Dr Brian Carson is an Exercise Physiologist in the Physical Education and Sport Sciences department at the University of Limerick. Brian's research interests are primarily focussed on the plasticity and metabolic adaptation of skeletal muscle in response to exercise and how this can be modified through interaction with nutrition. Brian’s current research projects are investigating the association between physical activity behaviours and metabolic health with a specific focus on how exercise regulates metabolic flexibility on a whole body level. Therefore, the regulation of whole body metabolism by skeletal muscle contraction and myokine release is of specific interest. In collaboration with a number of PIs at UL, Brian currently receives funding from the Food for Health Ireland 2 (FHI2) programme to investigate the efficacy of nutrient supplementation with proteins mined from milk to provide metabolic outcomes which support Healthy Ageing and Performance Nutrition (HAPN).
Carson B.P., Egan B. (2015) Comment on CrossTalk Debate 19. Motion to dismiss: Insufficient evidence to mount a case against protein synthesis as the dominant mechanism causing disuse muscle atrophy in the elderly. Journal of Physiology 592, s8. http://onlinelibrary.wiley.com/store/10.1113/jphysiol.2014.284406/asset/supinfo/tjp6414-sup-0001-SupInfo1.pdf?v=1&s=1ceaf0535dd8a638a38cfd2e4651918e786e85f4
Carson, B.P., Del Bas, J.M., Moreno-Navarrete, J.M., Fernandez-Real, J.M., & Mora, S. (2013). The Rab11 Effector Protein FIP1 Regulates Adiponectin Trafficking and Secretion. PLoS ONE. 8 (9) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0074687
Xu, X., Gopalacharyulu, P., Seppänen-Laakso, T., Ruskeepää, A.L., Aye, C.C., Carson, B.P., Mora, S., Orešič, M., Teleman, A.A. (2011). ‘Insulin Signaling Regulates Fatty Acid Catabolism at the Level of CoA Activation’. PLoS Genetics. 8(1):e1002478. http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002478
Egan, B., Carson, B.P., Garcia-Roves, P.M., Sarsfield, F.M., Chibalin, A.V., Monedero, J., O'Connor, P., Moyna, N.M., McCaffrey, N., Zierath, J.R., O'Gorman, D.J. (2010). ‘Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle’. Journal of Physiology 588(Pt 10),1779-90 http://jp.physoc.org/content/588/10/1779.long
Harrison, M., O'Gorman, D.J., McCaffrey, N., Hamilton, M.T., Zderic, T.W., Carson, B.P., Moyna, N.M. (2009). ‘Influence of acute exercise with and without carbohydrate replacement on postprandial lipid metabolism’. Journal of Applied Physiology 106(3), 943 http://jap.physiology.org/content/106/3/943.long