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Dr. James Brown


My major research interest is in how acetylation regulates genome stability, particularly in response to DNA double strand breaks (DSB) in a breast cancer model. My translational work is focused on pre-clinical and early clinical validation of small molecules he developed which target specific lysine acetyltransferases (KATi). Further research interests include investigating and validating novel breast cancer biomarkers (proteins and miRNA), for improved patient stratification and to enhance our understanding of the molecular changes seen in breast cancer.