ 2009

Prof. Gary Walsh
2009
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EPA National Research Conference 2010

Prof. Gary Walsh
2010
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Proceedings of the 5th international conference on sustainable energy and environmental protection

Prof. Gary Walsh
2012
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42nd IUPAC Congress

Prof. Gary Walsh
2009
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EPA National Research Conference 2010

Dr. Tom O'Dwyer
Prof. Gary Walsh
2010
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Environ 2012

Prof. Gary Walsh
2012
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20th European Biomass Conference

Prof. Gary Walsh
2012
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Environ 2009

Dr. Tom O'Dwyer
Prof. Gary Walsh
2009
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EPA National Research Conference 2010

Dr. Tom O'Dwyer
Prof. Gary Walsh
2010
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the 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Prof. Gary Walsh
2012
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Environ 2014

Prof. Gary Walsh
2014
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Environ 2010

Prof. Gary Walsh
2010
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EPA National Research Conference 2010

Prof. Gary Walsh
2010
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BIO World Congress on Industrial Biotechnology & Bioprocessing

Dr. Tom O'Dwyer
Prof. Gary Walsh
2012
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Environ 2014

Prof. Gary Walsh
2014
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Conference Contributions

This author has not written any publications of this type yet.

Published Reports

This author has not written any publications of this type yet.

Editorials

This author has not written any publications of this type yet.

Book Reviews

This author has not written any publications of this type yet.

Other Publications

This author has not written any publications of this type yet.