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Lunch & Learn Seminar Series - Wednesday, 9 December at 1.00pm - Dr Elizabeth Ryan, HRI & Bernal Institute

Wed, 09 Dec 2020

Date: Wednesday, December 9, 2020
Time: 1.00pm to
Location: via MS Teams, Ireland





This Seminar Series is organised by BD’s Research Centre Ireland (RCI), UL Cancer Network, the Bernal Institute Biomaterials Cluster and the Health Research Institute.


Dr Elizabeth Ryan

Department of Biological Sciences and Health Research Institute & Bernal Institute, University of Limerick



Understanding Myeloid Cell Subset Distribution and Activation State in Tissues



Wednesday, 9 December at 1.00pm

(via MS Teams, Link given below)




“All immunologists have a favourite cell, mine is the dendritic cell. These cells reside in our tissue and act as the sentinels of the immune response, detecting invaders and coordinating the appropriate immune response. I have studied these cells in lung, liver and colon, in both health and disease. Knowing how to activate these cells is important for the development of good vaccines. Knowing how to switch them off is required to treat autoimmune disease.”

During this seminar, Dr Ryan will introduce human myeloid cells and discuss their role in human health focusing on inflammatory bowel disease and colorectal cancer. Tracking myeloid cell subset distribution and activation state may provide an avenue for prognostic and predictive biomarkers to enable precision medicine for these conditions. Many factors contribute to immune cell recruitment into tissue and key chemotactic pathways will be discussed during this seminar. In addition, the activation state of mucosal immune cells depends on external factors such as oxygen levels and nutrient availability. By the end of the seminar, Dr Ryan hopes that the audience will begin to understand why she has studied Dendritic Cells for 20 years and hopes to study them for another 20!



For her PhD, Elizabeth studied the mucosal delivery of vaccines with Professor Kingston Mills (studentship from Novartis Vaccines, Siena); and completed postdoctoral training at the University of Washington, Liver Transplant Centre at St. Vincent’s Hospital in Dublin, a Marie Curie Fellowship in Sanofi-Pasteur and she was a Senior Research Scientist at the Centre for Colorectal Disease, St. Vincent’s Hospital & UCD (2011-2018). Elizabeth joined UL in September 2018 to develop the BSc Bioscience programme and to continue her study on how to successfully manipulate the human immune response.


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BD is a leading global medical technology company with more than 70,000 employees worldwide. Since 1964, BD has invested significantly in creating Irish jobs and now employs more than 1300 highly skilled workers in Drogheda, Dun Laoghaire, Enniscorthy and Limerick. Building on this long history of success in Ireland, BD established Research Centre Ireland (RCI) Limerick in February 2017 as a global research & development hub located in Castletroy, Limerick.

RCI is a new state-of-the-art facility adjacent to the beautiful University of Limerick campus. RCI develop innovative technologies to improve biomedical discovery, clinical diagnosis of disease, and the delivery of care for patients and health care workers. It currently employs 200 experts in software development, software testing, systems engineering, mechanical and electronic engineering, project management, quality and biosciences including immunology. The diverse, collaborative team brings together people from 27 countries working in multidisciplinary teams to solve problems and advance the world of health.