PhD Scholarship in Cancer Sciences - B cell malignancies
The contribution of the oncogenic Epstein-Barr virus to the pathogenesis of B cell malignancies.
An appropriate Masters Degree or Primary Degree Level (first class hons or 2.1 hons) in a relevant discipline.
A CV, University transcripts, 2 academic references and a letter of application indicating why you think your skills and experience meet the requirement for the project. For Further Details, please contact via email Professor Paul Murray email@example.com
The majority of B cell malignancies arise within the germinal centre, a stage of B cell differentiation associated with significant genetic instability. The Epstein-Barr virus (EBV) is a human herpesvirus that can colonise germinal centre B cells as part of its natural life cycle in the asymptomatic host. However, EBV is associated with the development of germinal centre derived B cell malignancies.
This project seeks to unravel the contribution of EBV and its latent genes to the pathogenesis of germinal centre derived tumours using new models of disease to understand how EBV co-operates with other cellular mutations. There will be opportunities for study in other laboratories abroad as part of this studentship, including research groups at the University of Birmingham and the University of Cambridge.
For further reading see:
Young LS, Yap LF Murray PG. Nat Rev Cancer 2016 12: 789-802
Shannon-Lowe et al Philos Trans R Soc Lond B Biol Sci 2017 372:1732