Biography
Kieran McGourty is currently a lecturer below the bar in the Chemical Sciences department at the University of Limerick (UL). Kieran undertook his undergraduate studies at UL, in Industrial Biochemistry, where he worked with Dr. Jakki Cooney and Dr. Todd Kagawa. In 2006, motivated by these experiences, he went on to attain a Wellcome Trust funded PhD working with Prof. David Holden FRS, Imperial College London, studying the molecular basis of infection. During this time, Kieran published several high impact papers on the intracellular interaction of Salmonella Typhimurium with the host before changing field from cellular microbiology to cell biology.
Kieran took a post-doctoral research position in 2012 with Dr. Emmanuel Boucrot at University College London (UCL), with a primary research focus on the cell cycle and extracellular matrix (ECM) biology. Kieran's work here resulted in an extensive study into how ECM interaction evoke specific intracellular signalling profiles in quiescent cells. These findings are currently in preparation for publication.
Kieran's research aims to understand the signals that govern cell behaviour in the niche, especially the intestinal, muscular and epidermal niche. Kieran employs a number of high-throughput techniques to achieve this including; transcriptomics, phosphoproteomics, antibody signalling protein arrays and high content imaging, in addition to standard biochemical techniques.
https://www.linkedin.com/in/mcgourtykieran
https://twitter.com/KieranMcGourty @kieranmcgourty
https://twitter.com/biosciber
Research Interests
Kieran is one of the founding groups within the Bernal BioSciBER lab research space. The BioSciBER lab aims to carry out interdisciplinary research at the interface of Biomedical Engineering, Cell Biology and Microfluidics. They hope to reference in vivo systems and use that knowledge to inform in vitro experimentation and medical device design in areas such as the circulatory system, stem cell niche reconstitution, blood brain barrier research and tissue mechano-characterisation.
Specifically, Kieran's group aims to fuse biomedical engineering, ECM and cell biology to reconstitute the stem cell tissue niche in vitro by referencing and endeavouring to understand the in vivo system with a particular focus on the intestinal, muscular and epidermal niche.
Specific Research Areas
- Stem cell differentiation
- Stem cell niche
- Extracellular matrix biology
- Cell cycle
- Intracellular trafficking
- Cell signalling
- Infection and immunity
- Microbiome
- Proteomics, transcriptomics, pathway analysis
- Microscopy, especially high throughput imaging and confocal microscopy
Professional Activities
Award
- 2016 - Gordon research conference poster winner
- 2010 - Best PhD talk winner
Education
- 2007 Imperial College London - PhD
- 2006 Imperial College London - Masters by research
- 2001 University of Limerick - BSc (Hons)
Committee
- Ethics Committee Member UL,
Employment
- Pfizer, GE Healthcare, University College Cork, Imperial College London, University College London, University of Limerick - Various
Language
- French
Publications
Book Chapters
Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr
Ross, AM; Grabrucker, AM; McGourty, KD; Mulvihill, JE
(2020)
Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr
In Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents 1st Edition.;
Sigh RW, Singh D, Kanwar J, Singh Chauha N(Ed.)
Cambridge, Massachusetts, United States :
Academic Press
Peer Reviewed Journals
Measuring endocytosis during proliferative cell quiescence
C Hinze, McGourty K, Boucrot E
(2020)
Measuring endocytosis during proliferative cell quiescence
In Methods in molecular biology (Clifton, N.J.);
The in vitro inertial positions and viability of cells in suspension under different in vivo flow conditions
Connolly S.;*McGourty K.;*Newport D. *=Corresponding Author
(2020)
The in vitro inertial positions and viability of cells in suspension under different in vivo flow conditions
In Scientific Reports;
DOI: 10.1038/s41598-020-58161-w
[ULIR]
Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer
AF Mahdi, B Malacrida, J Nolan, K McGourty, AJ Lowery, PA Kiely
(2019)
Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer
In Cancer Research;
pp. 2027-2027-
Combinatorial effects of matrix stiffness and ECM proteins on cell behaviour and morphology
S Malijauskaite, V Boomsma, C O'Connor, K McGourty
(2019)
Combinatorial effects of matrix stiffness and ECM proteins on cell behaviour and morphology
In International Journal Of Experimental Pathology;
Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer
Amira F. Mahdi, Beatrice Malacrida, Kieran McGourty, Aoife J. Lowery and Patrick A. Kiely
(2018)
Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer
In Cancer Research;
Regional mechanical and biochemical properties of the porcine cortical meninges.
Walsh DR;Ross AM;Malijauskaite S;Flanagan BD;Newport DT;*McGourty KD;*Mulvihill JJE; * = Corresponding Author
(2018)
Regional mechanical and biochemical properties of the porcine cortical meninges.
In Acta Biomaterialia;
DOI: 10.1016/j.actbio.2018.09.004
[ULIR]
Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster
Augustin, H;McGourty, K;Allen, MJ;Adcott, J;Wong, CT;Boucrot, E;Partridge, L
(2018)
Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster
In Neurobiology Of Aging;
NEW YORK :
ELSEVIER SCIENCE INC
pp. 149-157
DOI: 10.1016/j.neurobiolaging.2018.02.027
Myostatin-like proteins regulate synaptic function and neuronal morphology.
Augustin H;McGourty K;Steinert JR;Cochemé HM;Adcott J;Cabecinha M;Vincent A;Halff EF;Kittler JT;Boucrot E;Partridge L;
(2017)
Myostatin-like proteins regulate synaptic function and neuronal morphology.
In Development (Cambridge);
DOI: 10.1242/dev.152975
Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies.
Augustin H;McGourty K;Allen MJ;Madem SK;Adcott J;Kerr F;Wong CT;Vincent A;Godenschwege T;Boucrot E;Partridge L;
(2017)
Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies.
In Plos Biology;
DOI: 10.1371/journal.pbio.2001655
PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.
McEwan DG;Richter B;Claudi B;Wigge C;Wild P;Farhan H;McGourty K;Coxon FP;Franz-Wachtel M;Perdu B;Akutsu M;Habermann A;Kirchof A;Helfrich MH;Odgren PR;Van Hul W;Frangakis AS;Rajalingam K;Macek B;Holden DW;Bumann D;Dikic I;
(2015)
PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.
In Cell Host & Microbe;
DOI: 10.1016/j.chom.2014.11.011
Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function.
McGourty K;Thurston TL;Matthews SA;Pinaud L;Mota LJ;Holden DW;
(2012)
Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function.
In Science;
DOI: 10.1126/science.1227037
Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
Maluquer de Motes C;Cooray S;Ren H;Almeida GM;McGourty K;Bahar MW;Stuart DI;Grimes JM;Graham SC;Smith GL;
(2011)
Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
In Plos Pathogens;
DOI: 10.1371/journal.ppat.1002430
Modulation of apoptosis and pro-inflammatory signalling by vaccinia virus protein N1
Maluquer de Motes, Carlos Cooray Samantha, Ren Hongwei, Gabriel MF Almeida, McGourty Kieran, Mohammad W Bahar, David I Stuart, Jonathan M Grimes, Stephen C Graham, Geoffrey L Smith
(2011)
Modulation of apoptosis and pro-inflammatory signalling by vaccinia virus protein N1
In Cytokine;
pH sensing by intracellular Salmonella induces effector translocation.
Yu XJ;McGourty K;Liu M;Unsworth KE;Holden DW;
(2010)
pH sensing by intracellular Salmonella induces effector translocation.
In Science;
DOI: 10.1126/science.1189000
HorB (HP0127) is a gastric epithelial cell adhesin
Snelling, WJ; Moran, AP; Ryan, KA; Scully, P; McGourty, K; Cooney, JC; Annuk, H; O'Toole, PW
(2007)
HorB (HP0127) is a gastric epithelial cell adhesin
In Helicobacter;
pp. 200-209
DOI: 10.1111/j.1523-5378.2007.00499.x
Other Journals
Signalling mediated survival in quiescence cells
McGourty K, Mendes-Pereira A, McMahon HT, Boucrot E
(2020)
Signalling mediated survival in quiescence cells
In Under review;
Conference Contributions
Signal Transduction by Engineered Extracellular Matrices, Gordon Research Seminar
McGourty K, (Poster) Boucrot E.
(2016)
Signal Transduction by Engineered Extracellular Matrices, Gordon Research Seminar
Biddeford, USA
Signal Transduction by Engineered Extracellular Matrices,
McGourty K, (Poster, Winner) Boucrot E.
(2016)
Signal Transduction by Engineered Extracellular Matrices,
Biddeford, USA
Fibronectins Integrins and Related Molecules
McGourty K, (Poster) Boucrot E.
(2015)
Fibronectins Integrins and Related Molecules
Lucca, Italy
EIMID 7th Annual Meeting
McGourty K (Speaker), Holden DW
(2011)
EIMID 7th Annual Meeting
Sanga-Saby, Sweden
Wellcome Trust PhD Molecular basis of infection seminar
McGourty K, (Speaker, Winner) Holden DW.
(2010)
Wellcome Trust PhD Molecular basis of infection seminar
London, UK
Workshop: Emerging Themes in Infection Biology
McGourty K, (Speaker) Holden DW
(2010)
Workshop: Emerging Themes in Infection Biology
La Colle sur Loup, France
EIMID 6th Annual Meeting
McGourty K, (Poster) Holden DW
(2009)
EIMID 6th Annual Meeting
Potsdam, Germany
UK Membrane Trafficking Meeting
McGourty K, (Speaker) Holden DW
(2009)
UK Membrane Trafficking Meeting
London, UK