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Emeritus Prof Michael Larvin

MB BS, MRCS, LRCP, MD, MA, FRCPS(Glas),

Research Interests

Pancreatic disease: acute and chronic pancreatitis, pancreatic cancer.  Obesity including bariatric surgery. GI surgery including minimally invasive procedures and flexible endoscopy.  Clinical trialling and systematic reviews. Surgical training and educational technology.

Teaching Interests

Basic medical sciences, post-graduate surgical training, multiprofessional learning, high-fidelity simulation, e-learning.

Professional Activities

Committee

  • 2012 An Bord Altranais agus Cnáimhseachais na hÉireann, Nominated to represent Irish Education 3rd sector - December 2012.

Publications

Other Journal

2012

Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study
Phillips B, Smith K, Liptrot S, Atherton P, Varadhan K, Rennie MJ, Larvin M, Lund JN, Williams JP
Journal of Cachexia, Sarcopenia and Muscle DOI: 10.1007/s13539-012-0073-7

2012

Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review.
Mitchell WK, Williams J, Atherton P, Larvin M, Lund J, Narici M.
Frontiers in Physiology DOI: 10.3389/fphys.2012.00260

Peer Reviewed Journal

2013

Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study.
Phillips BE, Smith K, Liptrot S, Atherton PJ, Varadhan K, Rennie MJ, Larvin M, Lund JN, Williams JP
Journal of cachexia, sarcopenia and muscle DOI: 10.1007/s13539-012-0073-7

2013

Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study
Phillips, B. E.,Smith, K.,Liptrot, S.,Atherton, P. J.,Varadhan, K.,Rennie, M. J.,Larvin, M.,Lund, J. N.,Williams, J. P.
J Cachexia Sarcopenia Muscle DOI: 10.1007/s13539-012-0073-7

2012

Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
Alhamoruni A, Wright KL, Larvin M, O'Sullivan SE.
British Journal Of Pharmacology DOI: 10.1111/j.1476-5381.2011.01589.x

2012

Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
Alhamoruni, A.,Wright, K. L.,Larvin, M.,O'Sullivan, S. E.
Br J Pharmacol

2012

MicroRNAs: Relevant Tools for a Colorectal Surgeon?
Peacock, O.,Lee, A. C.,Larvin, M.,Tufarelli, C.,Lund, J. N.
World Journal of Surgery DOI: 10.1007/s00268-012-1603-3

2012

MicroRNAs: relevant tools for a colorectal surgeon?
Peacock O, Lee AC, Larvin M, Tufarelli C, Lund JN
World Journal Of Surgery DOI: 10.1007/s00268-012-1603-3

2012
2012

Effect of tumor burden and subsequent surgical resection on skeletal muscle mass and protein turnover in colorectal cancer patients
Williams, J. P.,Phillips, B. E.,Smith, K.,Atherton, P. J.,Rankin, D.,Selby, A. L.,Liptrot, S.,Lund, J.,Larvin, M.,Rennie, M. J.
Am J Clin Nutr DOI: 10.3945/ajcn.112.045708

2012

Effect of tumor burden and subsequent surgical resection on skeletal muscle mass and protein turnover in colorectal cancer patients.
Williams JP, Phillips BE, Smith K, Atherton PJ, Rankin D, Selby AL, Liptrot S, Lund J, Larvin M, Rennie MJ
The American journal of clinical nutrition DOI: 10.3945/ajcn.112.045708

2012

MicroRNAs: relevant tools for a colorectal surgeon?
Peacock, O.,Lee, A. C.,Larvin, M.,Tufarelli, C.,Lund, J. N.
World J Surg

2011

Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma
Bhatti, I.,Lee, A.,James, V.,Hall, R. I.,Lund, J. N.,Tufarelli, C.,Lobo, D. N.,Larvin, M.
J Gastrointest Surg

2011

An unusual cause of dysuria
Kwak, H. C.,Tan, G.,Rickers, L.,Leeder, P.,Larvin, M.
Ann R Coll Surg Engl

2011

Upregulated Micro-RNA 21 targets PDCD4 inhibiting pancreatic cancer proliferation
Bhatti, I.,Lee, A.,Tufarelli, C.,Lund, J. N.,Hall, R. I.,Lobo, D. N.,Larvin, M.
British Journal of Surgery

2011

Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma
Bhatti, I.,Lee, A.,James, V.,Hall, R. I.,Lund, J. N.,Tufarelli, C.,Lobo, D. N.,Larvin, M.
Journal of Gastrointestinal Surgery DOI: 10.1007/s11605-010-1381-x

2011

Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma.
Bhatti I, Lee A, James V, Hall RI, Lund JN, Tufarelli C, Lobo DN, Larvin M
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract DOI: 10.1007/s11605-010-1381-x

2011

Increased BMI does not adversely affect vascular function measured in vitro in obese patients
Kwak, H. C.,Larvin, M.,O'Sullivan, S.
British Journal of Surgery

2010

Upregulated Micro-RNA 21 Targets PDCD4 and Inhibits Proliferation in Pancreatic Cancer
Bhatti, I.,Lee, V.,Lee, A.,Lund, J. N.,Hall, R. I.,Tufarelli, C.,Lobo, D.,Larvin, M.
Pancreas

2010

Antibacterial prophylaxis does not prevent mortality nor infection of pancreatic necrosis in acute pancreatitis
Villatoro, E.,Hill, P.,Mulla, M.,Hall, R. I.,Larvin, M.
British Journal of Surgery

2010

Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability
Alhamoruni, A.,Lee, A. C.,Wright, K. L.,Larvin, M.,O'Sullivan, S. E.
J Pharmacol Exp Ther

2010

A pre-operative elevated neutrophil: lymphocyte ratio does not predict survival from oesophageal cancer resection
Rashid, F.,Waraich, N.,Bhatti, I.,Saha, S.,Khan, R. N.,Ahmed, J.,Leeder, P. C.,Larvin, M.,Iftikhar, S. Y.
World J Surg Oncol DOI: 10.1186/1477-7819-8-1

2010
2010

A review article on gastric volvulus: a challenge to diagnosis and management
Rashid, F.,Thangarajah, T.,Mulvey, D.,Larvin, M.,Iftikhar, S. Y.
Int J Surg

2010

A potential new biomarker and treatment for oesophageal cancer
Rashid, F.,Warren, A.,Lee, A.,Leeder, P. C.,Larvin, M.,Khan, R.,Iftikhar, S. Y.
British Journal of Surgery

2010

A phase Ib/IIa trial to evaluate the CCK2 receptor antagonist Z-360 in combination with gemcitabine in patients with advanced pancreatic cancer
Meyer, T.,Caplin, M. E.,Palmer, D. H.,Valle, J. W.,Larvin, M.,Waters, J. S.,Coxon, F.,Borbath, I.,Peeters, M.,Nagano, E.,Kato, H.
Eur J Cancer DOI: 10.1016/j.ejca.2009.11.004

2010
2010

Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability
Alhamoruni, A.,Lee, A. C.,Wright, K. L.,Larvin, M.,O'Sullivan, S. E.
Journal of Pharmacology and Experimental Therapeutics DOI: 10.1124/jpet.110.168237

2010

A review article on gastric volvulus: A challenge to diagnosis and management
Rashid, F.,Thangarajah, T.,Mulvey, D.,Larvin, M.,Iftikhar, S. Y.
International Journal of Surgery DOI: 10.1016/j.ijsu.2009.11.002

2009

Small RNA: A Large Contributor to Carcinogenesis?
Bhatti, I.,Lee, A.,Lund, J.,Larvin, M.
Journal of Gastrointestinal Surgery DOI: 10.1007/s11605-009-0887-6

2009

Urinary iFABP: An Instant Predictor of Outcome From Acute Pancreatitis?
Villatoro, E.,Silk, R.,Mulla, M.,Hall, R.,Larvin, M.
Pancreas

2009

Small RNA: a large contributor to carcinogenesis?
Bhatti, I.,Lee, A.,Lund, J.,Larvin, M.
J Gastrointest Surg

2009

Antibacterial Prophylaxis in Pancreatic Necrosis: The Final Word?
Villatoro, E.,Mulla, M.,Hall, R.,Larvin, M.
Pancreas

2008

Diagnosis of biliary adenomyomatosis
Mulla, M. G.,Srivastava, V.,Hopper, I.,Klein, J.,Larvin, M.,Hall, R.
European Surgery-Acta Chirurgica Austriaca

2008

The SPINK1 N34S variant is associated with acute pancreatitis
O'Reilly, D. A.,Witt, H.,Rahman, S. H.,Schulz, H. U.,Sargen, K.,Kage, A.,Cartmell, M. T.,Landt, O.,Larvin, M.,Demaine, A. G.,McMahon, M. J.,Becker, M.,Kingsnorth, A. N.
Eur J Gastroenterol Hepatol

2008

A phase IB/IIA, multicentre, randomised, double-blind placebo controlled study to evaluate the safety and pharmacokinetics of Z-360 in subjects with unresectable advanced pancreatic cancer in combination with gemcitabine
Meyer, T.,Caplin, M.,Palmer, D.,Valle, J. W.,Larvin, M.,Waters, J.,Coxon, F.,Borbath, I.,Peeters, M.,Nagano, E.,Kato, H.
Journal of Clinical Oncology

2008

Antibacterial prophylaxis does not prevent infection of pancreatic necrosis in acute pancreatitis
Villatoro, E. A.,Mulla, M. G.,Hall, R. I.,Larvin, M.
Gastroenterology

2008

Which pre-operative factors predict adequate weight loss following laparoscopic gastric band insertion?
Mulla, M. G.,Singh, R.,Clarke, D.,Rickers, L.,Cresswell, K.,Parry, L.,Leeder, P. C.,Larvin, M.,Tan, G. D.
International Journal of Obesity

2008

The SPINK1 N34S variant is associated with acute pancreatitis
O'Reilly, D. A.,Witt, H.,Rahman, S. H.,Schulz, H. U.,Sargen, K.,Kage, A.,Cartmell, M. T.,Landt, F.,Larvin, M.,Demaine, A. G.,McMahon, M. J.,Becker, M.,Kingsnorth, A. N.
European Journal of Gastroenterology & Hepatology

2008

Management of infected pancreatic necrosis
Larvin, M.
Curr Gastroenterol Rep

2007

Large bowel obstruction due to sesame seed bezoar: a case report
Shaw, A. G.,Peacock, O.,Lund, J. N.,Tierney, G. M.,Larvin, M.,Speake, W.
J Med Case Rep

2006
2005

Clinical presentation and delayed treatment of cholangitis in older people
Rahman, S. H.,Larvin, M.,McMahon, M. J.,Thompson, D.
Dig Dis Sci

2005
2004

Association of antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis
Rahman, S. H.,Ibrahim, K.,Larvin, M.,Kingsnorth, A.,McMahon, M. J.
Gastroenterology

2004

Soluble CD14 receptor expression and monocyte heterogeneity but not the C-260T CD14 genotype are associated with severe acute pancreatitis
Rahman, S. H.,Salter, G.,Holmfield, J. H. M.,Larvin, M.,McMahon, M. J.
Critical Care Medicine

2003

Micropuncture cholecystectomy vs conventional laparoscopic cholecystectomy - A randomized controlled trial
Ainslie, W. G.,Catton, J. A.,Davides, D.,Dexter, S.,Gibson, J.,Larvin, M.,McMahon, M. J.,Moore, M.,Smith, S.,Vezakis, A.
Surgical Endoscopy and Other Interventional Techniques

2003

Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration in patients with presumed pancreatic cancer - Discussion
Way, L. W.,Raut, C. P.,Larvin, M.,Kirkwood, K. S.,Yeo, C. J.,Drebin, J. A.
Journal of Gastrointestinal Surgery

2003
2003

Hypocalcemia in patients with acute pancreatitis: A putative role for systemic endotoxin exposure
Ammori, B. J.,Barclay, G. R.,Larvin, M.,McMahon, M. J.
Pancreas

2003

Micropuncture cholecystectomy vs conventional laparoscopic cholecystectomy: a randomized controlled trial
Ainslie, W. G. and Catton, J. A. and Davides, D. and Dexter, S. and Gibson, J. and Larvin, M. and McMahon, M. J. and Moore, M. and Smith, S. and Vezakis, A.
Surg Endosc

2003

Micropuncture cholecystectomy vs conventional laparoscopic cholecystectomy - A randomized controlled trial
Ainslie, W. G.,Catton, J. A.,Davides, D.,Dexter, S.,Gibson, J.,Larvin, M.,McMahon, M. J.,Moore, M.,Smith, S.,Vezakis, A.
Surgical Endoscopy and Other Interventional Techniques

2003

Calcitonin precursors in the prediction of severity of acute pancreatitis on the day of admission
Ammori, B. J.,Becker, K. L.,Kite, P.,Snider, R. H.,Nylén, E. S.,White, J. C.,Larvin, M.,McMahon, M. J.
Br J Surg

2003

Intestinal hypoperfusion contributes to gut barrier failure in severe acute pancreatitis
Rahman, S. H.,Ammori, B. J.,Holmfield, J.,Larvin, M.,McMahon, M. J.
J Gastrointest Surg

2003

Calcitonin precursors: early markers of gut barrier dysfunction in patients with acute pancreatitis
Ammori, B. J.,Becker, K. L.,Kite, P.,Snider, R. H.,Nylén, E. S.,White, J. C.,Barclay, G. R.,Larvin, M.,McMahon, M. J.
Pancreas

2003

Day-case laparoscopic cholecystectomy: a prospective evaluation of a 6-year experience
Ammori, B. J.,Davides, D.,Vezakis, A.,Martin, I. G.,Larvin, M.,Smith, S.,Gibson, J. S.,McMahon, M. J.
J Hepatobiliary Pancreat Surg

2003

Micropuncture cholecystectomy vs conventional laparoscopic cholecystectomy: a randomized controlled trial
Ainslie, W. G.,Catton, J. A.,Davides, D.,Dexter, S.,Gibson, J.,Larvin, M.,McMahon, M. J.,Moore, M.,Smith, S.,Vezakis, A.
Surg Endosc

2003

Laparoscopic management of pseudocysts of the pancreas
Ainslie, W. G.,Maude, K. M.,Catton, J. A.,Ammori, B. J.,Larvin, M.,McMahon, M. J.
British Journal of Surgery

2003

Laparoscopic cholecystectomy - Are patients with biliary pancreatitis at increased operative risk?
Ammori, B. J.,Davides, D.,Vezakis, A.,Larvin, M.,McMahon, M. J.
Surgical Endoscopy and Other Interventional Techniques

2003

Hypocalcemia in patients with acute pancreatitis: a putative role for systemic endotoxin exposure
Ammori, B. J.,Barclay, G. R.,Larvin, M.,McMahon, M. J.
Pancreas

2003

Laparoscopic cholecystectomy: are patients with biliary pancreatitis at increased operative risk?
Ammori, B. J.,Davides, D.,Vezakis, A.,Larvin, M.,McMahon, M. J.
Surg Endosc

2002

Calcitonin precursors (CTpr): early markers of gut barrier dysfunction in patients with acute pancreatitis
Ammori, B. J.,Becker, K. L.,Kite, P.,Snider, R. H.,Nylen, E. S.,White, J. C.,Barclay, G. R.,Larvin, M.,McMahon, M. J.
British Journal of Surgery

2002

Down-regulation of hepatic function, the acute phase response and severe gallstone pancreatitis
Rahman, S. H.,Larvin, M.,McMahon, M. J.
British Journal of Surgery

2002

Altered intestinal morphology and immunity in patients with acute necrotizing pancreatitis
Ammori, B. J.,Cairns, A.,Dixon, M. F.,Larvin, M.,McMahon, M. J.
J Hepatobiliary Pancreat Surg

2002

Does pneumatic dilatation affect the outcome of laparoscopic cardiomyotomy?
Dolan, K.,Zafirellis, K.,Fountoulakis, A.,Martin, I. G.,Dexter, S. P.,Larvin, M.,McMahon, M. J.
Surg Endosc

2002

Cyst-gastrostomy via the cyst: an unusual laparoscopic approach
Ainslie, W. G.,Larvin, M.,McMahon, M. J.
Endoscopy

2002

Ischaemia-reperfusion injury, gut macromolecular permeability and severe acute pancreatitis
Rahman, S. H.,James, A. M.,Ammori, B.,Larvin, M.,McMahon, M. J.
British Journal of Surgery

2002

Intraoperative cholangiography during laparoscopic cholecystectomy - The author replies
McMahon, M. J.,Vezakis, A.,Davides, D.,Ammori, B. J.,Martin, I. G.,Larvin, M.
Surgical Endoscopy and Other Interventional Techniques

2001

Laparoscopic cholecystectomy in morbidly obese patients
Ammori, B. J.,Vezakis, A.,Davides, D.,Martin, I. G.,Larvin, M.,McMahon, M. J.
Surg Endosc

2001

A rapid and systematic review of the clinical effectiveness and cost-effectiveness of gemcitabine for the treatment of pancreatic cancer
Ward, S.,Morris, E.,Bansback, N.,Calvert, N.,Crellin, A.,Forman, D.,Larvin, M.,Radstone, D.
Health Technol Assess

2001
2001

Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis
Johnson, C. D.,Kingsnorth, A. N.,Imrie, C. W.,McMahon, M. J.,Neoptolemos, J. P.,McKay, C.,Toh, S. K.,Skaife, P.,Leeder, P. C.,Wilson, P.,Larvin, M.,Curtis, L. D.
Gut

2000

Relaparoscopy for the detection and treatment of complications of laparoscopic cholecystectomy
Dexter, S. P.,Miller, G. V.,Davides, D.,Martin, I. G.,Sue Ling, H. M.,Sagar, P. M.,Larvin, M.,McMahon, M. J.
Am J Surg

2000

Laparoscopic treatment of Mirizzi syndrome
Vezakis, A.,Davides, D.,Birbas, K.,Ammori, B. J.,Larvin, M.,McMahon, M. J.
Surg Laparosc Endosc Percutan Tech

2000

Intraoperative cholangiography during laparoscopic cholecystectomy
Vezakis, A.,Davides, D.,Ammori, B. J.,Martin, I. G.,Larvin, M.,McMahon, M. J.
Surg Endosc

2000
2000

Liver retraction techniques for laparoscopic cholecystectomy
Ainslie, W. B.,Larvin, M.,Martin, I. G.,McMahon, M. J.
Surg Endosc

1999

Randomized comparison between low-pressure laparoscopic cholecystectomy and gasless laparoscopic cholecystectomy
Vezakis, A. and Davides, D. and Gibson, J. S. and Moore, M. R. and Shah, H. and Larvin, M. and McMahon, M. J.
Surg Endosc

1999

Randomized comparison between low-pressure laparoscopic cholecystectomy and gasless laparoscopic cholecystectomy
Vezakis, A.,Davides, D.,Gibson, J. S.,Moore, M. R.,Shah, H.,Larvin, M.,McMahon, M. J.
Surg Endosc

1999

Randomized comparison between low-pressure laparoscopic cholecystectomy and gasless laparoscopic cholecystectomy
Vezakis, A. and Davides, D. and Gibson, J. S. and Moore, M. R. and Shah, H. and Larvin, M. and McMahon, M. J.
Surg Endosc

1999

Micropuncture laparoscopic cholecystectomy
Davides, D.,Dexter, S. P.,Vezakis, A.,Larvin, M.,Moran, P.,McMahon, M. J.
Surg Endosc

1999

Early increase in intestinal permeability in patients with severe acute pancreatitis: correlation with endotoxemia, organ failure, and mortality
Ammori, B. J.,Leeder, P. C.,King, R. F.,Barclay, G. R.,Martin, I. G.,Larvin, M.,McMahon, M. J.
J Gastrointest Surg

1999

Laparoscopic surgery combined with preservation of the spleen for distal pancreatic tumors
Vezakis, A.,Davides, D.,Larvin, M.,McMahon, M. J.
Surg Endosc

1998

Laparoscopic cholecystectomy after pancreatic debridement
Vezakis, A.,Dexter, S. P.,Martin, I. G.,Larvin, M.,McMahon, M. J.
Surg Endosc

1997

When should you suspect pancreatitis?
Larvin, M.
Practitioner

1997

Assessment of severity and prognosis in acute pancreatitis
Larvin, M.
Eur J Gastroenterol Hepatol

1997

T2-weighted and dynamic enhanced MRI in acute pancreatitis: comparison with contrast enhanced CT
Ward, J.,Chalmers, A. G.,Guthrie, A. J.,Larvin, M.,Robinson, P. J.
Clin Radiol

1997

Fatal hepatic air embolism following ERCP
Kennedy, C.,Larvin, M.,Linsell, J.
Gastrointest Endosc

1996
1994
1990

Gastric volvulus: a rare cause of hyperamylasaemia
Williams, L.,Lansdown, M. R.,Larvin, M.,Ward, D. C.
Br J Clin Pract

1989

Debridement and closed cavity irrigation for the treatment of pancreatic necrosis
Larvin, M.,Chalmers, A. G.,Robinson, P. J.,McMahon, M. J.
Br J Surg

1988

Hyperamylasaemia
Larvin, M.,McMahon, M. J.
J R Coll Surg Edinb

1988

Intra-peritoneal aprotinin therapy for acute pancreatitis. Preliminary pharmacodynamic studies
Larvin, M.,Mayer, A. D.,McMahon, M. J.,Müller-Esterl, W.,Fritz, H.
Biol Chem Hoppe Seyler

1988

Plasmapheresis and fulminant acute pancreatitis?
Larvin, M.,Lansdown, M. R.,McMahon, M. J.,Chalmer, A. G.,Turney, J. H.,Brownjohn, A. M.
BMJ

1988

Plasmapheresis: a rational treatment for fulminant acute pancreatitis?
Larvin, M.,Lansdown, M. R.,McMahon, M. J.,Chalmers, A. G.,Turney, J. H.,Brownjohn, A. M.
BMJ

1987