Professor Miguel Oliveira University of Minho Portugal
Biomaterials and Tissue Regeneration: What has been achieved and what’s next
Personalised medicine demands novel tissue engineered implants/products and approaches that not only can foster tissue regeneration but importantly allow ease of integration with patient anatomy at multi-scales. Bioprinting technology may help address this increasing demand. Advances in the field are still limited by the scarce numbers of biocompatible biomaterials and bioinks that can resemble the native extracellular matrix of different tissues.
This lecture will give an overview of our recent reports related to the development of advanced biomaterials of natural-origin and will also provide a personal perspective on the future directions of the field. We recently proposed gellan gum, silk fibroin and silk fibroin/elastin hydrogels and bioinks (e.g. ionic-, photo- and enzymatically crosslinked) for tissue engineering and 3D printing of personalised implants. It was possible to reverse engineer different musculoskeletal tissues (e.g. meniscus and IVD) by means of using both a fast setting enzymatic-crosslinked silk fibroin-based and gellan gum-based bioinks.
Our work showed that the natural-origin bioinks and bioprinted implants are biocompatible and possess memory-shape properties. In addition, we were able to functionalise these bioinks for imaging purposes, i.e., that can be detected under Mn-MRI. In summary, we aim to develop a novel class of multimodal biomaterials and bioinks that can open new possibilities in tissue engineering, imaging and personalised medicine.
About the Presenter
J. Miguel Oliveira BSc, PhD is a Principal Investigator “Investigador FCT 2012 and Investigador FCT 2015” at the PT Government Associate Laboratory ICVS/3B’s. (http://www.3bs.uminho.pt/users/migueloliveira). He is the Director of Pre-Clinical Research at the FIFA MEDICAL CENTER, Estádio do Dragão, Porto, PT since February 2013 and Pro-Director of the 3B’s Institute, University of Minho, PT. Currently, he is a Lecturer in the Doctoral Program in Tissue Engineering, Regenerative Medicine and Stem Cells (TERM&SC) at University of Minho, PT (since December 2013). He is also an Invited lecturer at the Faculty of Medicine, University of Porto (since September 2013) and Dept. of Polymer Eng., UM, PT (2009-present).
He has focused his work on the field of biomaterials for tissue engineering, nanomedicine, stem cells and cell/drug delivery. More recently, he set-up a new research line within the ICVS/3B’s on 3D in vitro models for cancer research. As result of his proficiency, he has published so far more than 250 scientific contributions in refereed scientific journals, 6 of those being invited review papers. One of his works, on cartilage regeneration, is amongst the top 50 globally for citations in the field. Miguel Oliveira has 16 patents approved, published 5 books, 2 special issues in scientific journals, and more than 70 book chapters in books with international circulation. He has participated in more than 250 communications in national/international conferences and has been invited/keynote speaker in more than 40 plenary sessions. He has an h-index of 34, i10 of 78 and has received more than 4800 citations. He has been awarded several prizes including the prestigious Jean Leray Award 2015 from the European Society for Biomaterials for Young Scientists for Outstanding Contributions within the field of Biomaterials.
He is very active on the elaboration and scientific coordination of several PT and international funded projects. At present, he is the PI or scientist responsible for grants totalling ~3.2 M€, but he has been involved in the preparation of other PT and EC funded projects at UMINHO (e.g. Infrastructure, Equipment’s, Promotion of Series of Events in TERM field and Human resources) totalling ~25 M€. In addition, he is member of the advisory /editorial board of the Journal Bio-Design and Manufacturing, Journal of Materials Science: Materials in Medicine, International Journal of Tissue Engineering, Journal ISRN Biomaterials, The Journal of Experimental Orthopaedics, Journal “Recent Patents on Corrosion Science”, and referee for more than 40 international journals.
Tea/coffee will be available at 11h45
For further information, please contact Maurice Collins