Biography

Kieran McGourty is currently a lecturer below the bar in the Chemical Sciences department at the University of Limerick (UL). Kieran undertook his undergraduate studies at UL, in Industrial Biochemistry, where he worked with Dr. Jakki Cooney and Dr. Todd Kagawa. In 2006, motivated by these experiences, he went on to attain a Wellcome Trust funded PhD working with Prof. David Holden FRS, Imperial College London, studying the molecular basis of infection. During this time, Kieran published several high impact papers on the intracellular interaction of Salmonella Typhimurium with the host before changing field from cellular microbiology to cell biology.

Kieran took a post-doctoral research position in 2012 with Dr. Emmanuel Boucrot at University College London (UCL), with a primary research focus on the cell cycle and extracellular matrix (ECM) biology. Kieran's work here resulted in an extensive study into how ECM interaction evoke specific intracellular signalling profiles in quiescent cells. These findings are currently in preparation for publication.

Kieran's research aims to understand the signals that govern cell behaviour in the niche, especially the intestinal, muscular and epidermal niche. Kieran employs a number of high-throughput techniques to achieve this including; transcriptomics, phosphoproteomics, antibody signalling protein arrays and high content imaging, in addition to standard biochemical techniques.

https://www.linkedin.com/in/mcgourtykieran
https://twitter.com/KieranMcGourty @kieranmcgourty
https://twitter.com/biosciber @biosciber

Research Interests

Kieran is one of the founding groups within the Bernal BioSciBER lab research space. The BioSciBER lab aims to carry out interdisciplinary research at the interface of Biomedical Engineering, Cell Biology and Microfluidics. They hope to reference in vivo systems and use that knowledge to inform in vitro experimentation and medical device design in areas such as the circulatory system, stem cell niche reconstitution, blood brain barrier research and tissue mechano-characterisation.

Specifically, Kieran's group aims to fuse biomedical engineering, ECM and cell biology to reconstitute the stem cell tissue niche in vitro by referencing and endeavouring to understand the in vivo system with a particular focus on the intestinal, muscular and epidermal niche.

Specific Research Areas

  • Stem cell differentiation
  • Stem cell niche
  • Extracellular matrix biology
  • Cell cycle
  • Intracellular trafficking
  • Cell signalling
  • Infection and immunity
  • Microbiome
  • Proteomics, transcriptomics, pathway analysis
  • Microscopy, especially high throughput imaging and confocal microscopy

Twitter

@biosciber
@kieranmcgourty

Professional Activities

Award

  • 2016 - Gordon research conference poster winner
  • 2010 - Best PhD talk winner

Education

  • 2007 Imperial College London - PhD
  • 2006 Imperial College London - Masters by research
  • 2001 University of Limerick - BSc (Hons)

Committee

  • Ethics Committee Member UL,

Employment

  • Pfizer, GE Healthcare, University College Cork, Imperial College London, University College London, University of Limerick - Various

Language

  • French

Books

This author has not written any publications of this type yet.

Book Chapters

Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr

Prof. Andreas Grabrucker
Dr. Kieran McGourty
2020
Cambridge, Massachusetts, United States
Academic Press
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Edited Books

This author has not written any publications of this type yet.

Peer Reviewed Journals

Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

Dr. Kieran McGourty
2018
NEW YORK
ELSEVIER SCIENCE INC
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HorB (HP0127) is a gastric epithelial cell adhesin

Dr. Kieran McGourty
2007
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PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.

Dr. Kieran McGourty
2015
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Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function.

Dr. Kieran McGourty
2012
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Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.

Dr. Kieran McGourty
2011
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pH sensing by intracellular Salmonella induces effector translocation.

Dr. Kieran McGourty
2010
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Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies.

Dr. Kieran McGourty
2017
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Myostatin-like proteins regulate synaptic function and neuronal morphology.

Dr. Kieran McGourty
2017
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Modulation of apoptosis and pro-inflammatory signalling by vaccinia virus protein N1

Dr. Kieran McGourty
2011
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Regional mechanical and biochemical properties of the porcine cortical meninges.

Dr. John Mulvihill
Dr. Kieran McGourty
2018
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Combinatorial effects of matrix stiffness and ECM proteins on cell behaviour and morphology

Dr. Kieran McGourty
2019
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Measuring endocytosis during proliferative cell quiescence

Dr. Kieran McGourty
2020
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Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer

Dr. Kieran McGourty
2018
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The in vitro inertial positions and viability of cells in suspension under different in vivo flow conditions

Dr. Kieran McGourty
2020
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Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer

Dr. Kieran McGourty
2019
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Other Journals

Signalling mediated survival in quiescence cells

Dr. Kieran McGourty
2020
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Conference Publications

This author has not written any publications of this type yet.

Conference Contributions

Workshop: Emerging Themes in Infection Biology

Dr. Kieran McGourty
2010
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EIMID 7th Annual Meeting

Dr. Kieran McGourty
2011
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Fibronectins Integrins and Related Molecules

Dr. Kieran McGourty
2015
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Signal Transduction by Engineered Extracellular Matrices, Gordon Research Seminar

Dr. Kieran McGourty
2016
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Signal Transduction by Engineered Extracellular Matrices,

Dr. Kieran McGourty
2016
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Wellcome Trust PhD Molecular basis of infection seminar

Dr. Kieran McGourty
2010
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EIMID 6th Annual Meeting

Dr. Kieran McGourty
2009
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UK Membrane Trafficking Meeting

Dr. Kieran McGourty
2009
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Published Reports

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Editorials

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Book Reviews

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Other Publications

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