Dr Alexandros Tsoupras is a Lecturer in Food Sciences at the Department of Biological Sciences (Faculty: Science and Engineering) in the University of Limerick. His research lies on the health benefits of dietary interventions and of bioactive ingredients from foods and food-related sustainable natural sources, including food by-products, as well as of food-supplements, nutraceuticals and drugs against inflammation-related chronic disorders (Cardiovascular Diseases, Renal Disorders, Neurodegenerative Disorders, Persistent Infections, allergy, Cancer and metastatic procedures, etc.).
Alexandros has developed novel bioanalytical methods for isolating food bioactives and for food-omics, as well as novel bioassays for evaluating the health benefits of food bioactives, food supplements, nutraceuticals and drugs against inflammation and related disorders. He has also participated in several peer-reviewed research outputs within the areas of Food Science & Health, some of which have been awarded (60 outputs with h-index 16, including articles, books/book-chapters, invention disclosures), and in several conferences.
His current research projects include:
- Isolation of bioactives from natural sources (foods, food by-products, marine sources, fermented products, medicinal plants, microorganisms of food-biotechnological interest, etc.) and evaluation of their anti-inflammatory properties and structure-activity-relationships, in vitro in cell models and ex vivo/in vivo in trials/interventions
- Utilization of such anti-inflammatory food-bioactives from sustainable sources and valorization of food by-products for the development of novel nutraceuticals and bio-functional foods for reducing the risk of the aforementioned inflammation-related chronic disorders.
Tsoupras A, Moran D, Pleskach H, Durkin M, Traas C, Zabetakis I. Beneficial Anti-Platelet and Anti-Inflammatory Properties of Irish Apple Juice and Cider Bioactives. Foods. 2021 Feb 12;10(2):412. doi: 10.3390/foods10020412. https://doi.org/10.3390/foods10020412
Tsoupras A, Lordan R, Shiels K, Saha SK, Nasopoulou C, Zabetakis I. In Vitro Antithrombotic Properties of Salmon (Salmo salar) Phospholipids in a Novel Food-Grade Extract. Mar Drugs. 2019 Jan 18;17(1). (awarded as one of the most cited articles of this journal). DOI: 10.3390/md17010062. https://doi.org/10.3390/md17010062
Tsoupras A, Lordan R, Zabetakis I. Inflammation, not Cholesterol, Is a Cause of Chronic Disease. Nutrients. 2018; 10(5):604. (awarded as one of the best articles published in this journal). DOI: 10.3390/nu10050604. https://doi.org/10.3390/nu10050604
Tsoupras AB, Iatrou C, Frangia C, Demopoulos CA. The implication of platelet activating factor in cancer growth and metastasis: potent beneficial role of PAF-inhibitors and antioxidants. Infect Disord Drug Targets. 2009 Aug;9(4):390-9. DOI: 10.2174/187152609788922555. https://doi.org/10.2174/187152609788922555.
Tsoupras AB, Fragopoulou E, Nomikos T, Iatrou C, Antonopoulou S, Demopoulos CA. Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells. Mediators Inflamm. 2007;2007:27683. doi: 10.1155/2007/27683. https://doi.org/10.1155/2007/27683