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Dr Patrick Kiely

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Dr Pat Kiely is Senior Lecturer in Molecular Sciences and Principal Investigator of the Laboratory of Cellular and Molecular Biology in the Graduate Entry Medical School, University of Limerick. He is a member of the Health Research Institute, the Bernal Institute and a member of the 4i Centre for Interventions in Infection, Inflammation and Immunology (University of Limerick). The research emphasis in Dr Kiely’s laboratory is on deciphering the localized and transient signalling events which occur in cells during migration. To help achieve their goals, his group works closely with several research groups and clinicians, and are using a series of complimentary and synergistic cellular and molecular approaches and novel technologies to investigate how protein complexes are assembled in signalling pathways. His group have a specific interest in defining the signalling pathways regulating cell migration in colon cancer and in understanding how the extracellular matrix contributes to the development and progression of cancer.

Publications

Kiernan MG, Coffey JC, McDermott K, Cotter PD, Cabrera-Rubio R, Kiely PA, Dunne CP. The Human Mesenteric Lymph Node Microbiome Differentiates Between Crohn’s Disease and Ulcerative Colitis. Journal of Crohn's and Colitis. 2018; jjy136. https://doi.org/10.1093/ecco-jcc/jjy136

Collins CM, Malacrida B, Burke C, Kiely PA, Dunleavy EM. ATP synthase F1 subunits recruited to centromeres by CENP-A are required for male meiosis. Nat Commun. 2018;9(1):2702. DOI: 10.1038/s41467-018-05093-9.   https://www.ncbi.nlm.nih.gov/pubmed/30006572

Carson BP, Patel B, Amigo‐Benavent M, Pauk M, Gujulla SK, Murphy SM, Kiely PA, Jakeman, PM. et al. Regulation of muscle protein synthesis in an in vitro cell model using ex vivo human serum. Exp Physiol. 2018;103:783–789. https://doi.org/10.1113/EP086860

Dowling CM, Hayes SL, Phelan JJ, Cathcart MC, Finn SP, Mehigan B, McCormick P, Coffey JC, O’Sullivan J, Kiely, PA.. Expression of protein kinase C gamma promotes cell migration in colon cancer. Oncotarget. 2017;8(42):72096-72107. DOI:10.18632/oncotarget.18916.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641114/

Hayes S, Malacrida B, Kiely M, Kiely PA. Studying protein–protein interactions: progress, pitfalls and solutions. Biochemical Society Transactions. 2016; 44 (4): 994-1104. DOI: 10.1042/BST20160092. http://www.biochemsoctrans.org/content/44/4/994.long