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Dr. Patrick Kiely

PhD

Biography

Dr Pat Kiely is a Lecturer in the Department of Life Sciences, Principal Investigator of the Laboratory of Cellular and Molecular Biology, and member of the Materials and Surface Science Institute and Stokes Institute. Dr Kiely has a BSc. in Biomedical Science and a PhD in Biochemistry from University College Cork. Dr Kiely’s work has led to a number of significant publications which were the foundation to the acquisition of several prestigious postdoctoral fellowships and international awards including European Association for Cancer Research (EACR) Young Scientist Award (2010), The Irish Cancer Society Research Fellowship (2009), The ‘Roche Gold Medal’ for Postdoctoral researcher of the year (2007), ‘The Pfizer Gold medal for Excellence in Research’ in 2007 and 2002, Career Development Fellowship (HRB, 2005) and ‘Young Investigator of the Year 2006’, awarded by the Biochemical Society, UK.

Research Interests:


The research emphasis in my laboratory is on deciphering the localized and transient signalling events which occur in cells during migration. Cell migration is orchestrated by a series of complex signalling cascades which requires crosstalk between cell surface receptors and components of the cell cytoskeleton. Understanding the molecular mechanisms that regulate cell migration is of important intellectual and clinical interest, and we believe this work may reveal fresh approaches to target cancer as well as developmental and neurodegenerative diseases.

Research projects ongoing in the laboratory range from the most fundamental, where the development of a better understanding of the molecular mechanism(s) regulating cell migration is the goal, to the very applied, where the identification of novel therapeutic targets and the design and synthesis of novel materials and surfaces to study cell behavior is the desired endpoint. To help us achieve our goals, we are using a series of complimentary and synergistic cellular and molecular approaches and novel technologies including: 3D cell culture models, neuronal models, 2D ESI MS/MS, peptide array technology, interferometry, label free live cell monitoring, qPCR and droplet qPCR, SEM, TEM, con-focal microscopy, and electro spinning of materials. In collaboration with Dr Tara Daltons group (Stokes Institute) we are applying novel gene expression techniques and droplet technology to decipher signaling pathways in breast and colon cancer.
 

Research Interests

                                             

Publications

Book Chapter

2004

The IGF-1 Receptor in Cells Survival: Signalling and Regulation.
P.A. Kiely, D.M. O'Gorman, A. Lyons, R. O'Connor
Cell Engineering

Peer Reviewed Journal

2014

RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK
Dwane, S,Durack, E,O'Connor, R,Kiely, PA
Cellular signalling DOI: 10.1016/j.cellsig.2013.08.036

2013

Pregnancy-Specific Glycoproteins Bind Integrin alpha IIb beta 3 and Inhibit the Platelet-Fibrinogen Interaction
Shanley, DK,Kiely, PA,Golla, K,Allen, S,Martin, K,O'Riordan, RT,Ball, M,Aplin, JD,Singer, BB,Caplice, N,Moran, N,Moore, T
Plos One DOI: 10.1371/journal.pone.0057491

2013

RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.
Dwane S, Durack E, O'Connor R, Kiely PA
Cellular signalling DOI: 10.1016/j.cellsig.2013.08.036

2013

RACK(1) to the future - a historical perspective
Ron, D,Adams, DR,Baillie, GS,Long, A,O'Connor, R,Kiely, PA
Cell Commun Signal DOI: 10.1186/1478-811X-11-53

2013

Deubiquitination of NF-kappa B by Ubiquitin-Specific Protease-7 promotes transcription
Colleran, A,Collins, PE,O'Carroll, C,Ahmed, A,Mao, XC,McManus, B,Kiely, PA,Burstein, E,Carmody, RJ
Proceedings Of The National Academy Of Sciences Of The United States Of America DOI: 10.1073/pnas.1208446110

2012

Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris.
Ryan RP, McCarthy Y, Kiely PA, O'Connor R, Farah CS, Armitage JP, Dow JM
Molecular microbiology DOI: 10.1111/mmi.12000

2012

GSK-3β phosphorylation of the IGF-1 Receptor C terminal tail restrains kinase activity and cell growth.
Kelly GM, Buckley DA, Kiely PA, Adams DR, O'Connor R
The Journal of biological chemistry DOI: 10.1074/jbc.M112.385757

2009

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.
Kiely PA, Baillie GS, Barrett R, Buckley DA, Adams DR, Houslay MD, O'Connor R
The Journal of biological chemistry DOI: 10.1074/jbc.M109.017640

2005

Gene expression profiles in cells transformed by overexpression of the IGF-I receptor.
Loughran G, Huigsloot M, Kiely PA, Smith LM, Floyd S, Ayllon V, O'Connor R
Oncogene DOI: 10.1038/sj.onc.1208772