The tumour microenvironment has emerged as a major determinant of tumour progression and patient response to therapy. Our work is revealing new insights into the complexity of tumour microenvironments and helping us to improve therapies for patients
Our cells are constantly subjected to both endogenous and exogenous agents which can directly (or indirectly) cause DNA damage and alter genomic integrity (including both genetic and epigenetic changes). A fundamental hallmark of cancer is genomic instability, which is both a cause and a consequence of the molecular evolution driving tumourigenesis.
Focusing expertise on the measurement and determinants of diet and exercise to develop interventions to improve health and quality of life in people with cancer and cancer survivors. The team utilises its expertise in muscle biology and lipid metabolism to study the underlying mechanisms which link exercise and diet to cancer growth and cancer survivorship
Infection-associated malignancies account for significant cancer-related morbidity and mortality across the world. This theme addresses the biology of several oncogenic viruses and is developing new ways to combat them.
Blood cancers are a major clinical theme within the Limerick DCRC with expertise in the study of the malignant lymphoma and the leukaemias