Prof Austin Stack

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Prof Austin
Stack
Phone: 
+353 (0) 61 485153
Email: 
Austin.Stack@ul.ie
Role: 
Professor of Medicine
Profile: 

Professor Stack is the Foundation Chair of Medicine at the School of Medicine and Consultant Nephrologist at University Hospital Limerick. His principal interests include: assessment of treatment strategies for chronic kidney disease (CKD) & end-stage kidney disease (ESKD); determinants and outcomes of acute kidney injury (AKI); cardiovascular disease and cardiovascular risk assessment; clinical impact of gout and hyperuricaemia; risk prediction models; and the application of IT communications systems in clinical and epidemiological research. He is leading an initiative to establish Ireland first National Surveillance System for Kidney Disease and is PI for several large-scale observational studies including a 3-year Health Research Board (HRB) funded study assessing the burden and progression of Chronic Kidney Disease in the Irish Health System. He is also co-investigator in the CDC funded CKD Surveillance programme that is lead by the University of Michigan and the University of California SanFrancisco (UCSF). The UL Kidney Health Consortium offers opportunities to nephrology trainees and interested researchers to participate in large research projects under his supervision. All trainees will benefit from weekly interdisciplinary research meetings with strong emphasis on statistical and epidemiological methods.

Introduction: 

Professor Austin Stack is Foundation Chair of Medicine at the School of Medicine and Consultant Nephrologist at University Hospital Limerick, Ireland. He is the Director Designate of the Health Research Institute (HRI) at the University of Limerick. His responsibilities and interests span the clinical, educational and research landscapes. Professor Stack’s clinical interests include the care of patients with chronic kidney disease, acute kidney injury, dialysis, haemodialysis therapies, peritoneal dialysis therapies, and kidney transplantation.

Academic Qualifications: 

MBBCH BAO University College Dublin MRCPI Royal College of Physicians in Ireland MSc University of Michigan Rackham School of Public Health MD University College Dublin

Professional Experience: 

1998 Lecturer in Medicine University of Michigan

2002 Assistant Professor University of Texas Medical School Houston

2007 Associate Professor of Medicine University of Texas Medical School Houston

2008 Project Clinical Director National Kidney Disease Information System HSE

2012 Chair and Professor of Medicine University of Limerick

2015 Director Designate Health Research Institute, University of Limerick

Professional Memberships: 

European Renal Association

American Society of Nephrology

International Society of Nephrology

American Heart Association

Irish Nephrology Society

Research Interests: 

Professor Stack’s research focus on a) complications and treatment strategies for chronic kidney disease (CKD) and end-stage renal disease (ESRD); b) acute kidney injury (AKI); c) cardiovascular disease and cardiovascular risk assessment; d) iron deficiency and anaemia in CKD and links with cardiovascular disease; e) gout and hyperuricaemia; f) risk prediction models, and the application of IT systems in clinical and epidemiological research.

Professor Stack is leading an initiative to establish Ireland’s first National Surveillance System for Kidney Disease. He is also principal investigator for several large-scale observational studies, including two Health Research Board (HRB)-funded studies to assess the burden and progression of Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in the Irish health system. He is a co-investigator in the US Centers for Disease Control and Prevention (CDC)-funded CKD surveillance programme.

Publication Record: 

2015

Elsayed, M. E. and Stack, A. G. (2015) 'What are the Consequences of Volume Expansion in Chronic Dialysis Patients?: Pulmonary Manifestations of Volume Expansion', Semin Dial, 28(3), 235-9.

Healy, D. A., Feeley, I., Keogh, C. J., Scanlon, T. G., Hodnett, P. A., Stack, A. G., Clarke Moloney, M., Whittaker, P. and Walsh, S. R. (2015) 'Remote ischemic conditioning and renal function after contrast-enhanced CT scan: A randomized trial', Clin Invest Med, 38(3), E110-8.

 

2014

Hatzell, M. C., Raju, M., Watson, V. J., Stack, A. G., van Duin, A. C. and Logan, B. E. (2014) 'Effect of strong acid functional groups on electrode rise potential in capacitive mixing by double layer expansion', Environ Sci Technol, 48(23), 14041-8.

Stack, A. G., Casserly, L. F., Cronin, C. J., Chernenko, T., Cullen, W., Hannigan, A., Saran, R., Johnson, H., Browne, G. and Ferguson, J. P. (2014a) 'Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme', BMC Nephrol, 15, 185.

Stack, A. G., Donigiewicz, U., Abdalla, A. A., Weiland, A., Casserly, L. F., Cronin, C. J., Nguyen, H. T. and Hannigan, A. (2014b) 'Plasma fibrinogen associates independently with total and cardiovascular mortality among subjects with normal and reduced kidney function in the general population', Qjm, 107(9), 701-13.

Stack, A. G., Fernandez-Martinez, A., Allard, L. F., Banuelos, J. L., Rother, G., Anovitz, L. M., Cole, D. R. and Waychunas, G. A. (2014c) 'Pore-size-dependent calcium carbonate precipitation controlled by surface chemistry', Environ Sci Technol, 48(11), 6177-83.

Stack, A. G., Mohamed, W. and Elsayed, M. (2014d) 'Transferrin saturation ratio: a method to estimate risk of cardiovascular mortality in the general population?', Biomark Med, 8(7), 913-5.

Stack, A. G., Mutwali, A. I., Nguyen, H. T., Cronin, C. J., Casserly, L. F. and Ferguson, J. (2014e) 'Transferrin saturation ratio and risk of total and cardiovascular mortality in the general population', Qjm, 107(8), 623-33.

 

2013

Bracco, J. N., Stack, A. G. and Steefel, C. I. (2013) 'Upscaling calcite growth rates from the mesoscale to the macroscale', Environ Sci Technol, 47(13), 7555-62.

Qin, L., Zhang, W., Lu, J., Stack, A. G. and Wang, L. (2013) 'Direct imaging of nanoscale dissolution of dicalcium phosphate dihydrate by an organic ligand: concentration matters', Environ Sci Technol, 47(23), 13365-74.

Rother, G., Ilton, E. S., Wallacher, D., Haubeta, T., Schaef, H. T., Qafoku, O., Rosso, K. M., Felmy, A. R., Krukowski, E. G., Stack, A. G., Grimm, N. and Bodnar, R. J. (2013) 'CO2 sorption to subsingle hydration layer montmorillonite clay studied by excess sorption and neutron diffraction measurements', Environ Sci Technol,47(1), 205-11.

Stack, A. G. and Casserly, L. F. (2013) 'Pulmonary congestion in hemodialysis: an old chestnut worth screening for?', Clin J Am Soc Nephrol, 8(8), 1279-81.

Stack, A. G., Hanley, A., Casserly, L. F., Cronin, C. J., Abdalla, A. A., Kiernan, T. J., Murthy, B. V., Hegarty, A., Hannigan, A. and Nguyen, H. T. (2013a) 'Independent and conjoint associations of gout and hyperuricaemia with total and cardiovascular mortality', Qjm, 106(7), 647-58.

Stack, A. G., Neylon, A. M., Abdalla, A. A., Hegarty, A., Hannigan, A., Cronin, C. J., Nguyen, H. T. and Casserly, L. F. (2013b) 'Declining mortality rates despite increases in clinical coronary artery disease among US dialysis patients: a national registry study', Am J Nephrol, 38(1), 66-74.

 

2012

Kent, B. D., Eltayeb, E. E., Woodman, A., Mutwali, A., Nguyen, H. T. and Stack, A. G. (2012) 'The impact of chronic obstructive pulmonary disease and smoking on mortality and kidney transplantation in end-stage kidney disease', Am J Nephrol,36(3), 287-95.

Stack, A. G., Raiteri, P. and Gale, J. D. (2012) 'Accurate rates of the complex mechanisms for growth and dissolution of minerals using a combination of rare-event theories', J Am Chem Soc, 134(1), 11-4.

 

2011

Stack, A. G., Mohammed, A., Hanley, A., Mutwali, A. and Nguyen, H. (2011) 'Survival trends of US dialysis patients with heart failure: 1995 to 2005', Clin J Am Soc Nephrol, 6(8), 1982-9.

Zhang, W., Stack, A. G. and Chen, Y. (2011) 'Interaction force measurement between E. coli cells and nanoparticles immobilized surfaces by using AFM', Colloids Surf B Biointerfaces, 82(2), 316-24.

 

2010

Stack, A. G. and Murthy, B. V. (2010) 'Cigarette use and cardiovascular risk in chronic kidney disease: an unappreciated modifiable lifestyle risk factor', Semin Dial, 23(3), 298-305.

Zhang, M., Ginn, B. R., Dichristina, T. J. and Stack, A. G. (2010) 'Adhesion of Shewanella oneidensis MR-1 to iron (Oxy)(Hydr)oxides: microcolony formation and isotherm', Environ Sci Technol, 44(5), 1602-9.

 

2008

Gilbert, T., Duddy, M., O'Shea, L. A. and Stack, A. G. (2008) 'A diabetic male with acute renal failure: a cautionary tale', CPD Clinical Biochem, 9(2), 61-62.

Stack, A. G. and Murthy, B. (2008) 'Exercise and limitations in physical activity levels among new dialysis patients in the United States: an epidemiologic study', Ann Epidemiol, 18(12), 880-8.

 

2006

Nguyen, H. T. and Stack, A. G. (2006) 'Ethnic disparities in cardiovascular risk factors and coronary disease prevalence among individuals with chronic kidney disease: findings from the Third National Health and Nutrition Examination Survey', J Am Soc Nephrol, 17(6), 1716-23.

Rustad, J. R. and Stack, A. G. (2006) 'Molecular dynamics calculation of the activation volume for water exchange on Li+', J Am Chem Soc, 128(46), 14778-9.

 

2005

Murthy, B. V., Molony, D. A. and Stack, A. G. (2005) 'Survival advantage of Hispanic patients initiating dialysis in the United States is modified by race', J Am Soc Nephrol, 16(3), 782-90.

Stack, A. G. (2005) 'Coronary artery disease and peripheral vascular disease in chronic kidney disease: an epidemiological perspective', Cardiol Clin, 23(3), 285-98.

Stack, A. G. and Martin, D. R. (2005) 'Association of patient autonomy with increased transplantation and survival among new dialysis patients in the United States', Am J Kidney Dis, 45(4), 730-42.

Stack, A. G., Molony, D. A., Rives, T., Tyson, J. and Murthy, B. V. (2005a) 'Association of physical activity with mortality in the US dialysis population', Am J Kidney Dis, 45(4), 690-701.

Stack, A. G., Rustad, J. R. and Casey, W. H. (2005b) 'Modeling water exchange on an aluminum polyoxocation', J Phys Chem B, 109(50), 23771-5.

 

2004

Stack, A. G., Eggleston, C. M. and Engelhard, M. H. (2004a) 'Reaction of hydroquinone with hematite; I. Study of adsorption by electrochemical-scanning tunneling microscopy and X-ray photoelectron spectroscopy', J Colloid Interface Sci, 274(2), 433-41.

Stack, A. G., Erni, R., Browning, N. D. and Casey, W. H. (2004b) 'Pyromorphite growth on lead-sulfide surfaces', Environ Sci Technol, 38(21), 5529-34.

Stack, A. G., Murthy, B. V. and Molony, D. A. (2004c) 'Survival differences between peritoneal dialysis and hemodialysis among "large" ESRD patients in the United States', Kidney Int, 65(6), 2398-408.

Stack, A. G., Rosso, K. M., Smith, D. M. and Eggleston, C. M. (2004d) 'Reaction of hydroquinone with hematite; II. Calculated electron-transfer rates and comparison to the reductive dissolution rate', J Colloid Interface Sci, 274(2), 442-50.

Stack, A. G., Serna, H., Ramsanahie, A. and Henry, C. (2004e) 'Determinants and prognostic importance of cardiomegaly among new ESRD patients in the United States', Ann Epidemiol, 14(9), 676-85.

 

2003

Ganesh, S. K., Hulbert-Shearon, T., Port, F. K., Eagle, K. and Stack, A. G. (2003) 'Mortality differences by dialysis modality among incident ESRD patients with and without coronary artery disease', J Am Soc Nephrol, 14(2), 415-24.

Stack, A. G. (2003) 'Impact of timing of nephrology referral and pre-ESRD care on mortality risk among new ESRD patients in the United States', Am J Kidney Dis, 41(2), 310-8.

Stack, A. G., Molony, D. A., Rahman, N. S., Dosekun, A. and Murthy, B. (2003) 'Impact of dialysis modality on survival of new ESRD patients with congestive heart failure in the United States', Kidney Int, 64(3), 1071-9.

 

2002

Okechukwu, C. N., Lopes, A. A., Stack, A. G., Feng, S., Wolfe, R. A. and Port, F. K. (2002) 'Impact of years of dialysis therapy on mortality risk and the characteristics of longer term dialysis survivors', Am J Kidney Dis, 39(3), 533-8.

Stack, A. G. (2002) 'Determinants of modality selection among incident US dialysis patients: results from a national study', J Am Soc Nephrol, 13(5), 1279-87.

Stack, A. G. and Saran, R. (2002) 'Clinical correlates and mortality impact of left ventricular hypertrophy among new ESRD patients in the United States', Am J Kidney Dis, 40(6), 1202-10.

 

2001

Ganesh, S. K., Stack, A. G., Levin, N. W., Hulbert-Shearon, T. and Port, F. K. (2001) 'Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients', J Am Soc Nephrol, 12(10), 2131-8.

Saran, R., Goel, S., Stack, A., Prowant, B., Moore, H., Nolph, K. D. and Khanna, R. (2001) 'Serum insulin-like growth factor I levels do not correlate with residual renal function in dialysis patients', Perit Dial Int, 21(5), 522-5.

Stack, A. G. and Bloembergen, W. E. (2001a) 'A cross-sectional study of the prevalence and clinical correlates of congestive heart failure among incident US dialysis patients', Am J Kidney Dis, 38(5), 992-1000.

Stack, A. G. and Bloembergen, W. E. (2001b) 'Prevalence and clinical correlates of coronary artery disease among new dialysis patients in the United States: a cross-sectional study', J Am Soc Nephrol, 12(7), 1516-23.

 

2000

Stack, A., Campbell, E., Browne, O., Saran, R., Dorman, T. and Donohoe, J. (2000) 'Prevalence and predictors of recurrent IgA nephropathy following renal transplantation', Ir J Med Sci, 169(4), 248-52.

Stack, A. G. and Messana, J. M. (2000) 'Renal replacement therapy in the elderly: medical, ethical, and psychosocial considerations', Adv Ren Replace Ther, 7(1), 52-62.

 

Conference Presentations

Elsayed, M. E., McCarthy, E., O Hare, J., Ferguson, J. and Stack, A. (2015) 'Relationship between glycosylated haemoglobin and death among diabetic patients undergoing dialysis: a national study', in EDTA-ERA, London, May,

Elsayed, M. E., Hickey, A., Sharif, M., Ferguson, J. and Stack, A. (2014) 'Association of substance abuse with mortality and kidney transplantation among new dialysis patients', in EDTA-ERA, London, May,

Ferguson, J. P., Elsayed, M. and Stack, A. G. (2015) 'Long term consequences of transient Acute Kidney Injury on risk of death and kidney failure in the Irish health system', in EDTA-ERA, London, May,

Stack, A., Elsayed, M., Sharif, M., Moloney, M. and Ferguson, J. (2015) 'Risk of ischaemic stroke for incident patients treated with peritoneal dialysis versus haemodialysis', in EDTA-ERA, London, May,

Research/Fellowship Awards: 

2013 Irish Heart Foundation Bursary

2008 European Health Care Award 2008: Cooperating and Working together (CAWT) Cross-Border Renal Project CAWT

2004 Patrick Meenan Medal in Medicine, Annual Scientific Meeting of the Medical Graduates UCD, Conway Institute, Ireland

2003 Sandra Daugherty Award for Excellence in Cardiovascular Disease and Epidemiology, American Heart Association

2003 National Scientist Development Award, American Heart Association, United States

Higher Degree Supervision: 

Professor Stack and the UL Kidney Research Consortium offer opportunities to prospective nephrology trainees, medical students and interested researchers to participate in research projects. All trainees have the opportunity to undertake MD or PhD programmes under his supervision. Candidates will benefit from weekly interdisciplinary research meetings with strong emphasis on statistical and epidemiological methods.