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Dr. Grace Brennan

Biography

https://scholar.google.com/citations?hl=en&user=MqvC84QAAAAJ

Currently working on:
1. Nonlinear optical characterisation of hybrid plasmonic nanodiscs and waveguides
2. Nanocrystal-based LEDs optical and electrical characterisation (low-temperature, time-resolved and DC biased photoluminescence, electron microscopy and photolithography)
3. ASINA H2020 project - optical characterisation

Under the supervision of Dr Ning Liu and Prof Tofail Syed.


PhD in Physics, University of Limerick 2016-2020
BSc in Applied Physics, University of Limerick 2012-2016

Research Interests

Plasmonics, microscopy, spectroscopy, magnetics, and nanomaterials.
https://scholar.google.com/citations?hl=en&user=MqvC84QAAAAJ&view_op=list_works&gmla=AJsN-F5Pm9NA9LK...


Through optical characterisation of multistage magnetite-gold (Fe3O4-Au) core-shell nanostructures, we found a substantial spectral drift between the optical scattering and extinction. Furthermore, we observed that this spectral drift enhances the photothermal behaviour of such nanostructures, facilitating spectrally selective photothermal therapy and diagnostic imaging.
https://doi.org/10.1039/D0NR01463J


Combined laser dark field microscopy and epi-detected coherent anti-Stokes Raman (CARS) microscopy to image the uptake of magnetic-plasmonic nanoparticles in human pancreatic cancer cells.
https://doi.org/10.3390/nano11030685



For this study, we quantified the efficacy of magnetic iron oxide cores with various gold shell thicknesses in a number of popular magnetic-based nanotheranostic applications; these included magnetic sorting and targeting (quantifying magnetic manipulability and magnetophoresis), MRI contrasting (quantifying benchtop nuclear magnetic resonance (NMR)-based T1 and T2 relaxivity), and magnetic hyperthermia therapy (quantifying alternating magnetic-field heating). We observed a general decrease in magnetic response and efficacy with an increase of the gold shell thickness.
https://doi.org/10.3390/nano10122424

Professional Activities

Education

  • 2020 University of Limerick - PhD
  • 2016 University of Limerick - BSc

Association

  • Member, Institute of Physics

Employment

  • University of Limerick - Postdoctoral researcher

Publications

Peer Reviewed Journals

2021

Dark Field and Coherent Anti-Stokes Raman (DF-CARS) Imaging of Cell Uptake of Core-Shell, Magnetic-Plasmonic Nanoparticles
Grace Brennan;Sally Ryan;Tewfik Soulimane;Syed A. M. Tofail;Christophe Silien;
(2021) Dark Field and Coherent Anti-Stokes Raman (DF-CARS) Imaging of Cell Uptake of Core-Shell, Magnetic-Plasmonic Nanoparticles
In Journal Of Nanomaterials;
DOI: 10.3390/nano11030685

2021

Photo-responsive functional gold nanocapsules for inactivation of community-acquired, highly virulent, multidrug-resistant MRSA
Nanasaheb D. Thorat;Ewa Dworniczek;Grace Brennan;Grzegorz Chodaczek;Rabah Mouras;Victoria Gascón Pérez;Christophe Silien;Syed A. M. Tofail;Joanna Bauer;
(2021) Photo-responsive functional gold nanocapsules for inactivation of community-acquired, highly virulent, multidrug-resistant MRSA
In Journal Of Materials Chemistry B;
DOI: 10.1039/D0TB02047H

2020

The Effects of a Varied Gold Shell Thickness on Iron Oxide Nanoparticle Cores in Magnetic Manipulation, T1 and T2 MRI Contrasting, and Magnetic Hyperthermia
Grace Brennan;Silvia Bergamino;Martina Pescio;Syed A. M. Tofail;Christophe Silien;
(2020) The Effects of a Varied Gold Shell Thickness on Iron Oxide Nanoparticle Cores in Magnetic Manipulation, T1 and T2 MRI Contrasting, and Magnetic Hyperthermia
In Journal Of Nanomaterials;
DOI: 10.3390/nano10122424

2020

Characterisation and Manipulation of Polarisation Response in Plasmonic and Magneto-Plasmonic Nanostructures and Metamaterials
(2020) Characterisation and Manipulation of Polarisation Response in Plasmonic and Magneto-Plasmonic Nanostructures and Metamaterials
In Symmetry;
DOI: 10.3390/sym12081365

2020

Spectral drifts in surface textured Fe3O4-Au, coreâ€'shell nanoparticles enhance spectra-selective photothermal heating and scatter imaging
Grace Brennan;Nanasaheb D. Thorat;Martina Pescio;Silvia Bergamino;Joanna Bauer;Ning Liu;Syed A. M. Tofail;Christophe Silien;
(2020) Spectral drifts in surface textured Fe3O4-Au, coreâ€'shell nanoparticles enhance spectra-selective photothermal heating and scatter imaging
In Nanoscale;
DOI: 10.1039/D0NR01463J

2020

Spectral drifts in surface textured Fe<inf>3</inf>O<inf>4</inf>-Au, core-shell nanoparticles enhance spectra-selective photothermal heating and scatter imaging
Brennan G.;Thorat N.D.;Pescio M.;Bergamino S.;Bauer J.;Liu N.;Tofail S.A.M.;Silien C.
(2020) Spectral drifts in surface textured Fe<inf>3</inf>O<inf>4</inf>-Au, core-shell nanoparticles enhance spectra-selective photothermal heating and scatter imaging
In Nanoscale; pp. 12632-12638
DOI: 10.1039/d0nr01463j

2020

Erratum: Progress in remotely triggered hybrid nanostructures for next-generation brain cancer theranostics (ACS Biomaterials Science &amp; Engineering (2019) 5:6 (2669âˆ'2687) DOI: 10.1021/acsbiomaterials.8b01173)
Thorat, N.D.;Townley, H.;Brennan, G.;Parchur, A.K.;Silien, C.;Bauer, J.;Tofail, S.A.M.;
(2020) Erratum: Progress in remotely triggered hybrid nanostructures for next-generation brain cancer theranostics (ACS Biomaterials Science &amp; Engineering (2019) 5:6 (2669âˆ'2687) DOI: 10.1021/acsbiomaterials.8b01173)
In Acs Biomaterials Science & Engineering;
DOI: 10.1021/acsbiomaterials.9b01810

2019

Physically stimulated nanotheranostics for next generation cancer therapy: Focus on magnetic and light stimulations
Nanasaheb D. Thorat;Syed A. M. Tofail;Brigitte von Rechenberg;Helen Townley;Grace Brennan;Christophe Silien;Hemraj M. Yadav;Thomas Steffen;Joanna Bauer;
(2019) Physically stimulated nanotheranostics for next generation cancer therapy: Focus on magnetic and light stimulations
In Applied Physics Reviews;
DOI: 10.1063/1.5049467

2019

Synthesis and Characterization of CuZnSe<inf>2</inf> Nanocrystals in Wurtzite, Zinc Blende, and Core-Shell Polytypes
Ren H.;Wang M.;Li Z.;Laffir F.;Brennan G.;Sun Y.;Stokes K.;Geaney H.;O'Reilly E.;Gao P.;Liu N.;McCarthy C.;Ryan K.
(2019) Synthesis and Characterization of CuZnSe<inf>2</inf> Nanocrystals in Wurtzite, Zinc Blende, and Core-Shell Polytypes
In Chemistry Of Materials;
DOI: 10.1021/acs.chemmater.9b03063

2019

Synthesis and Characterization of CuZnSe2 Nanocrystals in Wurtzite, Zinc Blende, and Coreâ€'Shell Polytypes
(2019) Synthesis and Characterization of CuZnSe2 Nanocrystals in Wurtzite, Zinc Blende, and Coreâ€'Shell Polytypes
In Chemistry Of Materials;
DOI: 10.1021/acs.chemmater.9b03063

2019

Progress in Remotely Triggered Hybrid Nanostructures for Next-Generation Brain Cancer Theranostics
Thorat N.;Townely H.;Brennan G.;Parchur A.;Silien C.;Bauer J.;Tofail S.
(2019) Progress in Remotely Triggered Hybrid Nanostructures for Next-Generation Brain Cancer Theranostics
In Acs Biomaterials Science & Engineering;
DOI: 10.1021/acsbiomaterials.8b01173