Biography

Professor Pat Kiely is a Lecturer in the Department of Life Sciences, Principal Investigator of the Laboratory of Cellular and Molecular Biology, and member of the Materials and Surface Science Institute and Stokes Institute. Dr Kiely has a BSc. in Biomedical Science and a PhD in Biochemistry from University College Cork. Dr Kiely's work has led to a number of significant publications which were the foundation to the acquisition of several prestigious postdoctoral fellowships and international awards including European Association for Cancer Research (EACR) Young Scientist Award (2010), The Irish Cancer Society Research Fellowship (2009), The Roche Gold Medal for Postdoctoral researcher of the year (2007) The Pfizer Gold medal for Excellence in Research in 2007 and 2002, Career Development Fellowship (HRB, 2005) and Young Investigator of the Year 2006, awarded by the Biochemical Society, UK.

Research Interests:
The research emphasis in my laboratory is on deciphering the localized and transient signalling events which occur in cells during migration. Cell migration is orchestrated by a series of complex signalling cascades which requires crosstalk between cell surface receptors and components of the cell cytoskeleton. Understanding the molecular mechanisms that regulate cell migration is of important intellectual and clinical interest, and we believe this work may reveal fresh approaches to target cancer as well as developmental and neurodegenerative diseases.

Research projects ongoing in the laboratory range from the most fundamental, where the development of a better understanding of the molecular mechanism(s) regulating cell migration is the goal, to the very applied, where the identification of novel therapeutic targets and the design and synthesis of novel materials and surfaces to study cell behavior is the desired endpoint. To help us achieve our goals, we are using a series of complimentary and synergistic cellular and molecular approaches and novel technologies including: 3D cell culture models, neuronal models, 2D ESI MS/MS, peptide array technology, interferometry, label free live cell monitoring, qPCR and droplet qPCR, SEM, TEM, con-focal microscopy, and electro spinning of materials. In collaboration with Dr Tara Daltons group (Stokes Institute) we are applying novel gene expression techniques and droplet technology to decipher signaling pathways in breast and colon cancer.

Research Interests

Peer Reviewed Journals

2021

Communication, collaboration and contagion: "Virtualisation" of anatomy during COVID-19.

Byrnes KG;Kiely PA;Dunne CP;McDermott KW;Coffey JC; (2021) Communication, collaboration and contagion: "Virtualisation" of anatomy during COVID-19.. Clinical Anatomy

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2021

Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism

Dwivedi, A;Kiely, PA;Hoey, DA (2021) Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism. SAN DIEGO : ACADEMIC PRESS INC ELSEVIER SCIENCE Biochemical and biophysical research communications :14-20

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2020

The relationship between post-surgery infection and breast cancer recurrence.

O'Connor RÍ;Kiely PA;Dunne CP; (2020) The relationship between post-surgery infection and breast cancer recurrence.. Journal Of Hospital Infection

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2018

Inclusion of the Mesentery in Ileocolic Resection for Crohn's Disease is Associated With Reduced Surgical Recurrence

Coffey, CJ;Kiernan, MG;Sahebally, SM;Jarrar, A;Burke, JP;Kiely, PA;Shen, B;Waldron, D;Peirce, C;Moloney, M;Skelly, M;Tibbitts, P;Hidayat, H;Faul, PN;Healy, V;O'Leary, PD;Walsh, LG;Dockery, P;O'Connell, RP;Martin, ST;Shanahan, F;Fiocchi, C;Dunne, CP (2018) Inclusion of the Mesentery in Ileocolic Resection for Crohn's Disease is Associated With Reduced Surgical Recurrence. OXFORD : OXFORD UNIV PRESS Journal Of Crohns &Amp; Colitis :1139-1150

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2018

ATP synthase F-1 subunits recruited to centromeres by CENP-A are required for male meiosis

Collins, CM;Malacrida, B;Burke, C;Kiely, PA;Dunleavy, EM (2018) ATP synthase F-1 subunits recruited to centromeres by CENP-A are required for male meiosis. LONDON : NATURE PUBLISHING GROUP Nature Communications

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2018

Regulation of muscle protein synthesis in an in vitro cell model using ex vivo human serum

Carson, BP;Patel, B;Amigo-Benavent, M;Pauk, M;Gujulla, S;Murphy, S;Kiely, PA;Jakeman, PM (2018) Regulation of muscle protein synthesis in an in vitro cell model using ex vivo human serum. HOBOKEN : WILEY Experimental Physiology :783-789

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2017

RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells

Kiely, M,Adams, DR,Hayes, SL,O'Connor, R,Baillie, GS,Kiely, PA (2017) RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells. Cellular signalling :290-300

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2017

P026 The role of fibrocytes in mesenteric Crohn's disease.

Kiernan MG, Sahebally SM, Kiely PA, Waldron D, Moloney M, Skelly M, Faul PN, O'Leary DP, Lowery AJ, Walsh LG, Dunne CP, Coffey JC. (2017) P026 The role of fibrocytes in mesenteric Crohn's disease.. Journal of Crohn's & colitis :S92-S93

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2017

Enhanced cell viability in hyaluronic acid coated poly(lactic-co-glycolic acid) porous scaffolds within microfluidic channels

Zamboni, F,Keays, M,Hayes, S,Albadarin, AB,Walker, GM,Kiely, PA,Collins, MN (2017) Enhanced cell viability in hyaluronic acid coated poly(lactic-co-glycolic acid) porous scaffolds within microfluidic channels. International journal of pharmaceutics :595-602

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2017

Expression of protein kinase C gamma promotes cell migration in colon cancer

Dowling, CM,Hayes, SL,Phelan, JJ,Cathcart, MC,Finn, SP,Mehigan, B,McCormick, P,Coffey, JC,O'Sullivan, J,Kiely, PA (2017) Expression of protein kinase C gamma promotes cell migration in colon cancer. Oncotarget :72096-72107

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2017

Mutant p53: a novel target for the treatment of patients with triple-negative breast cancer?

Synnott, NC,Murray, A,McGowan, PM,Kiely, M,Kiely, PA,O'Donovan, N,O'Connor, DP,Gallagher, WM,Crown, J,Duffy, MJ (2017) Mutant p53: a novel target for the treatment of patients with triple-negative breast cancer?. International Journal Of Cancer :234-246

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2016

Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival

Dowling, CM,Phelan, J,Callender, JA,Cathcart, MC,Mehigan, B,McCormick, P,Dalton, T,Coffey, JC,Newton, AC,O'Sullivan, J,Kiely, PA (2016) Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival. Oncotarget :20919-20933

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2016

Rapid identification of antibiotic resistance using droplet microfluidics

Keays, MC,O'Brien, M,Hussain, A,Kiely, PA,Dalton, T (2016) Rapid identification of antibiotic resistance using droplet microfluidics. Bioengineered :79-87

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2016

Activation of the cAMP Pathway Induces RACK1-Dependent Binding of beta-Actin to BDNF Promoter

Neasta, J,Fiorenza, A,He, DY,Phamluong, K,Kiely, PA,Ron, D (2016) Activation of the cAMP Pathway Induces RACK1-Dependent Binding of beta-Actin to BDNF Promoter. Plos One

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2016

The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue.

Dowling CM;Dara Walsh;Coffey JC;Kiely PA; (2016) The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue.. F1000research

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2016

The presence of C/EBP alpha and its degradation are both required for TRIB2-mediated leukaemia

O'Connor, C,Lohan, F,Campos, J,Ohlsson, E,Salome, M,Forde, C,Artschwager, R,Liskamp, RM,Cahill, MR,Kiely, PA,Porse, B,Keeshan, K (2016) The presence of C/EBP alpha and its degradation are both required for TRIB2-mediated leukaemia. Oncogene :5272-5281

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2016

Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.

Dowling CM;James J. Phelan;Callender JA;Cathcart MC;Brian J Mehigan;Paul mccormick;Dalton T;Coffey JC;Newton AC;Jacintha O'Sullivan;Kiely PA; (2016) Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.. Oncotarget

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2016

Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification

Hayes, CJ,Dowling, CM,Dwane, S,McCumiskey, ME,Tormey, SM,Merrigan, BA,Coffey, JC,Kiely, PA,Dalton, TM (2016) Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification. Biomicrofluidics

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2016

Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies

Houston, A,Williams, JM,Rovis, TL,Shanley, DK,O'Riordan, RT,Kiely, PA,Ball, M,Barry, OP,Kelly, J,Fanning, A,MacSharry, J,Mandelboim, O,Singer, BB,Jonjic, S,Moore, T (2016) Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies. Mabs :491-500

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2016

Studying protein-protein interactions: progress, pitfalls and solutions

Hayes, S,Malacrida, B,Kiely, M,Kiely, PA (2016) Studying protein-protein interactions: progress, pitfalls and solutions. Biochemical Society Transactions :994-1004

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2016

Optimization of an in vitro bioassay to monitor growth and formation of myotubes in real time

Murphy, SM,Kiely, M,Jakeman, PM,Kiely, PA,Carson, BP (2016) Optimization of an in vitro bioassay to monitor growth and formation of myotubes in real time. Bioscience reports

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2015

Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling.

Dowling CM, Kiely PA (2015) Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling.. Cancers :1271-1291

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2015

Real-time cell analysis of the inhibitory effect of vitamin K-2 on adhesion and proliferation of breast cancer cells

Kiely, M,Hodgins, SJ,Merrigan, BA,Tormey, S,Kiely, PA,O'Connor, EM (2015) Real-time cell analysis of the inhibitory effect of vitamin K-2 on adhesion and proliferation of breast cancer cells. Nutrition Research :736-743

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2015

High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol

Bezuidenhout, M,Kennedy, T,Belochapkine, S,Guo, Y,Mullane, E,Kiely, PA,Ryan, KM (2015) High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol. Journal Of Materials Chemistry C :7455-7462

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2015

Real-time cell analysis of the inhibitory effect of vitamin K<sub>2</sub> on adhesion and proliferation of breast cancer cells.

Kiely M, Hodgins SJ, Merrigan BA, Tormey S, Kiely PA, O'Connor EM (2015) Real-time cell analysis of the inhibitory effect of vitamin K<sub>2</sub> on adhesion and proliferation of breast cancer cells.. Nutrition Research

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2015

PP2A: The Wolf in Sheep's Clothing?

Kiely M, Kiely PA (2015) PP2A: The Wolf in Sheep's Clothing?. Cancers :648-669

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2015

Mapping the interaction of B cell leukaemia 3 (Bcl-3) and nuclear factor κB (NF-κB) p50 identifies a Bcl-3-mimetic anti-inflammatory peptide.

Collins PE, Grassia G, Colleran A, Kiely PA, Ialenti A, Maffia P, Carmody RJ (2015) Mapping the interaction of B cell leukaemia 3 (Bcl-3) and nuclear factor κB (NF-κB) p50 identifies a Bcl-3-mimetic anti-inflammatory peptide.. The Journal of biological chemistry

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2014

Promoting Cell Proliferation Using Water Dispersible Germanium Nanowires

Bezuidenhout, M,Liu, P,Singh, S,Kiely, M,Ryan, KM,Kiely, PA (2014) Promoting Cell Proliferation Using Water Dispersible Germanium Nanowires. Plos One

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2014

Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells

Dowling, CM,Ors, CH,Kiely, PA (2014) Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells. Bioscience reports :415-127

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2014

Inhibition of transcription by B Cell Leukaemia 3 (Bcl-3) requires interaction with Nuclear Factor (NF)-κB p50.

Collins PE, Kiely PA, Carmody RJ (2014) Inhibition of transcription by B Cell Leukaemia 3 (Bcl-3) requires interaction with Nuclear Factor (NF)-κB p50.. The Journal of biological chemistry

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2014

Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells.

Dowling CM;Herranz Ors C;Kiely PA; (2014) Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells. . Bioscience reports

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2014

Promoting Cell Proliferation Using Water Dispersible Germanium Nanowires

Bezuidenhout, Michael,Liu, Pai,Singh, Shalini,Kiely, Maeve,Ryan, Kevin M.,Kiely, Patrick A. (2014) Promoting Cell Proliferation Using Water Dispersible Germanium Nanowires. : Public Library of Science PLOS ONE

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2014

RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK

Dwane, S,Durack, E,O'Connor, R,Kiely, PA (2014) RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK. Cellular signalling :9-18

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2013

Optimising parameters for the differentiation of SH-SY5Y cells to study cell adhesion and cell migration

Dwane S, Durack E, Kiely PA (2013) Optimising parameters for the differentiation of SH-SY5Y cells to study cell adhesion and cell migration. BMC research notes

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2013

Deubiquitination of NF-kappa B by Ubiquitin-Specific Protease-7 promotes transcription

Colleran, A,Collins, PE,O'Carroll, C,Ahmed, A,Mao, XC,McManus, B,Kiely, PA,Burstein, E,Carmody, RJ (2013) Deubiquitination of NF-kappa B by Ubiquitin-Specific Protease-7 promotes transcription. Proceedings Of The National Academy Of Sciences Of The United States Of America :618-623

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2013

Pregnancy-Specific Glycoproteins Bind Integrin alpha IIb beta 3 and Inhibit the Platelet-Fibrinogen Interaction

Shanley, DK,Kiely, PA,Golla, K,Allen, S,Martin, K,O'Riordan, RT,Ball, M,Aplin, JD,Singer, BB,Caplice, N,Moran, N,Moore, T (2013) Pregnancy-Specific Glycoproteins Bind Integrin alpha IIb beta 3 and Inhibit the Platelet-Fibrinogen Interaction. Plos One

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2013

RACK(1) to the future - a historical perspective

Ron, D,Adams, DR,Baillie, GS,Long, A,O'Connor, R,Kiely, PA (2013) RACK(1) to the future - a historical perspective. Cell Commun Signal

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2013

RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.

Dwane S, Durack E, O'Connor R, Kiely PA (2013) RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.. Cellular signalling

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2012

Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription.

Neasta J, Kiely PA, He DY, Adams DR, O'Connor R, Ron D (2012) Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription.. The Journal of biological chemistry :322-336

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2012

GSK-3β phosphorylation of the IGF-1 Receptor C terminal tail restrains kinase activity and cell growth.

Kelly GM, Buckley DA, Kiely PA, Adams DR, O'Connor R (2012) GSK-3β phosphorylation of the IGF-1 Receptor C terminal tail restrains kinase activity and cell growth.. The Journal of biological chemistry

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2012

Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris.

Ryan RP, McCarthy Y, Kiely PA, O'Connor R, Farah CS, Armitage JP, Dow JM (2012) Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris.. Molecular microbiology

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2011

Tools used to study how protein complexes are assembled in signaling cascades.

Dwane S, Kiely PA (2011) Tools used to study how protein complexes are assembled in signaling cascades.. Bioengineered bugs :247-259

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2011

RACK1, A multifaceted scaffolding protein: Structure and function.

Adams DR, Ron D, Kiely PA (2011) RACK1, A multifaceted scaffolding protein: Structure and function.. Cell Commun Signal

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2009

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.

Kiely PA, Baillie GS, Barrett R, Buckley DA, Adams DR, Houslay MD, O'Connor R (2009) Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.. The Journal of biological chemistry :20263-20274

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2008

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.

Kiely PA, Baillie GS, Lynch MJ, Houslay MD, O'Connor R (2008) Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.. The Journal of biological chemistry :22952-22961

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2007

Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR.

O'Donovan HC, Kiely PA, O'Connor R (2007) Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR.. Cellular signalling :2588-2595

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2006

Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration.

Kiely PA, O'Gorman D, Luong K, Ron D, O'Connor R (2006) Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration.. Molecular and cellular biology :4041-4051

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2005

Gene expression profiles in cells transformed by overexpression of the IGF-I receptor.

Loughran G, Huigsloot M, Kiely PA, Smith LM, Floyd S, Ayllon V, O'Connor R (2005) Gene expression profiles in cells transformed by overexpression of the IGF-I receptor.. Oncogene :6185-6193

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2005

Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth.

Loughran G, Healy NC, Kiely PA, Huigsloot M, Kedersha NL, O'Connor R (2005) Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth.. Molecular biology of the cell :1811-1822

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2005

RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.

Kiely PA, Leahy M, O'Gorman D, O'Connor R (2005) RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.. The Journal of biological chemistry :7624-7633

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2002

Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts.

Buckley DA, Cheng A, Kiely PA, Tremblay ML, O'Connor R (2002) Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts.. Molecular and cellular biology :1998-2010

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2002

RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.

Kiely PA, Sant A, O'Connor R (2002) RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.. The Journal of biological chemistry :22581-22589

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Books

This author has not written any publications of this type yet.

Book Chapters

2004

The IGF-1 Receptor in Cells Survival: Signalling and Regulation.

P.A. Kiely, D.M. O'Gorman, A. Lyons, R. O'Connor (2004) The IGF-1 Receptor in Cells Survival: Signalling and Regulation.. Kluwer : Springer Cell Engineering

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Edited Books

This author has not written any publications of this type yet.

Other Journals

2015

High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol

Bezuidenhout, M and Kennedy, T and Belochapkine, S and Guo, Y and Mullane, E and Kiely, PA and Ryan, KM (2015) High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol. Journal of Materials Chemistry C :7455-7462

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Conference Publications

2014

Sylvester O'Halloran Surgical Conference

Kiely M, Hodgins SJ, Tormey S, Kiely PA, O'Connor EM (2014) Sylvester O'Halloran Surgical Conference.

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Conference Contributions

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Published Reports

This author has not written any publications of this type yet.

Editorials

2016

Big Data-Led Cancer Research, Application, and Insights

Brown, JAL,Chonghaile, TN,Matchett, KB,Lynam-Lennon, N,Kiely, PA (2016) Big Data-Led Cancer Research, Application, and Insights. Cancer research :6167-6170

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2013

RACK(1) to the future - a historical perspective

Ron, D,Adams, DR,Baillie, GS,Long, A,O'Connor, R,Kiely, PA (2013) RACK(1) to the future - a historical perspective. Cell Commun Signal

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Book Reviews

This author has not written any publications of this type yet.

Other Publications

2022

Characterisation of Chronic Lymphocytic Leukaemia (CLL) immune profiles using single cell multi-omics

Mahon, OR;King, C;Fennell, E;Hickey, SE;Kiely, PA;Clifford, R;McGourty, K (2022) Characterisation of Chronic Lymphocytic Leukaemia (CLL) immune profiles using single cell multi-omics. HOBOKEN : WILEY European Journal Of Immunology :70-70

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2020

The relationship between post-surgery infection and breast cancer recurrence

O&apos;Connor, RI;Kiely, PA;Dunne, CP (2020) The relationship between post-surgery infection and breast cancer recurrence. LONDON : W B SAUNDERS CO LTD Journal Of Hospital Infection :522-535

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2019

Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer

Mahdi, AF;Malacrida, B;Nolan, J;McGourty, K;Lowery, AJ;Kiely, PA (2019) Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer. PHILADELPHIA : AMER ASSOC CANCER RESEARCH Cancer Research

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2019

Direct mechanical characterization of prostate tissue-a systematic review

Kelly, NP;Flood, HD;Hoey, DA;Kiely, PA;Giri, SK;Coffey, JC;Walsh, MT (2019) Direct mechanical characterization of prostate tissue-a systematic review. HOBOKEN : WILEY Prostate :115-125

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2019

Using hierarchical clustering of differential gene expression patterns to study the contribution of the extracellular matrix in breast cancer

Nolan, J;Mandi, AF;Lowery, AJ;Dunne, CP;Kiely, PA (2019) Using hierarchical clustering of differential gene expression patterns to study the contribution of the extracellular matrix in breast cancer. PHILADELPHIA : AMER ASSOC CANCER RESEARCH Cancer Research

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2018

Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer

Mahdi, AF;Malacrida, B;McGourty, K;Lowery, AJ;Kiely, PA (2018) Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer. PHILADELPHIA : AMER ASSOC CANCER RESEARCH Cancer Research

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2018

Elongation factor 2: A novel target for cancer progression

Malacrida, B;Dowling, CM;Flygaard, RK;Kiely, M;Coffey, JC;Jenner, LB;Kiely, PA (2018) Elongation factor 2: A novel target for cancer progression. PHILADELPHIA : AMER ASSOC CANCER RESEARCH Cancer Research

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2018

Examining how the extracellular environment alters gene expression in breast cancer

Nolan, J;Kiely, M;Dunne, CP;Lowery, AJ;Kiely, PA (2018) Examining how the extracellular environment alters gene expression in breast cancer. PHILADELPHIA : AMER ASSOC CANCER RESEARCH Cancer Research

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2017

Faecal diversion is associated with a regression of mesenteric disease manifestations and a decrease in circulating fibrocytes in Crohn&apos;s disease

Kiernan, MG;Sahebally, SM;Tibbitts, P;Lyons, EM;Kiely, PA;O&apos;Leary, DP;Dunne, CP;Coffey, JC (2017) Faecal diversion is associated with a regression of mesenteric disease manifestations and a decrease in circulating fibrocytes in Crohn&apos;s disease. LONDON : SPRINGER LONDON LTD Irish journal of medical science :92-93

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2017

The role of fibrocytes in mesenteric Crohn's disease

Kiernan, MG,Sahebally, SM,Kiely, PA,Waldron, D,Moloney, M,Skelly, M,Faul, PN,O'Leary, DP,Lowery, AJ,Walsh, LG,Dunne, CP,Coffey, JC (2017) The role of fibrocytes in mesenteric Crohn's disease. Journal of Crohn's & colitis :92-93

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2017

The mesentery - antagonist in Crohn's Disease?

Kiernan, MG,Sahebally, SM,Jarrar, A,Burke, JP,Hogan, J,Kiely, PA,Shen, B,Waldron, D,Moloney, M,Hogan, N,Skelly, M,Hidayat, H,Faul, PN,Mulcahy, E,Healy, V,O'Leary, DP,Lowery, A,Walsh, LG,O'Connell, PR,Martin, S,Shanahan, F,Fiocchi, C,Dunne, C,Coffey, JC (2017) The mesentery - antagonist in Crohn's Disease?. British Journal Of Surgery :22-23

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2017

The surgical and pathobiologic importance of the peritoneal reflection

Walsh, LG,Walsh, D,Kiely, PA,Dockery, P,Coffey, JC (2017) The surgical and pathobiologic importance of the peritoneal reflection. Irish journal of medical science :96-96

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2016

Towards a better understanding of tumour heterogeneity: a case study examining the expression pattern of protein kinase c in a triple negative metaplastic carcinoma

McCumiskey, M,Dowling, C,Murphy, M,Kelly, E,Walsh, D,Tormey, S,Merrigan, A,Lal, A,Dalton, T,Kiely, PA (2016) Towards a better understanding of tumour heterogeneity: a case study examining the expression pattern of protein kinase c in a triple negative metaplastic carcinoma. Irish journal of medical science :97-97

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2016

The mesocolic hilum: an electron microscopic appraisal of anatomy

Walsh, LG,O'Brien, IS,O'Leary, DP,Kiely, PA,Dunne, C,Quandamatteo, F,Dockery, P,Coffey, JC (2016) The mesocolic hilum: an electron microscopic appraisal of anatomy. Irish journal of medical science :97-97

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2016

Big Data-Led Cancer Research, Application, and Insights

Brown, JAL,Chonghaile, TN,Matchett, KB,Lynam-Lennon, N,Kiely, PA (2016) Big Data-Led Cancer Research, Application, and Insights. Cancer research :6167-6170

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2016

Novel Role of Pregnancy Specific Glycoproteins in Platelet Integrin Binding

Golla, K,Shanley, DK,Kiely, PA,Allen, S,O'Riordan, RT,Moran, N,Moore, T (2016) Novel Role of Pregnancy Specific Glycoproteins in Platelet Integrin Binding. Irish journal of medical science :39-39

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2015

Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling

Dowling, CM,Kiely, PA (2015) Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling. Cancers :1271-1291

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2015

Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer

Dowling, CM,Phelan, JJ,Cathcart, MC,Mehigan, B,McCormick, P,Dalton, T,Coffey, JC,O'Sullivan, J,Kiely, PA (2015) Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer. Cancer research

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2015

High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol (vol 3, pg 7455, 2015)

Bezuidenhout, M;Kennedy, T;Belochapkine, S;Guo, Y;Mullane, E;Kiely, PA;Ryan, KM (2015) High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol (vol 3, pg 7455, 2015). CAMBRIDGE : ROYAL SOC CHEMISTRY Journal Of Materials Chemistry C :8434-8434

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2015

Protein Kinase C In Breast Cancer Downstream Of Growth Factor And Adhesion Signalling

McCumiskey, M,Dowling, C,Dwane, S,Merrigan, A,Lal, A,Tormey, S,Murphy, M,Kelly, E,Dalton, T,Kiely, PA (2015) Protein Kinase C In Breast Cancer Downstream Of Growth Factor And Adhesion Signalling. Irish journal of medical science :397-397

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2015

PRIMA-1(MET) (APR-246): A novel targeted therapy for triple negative breast cancer?

Synnott, NC,McGowan, PM,Pierce, A,Kiely, M,O'Donovan, N,Crown, J,Kiely, PA,Duffy, MJ (2015) PRIMA-1(MET) (APR-246): A novel targeted therapy for triple negative breast cancer?. Journal Of Clinical Oncology

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2015

Identification of TTBK1 as a novel RACK1 binding partner in breast cancer

Hayes, S,Kiely, M,McCumiskey, M,Tormey, S,Dalton, T,Kiely, PA (2015) Identification of TTBK1 as a novel RACK1 binding partner in breast cancer. Irish journal of medical science :186-186

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2015

Untangling the role of protein kinase C in breast cancer downstream of growth factor and adhesion signalling

McCumiskey, M,Dowling, C,Dwane, S,Tormey, S,Dalton, T,Kiely, PA (2015) Untangling the role of protein kinase C in breast cancer downstream of growth factor and adhesion signalling. Irish journal of medical science :186-186

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2015

PDLIM2: A cytoskeleton to nuclear courier protein for the IGF-1, Wnt and TGF beta signalling pathways in Epithelial to Mesenchymal Transition

Garrido, MB,Cox, OT,O'Flanagan, C,Buckley, DA,Kiely, PA,O'Connor, R (2015) PDLIM2: A cytoskeleton to nuclear courier protein for the IGF-1, Wnt and TGF beta signalling pathways in Epithelial to Mesenchymal Transition. Cancer research

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2015

PP2A: The Wolf in Sheep's Clothing?

Kiely, M,Kiely, PA (2015) PP2A: The Wolf in Sheep's Clothing?. Cancers :648-669

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2014

Closing a Small Gap in Our Understanding of Excitation-Contraction Coupling: JSR90/JFP90 is Junctophilin 1.

Kathleen K. English, Vincenzo Sorrentino, Anna Carla Aiello, Maeve Kiely, Patrick A. Kiely, Brian Mcdonagh, and John J. Mackrill. (2014) Closing a Small Gap in Our Understanding of Excitation-Contraction Coupling: JSR90/JFP90 is Junctophilin 1.. http://www.researchpub.org/journal/cs/cs.html Calcium Signaling

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2014

Vitamin K derivatives inhibit the growth and proliferation of triple negative breast cancer cells

Kiely, M,Hodgins, SJ,Tormey, S,Kiely, PA,O'Connor, EM (2014) Vitamin K derivatives inhibit the growth and proliferation of triple negative breast cancer cells. :27-28

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2014

Applying novel cell monitoring platforms to study the behaviour of triple negative breast cancer cells in 2-Dimensional and 3-Dimensional culture

Ogunsakin, A,Kiely, M,Tormey, S,Kiely, PA (2014) Applying novel cell monitoring platforms to study the behaviour of triple negative breast cancer cells in 2-Dimensional and 3-Dimensional culture. Irish journal of medical science :28-28

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2014

The mesenteric organ-a novel source of fibroblasts in benign and malignant colorectal disease

Sahebally, SM,Kiernan, MG,Dunne, C,Kiely, PA,Coffey, JC (2014) The mesenteric organ-a novel source of fibroblasts in benign and malignant colorectal disease. Irish journal of medical science :27-27

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2014

Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer

Dowling, CM,Hanly, J,Dalton, T,Kiely, PA (2014) Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer. Cancer Research

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