Prof. Calvin Coffey (Deputy Director)

Prof. Calvin Coffey – Deputy Director and Member of Executive Management Committee.
Professor of Surgery, Graduate Entry Medical School, University of Limerick and Consultant Surgeon, Health Services Executive.

calvin.coffey@ul.ie

Current posts/positions:
Foundation Chair of Surgery, Professor of Surgery, Graduate Entry Medical School, University of Limerick.
Deputy Director, 4i Centre for Interventions in Inflammation, Infection and Immunity.
Vice-Dean of postgraduate surgical education, RCSI, mid-western region.
Secretary of the Irish Association of Coloprotcology.
Council member, Irish Hospital Counsultant's Association.
James IV Travelling Fellow 2011/12.

Research interests and achievements:
Clinical research interests: Clinical trials, surgical technique, education related to surgical technique, colorectal cancer, laparoscopic surgery, robotic surgery, inflammatory bowel disease, ulcerative colitis, ileal pouch-anal anastomosis, the mesocolon, colorectal anatomy, Crohn's Disease, Recurrent Crohn's Disease.

Med-tech research interests: Developing devices for (1) safe enteral feeding and gastrointestinal decompression, (2) more effective transanal endoscopic microsurgery, (3) for enhancing rendition and recording of operative surgery and (5)   devices/mechanisms for automated retrieval and processing of lymph nodes from operative specimens.

Bioscience interests: Classification of colon and rectal cancer, database generation, outcome prediction, recurrent Crohn's disease, microbial ecology, Terminal Restriction Fragment Length Polymorphism(T-RFLP) analysis, 454 pyrosequencing, laser capture microscopy, development of techniques to harness the potential inherent in public gene expression repositories.

Surgery is committed to maintain a continuum of thematic research in a number of key areas. These involve multi-institutional collaborations with the department of Colorectal Surgery at the Cleveland clinic, Memorial Sloan-Kettering, Johns Hopkins, Surgery at University College Dublin, University College Galway and Anatomy at the NUIG. 

Publications

2017

Crickmer, M., Dunne, C., O'Regan, A., Coffey, J.C. and Dunne, S.S. (2017) 'Benefits of post-operative oral protein supplementation in gastrointestinal surgery patients- a systematic review of clinical trials', National Institute of Health Sciences, 7(4), 17.

Walsh, L., O'Brien, I., O'Leary, D.P., Kiely, P.A., Dunne, C., Quandamattoe, F., Dockery, P. and Coffey, J.C. (2017) 'The mesocolic hilum- An electron microscopic appraisal of anatomy', National Institute of Health Sciences, 7(4), 16.

Clancy, C., Coffey, J.C., O'Riordain, M.G. and Burke, J.P. (2017) 'A meta-analysis of the efficacy of prophylactic alpha-blockade for the prevention of urinary retention following primary unilateral inguinal hernia repair', Am J Surg, 2017/03/28

Coffey, J.C. and O’Leary, D.P. (2017) 'Defining the mesentery as an organ and what this means for understanding its roles in digestive disorders', Expert Review of Gastroenterology & Hepatology, 1-3

Coffey, J.C., Sehgal, R., Lavery, I. and Walsh, D. (2017) Mesenteric Principles of Gastrointestinal Surgery: Basic and Applied Science, 1st ed., CRC Press.

Kiernan, M.G., Sahebally, S.M., Tibbitts, P., Lyons, E.M., Kiely, P.A., O'Leary, D.P., Dunne, C.P. and Coffey, J.C. (2017) 'Faecal Diversion is Associated with a Regression of Mesenteric Disease Manifestations and a Decrease in Circulating Fibrocytes in Crohn's Disease', Gastroenterology, 152(5), S776

Zarog, M.A., Bolger, J.C., Kiernan, M.G., O'Leary, D.P., Tibbitts, P., Lowery, A.J., Byrnes, G.J. and Coffey, J.C. (2017) 'Su1799 - Circulating Fibrocytes are an Accurate Diagnostic Biomarker in Uncomplicated Appendicitis', Gastroenterology, 152(5, Supplement 1), S1258

 

2016

Chang, K. H., Johnson, J. A., Waldron, D., Condon, E. T., El-Bassiouni, M. and Coffey, J. C. (2016) 'A comparison of the usage of anal verge and dentate line in measuring distances within the rectum', International Journal of Surgery Open.

Crickmer, M., Dunne, C., O’Regan, A., Coffey, J. C. and Dunne, S. S. (2016) 'Benefits of post-operative oral protein supplementation in gastrointestinal surgery patients: A systematic review of clinical trials', World Journal Gastrointestinal Surgery.

Coffey, J. C. and O'Leary, D. P. (2016) 'The mesentery: structure, function, and role in disease', The Lancet Gastroenterology & Hepatology, 1(3), 238-247.

Coffey, J. C., O'Leary, D. P., Kiernan, M. G. and Faul, P. (2016) 'The mesentery in Crohn's disease: friend or foe?', Curr Opin Gastroenterol, 2016/04/27.

Dowling, C. M., Walsh, D., Coffey, J. C. and Kiely, P. A. (2016) 'The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue [version 1; referees: 1 approved]', 5(99). 

Dowling, C. M., Phelan, J., Callender, J. A., Cathcart, M. C., Mehigan, B., McCormick, P., Dalton, T., Coffey, J. C., Newton, A. C., O’Sullivan, J. and Kiely, P. A. (2016) Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.

O’Connor, C., Cormican, M., Boo, T. W., McGrath, E., Slevin, B., O’Gorman, A., Commane, M., Mahony, S., O’Donovan, E., Powell, J., Monahan, R., Finnegan, C., Kiernan, M. G., Coffey, J. C., Power, L., O’Connell, N. H. and Dunne, C. P. (2016) 'An Irish outbreak of New Delhi metallo-β-lactamase (NDM)-1 carbapenemase-producing Enterobacteriaceae: increasing but unrecognised prevalence', Journal of Hospital Infection.

Walsh, L. G., Kenny, B. J., El Bassiouni, M. and Coffey, J. C. (2016) 'Cancer arising from the remnant mucosa of the ileoanal anastomosis leading to pouchectomy', BMJ Case Rep, 2016.

2015

Chang, K. H., Kelly, N. P., Duff, G. P., Condon, E. T., Waldron, D. and Coffey, J. C. (2015) 'Neoadjuvant therapy does not affect lymph node ratio in rectal cancer', Surgeon.

Coffey, J. C., Culligan, K., Walsh, L. G., Sehgal, R., Dunne, C., McGrath, D., Walsh, D., Moore, M., Staunton, M., Scanlon, T., Dewhurst, C., Kenny, B., O'Riordan, C., O'Brien, J. M., Quondamatteo, F. and Dockery, P. (2015) 'An appraisal of the computed axial tomographic appearance of the human mesentery based on mesenteric contiguity from the duodenojejunal flexure to the mesorectal level', Eur Radiol.

Coffey, J. C., Dillon, M., Sehgal, R., Dockery, P., Quondamatteo, F., Walsh, D. and Walsh, L. (2015) 'Mesenteric-Based Surgery Exploits Gastrointestinal, Peritoneal, Mesenteric and Fascial Continuity from Duodenojejunal Flexure to the Anorectal Junction - A Review', Dig Surg, 32(4), 291-300.

Coffey, J. C., Dillon, M. F., O'Driscoll, J. S. and Faul, E. (2015) 'Transanal total mesocolic excision (taTME) as part of ileoanal pouch formation in ulcerative colitis-first report of a case', Int J Colorectal Dis.

Hogan, J., Chang, K. H., Duff, G., Samaha, G., Kelly, N., Burton, M., Burton, E. and Coffey, J. C. (2015) 'Lymphovascular invasion: a comprehensive appraisal in colon and rectal adenocarcinoma', Dis Colon Rectum, 58(6), 547-55.

Hogan, J., DeJulius, K., Li, X., Coffey, J. C. and Kalady, M. F. (2015) 'Transcriptional profiles underpin microsatellite status and associated features in colon cancer', Gene.

Hogan, J., Dejulius, K., Liu, X., Coffey, J. C. and Kalady, M. F. (2015) 'Transcriptomic profiles differentiate normal rectal epithelium and adenocarcinoma', Int Surg, 100(5), 818-826.

Hogan, J., Samaha, G., Burke, J., Chang, K. H., Condon, E., Waldron, D. and Coffey, J. C. (2015) 'Emergency presenting colon cancer is an independent predictor of adverse disease-free survival', Int Surg, 100(1), 77-86.

Lally, K., Nathan, V. Y., Dunne, S., McGrath, D., Cullen, W., Meagher, D., Coffey, J. C. and Dunne, C. (2015) 'Awareness of sexually transmitted infection and protection methods among university students in Ireland', Ir J Med Sci, 184(1), 135-42.

Lavelle, A., Lennon, G., O'Sullivan, O., Docherty, N., Balfe, A., Maguire, A., Mulcahy, H. E., Doherty, G., O'Donoghue, D., Hyland, J., Ross, R. P., Coffey, J. C., Sheahan, K., Cotter, P. D., Shanahan, F., Winter, D. C. and O'Connell, P. R. (2015) 'Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers', Gut.

Lawlor, A., Murphy, S. P., Rice, C., Kieswetter, L., O’Rourke, C., Fenton, J. E. and Coffey, J. C. (2015) 'What’s Dominating Surgical Research? A Review Of The Design Of All Trials Published In The Top Four Surgical Journals By Impact Factor In One Calendar Year', Ir J Med Sci, 184(Suppl 5), S127–S210 S133.

O'Connor, C., Powell, J., Finnegan, C., O'Gorman, A., Barrett, S., Hopkins, K. L., Pichon, B., Hill, R., Power, L., Woodford, N., Coffey, J. C., Kearns, A., O'Connell, N. H. and Dunne, C. (2015) 'Incidence, management and outcomes of the first cfr-mediated linezolid-resistant Staphylococcus epidermidis outbreak in a tertiary referral centre in the Republic of Ireland', J Hosp Infect

O'Sullivan, M., Kearney, D. E., Giri, S. K. and Coffey, J. C. (2015) 'Combined laparoscopic-assisted nephrectomy and complete mesocolic excision for synchronous renal and colon cancers', BMJ Case Rep, 2015.

2014

Clancy, C., Burke, J. P., Chang, K. H. and Coffey, J. C. (2014) 'The effect of hysterectomy on colonoscopy completion: a systematic review and meta-analysis', Dis Colon Rectum, 57(11), 1317-23.

Coffey, J. C., Sehgal, R., Culligan, K., Dunne, C., McGrath, D., Lawes, N. and Walsh, D. (2014) 'Terminology and nomenclature in colonic surgery: universal application of a rule-based approach derived from updates on mesenteric anatomy', Tech Coloproctol, 18(9), 789-94.

Culligan, K., Sehgal, R., Mulligan, D., Dunne, C., Walsh, S., Quondamatteo, F., Dockery, P. and Coffey, J. C. (2014) 'A detailed appraisal of mesocolic lymphangiology--an immunohistochemical and stereological analysis', J Anat, 225(4), 463-72.

Culligan, K., Walsh, S., Dunne, C., Walsh, M., Ryan, S., Quondamatteo, F., Dockery, P. and Coffey, J. C. (2014) 'The mesocolon: a histological and electron microscopic characterization of the mesenteric attachment of the colon prior to and after surgical mobilization', Ann Surg, 260(6), 1048-1056.

East, J. M., Hogan, J., Samaha, G., Medani, M., MacKerricher, W., Polinkevych, S., Walsh, S. R. and Coffey, J. C. (2014) 'Ratios derived from an array of standard haematological indices predict the oncological outcome in colon cancer', Colorectal Dis, 16(6), 442-9.

Hogan, J., Judge, C., O'Callaghan, M., Aziz, A., O'Connor, C., Burke, J., Dunne, C., Walsh, S., Kalady, M. and Coffey, J. C. (2014) 'Introducing a novel and robust technique for determining lymph node status in colorectal cancer', Ann Surg, 260(1), 94-102.

Hogan, J., O'Rourke, C., Duff, G., Burton, M., Kelly, N., Burke, J. and Coffey, J. C. (2014) 'Preoperative staging CT thorax in patients with colorectal cancer: its clinical importance', Dis Colon Rectum, 57(11), 1260-1266.

O’Connor, C., O'Connell, N., Power, L., Merrigan, A., Tormey, S., Coffey, J. C., Linnane, B. and Dunne, C. (2014) 'A case of Panton–Valentine leucocidin toxin‐positive Staphylococcus aureus‐mediated neonatal mastitis', JMM Case Reports, 3(2014), e004119.

O'Connell, N. H., O'Connor, C., O'Mahony, J., Lobo, R., Hayes, M., Masterson, E., Larvin, M., Coffey, J. C. and Dunne, C. (2014) 'A commentary on the disparate perspectives of clinical microbiologists and surgeons: Ad hoc antimicrobial use', Bioengineered, 5(4).

Sehgal, R. and Coffey, J. C. (2014) 'Comprehensive standardization of complete mesocolic surgery is now possible', Tech Coloproctol, 18(7), 675-6.

Sehgal, R. and Coffey, J. C. (2014) 'The development of consensus for complete mesocolic excision (CME) should commence with standardisation of anatomy and related terminology', Int J Colorectal Dis, 29(6), 763-4.

Sehgal, R. and Coffey, J. C. (2014) 'Historical development of mesenteric anatomy provides a universally applicable anatomic paradigm for complete/total mesocolic excision', Gastroenterol Rep (Oxf), 2(4), 245-50.

Sehgal, R. and Coffey, J. C. (2014) 'Standardization of the nomenclature based on contemporary mesocolic anatomy is paramount prior to performing a complete mesocolic excision', Int J Colorectal Dis, 29(4), 543-4.

2013

Burke, J. P., Nathan, Y., O'Connell, P. R. and Coffey, J. C. (2013) 'National trends in intestinal resection for Crohn's disease in the post-biologic era', Int J Colorectal Dis, 28(10), 1401-1406.

Chang, K. H., Burke, J. P. and Coffey, J. C. (2013) 'Infliximab versus cyclosporine as rescue therapy in acute severe steroid-refractory ulcerative colitis: a systematic review and meta-analysis', Int J Colorectal Dis, 28(3), 287-93.

Clancy, C., Burke, J. P. and Coffey, J. C. (2013) 'KRAS mutation does not predict the efficacy of neo-adjuvant chemoradiotherapy in rectal cancer: a systematic review and meta-analysis', Surg Oncol, 22(2), 105-11.

Coffey, J. C. (2013) 'Surgical anatomy and anatomic surgery - Clinical and scientific mutualism', Surgeon, 11(4), 177-82.

Culligan, K., Remzi, F. H., Soop, M. and Coffey, J. C. (2013) 'Review of nomenclature in colonic surgery--proposal of a standardised nomenclature based on mesocolic anatomy', Surgeon, 11(1), 1-5.

Duff, G. P., Chang, K. H., Peirce, C. and Coffey, J. C. (2013) 'Coexistent widespread small intestinal and colonic diverticular disease', BMJ Case Rep.

Healy, D. A., Murphy, S. P., Burke, J. P. and Coffey, J. C. (2013) 'Artificial interfaces ("AI") in surgery: historic development, current status and program implementation in the public health sector', Surg Oncol, 22(2), 77-85.

McCartan, D. P., Burke, J. P., Walsh, S. R. and Coffey, J. C. (2013) 'Purse-string approximation is superior to primary skin closure following stoma reversal: a systematic review and meta-analysis', Tech Coloproctol, 17(4), 345-51.

Medani, M., Kelly, N., Samaha, G., Duff, G., Healy, V., Mulcahy, E., Condon, E., Waldron, D., Saunders, J. and Coffey, J. C. (2013) 'An appraisal of lymph node ratio in colon and rectal cancer: not one size fits all', Int J Colorectal Dis, 28(10), 1377-1384.

O'Leary, D. P., Myers, E., Waldron, D. and Coffey, J. C. (2013) 'Beware the contracted gallbladder - Ultrasonic predictors of conversion', Surgeon, 11(4), 187-90.

Solon, J. G., Burke, J. P., Walsh, S. R. and Coffey, J. C. (2013) 'The effect of NOD2 polymorphism on postsurgical recurrence in Crohn's disease: a systematic review and meta-analysis of available literature', Inflamm Bowel Dis, 19(5), 1099-1105.

2012

Kiran, R. P., Ahmed Ali, U., Coffey, J. C., Vogel, J. D., Pokala, N. and Fazio, V. W. (2012) 'Impact of resident participation in surgical operations on postoperative outcomes: National Surgical Quality Improvement Program', Ann Surg, 256(3), 469-75.