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Prof. Gary Walsh

Research Interests

Enzyme biotechnology:  The development of renewable sources of liquid fuels as an alternative to fossil fuels is receiving increasing global attention due environmental, economic and energy security concerns.  The production of bioethanol from cellulose-based raw materials (e.g. grass, straw & wood) is at the forefront of this technology, but a major stumbling block is how to effectively degrade the cellulose to its glucose building blocks (the glucose is then fermented to ethanol, basically by brewing technology).  A major ongoing focus of my research group is the identification and use of enzymes (proteins that speed up chemical reactions) derived from thermoacidophilic bacteria (bugs that grow best in boiling acid) to more efficiently achieve cellulose degradation (a process that currently usually entails the use of boiling acid).  These enzymes are also academically interesting because they work best under such extreme conditions.  An additional focus of my research group is to identify selected enzymes produced by acidophilic bugs which can be used as digestive supplements in humans or animals (working in the acidic environs of the stomach).  For example, the identification of acid-active ‘lactase’ enzymes to degrade milk lactose in the stomach, thereby alleviating lactose intolerance (which effects up to 75% of the world’s adult population).   


 

Pharmaceutical biotechnology (Biopharmaceuticals):  Biopharmaceuticals are drugs (mainly proteins such as insulin and antibodies, but also pieces of DNA called ‘gene therapy’ products) that are synthesized biologically (as opposed to chemically), usually via genetic engineering.  These products are at the cutting edge of the pharmaceutical sector, recording sales of €107 billion in 2011.  My research in this area focuses largely upon altering the method of manufacturing (bioprocessing) of these products in order to achieve manufacturing more economically and making it more environmentally friendly in the process (green pharmaceutical manufacturing)  We also work on stabilizing such proteins by attaching a chemical called PEG to them, as well as on the identification & analysis of trends/ likely future directions in biopharmaceutical production systems/ products/regulatory science.   

Curriculum design.   
Curriculum design and development, particularly with reference to pharmaceutical biotechnology/ protein biotechnology.

Professional Activities

Education

  • 2009 University of Limerick - Graduate Diploma in Academic Practice
  • 1989 University College Galway - Ph.D.
  • 1986 University College Galway - B.Sc.

Award

  • 2006 - Special achievement in research award
  • 2003 - University of Limerick excellence in teaching award

Committee

  • 2004 International advisory committee, Pharma BioTec Europe 2004 conference,
  • 2002 Board of governors and executive committee, European Association of Pharma Biotechnology,
  • 2002 Scientific secretary, European Association of Pharma Biotechnology,

Employment

  • 1994 CES dept, UL. - Assistant lecturer
  • 1992 Alltech European Biosciences Research Centre - Senior research scientist
  • 1990 Vetrepharm Ireland - Production manager
  • 1989 Olympus diagnostics, Tulla. - Research scientist

Publications

Book

2008

Medical Product Regulatory Affairs
Tobin, J.J. and Walsh, G.

1994

Protein Biotechnology
Walsh, G; Headon, D

Book Chapter

2013

Posttranslational modifications to improve biopharmaceuticals
Walsh, G
Modern Biopharmaceuticals: recent success stories DOI: 10.1002/9783527669417.ch20

2011

Drug approval in the European Union and the United States
Walsh, G
An introduction to molecular biotechnology, second edition

2004

Drug approval in the European Union and the United States
Walsh, G
Applications of pharmaceutical biotechnology

1999

Biopharmaceutical regulatory affairs
Walsh, G
Biopharmaceuticals, an industrial perspective

1999

Biopharmaceuticals; an overview
Walsh, G
Biopharmaceuticals, an industrial perspective

1994

Biological control of pollution
Headon, DR; Walsh, G
Principles of pig science

1993

Industrial enzyme applications; matching enzyme to substrate in animal feed
Sears, A; Walsh, G
Biotechnology in the feed industry

Conference Publication

2014

Environ 2014
Ryan, M. and Walsh, G.

2014

Environ 2014
Boyce, A. and Walsh, G.

2012

Environ 2012
Boyce, A. and Walsh, G.

2012

20th European Biomass Conference
Boyce, A. and Walsh, G.

2011

Biotrends
Walsh, G.

2010

EPA National Research Conference 2010
Boyce, A. ans Walsh, G.

2010

Environ 2010
Boyce, A. and Walsh, G.

2009

Environ 2009
Boyce, A. and Walsh, G.

2009

42nd IUPAC Congress
Boyce, A., Piterina, A. and Walsh, G.

Edited Book

2009


Post-translational Modification of Protein Biopharmaceuticals

2006


Directory of Therapeutic Enzymes

Peer Reviewed Journal

2013
2012

New Biopharmaceuticals
Walsh, G
Biopharm International

2010

Engineering of a fungal beta-galactosidase to remove product inhibition by galactose
Hu, XJ; Robin, S; O'Connell, S; Walsh, G; Wall, JG
Applied Microbiology And Biotechnology DOI: 10.1007/s00253-010-2662-8

2010

Biopharmaceutical Approval Trends in 2009
Walsh, G
Biopharm International

2010

Biopharmaceutical benchmarks 2010
Walsh, G
Nature Biotechnology DOI: 10.1038/nbt0910-917

2010

The importance of and an approach to comprehensive reflective practice
Walsh, G.
Biochemistry And Molecular Biology Education DOI: 10.1002/bmb.20370

2009

Biopharmaceuticals: Approval Trends in 2008
Walsh, G
Biopharm International

2008

Biopharmaceuticals: Approval Trends in 2007
Walsh, G
Biopharm International

2007

Protein engineering - Case studies of commercialized engineered products
Walsh, G
Biochemistry And Molecular Biology Education DOI: 10.1002/bmb.21

2007

Approval trends in 2006
Walsh, G
Biopharm International

2007

Engineering biopharmaceuticals
Walsh, G
Biopharm International

2006

Biopharmaceuticals: Approval trends in 2005
Walsh, G
Biopharm International

2006

Biopharmaceutical benchmarks 2006
Walsh, G
Nature Biotechnology DOI: 10.1038/nbt0706-769

2006
2006

Comparison of selected physicochemical characteristics of commercial phytases relevant to their application in phosphate pollution abatement
Boyce, A; Walsh, G
Journal Of Environmental Science And Health Part A-Toxic/Hazardous Substances & Environmental Engineering DOI: 10.1080/10934520600614397

2005
2005
2005

Quantification of supplemental enzymes in animal feedingstuffs by radial enzyme diffusion
Walsh, G; Murphy, RA; Killeen, GF; Power, RF
Applied Microbiology And Biotechnology DOI: 10.1007/s00253-004-1826-9

2005
2005

The use of proteases to remove protein-based residues from solid surfaces
Turner, K; Serantoni, M; Boyce, A; Walsh, G
Process Biochemistry DOI: 10.1016/j.procbio.2005.03.040

2005

Scaling the biobusiness information mountain
Williams, G; Walsh, G
Nature Biotechnology DOI: 10.1038/bioent836

2005

Therapeutic insulins and their large scale manufacture
Walsh, G
Applied Microbiology And Biotechnology

2004

Modern antibody-based therapeutics
Walsh, G
Biopharm International

2004

Thermostable phytase enzyme
Walsh G.
Industrial Bioprocessing

2004

Second generation biopharmaceuticals
Walsh, G
European J. Pharmaceutics & Biopharmaceutics

2003

Biopharmaceutical benchmarks - 2003
Walsh, G
Nature Biotechnology DOI: 10.1038/nbt0803-865

2003

Pharmaceutical biotechnology products approved within the European Union
Walsh, G
European J. Pharmaceutics & Biopharmaceutics

2002
2002
2001

Biopharmaceuticals
Walsh, G
New Drugs

2001

Monoclonal antibody based therapeutics
Walsh, G
Pharmaceutical Technology Europe

2000

Biopharmaceutical benchmarks
Walsh, G
Nature Biotechnology DOI: 10.1038/78720

1998

Antimicrobial Saponins of Yucca schidigera and the Implications of Their in Vitro Properties for Their in Vivo Impact
Killeen G.F., Madigan C.A., Connolly C.R., Walsh G.A., Clark C., Hynes M.J., Timmins B.F., James P., Headon D.R., Power R.F.
Journal Of Agricultural And Food Chemistry

1998

A simple immunoassay-based system capable of detecting antibody raised against human IgG
Walsh, G; O'Shaughnessy, B; Shanley, N; Tobin, JJ
Biochemical Education DOI: 10.1016/S0307-4412(98)00049-1

1996

Biopharmaceuticals, the future
Walsh, G
The Biologist

1996

Enzymes, the workhorses of biotechnology
Walsh, G; Adley, C; Pembroke, JT
The Biologist

1995
1995

Technical note: detection and quantification of supplemental beta glucanase activity in animal feed.
Walsh, G., Murphy, R., Killeen, G., Headon, D. and Power, R.
Journal Of Animal Science

1995

Nervous excitement over neurotrophic factors
Walsh G.
Nature Biotechnology

1994

Influence of Yucca Shidigera preparations on the activity of urease from Bacillus pasteurii
Killeen, G., Buggle, K. Hynes. M., Walsh, G. Power, R. and Headon, D
Journal Of The Science Of Food And Agriculture

1994

The industrial production of enzymes.
Headon, D. and Walsh, G.
Biotechnology Advances

1994

Enzymes in the animal feed industry
Walsh, G. Power, R. and Headon, D.
Trends In Food Science & Technology

1994

Recombinant reproduction
DeKoning, W., Walsh, G., Wrenn, A., and Headon, D.
Nature Biotechnology

1993

Enzymes in the animal feed industry
walsh, G. Power, R. and Headon, D.
Trends In Biotechnology