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Dr. Kieran Mcgourty

Biography

Kieran McGourty is currently a lecturer below the bar in the Chemical Sciences department at the University of Limerick (UL). Kieran undertook his undergraduate studies at UL, in Industrial Biochemistry, where he worked with Dr. Jakki Cooney and Dr. Todd Kagawa. In 2006, motivated by these experiences, he went on to attain a Wellcome Trust funded PhD working with Prof. David Holden FRS, Imperial College London, studying the molecular basis of infection. During this time, Kieran published several high impact papers on the intracellular interaction of Salmonella Typhimurium with the host before changing field from cellular microbiology to cell biology.

Kieran took a post-doctoral research position in 2012 with Dr. Emmanuel Boucrot at University College London (UCL), with a primary research focus on the cell cycle and extracellular matrix (ECM) biology. Kieran's work here resulted in an extensive study into how ECM interaction evoke specific intracellular signalling profiles in quiescent cells. These findings are currently in preparation for publication.

Kieran's research aims to understand the signals that govern cell behaviour in the niche, especially the intestinal, muscular and epidermal niche. Kieran employs a number of high-throughput techniques to achieve this including; transcriptomics, phosphoproteomics, antibody signalling protein arrays and high content imaging, in addition to standard biochemical techniques.

https://www.linkedin.com/in/mcgourtykieran
https://twitter.com/KieranMcGourty @kieranmcgourty
https://twitter.com/biosciber

@biosciber

Research Interests

Kieran is one of the founding groups within the Bernal BioSciBER lab research space. The BioSciBER lab aims to carry out interdisciplinary research at the interface of Biomedical Engineering, Cell Biology and Microfluidics. They hope to reference in vivo systems and use that knowledge to inform in vitro experimentation and medical device design in areas such as the circulatory system, stem cell niche reconstitution, blood brain barrier research and tissue mechano-characterisation.

Specifically, Kieran's group aims to fuse biomedical engineering, ECM and cell biology to reconstitute the stem cell tissue niche in vitro by referencing and endeavouring to understand the in vivo system with a particular focus on the intestinal, muscular and epidermal niche.

Specific Research Areas

  • Stem cell differentiation
  • Stem cell niche
  • Extracellular matrix biology
  • Cell cycle
  • Intracellular trafficking
  • Cell signalling
  • Infection and immunity
  • Microbiome
  • Proteomics, transcriptomics, pathway analysis
  • Microscopy, especially high throughput imaging and confocal microscopy

Twitter

@biosciber
@kieranmcgourty

Professional Activities

Award

  • 2016 - Gordon research conference poster winner
  • 2010 - Best PhD talk winner

Education

  • 2007 Imperial College London - PhD
  • 2006 Imperial College London - Masters by research
  • 2001 University of Limerick - BSc (Hons)

Committee

  • Ethics Committee Member UL,

Employment

  • Pfizer, GE Healthcare, University College Cork, Imperial College London, University College London, University of Limerick - Various

Language

  • French

Publications

Book Chapters

2020

Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr
Ross, AM; Grabrucker, AM; McGourty, KD; Mulvihill, JE
(2020) Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr
In Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents 1st Edition.; Sigh RW, Singh D, Kanwar J, Singh Chauha N(Ed.) Cambridge, Massachusetts, United States : Academic Press

Peer Reviewed Journals

2020

Measuring endocytosis during proliferative cell quiescence
C Hinze, McGourty K, Boucrot E
(2020) Measuring endocytosis during proliferative cell quiescence
In Methods in molecular biology (Clifton, N.J.);

2020

The in vitro inertial positions and viability of cells in suspension under different in vivo flow conditions
Connolly S.;*McGourty K.;*Newport D. *=Corresponding Author
(2020) The in vitro inertial positions and viability of cells in suspension under different in vivo flow conditions
In Scientific Reports;
DOI: 10.1038/s41598-020-58161-w
[ULIR]

2019

Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer
AF Mahdi, B Malacrida, J Nolan, K McGourty, AJ Lowery, PA Kiely
(2019) Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer
In Cancer Research; pp. 2027-2027-

2019

Combinatorial effects of matrix stiffness and ECM proteins on cell behaviour and morphology
S Malijauskaite, V Boomsma, C O'Connor, K McGourty
(2019) Combinatorial effects of matrix stiffness and ECM proteins on cell behaviour and morphology
In International Journal Of Experimental Pathology;

2018

Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer
Amira F. Mahdi, Beatrice Malacrida, Kieran McGourty, Aoife J. Lowery and Patrick A. Kiely
(2018) Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer
In Cancer Research;

2018

Regional mechanical and biochemical properties of the porcine cortical meninges.
Walsh DR;Ross AM;Malijauskaite S;Flanagan BD;Newport DT;*McGourty KD;*Mulvihill JJE; * = Corresponding Author
(2018) Regional mechanical and biochemical properties of the porcine cortical meninges.
In Acta Biomaterialia;
DOI: 10.1016/j.actbio.2018.09.004
[ULIR]

2018

Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster
Augustin, H;McGourty, K;Allen, MJ;Adcott, J;Wong, CT;Boucrot, E;Partridge, L
(2018) Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster
In Neurobiology Of Aging; NEW YORK : ELSEVIER SCIENCE INC pp. 149-157
DOI: 10.1016/j.neurobiolaging.2018.02.027

2017

Myostatin-like proteins regulate synaptic function and neuronal morphology.
Augustin H;McGourty K;Steinert JR;Cochemé HM;Adcott J;Cabecinha M;Vincent A;Halff EF;Kittler JT;Boucrot E;Partridge L;
(2017) Myostatin-like proteins regulate synaptic function and neuronal morphology.
In Development (Cambridge);
DOI: 10.1242/dev.152975

2017

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies.
Augustin H;McGourty K;Allen MJ;Madem SK;Adcott J;Kerr F;Wong CT;Vincent A;Godenschwege T;Boucrot E;Partridge L;
(2017) Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies.
In Plos Biology;
DOI: 10.1371/journal.pbio.2001655

2015

PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.
McEwan DG;Richter B;Claudi B;Wigge C;Wild P;Farhan H;McGourty K;Coxon FP;Franz-Wachtel M;Perdu B;Akutsu M;Habermann A;Kirchof A;Helfrich MH;Odgren PR;Van Hul W;Frangakis AS;Rajalingam K;Macek B;Holden DW;Bumann D;Dikic I;
(2015) PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.
In Cell Host & Microbe;
DOI: 10.1016/j.chom.2014.11.011

2012

Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function.
McGourty K;Thurston TL;Matthews SA;Pinaud L;Mota LJ;Holden DW;
(2012) Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function.
In Science;
DOI: 10.1126/science.1227037

2011

Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
Maluquer de Motes C;Cooray S;Ren H;Almeida GM;McGourty K;Bahar MW;Stuart DI;Grimes JM;Graham SC;Smith GL;
(2011) Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
In Plos Pathogens;
DOI: 10.1371/journal.ppat.1002430

2011

Modulation of apoptosis and pro-inflammatory signalling by vaccinia virus protein N1
Maluquer de Motes, Carlos Cooray Samantha, Ren Hongwei, Gabriel MF Almeida, McGourty Kieran, Mohammad W Bahar, David I Stuart, Jonathan M Grimes, Stephen C Graham, Geoffrey L Smith
(2011) Modulation of apoptosis and pro-inflammatory signalling by vaccinia virus protein N1
In Cytokine;

2010

pH sensing by intracellular Salmonella induces effector translocation.
Yu XJ;McGourty K;Liu M;Unsworth KE;Holden DW;
(2010) pH sensing by intracellular Salmonella induces effector translocation.
In Science;
DOI: 10.1126/science.1189000

2007

HorB (HP0127) is a gastric epithelial cell adhesin
Snelling, WJ; Moran, AP; Ryan, KA; Scully, P; McGourty, K; Cooney, JC; Annuk, H; O'Toole, PW
(2007) HorB (HP0127) is a gastric epithelial cell adhesin
In Helicobacter; pp. 200-209
DOI: 10.1111/j.1523-5378.2007.00499.x

Other Journals

2020

Signalling mediated survival in quiescence cells
McGourty K, Mendes-Pereira A, McMahon HT, Boucrot E
(2020) Signalling mediated survival in quiescence cells
In Under review;

Conference Contributions

2016

Signal Transduction by Engineered Extracellular Matrices, Gordon Research Seminar
McGourty K, (Poster) Boucrot E.
(2016) Signal Transduction by Engineered Extracellular Matrices, Gordon Research Seminar
Biddeford, USA

2016

Signal Transduction by Engineered Extracellular Matrices,
McGourty K, (Poster, Winner) Boucrot E.
(2016) Signal Transduction by Engineered Extracellular Matrices,
Biddeford, USA

2015

Fibronectins Integrins and Related Molecules
McGourty K, (Poster) Boucrot E.
(2015) Fibronectins Integrins and Related Molecules
Lucca, Italy

2011

EIMID 7th Annual Meeting
McGourty K (Speaker), Holden DW
(2011) EIMID 7th Annual Meeting
Sanga-Saby, Sweden

2010

Wellcome Trust PhD Molecular basis of infection seminar
McGourty K, (Speaker, Winner) Holden DW.
(2010) Wellcome Trust PhD Molecular basis of infection seminar
London, UK

2010

Workshop: Emerging Themes in Infection Biology
McGourty K, (Speaker) Holden DW
(2010) Workshop: Emerging Themes in Infection Biology
La Colle sur Loup, France

2009

EIMID 6th Annual Meeting
McGourty K, (Poster) Holden DW
(2009) EIMID 6th Annual Meeting
Potsdam, Germany

2009

UK Membrane Trafficking Meeting
McGourty K, (Speaker) Holden DW
(2009) UK Membrane Trafficking Meeting
London, UK