Biography

Patricia studied Industrial Biochemistry and graduated from the University of Limerick in 2008. On completion of her degree, she was awarded the Silver Medal for Academic Performance in the College of Science. She completed a Ph.D. in Molecular Microbiology in 2012. The focus of her work was on the analysis of a group of Mobile Genetic Elements termed the SXT/R391 family of Integrative Conjugative Elements. These mobile elements are known to spread antibiotic resistance determinants among gram-negative bacteria, specifically Vibrio cholerae and other enteric pathogens. On completion of her Ph.D., she then became involved in the DEMA project [http://www.dema-etoh.eu/en/]. The DEMA consortium aims to develop low cost technologies that allow for the direct production of bioethanol from microalgae. Within the consortium, she is primarily involved in the generation of a library of metabolically engineered high ethanol-producing microalgae strains. Patricia has recently joined the CES department as a lecturer in Industrial Biochemistry while she continues her work within the DEMA consortium.

Research Interests

Due to a rise in global CO2 levels and depletion of fossil fuel resources, biofuel energy solutions are of increasing importance. With the EU mandatory target of 10% substitution of fossil fuels by 2020, it is crucial that we rapidly find alternative cost effective sustainable solutions for biofuel production. With this in mind, my current research plans are focused on the production of 3rd generation biofuel solutions [biofuels derived from algae and cyanobacteria] which aim to directly convert solar energy to biofuel products. I am also interested in developing technologies that can utilise the spent cell biomass for environmentally beneficial applications and the optimisation of conversion processes for industrial waste materials to biodiesel and other bio-products.

Within the DEMA project, I am currently focused on the investigation of the utility of the cyanobacterial strain Synechocystis sp. PCC 6803 for the production of bioethanol. The utilisation of cyanobacteria for the production of biofuels has recently received significant attention due to the phototrophic nature of the organism and minimal requirement for land usage compared to 2nd generation biofuels. Synechocystis PCC 6803 is a model cyanobacterium for genetic manipulation and has been widely used to produce a range of biotechnological products such as isobutanol and lactic acid. We have integrated several versions of a non-native ethanol biosynthesis pathway into Synechocystis PCC 6803 and have generated a large library of ethanol-producing mutants. Under laboratory conditions, some of these strains produce levels of ethanol that are above that of the current state of the art. Currently, we are optimising these high-producing strains to further enhance ethanol productivity rates to improve the commercialisation potential of the DEMA process. To this end, a number of novel strategies are being investigated including the deletion of genes involved in storage compound accumulation and over-expression of pyruvate, the internal energy resource for ethanol production.

Professional Activities

Education

  • 2012 University of Limerick - PhD
  • 2008 University of Limerick - BSc (Hons)

Award

  • 2012 - BOC Gases Postgraduate Award
  • 2008 - Irish Research Council for Science, Engineering and Technology PhD research study grant
  • 2008 - Silver Medal for Academic Performance
  • 2005 - UREKA scholarship

Books

This author has not written any publications of this type yet.

Book Chapters

The use of ACT as an educational tool for examining the spread of Antibiotic Resistance.

Dr. Patricia Armshaw
2015
Spain
Formatex
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The Potential of the Photoautotroph Synechocystis for Metal Bioremediation.

Dr. Patricia Armshaw
2015
Croatia
In Tech
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UV stress responsive genes associated with enterobacterial Integrative Conjugative Elements of the ICE SXT/R391 group.

Dr. Patricia Armshaw
2015
USA
Wiley/Blackwell
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Integrative Conjugative Elements (ICEs) of the SXT/R391 group as vehicles for acquisition of resistance determinants, stable maintenance and transfer to a wide range of enterobacterial pathogens

Dr. Patricia Armshaw
2013
Spain
Formatex
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Edited Books

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Peer Reviewed Journals

Utilising the native plasmid, pCA2.4, from the cyanobacterium Synechocystis sp. strain PCC6803 as a cloning site for enhanced product production

Dr. Patricia Armshaw
2015
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Ultrasonic intensification as a tool for enhanced microbial biofuel yields

Dr. Patricia Armshaw
2015
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The state of autotrophic ethanol production in Cyanobacteria

Dr. Patricia Armshaw
2015
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Examination of the cell sensitizing gene orf43 of ICE R391 suggests a role in ICE transfer enhancement to recipient cells

Dr. Patricia Armshaw
2015
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Control of expression of the ICE R391 encoded UV-inducible cell-sensitising function

Dr. Patricia Armshaw
2013
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Generation and analysis of an ICE R391 deletion library identifies genes involved in the element encoded UV-inducible cell-sensitising function

Dr. Patricia Armshaw
2013
tony.pembroke@ul.ie
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Other Journals

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Conference Publications

Society for General Microbiology Irish Division Meeting: Microbial Interfaces NUI Galway

Dr. Patricia Armshaw
2015
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Society for General Microbiology Irish Division Meeting: Microbial Interfaces NUI Galway

Dr. Patricia Armshaw
2015
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Society for General Microbiology Irish Division Meeting: Microbial Interfaces

Dr. Patricia Armshaw
2015
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Society for General Microbiology Irish Division Meeting: Microbial Interfaces NUI Galway

Dr. Patricia Armshaw
2015
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Society for General Microbiology Irish Division meeting

Dr. Patricia Armshaw
2014
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Society for General Microbiology Irish Division Meeting: Microbial Interfaces NUI Galway

Dr. Patricia Armshaw
2015
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Proceedings of the Microscopy Society of Ireland Annual Symposium, CRANN, Trinity College Dublin, Ireland

Dr. Patricia Armshaw
2011
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1st International Solar Fuels Conference (ISF-1)

Dr. Patricia Armshaw
2015
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Society for General Microbiology Spring Conference 2011, Harrogate International Centre, Harrogate, UK,

Dr. Patricia Armshaw
2011
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Young microbiologist mini-symposium: microbe signalling, organisation and pathogenesis,

Dr. Patricia Armshaw
2009
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Society for General Microbiology Spring Conference 2012

Dr. Patricia Armshaw
2012
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Conference Contributions

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Published Reports

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Editorials

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Book Reviews

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Other Publications

Functional genomic analysis of the UV-inducible ‘cytotoxic' gene from the ICE R391, an archetypal member of the SXT/R391 family of Integrative Conjugative Elements

Dr. Patricia Armshaw
2012
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